Detail Information

Basic Information:


  VIRBase ID:  

HHID00061926

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-454-3p:           VPS37A:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-454-3p VPS37A
miRBase
Accession/Entrez ID		 MIMAT0003885 137492
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - HCRP1//PQBP2//SPG53

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-454-3p
rs1450965019 chr17:59137799    A/G
rs377123764 chr17:59137788    C/G
rs377123764 chr17:59137788    C/T
rs771457463 chr17:59137792    A/G
rs779514158 chr17:59137798    A/G
rs1391884708 chr17:59137808    TACTCAGAACTATTTACAC/T
rs555225543 chr17:59137803    T/G
rs772555392 chr17:59137806    A/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR VPS37A
chr8:17112825(+) A-I      intronic
chr8:17112830(+) A-I      intronic
chr8:17112831(+) A-I      intronic
chr8:17120394(+) A-I      intronic
chr8:17109737(+) A-I      intronic
chr8:17109721(+) A-I      intronic
chr8:17104982(+) A-I      intronic
chr8:17124356(+) A-I      intronic
chr8:17124361(+) A-I      intronic
chr8:17124399(+) A-I      intronic
chr8:17148584(+) A-I      intronic
chr8:17148774(+) A-I      intronic
chr8:17148783(+) A-I      intronic
chr8:17109725(+) A-I      intronic
chr8:17112806(+) A-I      intronic
chr8:17121224(+) A-I      intronic
chr8:17109730(+) A-I      intronic
chr8:17148784(+) A-I      intronic
chr8:17112780(+) A-I      intronic
chr8:17109749(+) A-I      intronic
chr8:17109746(+) A-I      intronic
chr8:17155353(+) A-I      3'UTR
chr8:17155389(+) A-I      3'UTR
chr8:17153744(+) A-I      3'UTR
chr8:17155364(+) A-I      3'UTR
chr8:17155363(+) A-I      3'UTR
chr8:17155354(+) A-I      3'UTR
chr8:17155380(+) A-I      3'UTR
chr8:17155405(+) A-I      3'UTR
chr8:17155384(+) A-I      3'UTR
chr8:17153808(+) A-I      3'UTR
chr8:17155385(+) A-I      3'UTR
chr8:17153751(+) A-I      3'UTR
chr8:17155392(+) A-I      3'UTR
chr8:17155361(+) A-I      3'UTR
chr8:17155391(+) A-I      3'UTR
chr8:17153809(+) A-I      3'UTR
chr8:17109787(+) A-I      intronic
chr8:17105913(+) A-I      intronic
chr8:17124462(+) A-I      intronic
chr8:17148587(+) A-I      intronic
chr8:17109800(+) A-I      intronic
chr8:17124519(+) A-I      intronic
chr8:17120449(+) A-I      intronic
chr8:17121439(+) A-I      intronic
chr8:17124511(+) A-I      intronic
chr8:17120316(+) A-I      intronic
chr8:17121319(+) A-I      intronic
chr8:17114314(+) A-I      intronic
chr8:17124382(+) A-I      intronic
chr8:17148597(+) A-I      intronic
chr8:17124302(+) A-I      intronic
chr8:17128860(+) A-I      intronic
chr8:17112955(+) A-I      intronic
chr8:17114262(+) A-I      intronic
chr8:17112804(+) A-I      intronic
chr8:17109705(+) A-I      intronic
chr8:17112869(+) A-I      intronic
chr8:17112922(+) A-I      intronic
chr8:17112905(+) A-I      intronic
chr8:17121357(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED VPS37A
chr8:17109705(+) A-G intron -    22484847
chr8:17109800(+) A-G intron -    22484847
chr8:17112804(+) A-G intron -    22484847
chr8:17112814(+) A-G intron -    22484847
chr8:17112869(+) A-G intron -    22484847
chr8:17112870(+) A-G intron -    22484847
chr8:17112905(+) A-G intron -    22484847
chr8:17112931(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase VPS37A
chr8:17104229-17104230(+) m6A 5'UTR       24981863//27371828
chr8:17104293-17104294(+) m6A 5'UTR       24981863//27371828//27773536
chr8:17104523-17104524(+) m6A 5'UTR       24284625
chr8:17104588-17104589(+) m6A 5'UTR       -
chr8:17104608-17104609(+) m6A 5'UTR       -
chr8:17104681-17104682(+) m6A 5'UTR       25456834
chr8:17104742-17104743(+) m6A 5'UTR       -
chr8:17132324-17132325(+) m6A CDS       24981863
chr8:17142063-17142064(+) m6A 3'UTR//CDS       27773535
chr8:17142122-17142123(+) m6A 3'UTR//CDS       27773535
chr8:17157367-17157368(+) m6A exon//intron       25456834//22608085
chr8:17157384-17157385(+) m6A exon//intron       25456834//22608085
chr8:17157453-17157454(+) m6A exon//intron       25456834//24981863//22608085
chr8:17157480-17157481(+) m6A exon//intron       25456834//24981863//22608085
chr8:17157517-17157518(+) m6A exon//intron       25456834//24981863//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-454-3p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Serum     18589210
Exosome Saliva     19627513
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Plasma     23663360
Exosome Endothelial cells     -
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Nucleolus HeLa cells     23940654
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
VPS37A
Chromatin K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells|K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-454-3p
4-(2-Pyridylazo)-N,N-dimethylaniline 81528 Drug sensitive
o-Aminoazotoluene 7340 Drug sensitive
Piperidinium pentamethylenedithiocarbamate 72508 Drug sensitive
Crotonoside 65085 Drug sensitive
Trihydroxygermaeranolide isobutyrate 6436277 Drug sensitive
(Z)-6-(2-(Pyridin-2-ylmethylene)hydrazinyl)-9H-purine 60147744 Drug sensitive
Ketone, methyl 2-pyridyl, 4,4-dimethyl-3-thiosemicarbazone 5843399 Drug sensitive
Incomptina B 54612584 Drug sensitive
Selendale 54601159 Drug resistant
Aspiculamycin hcl 54600418 Drug resistant
Methyl (1R,4R,7E,9S,10R,11S)-9-acetyloxy-10-(2,3-dimethyloxirane-2-carbonyl)oxy-4-methyl-12-methylidene-13-oxo-3,14-dioxatricyclo[9.3.0.02,4]tetradec-7-ene-8-carboxylate 5458601 Drug sensitive
7-(3-Methoxyphenyl)-N-(pyridin-4-ylmethylideneamino)-5H-pyrrolo[3,2-d]pyrimidin-4-amine 53239944 Drug resistant
Herbimycin 5311102 Drug sensitive
Vorinostat 5311 Drug sensitive
Amonafide 50515 Drug sensitive
Fastigilin C 442242 Drug sensitive
trans-Bis(acetato)amminepyridineplatinum(II) 405450 Drug sensitive
Antineoplastic-690271 391308 Drug sensitive
Idebenone 3686 Drug sensitive
2,7-Dicyanoxanthone 363841 Drug resistant
2-Hydroxy discorhabdin D 362391 Drug sensitive
Maxima isoflavone D 343081 Drug resistant
6-[(7-Nitro-2,1,3-benzoxadiazol-4-yl)sulfanyl]-7H-purin-2-amine 3246652 Drug sensitive
1,4-Naphthalenedione, 5,8-dihydroxy-2,3-bis(hydroxymethyl)- 313371 Drug sensitive
Razoxane 30623 Drug sensitive
[(5Z)-1,7,7-Trimethyl-5-(nitromethylene)-6-oxo-norbornan-2-yl] acetate 3004516 Drug sensitive
Salarin C 24867082 Drug resistant
2-(4-((Oxiran-2-yl)methoxy)styryl)-4,5-dihydrooxazole 24206038 Drug sensitive
Haterumalide NA methyl esters 24204452 Drug resistant
Pirarubicin hydrochloride 20846247 Drug sensitive
1,2:5,6-Dianhydrogalactitol 15942827 Drug sensitive
12-Iminodaunorubicin hcl 135539784 Drug sensitive
5-Hydroxypicolinaldehyde thiosemicarbazone 135453292 Drug sensitive
Formycin b 135449281 Drug sensitive
Kinamycin C 135430800 Drug sensitive
Veracoquinazole 135416663 Drug sensitive
Inosine dialdehyde 135400916 Drug sensitive
43-Dioxypectenotoxin 131751434 Drug resistant
Epilactose 128037 Drug resistant
Cytochalasin q 11970174 Drug sensitive
(3S,6R,10R,13Z,16S)-10-[(4-Methoxyphenyl)methyl]-6-methyl-3-(2-methylpropyl)-16-[(1S)-1-[(2R,3R)-3-phenyloxiran-2-yl]ethyl]-1,4-dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone 101917006 Drug resistant
Cyanocycline A 100158 Drug sensitive
1,3-diphenyl-4-(3-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1H-pyrazole - Drug resistant
9h-quino[4,3,2-de][1,10]phenanthrolin-9-one, 5-methoxy- - Drug resistant
N-(4-{2-[(1R,6R,11aS,13S,14aR)-1,13-dihydroxy-4-oxo-1,6,7,8,9,11a,12,13,14,14a-decahydro-4H-cyclopenta[f]oxacyclotridecin-6-yl]ethyl}phenyl)acetamide - Drug resistant
(1s,2e,4r,6r,7e,10r,11e)-2,7,11-cembratriene-4,6,10-triol - Drug sensitive
(2r,3r)-(+)-methyl 3-phenyloxirane-carboxylate - Drug sensitive
1h-benzo[a]carbazole-1,4(11h)-dione, 11-phenyl- - Drug sensitive
2,6-bis(4-morpholinylmethyl)cyclohexanone,dihydrochloride - Drug sensitive
2-bromo-5,8-dihydroxy-3-methyl-1,4-naphthoquinone - Drug sensitive
4-(2-pyridinyl)-5h-1,2,3-dithiazole-5-thione - Drug sensitive
6h-purine-6-thione, 1,7-dihydro-, mercury complex (9ci) - Drug sensitive
benzofurazan, 5-nitro-6-(1-piperidinyl)-, 1-oxide - Drug sensitive
cyclohexanone, 2,6-bis(piperidinomethyl)- - Drug sensitive
ethanone, 1-(2-pyrimidinyl)-, (2-benzoxazolyl)hydrazone - Drug sensitive
(s)(-)-methyl perillate - Drug sensitive
antineoplastic-654379 - Drug sensitive
Camptothecin Derivative - Drug sensitive
chlorobis(4-ethyltropolonato)bismuth(iii) - Drug sensitive
cyclo [n-naphthoyl-d-lys-asn-gln-trp-ala-val-d-ala-his-leu] - Drug sensitive
Indenoisoquinoline derivative - Drug sensitive
n-acetyl-4-s-cystaminyl phenol - Drug sensitive
o-linoleoyl-2-butoxy-1-desoamine - Drug sensitive
Tetraplatin - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-454-3p
Formaldehyde 712 Drug interaction    RC00006668
Gemcitabine 60750 Drug interaction    RC00006676
Vincristine 5978 Drug interaction    RC00006673
Floxuridine 5790 Drug interaction    RC00006672
Prednisolone 5755 Drug interaction    RC00006671
Sunitinib 5329102 Drug interaction    RC00006681
4-Hydroxynonenal 5283344 Drug interaction    RC00006680
Diethylstilbestrol 448537 Drug interaction    RC00006679
5-Fluorouracil 3385 Drug interaction    RC00006670
Doxorubicin 31703 Drug interaction    RC00006675
Daunorubicin 30323 Drug interaction    RC00006674
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00006677
Verapamil 2520 Drug interaction    RC00006669
Docetaxel 148124 Drug interaction    RC00006678
Asparaginase Escherichia coli - Drug interaction    RC00006683
FdUMP[10] - Drug interaction    RC00006682
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-454-3p
Cisplatin 5702198       30099826

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-454-3p
Interactor2: VPS37A

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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