Basic Information:

  VIRBase ID:  

HHID00062217

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-let-7a-3p:  MIMAT0004481          ZNF257:  NM_001316998     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-let-7a-3p	ZNF257
miRBase Accession/Entrez ID	MIMAT0004481	113835
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	BMZF-4//BMZF4

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-let-7a-3p	rs1219969167 chr9:94176028    T/G rs1399588338 chr9:94176027    G/A rs1453867589 chr9:94176023    T/A rs770208205 chr9:94176022    C/T rs1265084977 chr22:46112817    T/C rs372596018 chr22:46112808    T/C rs1198423693 chr9:94176020    A/G rs748585376 chr9:94176015    A/G rs781681931 chr9:94176014    T/G rs972845958 chr9:94176013    CTA/C rs779353569 chr22:46112805    C/T rs970921980 chr22:46112807    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ZNF257	chr19:22266214(+) A-I      intronic chr19:22273119(+) A-I      3'UTR chr19:22273135(+) A-I      3'UTR chr19:22273138(+) A-I      3'UTR chr19:22236050(+) A-I      intronic chr19:22236049(+) A-I      intronic chr19:22273279(+) A-I      3'UTR chr19:22273301(+) A-I      3'UTR chr19:22266218(+) A-I      intronic chr19:22236021(+) A-I      intronic chr19:22266222(+) A-I      intronic chr19:22266223(+) A-I      intronic chr19:22273310(+) A-I      3'UTR chr19:22273321(+) A-I      3'UTR chr19:22266198(+) A-I      intronic chr19:22236047(+) A-I      intronic chr19:22266194(+) A-I      intronic chr19:22273322(+) A-I      3'UTR chr19:22236055(+) A-I      intronic chr19:22267714(+) A-I      intronic chr19:22266175(+) A-I      intronic chr19:22266154(+) A-I      intronic chr19:22266170(+) A-I      intronic chr19:22273092(+) A-I      3'UTR chr19:22273112(+) A-I      3'UTR chr19:22236513(+) A-I      intronic chr19:22236541(+) A-I      intronic chr19:22236542(+) A-I      intronic chr19:22236672(+) A-I      intronic chr19:22248128(+) A-I      intronic chr19:22259571(+) A-I      intronic chr19:22260055(+) A-I      intronic chr19:22260890(+) A-I      intronic chr19:22260893(+) A-I      intronic chr19:22260933(+) A-I      intronic chr19:22262923(+) A-I      intronic chr19:22263797(+) A-I      intronic chr19:22264362(+) A-I      intronic chr19:22264506(+) A-I      intronic chr19:22266010(+) A-I      intronic chr19:22266086(+) A-I      intronic chr19:22266114(+) A-I      intronic chr19:22266119(+) A-I      intronic chr19:22266131(+) A-I      intronic chr19:22266811(+) A-I      intronic chr19:22266822(+) A-I      intronic chr19:22267608(+) A-I      intronic chr19:22267720(+) A-I      intronic chr19:22268004(+) A-I      intronic chr19:22268105(+) A-I      intronic chr19:22236679(+) A-I      intronic chr19:22236975(+) A-I      intronic chr19:22237004(+) A-I      intronic chr19:22238710(+) A-I      intronic chr19:22239562(+) A-I      intronic chr19:22247679(+) A-I      intronic chr19:22247680(+) A-I      intronic chr19:22248079(+) A-I      intronic chr19:22247633(+) A-I      intronic chr19:22238697(+) A-I      intronic chr19:22238269(+) A-I      intronic chr19:22238068(+) A-I      intronic chr19:22237106(+) A-I      intronic chr19:22237055(+) A-I      intronic chr19:22237044(+) A-I      intronic chr19:22247733(+) A-I      intronic chr19:22248082(+) A-I      intronic chr19:22248101(+) A-I      intronic chr19:22236063(+) A-I      intronic chr19:22236076(+) A-I      intronic chr19:22236505(+) A-I      intronic chr19:22236508(+) A-I      intronic chr19:22266094(+) A-I      intronic chr19:22267972(+) A-I      intronic chr19:22261856(+) A-I      intronic chr19:22243490(+) A-I      intronic chr19:22263861(+) A-I      intronic chr19:22260109(+) A-I      intronic chr19:22261857(+) A-I      intronic chr19:22250475(+) A-I      intronic chr19:22268093(+) A-I      intronic chr19:22266057(+) A-I      intronic chr19:22237100(+) A-I      intronic chr19:22237032(+) A-I      intronic chr19:22239059(+) A-I      intronic chr19:22236906(+) A-I      intronic chr19:22267649(+) A-I      intronic chr19:22236893(+) A-I      intronic chr19:22236897(+) A-I      intronic chr19:22267980(+) A-I      intronic chr19:22247646(+) A-I      intronic chr19:22236607(+) A-I      intronic chr19:22260036(+) A-I      intronic chr19:22259863(+) A-I      intronic chr19:22259510(+) A-I      intronic chr19:22248143(+) A-I      intronic chr19:22237133(+) A-I      intronic chr19:22238032(+) A-I      intronic chr19:22262813(+) A-I      intronic chr19:22266127(+) A-I      intronic chr19:22263953(+) A-I      intronic chr19:22259764(+) A-I      intronic chr19:22266051(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ZNF257	chr19:22259860(+) A-G intron -    22484847 chr19:22259869(+) A-G intron -    22484847 chr19:22260036(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZNF257	chr19:22256340-22256341(+) m6A 3'UTR//CDS//intron       27773535 chr19:22256358-22256359(+) m6A 3'UTR//CDS//intron       27773535 chr19:22257198-22257199(+) m6A CDS//intron       27773535 chr19:22257234-22257235(+) m6A CDS//intron       27773535 chr19:22270872-22270873(+) m6A 3'UTR//CDS       27773535 chr19:22270947-22270948(+) m6A 3'UTR//CDS       27773535 chr19:22271037-22271038(+) m6A 3'UTR//CDS       27773535 chr19:22271049-22271050(+) m6A 3'UTR//CDS       27773535 chr19:22271065-22271066(+) m6A 3'UTR//CDS       27773535 chr19:22272173-22272174(+) m6A 3'UTR//CDS       27773535 chr19:22272221-22272222(+) m6A 3'UTR//CDS       27773535 chr19:22272231-22272232(+) m6A 3'UTR//CDS       27773535 chr19:22272253-22272254(+) m6A 3'UTR       27773535 chr19:22272310-22272311(+) m6A 3'UTR       27773535 chr19:22272335-22272336(+) m6A 3'UTR       27773535 chr19:22272419-22272420(+) m6A 3'UTR       27773535 chr19:22272476-22272477(+) m6A 3'UTR       27773535 chr19:22272484-22272485(+) m6A 3'UTR       27773535 chr19:22272573-22272574(+) m6A 3'UTR       27773535 chr19:22272662-22272663(+) m6A 3'UTR       27773535 chr19:22272707-22272708(+) m6A 3'UTR       27773535 chr19:22272717-22272718(+) m6A 3'UTR       27773535 chr19:22272745-22272746(+) m6A 3'UTR       27773535 chr19:22272763-22272764(+) m6A 3'UTR       27773535 chr19:22272772-22272773(+) m6A 3'UTR       27773535 chr19:22272827-22272828(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-let-7a-3p	Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Extracellular vesicle Colon cancer cell line (LIM1863)     25330373 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	ZNF257	Chromatin K562 cells     - Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-let-7a-3p
Interactor2: ZNF257

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.