Basic Information:

  VIRBase ID:  

HHID00061955

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-454-3p:  MIMAT0003885          ASPM:  NM_001206846     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-454-3p	ASPM
miRBase Accession/Entrez ID	MIMAT0003885	259266
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ASP//Calmbp1//MCPH5

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-454-3p	rs1450965019 chr17:59137799    A/G rs377123764 chr17:59137788    C/G rs377123764 chr17:59137788    C/T rs771457463 chr17:59137792    A/G rs779514158 chr17:59137798    A/G rs1391884708 chr17:59137808    TACTCAGAACTATTTACAC/T rs555225543 chr17:59137803    T/G rs772555392 chr17:59137806    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ASPM	chr1:197067859(-) A-I      intronic chr1:197107709(-) A-I      intronic chr1:197067849(-) A-I      intronic chr1:197067183(-) A-I      intronic chr1:197067244(-) A-I      intronic chr1:197067850(-) A-I      intronic chr1:197067182(-) A-I      intronic chr1:197056302(-) A-I      intronic chr1:197104889(-) A-I      intronic chr1:197067790(-) A-I      intronic chr1:197067811(-) A-I      intronic chr1:197067851(-) A-I      intronic chr1:197067844(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ASPM	chr1:197067851(-) A-I intron -    22327324 chr1:197067790(-) A-G intron -    22484847 chr1:197067811(-) A-G intron -    22484847 chr1:197067844(-) A-G intron -    22484847 chr1:197067849(-) A-G intron -    22484847 chr1:197067850(-) A-G intron -    22484847 chr1:197067851(-) A-G intron -    22484847 chr1:197067183(-) A-G intron -    22484847 chr1:197067244(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ASPM	chr1:197053328-197053329(-) m6A 3'UTR       27773535 chr1:197053334-197053335(-) m6A 3'UTR       27773535 chr1:197053443-197053444(-) m6A 3'UTR       27773535 chr1:197069671-197069672(-) m6A CDS//intron       24981863//22608085 chr1:197069680-197069681(-) m6A CDS//intron       24981863//22608085 chr1:197069749-197069750(-) m6A CDS//intron       24981863//22575960//22608085 chr1:197069757-197069758(-) m6A CDS//intron       24981863//22575960//22608085 chr1:197069877-197069878(-) m6A CDS//intron       27371828//22575960//22608085 chr1:197069884-197069885(-) m6A CDS//intron       27371828//22575960//22608085 chr1:197070036-197070037(-) m6A CDS//intron       27773535//22608085 chr1:197070115-197070116(-) m6A CDS//intron       24284625//24981863//27773535//22608085 chr1:197070150-197070151(-) m6A CDS//intron       24284625//24981863//27773535//22608085 chr1:197070179-197070180(-) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085 chr1:197070192-197070193(-) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085 chr1:197070243-197070244(-) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085 chr1:197070252-197070253(-) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085 chr1:197070400-197070401(-) m6A CDS//intron       24284625//24981863//27773535//22608085 chr1:197070511-197070512(-) m6A CDS//intron       24284625//24209618//24981863//28052920//27773535//22575960//22608085 chr1:197070522-197070523(-) Cm CDS//intron       - chr1:197070523-197070524(-) m6A CDS//intron       24284625//24209618//24981863//28052920//27773535//22575960//22608085 chr1:197070533-197070534(-) m6A CDS//intron       24284625//24209618//24981863//28052920//27773535//22575960//22608085 chr1:197070539-197070540(-) m6A CDS//intron       24284625//24209618//24981863//28052920//27773535//22575960//22608085 chr1:197070564-197070565(-) m6A CDS//intron       24284625//24209618//24981863//28052920//27773535//22575960//22608085 chr1:197070577-197070578(-) m6A CDS//intron       24284625//24209618//24981863//28052920//27773535//22575960//22608085 chr1:197070601-197070602(-) m6A CDS//intron       24284625//24981863//27773535//22575960//22608085 chr1:197070721-197070722(-) m6A CDS//intron       24284625//24981863//27773535//22575960//22608085 chr1:197070739-197070740(-) m6A CDS//intron       24284625//24981863//27773535//22575960//22608085 chr1:197070793-197070794(-) m6A CDS//intron       24284625//24981863//27773535//22608085 chr1:197070834-197070835(-) m6A CDS//intron       24284625//24981863//27773535//22608085 chr1:197070868-197070869(-) m6A CDS//intron       24284625//24981863//27773535//22575960//22608085 chr1:197070876-197070877(-) m6A CDS//intron       24284625//24981863//27773535//22575960//22608085 chr1:197070894-197070895(-) m6A CDS//intron       24284625//24981863//27773535//22575960//22608085 chr1:197070970-197070971(-) m6A CDS//intron       24981863//27773535//22608085 chr1:197071036-197071037(-) m6A CDS//intron       27773535//22608085 chr1:197071174-197071175(-) m6A CDS//intron       24284625//24981863//22575960//22608085 chr1:197071182-197071183(-) m6A CDS//intron       24284625//24981863//22575960//22608085 chr1:197071225-197071226(-) m6A CDS//intron       24284625//24981863//22575960//22608085 chr1:197071231-197071232(-) m6A CDS//intron       24284625//24981863//22575960//22608085 chr1:197071255-197071256(-) m6A CDS//intron       24284625//24981863//22575960//22608085 chr1:197071306-197071307(-) m6A CDS//intron       24284625//24981863//22575960//22608085 chr1:197071518-197071519(-) m6A CDS//intron       24981863//27773535//22608085 chr1:197071557-197071558(-) m6A CDS//intron       24981863//27773535//22608085 chr1:197071609-197071610(-) m6A CDS//intron       24981863//27773535//22608085 chr1:197071666-197071667(-) m6A CDS//intron       24981863//27773535//22608085 chr1:197071691-197071692(-) m6A CDS//intron       24981863//27773535//22608085 chr1:197071728-197071729(-) m6A CDS//intron       24981863//27773535//22608085 chr1:197071761-197071762(-) m6A CDS//intron       24981863//27773535//22608085 chr1:197071768-197071769(-) m6A CDS//intron       24981863//27773535//22608085 chr1:197071784-197071785(-) m6A CDS//intron       24981863//27773535//22608085 chr1:197071809-197071810(-) m6A CDS//intron       24981863//27773535//22608085 chr1:197071827-197071828(-) m6A CDS//intron       24981863//27773535//22608085 chr1:197072047-197072048(-) m6A CDS//intron       27773535 chr1:197072094-197072095(-) m6A CDS//intron       27773535//22608085 chr1:197072129-197072130(-) m6A CDS//intron       27773535//22608085 chr1:197072205-197072206(-) m6A CDS//intron       24981863//27773535//22608085 chr1:197072322-197072323(-) m6A CDS//intron       24284625//24981863//27773535//22608085 chr1:197072344-197072345(-) m6A CDS//intron       24284625//24981863//27773535//22608085 chr1:197072485-197072486(-) m6A CDS//intron       24284625//24981863//27773535//27371828//22575960//22608085 chr1:197072496-197072497(-) m6A CDS//intron       24284625//24981863//27773535//27371828//22575960//22608085 chr1:197072542-197072543(-) m6A CDS//intron       24284625//24981863//27773535//27371828//22575960//22608085 chr1:197072577-197072578(-) m6A CDS//intron       24284625//24981863//27773535//27371828//22575960//22608085 chr1:197072616-197072617(-) m6A CDS//intron       24284625//24981863//27773535//22575960//22608085 chr1:197072635-197072636(-) m6A CDS//intron       24284625//24981863//27773535//22575960//22608085 chr1:197072689-197072690(-) m6A CDS//intron       27773535//22575960//22608085 chr1:197072703-197072704(-) Cm CDS//intron       - chr1:197072704-197072705(-) m6A CDS//intron       22575960//22608085 chr1:197072760-197072761(-) m6A CDS//intron       24981863//22575960//22608085 chr1:197072775-197072776(-) m6A CDS//intron       24981863//22575960//22608085 chr1:197072793-197072794(-) m6A CDS//intron       24981863//22608085 chr1:197072914-197072915(-) m6A CDS//intron       24284625//24981863//27773535//22608085 chr1:197072990-197072991(-) m6A CDS//intron       24284625//24981863//27773535//27371828//22608085 chr1:197073178-197073179(-) m6A CDS//intron       24284625//27773535//22608085 chr1:197073292-197073293(-) m6A CDS//intron       24284625//24981863//27773535//22608085 chr1:197073304-197073305(-) m6A CDS//intron       24284625//24981863//27773535//22608085 chr1:197073486-197073487(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr1:197073540-197073541(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr1:197073595-197073596(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr1:197073627-197073628(-) m6A CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr1:197073638-197073639(-) m6A CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr1:197073656-197073657(-) m6A CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr1:197073661-197073662(-) m6A CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr1:197073706-197073707(-) m6A CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr1:197073730-197073731(-) m6A CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr1:197074000-197074001(-) m6A CDS//intron       24981863//27773535 chr1:197074147-197074148(-) m6A CDS//intron       24981863//27773535//22608085 chr1:197104298-197104299(-) m6A CDS//intron       27773535 chr1:197104335-197104336(-) m6A CDS//intron       27773535 chr1:197104361-197104362(-) m6A CDS//intron       27773535 chr1:197107986-197107987(-) m6A intron       27773535//27371828//22608085 chr1:197108050-197108051(-) m6A intron       27773535//27371828//22608085 chr1:197108101-197108102(-) m6A intron       27773535//27371828//22608085 chr1:197108143-197108144(-) m6A intron       27773535//27371828//22608085 chr1:197108186-197108187(-) m6A intron       27773535//27371828//22608085 chr1:197108221-197108222(-) m6A intron       27371828//22608085 chr1:197108899-197108900(-) m6A CDS//intron       27773535 chr1:197108909-197108910(-) m6A CDS//intron       27773535 chr1:197108951-197108952(-) m6A CDS//intron       27773535 chr1:197108956-197108957(-) m6A CDS//intron       27773535 chr1:197108968-197108969(-) m6A CDS//intron       24981863//27773535 chr1:197108983-197108984(-) m6A CDS//intron       24981863//27773535 chr1:197111463-197111464(-) m6A CDS//intron       24981863//27773535//22608085 chr1:197111477-197111478(-) m6A CDS//intron       24981863//27773535//22608085 chr1:197111532-197111533(-) m6A CDS//intron       24981863//27773535//22608085 chr1:197111550-197111551(-) m6A CDS//intron       24981863//27773535//22608085 chr1:197111605-197111606(-) m6A CDS//intron       24981863//27773535//22608085 chr1:197111800-197111801(-) m6A CDS//intron       24284625//24981863//27773535//22608085 chr1:197111839-197111840(-) m6A CDS//intron       24284625//24981863//27773535//22608085 chr1:197111853-197111854(-) m6A CDS//intron       24284625//24981863//27773535//22608085 chr1:197111858-197111859(-) m6A CDS//intron       24284625//24981863//27773535//22608085 chr1:197111926-197111927(-) m6A CDS//intron       24284625//24981863//27773535//22608085 chr1:197111983-197111984(-) m6A CDS//intron       24284625//24981863//27773535//22608085 chr1:197112022-197112023(-) m6A CDS//intron       24284625//27773535//22608085 chr1:197112153-197112154(-) m6A CDS//intron       27773535 chr1:197112250-197112251(-) m6A CDS//intron       27773535 chr1:197112496-197112497(-) m6A CDS//intron       27773535 chr1:197112546-197112547(-) m6A CDS//intron       27773535 chr1:197112610-197112611(-) m6A CDS//intron       27773535 chr1:197112755-197112756(-) m6A CDS//intron       24981863//27773535 chr1:197112791-197112792(-) m6A CDS//intron       24981863//27773535 chr1:197112849-197112850(-) m6A CDS       24981863//27773535 chr1:197113134-197113135(-) m6A CDS       24981863 chr1:197113196-197113197(-) m6A CDS       - chr1:197115310-197115311(-) m6A CDS       - chr1:197115364-197115365(-) m6A CDS       27773536 chr1:197115559-197115560(-) m6A CDS       27773536//22575960 chr1:197115800-197115801(-) m6A 5'UTR       24284625//27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-454-3p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Serum     18589210 Exosome Saliva     19627513 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Primary dendritic cells|T cell line (J77)     21505438 Exosome Plasma     23663360 Exosome Endothelial cells     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Nucleolus HeLa cells     23940654 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	ASPM	Centrosome Cells (HeLa-Kyoto|HeLa)     33649340 Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Insoluble cytoplasm K562 cells     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-454-3p	4-(2-Pyridylazo)-N,N-dimethylaniline 81528 Drug sensitive o-Aminoazotoluene 7340 Drug sensitive Piperidinium pentamethylenedithiocarbamate 72508 Drug sensitive Crotonoside 65085 Drug sensitive Trihydroxygermaeranolide isobutyrate 6436277 Drug sensitive (Z)-6-(2-(Pyridin-2-ylmethylene)hydrazinyl)-9H-purine 60147744 Drug sensitive Ketone, methyl 2-pyridyl, 4,4-dimethyl-3-thiosemicarbazone 5843399 Drug sensitive Incomptina B 54612584 Drug sensitive Selendale 54601159 Drug resistant Aspiculamycin hcl 54600418 Drug resistant Methyl (1R,4R,7E,9S,10R,11S)-9-acetyloxy-10-(2,3-dimethyloxirane-2-carbonyl)oxy-4-methyl-12-methylidene-13-oxo-3,14-dioxatricyclo[9.3.0.02,4]tetradec-7-ene-8-carboxylate 5458601 Drug sensitive 7-(3-Methoxyphenyl)-N-(pyridin-4-ylmethylideneamino)-5H-pyrrolo[3,2-d]pyrimidin-4-amine 53239944 Drug resistant Herbimycin 5311102 Drug sensitive Vorinostat 5311 Drug sensitive Amonafide 50515 Drug sensitive Fastigilin C 442242 Drug sensitive trans-Bis(acetato)amminepyridineplatinum(II) 405450 Drug sensitive Antineoplastic-690271 391308 Drug sensitive Idebenone 3686 Drug sensitive 2,7-Dicyanoxanthone 363841 Drug resistant 2-Hydroxy discorhabdin D 362391 Drug sensitive Maxima isoflavone D 343081 Drug resistant 6-[(7-Nitro-2,1,3-benzoxadiazol-4-yl)sulfanyl]-7H-purin-2-amine 3246652 Drug sensitive 1,4-Naphthalenedione, 5,8-dihydroxy-2,3-bis(hydroxymethyl)- 313371 Drug sensitive Razoxane 30623 Drug sensitive [(5Z)-1,7,7-Trimethyl-5-(nitromethylene)-6-oxo-norbornan-2-yl] acetate 3004516 Drug sensitive Salarin C 24867082 Drug resistant 2-(4-((Oxiran-2-yl)methoxy)styryl)-4,5-dihydrooxazole 24206038 Drug sensitive Haterumalide NA methyl esters 24204452 Drug resistant Pirarubicin hydrochloride 20846247 Drug sensitive 1,2:5,6-Dianhydrogalactitol 15942827 Drug sensitive 12-Iminodaunorubicin hcl 135539784 Drug sensitive 5-Hydroxypicolinaldehyde thiosemicarbazone 135453292 Drug sensitive Formycin b 135449281 Drug sensitive Kinamycin C 135430800 Drug sensitive Veracoquinazole 135416663 Drug sensitive Inosine dialdehyde 135400916 Drug sensitive 43-Dioxypectenotoxin 131751434 Drug resistant Epilactose 128037 Drug resistant Cytochalasin q 11970174 Drug sensitive (3S,6R,10R,13Z,16S)-10-[(4-Methoxyphenyl)methyl]-6-methyl-3-(2-methylpropyl)-16-[(1S)-1-[(2R,3R)-3-phenyloxiran-2-yl]ethyl]-1,4-dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone 101917006 Drug resistant Cyanocycline A 100158 Drug sensitive 1,3-diphenyl-4-(3-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1H-pyrazole - Drug resistant 9h-quino[4,3,2-de][1,10]phenanthrolin-9-one, 5-methoxy- - Drug resistant N-(4-{2-[(1R,6R,11aS,13S,14aR)-1,13-dihydroxy-4-oxo-1,6,7,8,9,11a,12,13,14,14a-decahydro-4H-cyclopenta[f]oxacyclotridecin-6-yl]ethyl}phenyl)acetamide - Drug resistant (1s,2e,4r,6r,7e,10r,11e)-2,7,11-cembratriene-4,6,10-triol - Drug sensitive (2r,3r)-(+)-methyl 3-phenyloxirane-carboxylate - Drug sensitive 1h-benzo[a]carbazole-1,4(11h)-dione, 11-phenyl- - Drug sensitive 2,6-bis(4-morpholinylmethyl)cyclohexanone,dihydrochloride - Drug sensitive 2-bromo-5,8-dihydroxy-3-methyl-1,4-naphthoquinone - Drug sensitive 4-(2-pyridinyl)-5h-1,2,3-dithiazole-5-thione - Drug sensitive 6h-purine-6-thione, 1,7-dihydro-, mercury complex (9ci) - Drug sensitive benzofurazan, 5-nitro-6-(1-piperidinyl)-, 1-oxide - Drug sensitive cyclohexanone, 2,6-bis(piperidinomethyl)- - Drug sensitive ethanone, 1-(2-pyrimidinyl)-, (2-benzoxazolyl)hydrazone - Drug sensitive (s)(-)-methyl perillate - Drug sensitive antineoplastic-654379 - Drug sensitive Camptothecin Derivative - Drug sensitive chlorobis(4-ethyltropolonato)bismuth(iii) - Drug sensitive cyclo [n-naphthoyl-d-lys-asn-gln-trp-ala-val-d-ala-his-leu] - Drug sensitive Indenoisoquinoline derivative - Drug sensitive n-acetyl-4-s-cystaminyl phenol - Drug sensitive o-linoleoyl-2-butoxy-1-desoamine - Drug sensitive Tetraplatin - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-454-3p	Formaldehyde 712 Drug interaction    RC00006668 Gemcitabine 60750 Drug interaction    RC00006676 Vincristine 5978 Drug interaction    RC00006673 Floxuridine 5790 Drug interaction    RC00006672 Prednisolone 5755 Drug interaction    RC00006671 Sunitinib 5329102 Drug interaction    RC00006681 4-Hydroxynonenal 5283344 Drug interaction    RC00006680 Diethylstilbestrol 448537 Drug interaction    RC00006679 5-Fluorouracil 3385 Drug interaction    RC00006670 Doxorubicin 31703 Drug interaction    RC00006675 Daunorubicin 30323 Drug interaction    RC00006674 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00006677 Verapamil 2520 Drug interaction    RC00006669 Docetaxel 148124 Drug interaction    RC00006678 Asparaginase Escherichia coli - Drug interaction    RC00006683 FdUMP[10] - Drug interaction    RC00006682

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-454-3p	Cisplatin 5702198       30099826

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-454-3p
Interactor2: ASPM

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.