Detail Information

Basic Information:


  VIRBase ID:  

HHID00061899

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-454-3p:           STARD13:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-454-3p STARD13
miRBase
Accession/Entrez ID		 MIMAT0003885 90627
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - ARHGAP37//DLC2//GT650//LINC00464

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-454-3p
rs1450965019 chr17:59137799    A/G
rs377123764 chr17:59137788    C/G
rs377123764 chr17:59137788    C/T
rs771457463 chr17:59137792    A/G
rs779514158 chr17:59137798    A/G
rs1391884708 chr17:59137808    TACTCAGAACTATTTACAC/T
rs555225543 chr17:59137803    T/G
rs772555392 chr17:59137806    A/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR STARD13
chr13:33695642(-) A-I      intronic
chr13:33695648(-) A-I      intronic
chr13:33761948(-) A-I      intronic
chr13:33761998(-) A-I      intronic
chr13:33824135(-) A-I      intronic
chr13:33824141(-) A-I      intronic
chr13:33824146(-) A-I      intronic
chr13:33761999(-) A-I      intronic
chr13:33695597(-) A-I      intronic
chr13:33762000(-) A-I      intronic
chr13:33824131(-) A-I      intronic
chr13:33695071(-) A-I      intronic
chr13:33695060(-) A-I      intronic
chr13:33695041(-) A-I      intronic
chr13:33695045(-) A-I      intronic
chr13:33695157(-) A-I      intronic
chr13:33695643(-) A-I      intronic
chr13:33696075(-) A-I      intronic
chr13:33697070(-) A-I      intronic
chr13:33715115(-) A-I      intronic
chr13:33796346(-) A-I      intronic
chr13:33694939(-) A-I      intronic
chr13:33824096(-) A-I      intronic
chr13:33696165(-) A-I      intronic
chr13:33824059(-) A-I      intronic
chr13:33800844(-) A-I      intronic
chr13:33716319(-) A-I      intronic
chr13:33800839(-) A-I      intronic
chr13:33800674(-) A-I      intronic
chr13:33695928(-) A-I      intronic
chr13:33800643(-) A-I      intronic
chr13:33797750(-) A-I      intronic
chr13:33695105(-) A-I      intronic
chr13:33764884(-) A-I      intronic
chr13:33797749(-) A-I      intronic
chr13:33766988(-) A-I      intronic
chr13:33696400(-) A-I      intronic
chr13:33766848(-) A-I      intronic
chr13:33735655(-) A-I      intronic
chr13:33696178(-) A-I      intronic
chr13:33695482(-) A-I      intronic
chr13:33695538(-) A-I      intronic
chr13:33823957(-) A-I      intronic
chr13:33695981(-) A-I      intronic
chr13:33695909(-) A-I      intronic
chr13:33731669(-) A-I      intronic
chr13:33695878(-) A-I      intronic
chr13:33695653(-) A-I      intronic
chr13:33695581(-) A-I      intronic
chr13:33731730(-) A-I      intronic
chr13:33696398(-) A-I      intronic
chr13:33761957(-) A-I      intronic
chr13:33764848(-) A-I      intronic
chr13:33710175(-) A-I      intronic
chr13:33731747(-) A-I      intronic
chr13:33695025(-) A-I      intronic
chr13:33824075(-) A-I      intronic
chr13:33764918(-) A-I      intronic
chr13:33764919(-) A-I      intronic
chr13:33764950(-) A-I      intronic
chr13:33764791(-) A-I      intronic
chr13:33766923(-) A-I      intronic
chr13:33824127(-) A-I      intronic
chr13:33700245(-) A-I      Syn:Arg->Arg
chr13:33796609(-) A-I      intronic
chr13:33795331(-) A-I      intronic
chr13:33695674(-) A-I      intronic
chr13:33710176(-) A-I      intronic
chr13:33696176(-) A-I      intronic
chr13:33731725(-) A-I      intronic
chr13:33695883(-) A-I      intronic
chr13:33764872(-) A-I      intronic
chr13:33824091(-) A-I      intronic
chr13:33715060(-) A-I      intronic
chr13:33695512(-) A-I      intronic
chr13:33695303(-) A-I      intronic
chr13:33695622(-) A-I      intronic
chr13:33764506(-) A-I      intronic
chr13:33695888(-) A-I      intronic
chr13:33694944(-) A-I      intronic
chr13:33694009(-) A-I      intronic
chr13:33824121(-) A-I      intronic
chr13:33695629(-) A-I      intronic
chr13:33764474(-) A-I      intronic
chr13:33762097(-) A-I      intronic
chr13:33824065(-) A-I      intronic
chr13:33695573(-) A-I      intronic
chr13:33844359(-) A-I      intronic
chr13:33822371(-) A-I      intronic
chr13:33764552(-) A-I      intronic
chr13:33796449(-) A-I      intronic
chr13:33696394(-) A-I      intronic
chr13:33695536(-) A-I      intronic
chr13:33695001(-) A-I      intronic
chr13:33696177(-) A-I      intronic
chr13:33764888(-) A-I      intronic
chr13:33795385(-) A-I      intronic
chr13:33796463(-) A-I      intronic
chr13:33795452(-) A-I      intronic
chr13:33796510(-) A-I      intronic
chr13:33796388(-) A-I      intronic
chr13:33695459(-) A-I      intronic
chr13:33844297(-) A-I      intronic
chr13:33696153(-) A-I      intronic
chr13:33696068(-) A-I      intronic
chr13:33764862(-) A-I      intronic
chr13:33764901(-) A-I      intronic
chr13:33766793(-) A-I      intronic
chr13:33764522(-) A-I      intronic
chr13:33695815(-) A-I      intronic
chr13:33694938(-) A-I      intronic
chr13:33764821(-) A-I      intronic
chr13:33796564(-) A-I      intronic
chr13:33796409(-) A-I      intronic
chr13:33764792(-) A-I      intronic
chr13:33764861(-) A-I      intronic
chr13:33795525(-) A-I      intronic
chr13:33696209(-) A-I      intronic
chr13:33796565(-) A-I      intronic
chr13:33762111(-) A-I      intronic
chr13:33696152(-) A-I      intronic
chr13:33795457(-) A-I      intronic
chr13:33695593(-) A-I      intronic
chr13:33695620(-) A-I      intronic
chr13:33716329(-) A-I      intronic
chr13:33696151(-) A-I      intronic
chr13:33695610(-) A-I      intronic
chr13:33806233(-) A-I      intronic
chr13:33806224(-) A-I      intronic
chr13:33764820(-) A-I      intronic
chr13:33844342(-) A-I      intronic
chr13:33796332(-) A-I      intronic
chr13:33695460(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED STARD13
chr13:33870284(-) A-I intron -    22327324
chr13:33915608(-) A-I intron -    22327324
chr13:33915611(-) A-I intron -    22327324
chr13:33921583(-) A-I intron -    22327324
chr13:33974330(-) A-I intron -    22327324
chr13:34085278(-) A-I intron -    22327324
chr13:34148757(-) A-I intron -    22327324
chr13:34148771(-) A-I intron -    22327324
chr13:34148848(-) A-I intron -    22327324
chr13:34148857(-) A-I intron -    22327324
chr13:34149145(-) A-I intron -    22327324
chr13:34178767(-) A-I intron -    22327324
chr13:34178850(-) A-I intron -    22327324
chr13:34181566(-) A-I intron -    22327324
chr13:34181572(-) A-I intron -    22327324
chr13:34182317(-) A-I intron -    22327324
chr13:34194008(-) A-I intron -    22327324
chr13:34194034(-) A-I intron -    22327324
chr13:34194037(-) A-I intron -    22327324
chr13:34194111(-) A-I intron -    22327324
chr13:34194150(-) A-I intron -    22327324
chr13:34194158(-) A-I intron -    22327324
chr13:34194517(-) A-I intron -    22327324
chr13:34195647(-) A-I intron -    22327324
chr13:34196221(-) A-I intron -    22327324
chr13:34199541(-) A-I intron -    22327324
chr13:34199669(-) A-I intron -    22327324
chr13:34200018(-) A-I intron -    22327324
chr13:34200021(-) A-I intron -    22327324
chr13:34222330(-) A-I intron -    22327324
chr13:34223578(-) A-I intron -    22327324
chr13:34223633(-) A-I intron -    22327324
chr13:34223636(-) A-I intron -    22327324
chr13:34223637(-) A-I intron -    22327324
chr13:34232328(-) A-I intron -    22327324
chr13:34241002(-) A-I intron -    22327324
chr13:34243784(-) A-I intron -    22327324
chr13:34245032(-) A-I intron -    22327324
chr13:34245791(-) A-I intron -    22327324
chr13:33795331(-) A-G intron -    22484847
chr13:33795385(-) A-G intron -    22484847
chr13:33795452(-) A-G intron -    22484847
chr13:33795457(-) A-G intron -    22484847
chr13:33795525(-) A-G intron -    22484847
chr13:33796510(-) A-G intron -    22484847
chr13:33796564(-) A-G intron -    22484847
chr13:33796565(-) A-G intron -    22484847
chr13:33796609(-) A-G intron -    22484847
chr13:34159881(-) A-G intron -    22484847
chr13:34223585(-) A-G intron -    22484847
chr13:34223591(-) A-G intron -    22484847
chr13:34223632(-) A-G intron -    22484847
chr13:34223633(-) A-G intron -    22484847
chr13:34223636(-) A-G intron -    22484847
chr13:34223637(-) A-G intron -    22484847
chr13:34244436(-) A-G intron -    22484847
chr13:34244448(-) A-G intron -    22484847
chr13:34244467(-) A-G intron -    22484847
chr13:34244485(-) A-G intron -    22484847
chr13:34244974(-) A-G intron -    22484847
chr13:34245017(-) A-G intron -    22484847
chr13:34245032(-) A-G intron -    22484847
chr13:33765012(-) A-G intron -    22484847
chr13:33905486(-) A-C intron -    22484847
chr13:34030464(-) A-G intron -    22484847
chr13:34033144(-) A-G intron -    22484847
chr13:34148757(-) A-G intron -    22484847
chr13:34148770(-) A-G intron -    22484847
chr13:34148771(-) A-G intron -    22484847
chr13:34161100(-) A-G intron -    22484847
chr13:34181566(-) A-G intron -    22484847
chr13:34181572(-) A-G intron -    22484847
chr13:34182081(-) A-G intron -    22484847
chr13:34196047(-) A-G intron -    22484847
chr13:34196079(-) A-G intron -    22484847
chr13:34243846(-) A-G intron -    22484847
chr13:34243852(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase STARD13
chr13:33677513-33677514(-) m6A 3'UTR       27773535
chr13:33677757-33677758(-) m6A 3'UTR       27773535
chr13:33677764-33677765(-) m6A 3'UTR       27773535
chr13:33679470-33679471(-) m6A 3'UTR       24981863//27773535//22608085
chr13:33679500-33679501(-) m6A 3'UTR       24981863//27773535//22608085
chr13:33679558-33679559(-) m6A 3'UTR       24209618//24981863//27773535//22608085
chr13:33679634-33679635(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//22608085
chr13:33679706-33679707(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//22575960//22608085
chr13:33679740-33679741(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//22575960//22608085
chr13:33679775-33679776(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr13:33679810-33679811(-) m6A CDS       24284625//24209618//24981863//22608085
chr13:33680900-33680901(-) m6A CDS       24209618//24981863//22608085
chr13:33680923-33680924(-) m6A CDS       22608085
chr13:33680947-33680948(-) m6A CDS       22608085
chr13:33703253-33703254(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr13:33703276-33703277(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr13:33703283-33703284(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr13:33703386-33703387(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//22575960//22608085
chr13:33703531-33703532(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr13:33703600-33703601(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr13:33703607-33703608(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr13:33703674-33703675(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27773536//22575960//22608085
chr13:33703696-33703697(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27773536//22575960//22608085
chr13:33703716-33703717(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27773536//22575960//22608085
chr13:33703972-33703973(-) m6A CDS       24284625//25456834//24981863
chr13:33704020-33704021(-) m6A CDS       24284625//25456834//24981863
chr13:33704160-33704161(-) m6A CDS       24209618//27773536
chr13:33704247-33704248(-) m6A CDS       -
chr13:33704277-33704278(-) m6A CDS       25456834//27773535
chr13:33704313-33704314(-) m6A CDS       25456834//24981863//27773535
chr13:33704368-33704369(-) m6A CDS       24981863//27773535
chr13:33704380-33704381(-) m6A CDS       24981863//27773535
chr13:33923163-33923164(-) m6A 3'UTR//intron       -
chr13:33923202-33923203(-) m6A 3'UTR//intron       -
chr13:33923227-33923228(-) m6A 3'UTR//intron       -
chr13:33923264-33923265(-) m6A 3'UTR//intron       -
chr13:33924660-33924661(-) m6A 5'UTR       27773536
chr13:33924694-33924695(-) m6A 5'UTR       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-454-3p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Serum     18589210
Exosome Saliva     19627513
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Plasma     23663360
Exosome Endothelial cells     -
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Nucleolus HeLa cells     23940654
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
STARD13
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-454-3p
4-(2-Pyridylazo)-N,N-dimethylaniline 81528 Drug sensitive
o-Aminoazotoluene 7340 Drug sensitive
Piperidinium pentamethylenedithiocarbamate 72508 Drug sensitive
Crotonoside 65085 Drug sensitive
Trihydroxygermaeranolide isobutyrate 6436277 Drug sensitive
(Z)-6-(2-(Pyridin-2-ylmethylene)hydrazinyl)-9H-purine 60147744 Drug sensitive
Ketone, methyl 2-pyridyl, 4,4-dimethyl-3-thiosemicarbazone 5843399 Drug sensitive
Incomptina B 54612584 Drug sensitive
Selendale 54601159 Drug resistant
Aspiculamycin hcl 54600418 Drug resistant
Methyl (1R,4R,7E,9S,10R,11S)-9-acetyloxy-10-(2,3-dimethyloxirane-2-carbonyl)oxy-4-methyl-12-methylidene-13-oxo-3,14-dioxatricyclo[9.3.0.02,4]tetradec-7-ene-8-carboxylate 5458601 Drug sensitive
7-(3-Methoxyphenyl)-N-(pyridin-4-ylmethylideneamino)-5H-pyrrolo[3,2-d]pyrimidin-4-amine 53239944 Drug resistant
Herbimycin 5311102 Drug sensitive
Vorinostat 5311 Drug sensitive
Amonafide 50515 Drug sensitive
Fastigilin C 442242 Drug sensitive
trans-Bis(acetato)amminepyridineplatinum(II) 405450 Drug sensitive
Antineoplastic-690271 391308 Drug sensitive
Idebenone 3686 Drug sensitive
2,7-Dicyanoxanthone 363841 Drug resistant
2-Hydroxy discorhabdin D 362391 Drug sensitive
Maxima isoflavone D 343081 Drug resistant
6-[(7-Nitro-2,1,3-benzoxadiazol-4-yl)sulfanyl]-7H-purin-2-amine 3246652 Drug sensitive
1,4-Naphthalenedione, 5,8-dihydroxy-2,3-bis(hydroxymethyl)- 313371 Drug sensitive
Razoxane 30623 Drug sensitive
[(5Z)-1,7,7-Trimethyl-5-(nitromethylene)-6-oxo-norbornan-2-yl] acetate 3004516 Drug sensitive
Salarin C 24867082 Drug resistant
2-(4-((Oxiran-2-yl)methoxy)styryl)-4,5-dihydrooxazole 24206038 Drug sensitive
Haterumalide NA methyl esters 24204452 Drug resistant
Pirarubicin hydrochloride 20846247 Drug sensitive
1,2:5,6-Dianhydrogalactitol 15942827 Drug sensitive
12-Iminodaunorubicin hcl 135539784 Drug sensitive
5-Hydroxypicolinaldehyde thiosemicarbazone 135453292 Drug sensitive
Formycin b 135449281 Drug sensitive
Kinamycin C 135430800 Drug sensitive
Veracoquinazole 135416663 Drug sensitive
Inosine dialdehyde 135400916 Drug sensitive
43-Dioxypectenotoxin 131751434 Drug resistant
Epilactose 128037 Drug resistant
Cytochalasin q 11970174 Drug sensitive
(3S,6R,10R,13Z,16S)-10-[(4-Methoxyphenyl)methyl]-6-methyl-3-(2-methylpropyl)-16-[(1S)-1-[(2R,3R)-3-phenyloxiran-2-yl]ethyl]-1,4-dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone 101917006 Drug resistant
Cyanocycline A 100158 Drug sensitive
1,3-diphenyl-4-(3-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1H-pyrazole - Drug resistant
9h-quino[4,3,2-de][1,10]phenanthrolin-9-one, 5-methoxy- - Drug resistant
N-(4-{2-[(1R,6R,11aS,13S,14aR)-1,13-dihydroxy-4-oxo-1,6,7,8,9,11a,12,13,14,14a-decahydro-4H-cyclopenta[f]oxacyclotridecin-6-yl]ethyl}phenyl)acetamide - Drug resistant
(1s,2e,4r,6r,7e,10r,11e)-2,7,11-cembratriene-4,6,10-triol - Drug sensitive
(2r,3r)-(+)-methyl 3-phenyloxirane-carboxylate - Drug sensitive
1h-benzo[a]carbazole-1,4(11h)-dione, 11-phenyl- - Drug sensitive
2,6-bis(4-morpholinylmethyl)cyclohexanone,dihydrochloride - Drug sensitive
2-bromo-5,8-dihydroxy-3-methyl-1,4-naphthoquinone - Drug sensitive
4-(2-pyridinyl)-5h-1,2,3-dithiazole-5-thione - Drug sensitive
6h-purine-6-thione, 1,7-dihydro-, mercury complex (9ci) - Drug sensitive
benzofurazan, 5-nitro-6-(1-piperidinyl)-, 1-oxide - Drug sensitive
cyclohexanone, 2,6-bis(piperidinomethyl)- - Drug sensitive
ethanone, 1-(2-pyrimidinyl)-, (2-benzoxazolyl)hydrazone - Drug sensitive
(s)(-)-methyl perillate - Drug sensitive
antineoplastic-654379 - Drug sensitive
Camptothecin Derivative - Drug sensitive
chlorobis(4-ethyltropolonato)bismuth(iii) - Drug sensitive
cyclo [n-naphthoyl-d-lys-asn-gln-trp-ala-val-d-ala-his-leu] - Drug sensitive
Indenoisoquinoline derivative - Drug sensitive
n-acetyl-4-s-cystaminyl phenol - Drug sensitive
o-linoleoyl-2-butoxy-1-desoamine - Drug sensitive
Tetraplatin - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-454-3p
Formaldehyde 712 Drug interaction    RC00006668
Gemcitabine 60750 Drug interaction    RC00006676
Vincristine 5978 Drug interaction    RC00006673
Floxuridine 5790 Drug interaction    RC00006672
Prednisolone 5755 Drug interaction    RC00006671
Sunitinib 5329102 Drug interaction    RC00006681
4-Hydroxynonenal 5283344 Drug interaction    RC00006680
Diethylstilbestrol 448537 Drug interaction    RC00006679
5-Fluorouracil 3385 Drug interaction    RC00006670
Doxorubicin 31703 Drug interaction    RC00006675
Daunorubicin 30323 Drug interaction    RC00006674
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00006677
Verapamil 2520 Drug interaction    RC00006669
Docetaxel 148124 Drug interaction    RC00006678
Asparaginase Escherichia coli - Drug interaction    RC00006683
FdUMP[10] - Drug interaction    RC00006682
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-454-3p
Cisplatin 5702198       30099826

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-454-3p
Interactor2: STARD13

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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