Detail Information

Basic Information:


  VIRBase ID:  

HHID00061931

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-454-3p:           CEP120:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-454-3p CEP120
miRBase
Accession/Entrez ID		 MIMAT0003885 153241
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CCDC100//JBTS31//SRTD13

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-454-3p
rs1450965019 chr17:59137799    A/G
rs377123764 chr17:59137788    C/G
rs377123764 chr17:59137788    C/T
rs771457463 chr17:59137792    A/G
rs779514158 chr17:59137798    A/G
rs1391884708 chr17:59137808    TACTCAGAACTATTTACAC/T
rs555225543 chr17:59137803    T/G
rs772555392 chr17:59137806    A/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR CEP120
chr5:122754429(-) A-I      intronic
chr5:122755129(-) A-I      intronic
chr5:122754435(-) A-I      intronic
chr5:122755181(-) A-I      intronic
chr5:122755155(-) A-I      intronic
chr5:122743769(-) A-I      intronic
chr5:122743758(-) A-I      intronic
chr5:122754428(-) A-I      intronic
chr5:122731452(-) A-I      intronic
chr5:122728462(-) A-I      intronic
chr5:122743754(-) A-I      intronic
chr5:122755218(-) A-I      intronic
chr5:122733666(-) A-I      intronic
chr5:122755119(-) A-I      intronic
chr5:122751363(-) A-I      intronic
chr5:122732958(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED CEP120
chr5:122742327(-) A-G intron -    22484847
chr5:122732958(-) A-G intron -    22484847
chr5:122733666(-) A-G intron -    22484847
chr5:122745665(-) G-T intron -    22484847
chr5:122755119(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CEP120
chr5:122680675-122680676(-) m6A 3'UTR       27773535
chr5:122680807-122680808(-) m6A 3'UTR       27773535
chr5:122682153-122682154(-) m6A 3'UTR       24981863//27773535//22608085
chr5:122682186-122682187(-) m6A 3'UTR       24209618//24981863//27773535//22608085
chr5:122682253-122682254(-) Cm 3'UTR//CDS       -
chr5:122682263-122682264(-) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//27371828//22608085
chr5:122682425-122682426(-) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr5:122685640-122685641(-) m6A 3'UTR//CDS       24284625//24981863//27773535//27371828//22608085
chr5:122685680-122685681(-) m6A 3'UTR//CDS       24284625//24981863//27773535//27371828//22608085
chr5:122685720-122685721(-) m6A 3'UTR//CDS       24981863//27773535//22608085
chr5:122685729-122685730(-) m6A 3'UTR//CDS       24981863//27773535//22608085
chr5:122685747-122685748(-) m6A 3'UTR//CDS       24981863//27773535//22608085
chr5:122694015-122694016(-) m6A 3'UTR//intron       27773535
chr5:122694129-122694130(-) m6A 3'UTR//intron       24981863
chr5:122700192-122700193(-) m6A 3'UTR//CDS       24981863
chr5:122700198-122700199(-) m6A 3'UTR//CDS       24981863
chr5:122700207-122700208(-) m6A 3'UTR//CDS       24981863
chr5:122700246-122700247(-) m6A 3'UTR//CDS       24981863
chr5:122700282-122700283(-) m6A 3'UTR//CDS       24981863
chr5:122713085-122713086(-) m6A 3'UTR//CDS       24981863
chr5:122713102-122713103(-) Cm 3'UTR//CDS       -
chr5:122713103-122713104(-) m6A 3'UTR//CDS       24981863
chr5:122713124-122713125(-) m6A 3'UTR//CDS       24981863
chr5:122713143-122713144(-) m6A 3'UTR//CDS       24981863
chr5:122713167-122713168(-) m6A 3'UTR//CDS       24981863
chr5:122713175-122713176(-) m6A 3'UTR//CDS       24981863
chr5:122713185-122713186(-) m6A 3'UTR//CDS       24981863
chr5:122713208-122713209(-) m6A 3'UTR//CDS       24981863
chr5:122714082-122714083(-) m6A 3'UTR//CDS       24981863
chr5:122714092-122714093(-) m6A 3'UTR//CDS       24981863
chr5:122717835-122717836(-) m6A 3'UTR//CDS       24981863
chr5:122717879-122717880(-) m6A 3'UTR//CDS       24981863
chr5:122725752-122725753(-) m6A 3'UTR//CDS       24981863//27773535
chr5:122725804-122725805(-) m6A 3'UTR//CDS       24981863//27773535
chr5:122725815-122725816(-) m6A 3'UTR//CDS       24981863//27773535
chr5:122725908-122725909(-) m6A 3'UTR//intron       27773535
chr5:122725938-122725939(-) m6A 3'UTR//intron       27773535
chr5:122736794-122736795(-) m6A intron       24284625
chr5:122736814-122736815(-) m6A intron       24284625
chr5:122736883-122736884(-) m6A intron       24284625
chr5:122736940-122736941(-) m6A intron       24284625//22575960
chr5:122737098-122737099(-) m6A intron       24284625//22608085
chr5:122737104-122737105(-) m6A intron       24284625//22608085
chr5:122737123-122737124(-) m6A intron       24284625//22608085
chr5:122737266-122737267(-) m6A intron       24284625
chr5:122737272-122737273(-) m6A intron       24284625
chr5:122737290-122737291(-) m6A intron       24284625
chr5:122737314-122737315(-) m6A intron       24284625
chr5:122737507-122737508(-) m6A intron       24284625//27773535//22608085
chr5:122737516-122737517(-) m6A intron       24284625//27773535//22608085
chr5:122737563-122737564(-) m6A intron       24284625//27371828//22608085
chr5:122737580-122737581(-) m6A intron       24284625//24209618//27773535//27371828//22608085
chr5:122737627-122737628(-) m6A intron       24284625//24209618//22608085
chr5:122737676-122737677(-) m6A intron       24284625//22608085
chr5:122737690-122737691(-) m6A intron       24284625
chr5:122737717-122737718(-) m6A intron       24284625
chr5:122737748-122737749(-) m6A intron       24284625
chr5:122738021-122738022(-) m6A intron       24284625
chr5:122758707-122758708(-) m6A 5'UTR//intron       25456834//27773536
chr5:122758740-122758741(-) m6A 5'UTR//intron       25456834//27773536
chr5:122758799-122758800(-) m6A 5'UTR//intron       25456834//27773536
chr5:122758832-122758833(-) m6A 5'UTR//intron       27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-454-3p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Serum     18589210
Exosome Saliva     19627513
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Plasma     23663360
Exosome Endothelial cells     -
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Nucleolus HeLa cells     23940654
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
CEP120
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-454-3p
4-(2-Pyridylazo)-N,N-dimethylaniline 81528 Drug sensitive
o-Aminoazotoluene 7340 Drug sensitive
Piperidinium pentamethylenedithiocarbamate 72508 Drug sensitive
Crotonoside 65085 Drug sensitive
Trihydroxygermaeranolide isobutyrate 6436277 Drug sensitive
(Z)-6-(2-(Pyridin-2-ylmethylene)hydrazinyl)-9H-purine 60147744 Drug sensitive
Ketone, methyl 2-pyridyl, 4,4-dimethyl-3-thiosemicarbazone 5843399 Drug sensitive
Incomptina B 54612584 Drug sensitive
Selendale 54601159 Drug resistant
Aspiculamycin hcl 54600418 Drug resistant
Methyl (1R,4R,7E,9S,10R,11S)-9-acetyloxy-10-(2,3-dimethyloxirane-2-carbonyl)oxy-4-methyl-12-methylidene-13-oxo-3,14-dioxatricyclo[9.3.0.02,4]tetradec-7-ene-8-carboxylate 5458601 Drug sensitive
7-(3-Methoxyphenyl)-N-(pyridin-4-ylmethylideneamino)-5H-pyrrolo[3,2-d]pyrimidin-4-amine 53239944 Drug resistant
Herbimycin 5311102 Drug sensitive
Vorinostat 5311 Drug sensitive
Amonafide 50515 Drug sensitive
Fastigilin C 442242 Drug sensitive
trans-Bis(acetato)amminepyridineplatinum(II) 405450 Drug sensitive
Antineoplastic-690271 391308 Drug sensitive
Idebenone 3686 Drug sensitive
2,7-Dicyanoxanthone 363841 Drug resistant
2-Hydroxy discorhabdin D 362391 Drug sensitive
Maxima isoflavone D 343081 Drug resistant
6-[(7-Nitro-2,1,3-benzoxadiazol-4-yl)sulfanyl]-7H-purin-2-amine 3246652 Drug sensitive
1,4-Naphthalenedione, 5,8-dihydroxy-2,3-bis(hydroxymethyl)- 313371 Drug sensitive
Razoxane 30623 Drug sensitive
[(5Z)-1,7,7-Trimethyl-5-(nitromethylene)-6-oxo-norbornan-2-yl] acetate 3004516 Drug sensitive
Salarin C 24867082 Drug resistant
2-(4-((Oxiran-2-yl)methoxy)styryl)-4,5-dihydrooxazole 24206038 Drug sensitive
Haterumalide NA methyl esters 24204452 Drug resistant
Pirarubicin hydrochloride 20846247 Drug sensitive
1,2:5,6-Dianhydrogalactitol 15942827 Drug sensitive
12-Iminodaunorubicin hcl 135539784 Drug sensitive
5-Hydroxypicolinaldehyde thiosemicarbazone 135453292 Drug sensitive
Formycin b 135449281 Drug sensitive
Kinamycin C 135430800 Drug sensitive
Veracoquinazole 135416663 Drug sensitive
Inosine dialdehyde 135400916 Drug sensitive
43-Dioxypectenotoxin 131751434 Drug resistant
Epilactose 128037 Drug resistant
Cytochalasin q 11970174 Drug sensitive
(3S,6R,10R,13Z,16S)-10-[(4-Methoxyphenyl)methyl]-6-methyl-3-(2-methylpropyl)-16-[(1S)-1-[(2R,3R)-3-phenyloxiran-2-yl]ethyl]-1,4-dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone 101917006 Drug resistant
Cyanocycline A 100158 Drug sensitive
1,3-diphenyl-4-(3-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1H-pyrazole - Drug resistant
9h-quino[4,3,2-de][1,10]phenanthrolin-9-one, 5-methoxy- - Drug resistant
N-(4-{2-[(1R,6R,11aS,13S,14aR)-1,13-dihydroxy-4-oxo-1,6,7,8,9,11a,12,13,14,14a-decahydro-4H-cyclopenta[f]oxacyclotridecin-6-yl]ethyl}phenyl)acetamide - Drug resistant
(1s,2e,4r,6r,7e,10r,11e)-2,7,11-cembratriene-4,6,10-triol - Drug sensitive
(2r,3r)-(+)-methyl 3-phenyloxirane-carboxylate - Drug sensitive
1h-benzo[a]carbazole-1,4(11h)-dione, 11-phenyl- - Drug sensitive
2,6-bis(4-morpholinylmethyl)cyclohexanone,dihydrochloride - Drug sensitive
2-bromo-5,8-dihydroxy-3-methyl-1,4-naphthoquinone - Drug sensitive
4-(2-pyridinyl)-5h-1,2,3-dithiazole-5-thione - Drug sensitive
6h-purine-6-thione, 1,7-dihydro-, mercury complex (9ci) - Drug sensitive
benzofurazan, 5-nitro-6-(1-piperidinyl)-, 1-oxide - Drug sensitive
cyclohexanone, 2,6-bis(piperidinomethyl)- - Drug sensitive
ethanone, 1-(2-pyrimidinyl)-, (2-benzoxazolyl)hydrazone - Drug sensitive
(s)(-)-methyl perillate - Drug sensitive
antineoplastic-654379 - Drug sensitive
Camptothecin Derivative - Drug sensitive
chlorobis(4-ethyltropolonato)bismuth(iii) - Drug sensitive
cyclo [n-naphthoyl-d-lys-asn-gln-trp-ala-val-d-ala-his-leu] - Drug sensitive
Indenoisoquinoline derivative - Drug sensitive
n-acetyl-4-s-cystaminyl phenol - Drug sensitive
o-linoleoyl-2-butoxy-1-desoamine - Drug sensitive
Tetraplatin - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-454-3p
Formaldehyde 712 Drug interaction    RC00006668
Gemcitabine 60750 Drug interaction    RC00006676
Vincristine 5978 Drug interaction    RC00006673
Floxuridine 5790 Drug interaction    RC00006672
Prednisolone 5755 Drug interaction    RC00006671
Sunitinib 5329102 Drug interaction    RC00006681
4-Hydroxynonenal 5283344 Drug interaction    RC00006680
Diethylstilbestrol 448537 Drug interaction    RC00006679
5-Fluorouracil 3385 Drug interaction    RC00006670
Doxorubicin 31703 Drug interaction    RC00006675
Daunorubicin 30323 Drug interaction    RC00006674
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00006677
Verapamil 2520 Drug interaction    RC00006669
Docetaxel 148124 Drug interaction    RC00006678
Asparaginase Escherichia coli - Drug interaction    RC00006683
FdUMP[10] - Drug interaction    RC00006682
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-454-3p
Cisplatin 5702198       30099826

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-454-3p
Interactor2: CEP120

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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