Basic Information:

  VIRBase ID:  

HHID00062234

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-let-7a-3p:  MIMAT0004481          INTS6L:  NM_001351606     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-let-7a-3p	INTS6L
miRBase Accession/Entrez ID	MIMAT0004481	203522
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	DDX26B

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-let-7a-3p	rs1219969167 chr9:94176028    T/G rs1399588338 chr9:94176027    G/A rs1453867589 chr9:94176023    T/A rs770208205 chr9:94176022    C/T rs1265084977 chr22:46112817    T/C rs372596018 chr22:46112808    T/C rs1198423693 chr9:94176020    A/G rs748585376 chr9:94176015    A/G rs781681931 chr9:94176014    T/G rs972845958 chr9:94176013    CTA/C rs779353569 chr22:46112805    C/T rs970921980 chr22:46112807    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	INTS6L	chrX:134692797(+) A-I      intronic chrX:134694530(+) A-I      intronic chrX:134694534(+) A-I      intronic chrX:134694589(+) A-I      intronic chrX:134694512(+) A-I      intronic chrX:134694619(+) A-I      intronic chrX:134694942(+) A-I      intronic chrX:134694978(+) A-I      intronic chrX:134694988(+) A-I      intronic chrX:134695075(+) A-I      intronic chrX:134695093(+) A-I      intronic chrX:134698396(+) A-I      intronic chrX:134694513(+) A-I      intronic chrX:134698514(+) A-I      intronic chrX:134702575(+) A-I      intronic chrX:134694615(+) A-I      intronic chrX:134674857(+) A-I      intronic chrX:134698423(+) A-I      intronic chrX:134674839(+) A-I      intronic chrX:134674721(+) A-I      intronic chrX:134676280(+) A-I      intronic chrX:134698578(+) A-I      intronic chrX:134676151(+) A-I      intronic chrX:134689799(+) A-I      intronic chrX:134702693(+) A-I      intronic chrX:134692891(+) A-I      intronic chrX:134694772(+) A-I      intronic chrX:134666855(+) A-I      intronic chrX:134698443(+) A-I      intronic chrX:134688956(+) A-I      intronic chrX:134694758(+) A-I      intronic chrX:134710105(+) A-I      intronic chrX:134695043(+) A-I      intronic chrX:134657175(+) A-I      intronic chrX:134702514(+) A-I      intronic chrX:134657046(+) A-I      intronic chrX:134695088(+) A-I      intronic chrX:134676181(+) A-I      intronic chrX:134692910(+) A-I      intronic chrX:134694947(+) A-I      intronic chrX:134698510(+) A-I      intronic chrX:134676167(+) A-I      intronic chrX:134694613(+) A-I      intronic chrX:134710173(+) A-I      intronic chrX:134674942(+) A-I      intronic chrX:134695112(+) A-I      intronic chrX:134694638(+) A-I      intronic chrX:134698577(+) A-I      intronic chrX:134692930(+) A-I      intronic

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-let-7a-3p	Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Extracellular vesicle Colon cancer cell line (LIM1863)     25330373 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	INTS6L	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-let-7a-3p
Interactor2: INTS6L

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.