Basic Information:

  VIRBase ID:  

HHID00062039

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-let-7a-3p:  MIMAT0004481          GYG1:  NM_004130     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-let-7a-3p	GYG1
miRBase Accession/Entrez ID	MIMAT0004481	2992
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	GSD15//GYG

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-let-7a-3p	rs1219969167 chr9:94176028    T/G rs1399588338 chr9:94176027    G/A rs1453867589 chr9:94176023    T/A rs770208205 chr9:94176022    C/T rs1265084977 chr22:46112817    T/C rs372596018 chr22:46112808    T/C rs1198423693 chr9:94176020    A/G rs748585376 chr9:94176015    A/G rs781681931 chr9:94176014    T/G rs972845958 chr9:94176013    CTA/C rs779353569 chr22:46112805    C/T rs970921980 chr22:46112807    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	GYG1	chr3:148720598(+) A-I      intronic chr3:148723999(+) A-I      intronic chr3:148736656(+) A-I      intronic chr3:148736832(+) A-I      intronic chr3:148728240(+) A-I      intronic chr3:148720561(+) A-I      intronic chr3:148728243(+) A-I      intronic chr3:148721089(+) A-I      intronic chr3:148721086(+) A-I      intronic chr3:148712872(+) A-I      intronic chr3:148720574(+) A-I      intronic chr3:148720643(+) A-I      intronic chr3:148721020(+) A-I      intronic chr3:148730713(+) A-I      intronic chr3:148730745(+) A-I      intronic chr3:148730874(+) A-I      intronic chr3:148732298(+) A-I      intronic chr3:148732561(+) A-I      intronic chr3:148732625(+) A-I      intronic chr3:148736808(+) A-I      intronic chr3:148720623(+) A-I      intronic chr3:148733901(+) A-I      intronic chr3:148736701(+) A-I      intronic chr3:148736710(+) A-I      intronic chr3:148736714(+) A-I      intronic chr3:148736801(+) A-I      intronic chr3:148736806(+) A-I      intronic chr3:148736816(+) A-I      intronic chr3:148741593(+) A-I      intronic chr3:148721042(+) A-I      intronic chr3:148733795(+) A-I      intronic chr3:148721044(+) A-I      intronic chr3:148721083(+) A-I      intronic chr3:148733838(+) A-I      intronic chr3:148720737(+) A-I      intronic chr3:148720720(+) A-I      intronic chr3:148730698(+) A-I      intronic chr3:148720579(+) A-I      intronic chr3:148736606(+) A-I      intronic chr3:148720661(+) A-I      intronic chr3:148735530(+) A-I      intronic chr3:148730712(+) A-I      intronic chr3:148720750(+) A-I      intronic chr3:148720946(+) A-I      intronic chr3:148736792(+) A-I      intronic chr3:148730673(+) A-I      intronic chr3:148736627(+) A-I      intronic chr3:148726769(+) A-I      intronic chr3:148726761(+) A-I      intronic chr3:148720747(+) A-I      intronic chr3:148732349(+) A-I      intronic chr3:148741627(+) A-I      intronic chr3:148730631(+) A-I      intronic chr3:148730660(+) A-I      intronic chr3:148730868(+) A-I      intronic chr3:148732576(+) A-I      intronic chr3:148720588(+) A-I      intronic chr3:148741590(+) A-I      intronic chr3:148720647(+) A-I      intronic chr3:148720552(+) A-I      intronic chr3:148720559(+) A-I      intronic chr3:148732508(+) A-I      intronic chr3:148721137(+) A-I      intronic chr3:148741729(+) A-I      intronic chr3:148726767(+) A-I      intronic chr3:148736720(+) A-I      intronic chr3:148721163(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	GYG1	chr3:148720579(+) A-G intron -    22484847 chr3:148720588(+) A-G intron -    22484847 chr3:148720759(+) A-G intron -    22484847 chr3:148720946(+) A-G intron -    22484847 chr3:148723867(+) C-T intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	GYG1	chr3:148727163-148727164(+) Y CDS//exon//intron       26075521 chr3:148744644-148744645(+) m6A 3'UTR//CDS//exon       24981863 chr3:148744698-148744699(+) m6A 3'UTR//CDS//exon       24981863 chr3:148744722-148744723(+) m6A 3'UTR//CDS//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-let-7a-3p	Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Extracellular vesicle Colon cancer cell line (LIM1863)     25330373 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	GYG1	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-let-7a-3p
Interactor2: GYG1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.