Basic Information:

  VIRBase ID:  

HHID00062209

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-let-7a-3p:  MIMAT0004481          MFSD5:  NM_001170790     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-let-7a-3p	MFSD5
miRBase Accession/Entrez ID	MIMAT0004481	84975
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	hsMOT2//SLC61A1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-let-7a-3p	rs1219969167 chr9:94176028    T/G rs1399588338 chr9:94176027    G/A rs1453867589 chr9:94176023    T/A rs770208205 chr9:94176022    C/T rs1265084977 chr22:46112817    T/C rs372596018 chr22:46112808    T/C rs1198423693 chr9:94176020    A/G rs748585376 chr9:94176015    A/G rs781681931 chr9:94176014    T/G rs972845958 chr9:94176013    CTA/C rs779353569 chr22:46112805    C/T rs970921980 chr22:46112807    A/G

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MFSD5	chr12:53645114-53645115(+) m6A exon       24981863 chr12:53645496-53645497(+) m6A 5'UTR//exon       22608085 chr12:53645547-53645548(+) m6A CDS//exon       - chr12:53645556-53645557(+) m6A CDS//exon       - chr12:53645960-53645961(+) m6A 5'UTR//intron       24284625//25456834//24981863 chr12:53646039-53646040(+) m6A 5'UTR//intron       24284625//24209618//25456834//24981863 chr12:53646678-53646679(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr12:53646699-53646700(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr12:53646749-53646750(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr12:53646813-53646814(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr12:53646984-53646985(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr12:53646995-53646996(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22608085 chr12:53647151-53647152(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr12:53647280-53647281(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr12:53647292-53647293(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr12:53647321-53647322(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr12:53647355-53647356(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr12:53647429-53647430(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr12:53647442-53647443(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr12:53647732-53647733(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22608085 chr12:53647825-53647826(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr12:53647893-53647894(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr12:53647984-53647985(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr12:53647998-53647999(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr12:53648101-53648102(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr12:53648119-53648120(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr12:53648173-53648174(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-let-7a-3p	Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Extracellular vesicle Colon cancer cell line (LIM1863)     25330373 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	MFSD5	Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-let-7a-3p
Interactor2: MFSD5

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.