Basic Information:

  VIRBase ID:  

HHID00061965

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-769-5p:  MIMAT0003886          CEP57:  NM_014679     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-769-5p	CEP57
miRBase Accession/Entrez ID	MIMAT0003886	9702
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	MVA2//PIG8//TSP57

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-769-5p	rs1270950121 chr19:46018982    T/C rs375088831 chr19:46018978    G/C rs760735520 chr19:46018969    C/T rs910184294 chr19:46018976    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CEP57	chr11:95562171(+) A-I      intronic chr11:95547407(+) A-I      intronic chr11:95530515(+) A-I      intronic chr11:95557325(+) A-I      intronic chr11:95558873(+) A-I      intronic chr11:95547346(+) A-I      intronic chr11:95547358(+) A-I      intronic chr11:95547310(+) A-I      intronic chr11:95557354(+) A-I      intronic chr11:95547410(+) A-I      intronic chr11:95533586(+) A-I      intronic chr11:95548871(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CEP57	chr11:95547407(+) A-G intron -    22484847 chr11:95553570(+) C-T intron -    22484847 chr11:95557354(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CEP57	chr11:95523259-95523260(+) m6A 5'UTR       24284625//27773535 chr11:95546144-95546145(+) m6A 3'UTR//CDS//exon       24981863//27773535 chr11:95546178-95546179(+) m6A 3'UTR//CDS//exon       24981863//27773535 chr11:95546193-95546194(+) m6A 3'UTR//CDS//exon       24981863//27773535 chr11:95546222-95546223(+) m6A 3'UTR//CDS//exon       24981863//27773535 chr11:95546230-95546231(+) Am 3'UTR//CDS//exon       - chr11:95546683-95546684(+) m6A 3'UTR//CDS//exon       27773535 chr11:95546732-95546733(+) m6A 3'UTR//CDS//exon       27773535 chr11:95546749-95546750(+) m6A 3'UTR//CDS//exon       27773535 chr11:95548304-95548305(+) m6A exon//intron       27773535 chr11:95551039-95551040(+) m6A 3'UTR//CDS//exon       27773535 chr11:95552016-95552017(+) m6A 3'UTR//CDS       24981863 chr11:95552031-95552032(+) m6A 3'UTR//CDS       24981863 chr11:95555040-95555041(+) m6A 3'UTR//CDS//intron       24981863 chr11:95555052-95555053(+) m6A 3'UTR//CDS//intron       24981863 chr11:95555060-95555061(+) m6A 3'UTR//CDS//intron       24981863 chr11:95562371-95562372(+) m6A 3'UTR//CDS//exon       - chr11:95562398-95562399(+) m6A 3'UTR//CDS//exon       - chr11:95562406-95562407(+) m6A 3'UTR//CDS//exon       - chr11:95564197-95564198(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22608085 chr11:95564243-95564244(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//22608085 chr11:95564262-95564263(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//22608085 chr11:95564291-95564292(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//22608085 chr11:95564317-95564318(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//22608085 chr11:95564323-95564324(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//22608085 chr11:95564364-95564365(+) m6A 3'UTR//CDS       24284625//25456834//24981863//26404942//27773535//22608085 chr11:95565017-95565018(+) Y 3'UTR       26075521

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-769-5p	Exosome B cell line (Raji)|Primary dendritic cells|T cell line (J77)     21505438 Exosome Plasma     23663360 Exosome B lymphoblastoid cells|Endothelial cells|Lymphoma tissue|Mast cells|Tongue tissue     - Microvesicle Seminal plasma     23539611 Microvesicle Follicular fluid     23666971 Microvesicle Cerebrospinal fluid     24797360 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Skeletal muscle myoblasts     21637849
	CEP57	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus K562 cells     - Ribosome HEK-293 cells     22199352

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-769-5p	8-Aminoadenosine 96851 Drug resistant Morpholine-N-dithiocarbamate 72675 Drug sensitive 10-Hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12-dodecahydro-1H-picene-4a-carboxylic acid 495604 Drug sensitive Benzamide riboside 458027 Drug sensitive Predorine 333830 Drug sensitive Stannane, trimethyl[(4-morpholinylthioxomethyl)thio]- 300936 Drug sensitive Hydrazine sulfate 24842 Drug sensitive 2h-naphtho[1,2-b]pyran-2-one, 9-hydroxy-4-phenyl- - Drug sensitive 4-morpholinecarbodithioic acid, antimony complex - Drug sensitive 4-thiomorpholinecarbodithioic acid, antimony complex - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-769-5p	Hyaluronidase 91820602 Drug interaction    RC00006691 Vorinostat 5311 Drug interaction    RC00006685 Eloxatine 5310940 Drug interaction    RC00006689 Paclitaxel 36314 Drug interaction    RC00006687 Doxorubicin 31703 Drug interaction    RC00006686 Tamoxifen 2733526 Drug interaction    RC00006688 Verapamil 2520 Drug interaction    RC00006684 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00006690

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-769-5p	N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124 Gefitinib 123631       30601026

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-769-5p
Interactor2: CEP57

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.