Basic Information:

  VIRBase ID:  

HHID00061937

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-454-3p:  MIMAT0003885          ZNF567:  NM_001322920     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-454-3p	ZNF567
miRBase Accession/Entrez ID	MIMAT0003885	163081
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-454-3p	rs1450965019 chr17:59137799    A/G rs377123764 chr17:59137788    C/G rs377123764 chr17:59137788    C/T rs771457463 chr17:59137792    A/G rs779514158 chr17:59137798    A/G rs1391884708 chr17:59137808    TACTCAGAACTATTTACAC/T rs555225543 chr17:59137803    T/G rs772555392 chr17:59137806    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ZNF567	chr19:37182186(+) A-I      intronic chr19:37182160(+) A-I      intronic chr19:37203049(+) A-I      intronic chr19:37209326(+) A-I      intronic chr19:37209333(+) A-I      intronic chr19:37204765(+) A-I      intronic chr19:37204758(+) A-I      intronic chr19:37204757(+) A-I      intronic chr19:37209286(+) A-I      intronic chr19:37181293(+) A-I      intronic chr19:37204656(+) A-I      intronic chr19:37183342(+) A-I      intronic chr19:37183414(+) A-I      intronic chr19:37182190(+) A-I      intronic chr19:37183439(+) A-I      intronic chr19:37183330(+) A-I      intronic chr19:37184000(+) A-I      intronic chr19:37182083(+) A-I      intronic chr19:37203971(+) A-I      intronic chr19:37181294(+) A-I      intronic chr19:37209384(+) A-I      intronic chr19:37205163(+) A-I      intronic chr19:37207832(+) A-I      intronic chr19:37207991(+) A-I      intronic chr19:37209280(+) A-I      intronic chr19:37209281(+) A-I      intronic chr19:37183344(+) A-I      intronic chr19:37184059(+) A-I      intronic chr19:37207808(+) A-I      intronic chr19:37205157(+) A-I      intronic chr19:37205095(+) A-I      intronic chr19:37183952(+) A-I      intronic chr19:37181381(+) A-I      intronic chr19:37186284(+) A-I      intronic chr19:37206126(+) A-I      intronic chr19:37207990(+) A-I      intronic chr19:37183540(+) A-I      intronic chr19:37204756(+) A-I      intronic chr19:37203185(+) A-I      intronic chr19:37202074(+) A-I      intronic chr19:37183420(+) A-I      intronic chr19:37204066(+) A-I      intronic chr19:37207746(+) A-I      intronic chr19:37207911(+) A-I      intronic chr19:37185045(+) A-I      intronic chr19:37181313(+) A-I      intronic chr19:37184336(+) A-I      intronic chr19:37206102(+) A-I      intronic chr19:37204461(+) A-I      intronic chr19:37182296(+) A-I      intronic chr19:37205266(+) A-I      intronic chr19:37205189(+) A-I      intronic chr19:37207797(+) A-I      intronic chr19:37207867(+) A-I      intronic chr19:37204147(+) A-I      intronic chr19:37182084(+) A-I      intronic chr19:37203953(+) A-I      intronic chr19:37183498(+) A-I      intronic chr19:37183404(+) A-I      intronic chr19:37183325(+) A-I      intronic chr19:37181309(+) A-I      intronic chr19:37209205(+) A-I      intronic chr19:37182689(+) A-I      intronic chr19:37209130(+) A-I      intronic chr19:37181233(+) A-I      intronic chr19:37183328(+) A-I      intronic chr19:37181240(+) A-I      intronic chr19:37207914(+) A-I      intronic chr19:37182692(+) A-I      intronic chr19:37204028(+) A-I      intronic chr19:37183506(+) A-I      intronic chr19:37186448(+) A-I      intronic chr19:37182694(+) A-I      intronic chr19:37202073(+) A-I      intronic chr19:37204451(+) A-I      intronic chr19:37204158(+) A-I      intronic chr19:37202153(+) A-I      intronic chr19:37203048(+) A-I      intronic chr19:37204432(+) A-I      intronic chr19:37209140(+) A-I      intronic chr19:37202178(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ZNF567	chr19:37181233(+) A-G intron -    22484847 chr19:37182692(+) A-G intron -    22484847 chr19:37182694(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZNF567	chr19:37180345-37180346(+) m6A 5'UTR//exon       25456834//24981863 chr19:37180358-37180359(+) m6A 5'UTR//exon       25456834//24981863 chr19:37185705-37185706(+) m6A 5'UTR//exon//intron       - chr19:37203741-37203742(+) m6A CDS       22608085 chr19:37209855-37209856(+) m6A CDS//intron       24981863//27773535//22608085 chr19:37209870-37209871(+) m6A CDS//intron       24981863//27773535//22608085 chr19:37209892-37209893(+) m6A CDS//intron       24981863//27773535//22608085 chr19:37209940-37209941(+) m6A CDS//intron       24981863//27773535//22608085 chr19:37209974-37209975(+) m6A CDS//intron       24981863//27773535//22608085 chr19:37209993-37209994(+) m6A CDS//intron       24981863//27773535//22608085 chr19:37210099-37210100(+) m6A CDS//intron       24284625//24981863//27773535//22608085 chr19:37210144-37210145(+) m6A CDS//intron       24284625//24981863//27773535//22608085 chr19:37210151-37210152(+) m6A CDS//intron       24284625//24981863//27773535//22608085 chr19:37210238-37210239(+) m6A CDS//intron       24981863//27773535//22608085 chr19:37210315-37210316(+) m6A CDS//intron       24981863//27773535//22608085 chr19:37210332-37210333(+) m6A CDS//intron       24981863//27773535//22608085 chr19:37210381-37210382(+) m6A CDS//intron       24981863//27773535//22608085 chr19:37210462-37210463(+) m6A CDS//intron       24981863//27773535//22608085 chr19:37210529-37210530(+) m6A CDS//intron       24981863//27773535//22608085 chr19:37210546-37210547(+) m6A CDS//intron       24981863//27773535//22608085 chr19:37210589-37210590(+) m6A CDS//intron       24981863//27773535//22608085 chr19:37210613-37210614(+) m6A CDS//intron       24981863//27773535//22608085 chr19:37210697-37210698(+) m6A CDS//intron       24981863//27773535//22608085 chr19:37210714-37210715(+) m6A CDS//intron       24981863//27773535//22608085 chr19:37210757-37210758(+) m6A CDS//intron       24981863//22608085 chr19:37210798-37210799(+) m6A CDS//intron       24981863//22608085 chr19:37210865-37210866(+) m6A CDS//intron       24981863//27773535//22608085 chr19:37210925-37210926(+) m6A CDS//intron       24981863//27773535//22608085 chr19:37210949-37210950(+) m6A CDS//intron       24284625//24981863//27773535//22608085 chr19:37210966-37210967(+) m6A CDS//intron       24284625//24981863//27773535//22608085 chr19:37211009-37211010(+) m6A CDS//intron       24981863//27773535//22608085 chr19:37211033-37211034(+) m6A CDS//intron       24209618//24981863//27773535//22608085 chr19:37211117-37211118(+) m6A CDS//intron       24209618//24981863//27773535//22608085 chr19:37211134-37211135(+) m6A CDS//intron       24981863//27773535//22608085 chr19:37211177-37211178(+) m6A CDS//intron       24981863//27773535//22608085 chr19:37211218-37211219(+) m6A CDS//intron       24284625//24981863//27773535//22608085 chr19:37211369-37211370(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085 chr19:37211386-37211387(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085 chr19:37211429-37211430(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085 chr19:37211453-37211454(+) m6A CDS//intron       24209618//24981863//27773535//22608085 chr19:37211470-37211471(+) m6A CDS//intron       24209618//24981863//27773535//22608085 chr19:37211517-37211518(+) m6A CDS//intron       24981863//27773535//22608085 chr19:37211537-37211538(+) m6A CDS//intron       24981863//22608085 chr19:37211553-37211554(+) m6A CDS//intron       24981863//22608085 chr19:37211612-37211613(+) m6A 3'UTR//intron       24981863 chr19:37211644-37211645(+) m6A 3'UTR//intron       24981863 chr19:37211753-37211754(+) m6A 3'UTR//intron       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-454-3p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Serum     18589210 Exosome Saliva     19627513 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Primary dendritic cells|T cell line (J77)     21505438 Exosome Plasma     23663360 Exosome Endothelial cells     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Nucleolus HeLa cells     23940654 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	ZNF567	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleolus K562 cells     - Nucleus HeLa-S3 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-454-3p	4-(2-Pyridylazo)-N,N-dimethylaniline 81528 Drug sensitive o-Aminoazotoluene 7340 Drug sensitive Piperidinium pentamethylenedithiocarbamate 72508 Drug sensitive Crotonoside 65085 Drug sensitive Trihydroxygermaeranolide isobutyrate 6436277 Drug sensitive (Z)-6-(2-(Pyridin-2-ylmethylene)hydrazinyl)-9H-purine 60147744 Drug sensitive Ketone, methyl 2-pyridyl, 4,4-dimethyl-3-thiosemicarbazone 5843399 Drug sensitive Incomptina B 54612584 Drug sensitive Selendale 54601159 Drug resistant Aspiculamycin hcl 54600418 Drug resistant Methyl (1R,4R,7E,9S,10R,11S)-9-acetyloxy-10-(2,3-dimethyloxirane-2-carbonyl)oxy-4-methyl-12-methylidene-13-oxo-3,14-dioxatricyclo[9.3.0.02,4]tetradec-7-ene-8-carboxylate 5458601 Drug sensitive 7-(3-Methoxyphenyl)-N-(pyridin-4-ylmethylideneamino)-5H-pyrrolo[3,2-d]pyrimidin-4-amine 53239944 Drug resistant Herbimycin 5311102 Drug sensitive Vorinostat 5311 Drug sensitive Amonafide 50515 Drug sensitive Fastigilin C 442242 Drug sensitive trans-Bis(acetato)amminepyridineplatinum(II) 405450 Drug sensitive Antineoplastic-690271 391308 Drug sensitive Idebenone 3686 Drug sensitive 2,7-Dicyanoxanthone 363841 Drug resistant 2-Hydroxy discorhabdin D 362391 Drug sensitive Maxima isoflavone D 343081 Drug resistant 6-[(7-Nitro-2,1,3-benzoxadiazol-4-yl)sulfanyl]-7H-purin-2-amine 3246652 Drug sensitive 1,4-Naphthalenedione, 5,8-dihydroxy-2,3-bis(hydroxymethyl)- 313371 Drug sensitive Razoxane 30623 Drug sensitive [(5Z)-1,7,7-Trimethyl-5-(nitromethylene)-6-oxo-norbornan-2-yl] acetate 3004516 Drug sensitive Salarin C 24867082 Drug resistant 2-(4-((Oxiran-2-yl)methoxy)styryl)-4,5-dihydrooxazole 24206038 Drug sensitive Haterumalide NA methyl esters 24204452 Drug resistant Pirarubicin hydrochloride 20846247 Drug sensitive 1,2:5,6-Dianhydrogalactitol 15942827 Drug sensitive 12-Iminodaunorubicin hcl 135539784 Drug sensitive 5-Hydroxypicolinaldehyde thiosemicarbazone 135453292 Drug sensitive Formycin b 135449281 Drug sensitive Kinamycin C 135430800 Drug sensitive Veracoquinazole 135416663 Drug sensitive Inosine dialdehyde 135400916 Drug sensitive 43-Dioxypectenotoxin 131751434 Drug resistant Epilactose 128037 Drug resistant Cytochalasin q 11970174 Drug sensitive (3S,6R,10R,13Z,16S)-10-[(4-Methoxyphenyl)methyl]-6-methyl-3-(2-methylpropyl)-16-[(1S)-1-[(2R,3R)-3-phenyloxiran-2-yl]ethyl]-1,4-dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone 101917006 Drug resistant Cyanocycline A 100158 Drug sensitive 1,3-diphenyl-4-(3-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1H-pyrazole - Drug resistant 9h-quino[4,3,2-de][1,10]phenanthrolin-9-one, 5-methoxy- - Drug resistant N-(4-{2-[(1R,6R,11aS,13S,14aR)-1,13-dihydroxy-4-oxo-1,6,7,8,9,11a,12,13,14,14a-decahydro-4H-cyclopenta[f]oxacyclotridecin-6-yl]ethyl}phenyl)acetamide - Drug resistant (1s,2e,4r,6r,7e,10r,11e)-2,7,11-cembratriene-4,6,10-triol - Drug sensitive (2r,3r)-(+)-methyl 3-phenyloxirane-carboxylate - Drug sensitive 1h-benzo[a]carbazole-1,4(11h)-dione, 11-phenyl- - Drug sensitive 2,6-bis(4-morpholinylmethyl)cyclohexanone,dihydrochloride - Drug sensitive 2-bromo-5,8-dihydroxy-3-methyl-1,4-naphthoquinone - Drug sensitive 4-(2-pyridinyl)-5h-1,2,3-dithiazole-5-thione - Drug sensitive 6h-purine-6-thione, 1,7-dihydro-, mercury complex (9ci) - Drug sensitive benzofurazan, 5-nitro-6-(1-piperidinyl)-, 1-oxide - Drug sensitive cyclohexanone, 2,6-bis(piperidinomethyl)- - Drug sensitive ethanone, 1-(2-pyrimidinyl)-, (2-benzoxazolyl)hydrazone - Drug sensitive (s)(-)-methyl perillate - Drug sensitive antineoplastic-654379 - Drug sensitive Camptothecin Derivative - Drug sensitive chlorobis(4-ethyltropolonato)bismuth(iii) - Drug sensitive cyclo [n-naphthoyl-d-lys-asn-gln-trp-ala-val-d-ala-his-leu] - Drug sensitive Indenoisoquinoline derivative - Drug sensitive n-acetyl-4-s-cystaminyl phenol - Drug sensitive o-linoleoyl-2-butoxy-1-desoamine - Drug sensitive Tetraplatin - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-454-3p	Formaldehyde 712 Drug interaction    RC00006668 Gemcitabine 60750 Drug interaction    RC00006676 Vincristine 5978 Drug interaction    RC00006673 Floxuridine 5790 Drug interaction    RC00006672 Prednisolone 5755 Drug interaction    RC00006671 Sunitinib 5329102 Drug interaction    RC00006681 4-Hydroxynonenal 5283344 Drug interaction    RC00006680 Diethylstilbestrol 448537 Drug interaction    RC00006679 5-Fluorouracil 3385 Drug interaction    RC00006670 Doxorubicin 31703 Drug interaction    RC00006675 Daunorubicin 30323 Drug interaction    RC00006674 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00006677 Verapamil 2520 Drug interaction    RC00006669 Docetaxel 148124 Drug interaction    RC00006678 Asparaginase Escherichia coli - Drug interaction    RC00006683 FdUMP[10] - Drug interaction    RC00006682

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-454-3p	Cisplatin 5702198       30099826

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-454-3p
Interactor2: ZNF567

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.