Basic Information:

  VIRBase ID:  

HHID00062137

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-let-7a-3p:  MIMAT0004481          NNT:  NM_001331026     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-let-7a-3p	NNT
miRBase Accession/Entrez ID	MIMAT0004481	23530
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	GCCD4

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-let-7a-3p	rs1219969167 chr9:94176028    T/G rs1399588338 chr9:94176027    G/A rs1453867589 chr9:94176023    T/A rs770208205 chr9:94176022    C/T rs1265084977 chr22:46112817    T/C rs372596018 chr22:46112808    T/C rs1198423693 chr9:94176020    A/G rs748585376 chr9:94176015    A/G rs781681931 chr9:94176014    T/G rs972845958 chr9:94176013    CTA/C rs779353569 chr22:46112805    C/T rs970921980 chr22:46112807    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	NNT	chr5:43681711(+) A-I      intronic chr5:43681619(+) A-I      intronic chr5:43681627(+) A-I      intronic chr5:43681631(+) A-I      intronic chr5:43681702(+) A-I      intronic chr5:43605524(+) A-I      intronic chr5:43681113(+) A-I      intronic chr5:43681170(+) A-I      intronic chr5:43681251(+) A-I      intronic chr5:43681287(+) A-I      intronic chr5:43605471(+) A-I      intronic chr5:43681519(+) A-I      intronic chr5:43681540(+) A-I      intronic chr5:43681580(+) A-I      intronic chr5:43604818(+) A-I      intronic chr5:43681177(+) A-I      intronic chr5:43681107(+) A-I      intronic chr5:43604886(+) A-I      intronic chr5:43681108(+) A-I      intronic chr5:43681570(+) A-I      intronic chr5:43604835(+) A-I      intronic chr5:43681160(+) A-I      intronic chr5:43681606(+) A-I      intronic chr5:43681531(+) A-I      intronic chr5:43604891(+) A-I      intronic chr5:43608313(+) A-I      intronic chr5:43681196(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	NNT	chr5:43659697(+) G-A intron -    22484847 chr5:43681107(+) A-G intron -    22484847 chr5:43681108(+) A-G intron -    22484847 chr5:43681160(+) A-G intron -    22484847 chr5:43681177(+) A-G intron -    22484847 chr5:43681196(+) A-G intron -    22484847 chr5:43681531(+) A-G intron -    22484847 chr5:43681570(+) A-G intron -    22484847 chr5:43681676(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	NNT	chr5:43602900-43602901(+) m6A 5'UTR//intron       24284625 chr5:43602912-43602913(+) m6A 5'UTR//intron       24284625 chr5:43602966-43602967(+) m6A 5'UTR//intron       24284625 chr5:43616006-43616007(+) m6A CDS       - chr5:43628321-43628322(+) Y CDS       26075521 chr5:43644411-43644412(+) m6A CDS       24981863 chr5:43644737-43644738(+) m6A CDS       24981863 chr5:43704557-43704558(+) m6A 3'UTR       24284625//24981863//22608085 chr5:43704625-43704626(+) m6A 3'UTR       24284625//24981863//22608085 chr5:43704646-43704647(+) m6A 3'UTR       24284625//24981863//22608085 chr5:43704842-43704843(+) m6A 3'UTR       22575960 chr5:43704864-43704865(+) m6A 3'UTR       22575960 chr5:43704905-43704906(+) m6A 3'UTR       22575960 chr5:43704962-43704963(+) m6A 3'UTR       22575960 chr5:43704972-43704973(+) m6A 3'UTR       22575960 chr5:43705108-43705109(+) m6A 3'UTR       24981863 chr5:43705136-43705137(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-let-7a-3p	Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Extracellular vesicle Colon cancer cell line (LIM1863)     25330373 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	NNT	Chromatin K562 cells     - Cytosol K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-let-7a-3p
Interactor2: NNT

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.