Basic Information:

  VIRBase ID:  

HHID00061814

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-454-3p:  MIMAT0003885          RC3H2:  NM_001354482     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-454-3p	RC3H2
miRBase Accession/Entrez ID	MIMAT0003885	54542
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	MNAB//RNF164

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-454-3p	rs1450965019 chr17:59137799    A/G rs377123764 chr17:59137788    C/G rs377123764 chr17:59137788    C/T rs771457463 chr17:59137792    A/G rs779514158 chr17:59137798    A/G rs1391884708 chr17:59137808    TACTCAGAACTATTTACAC/T rs555225543 chr17:59137803    T/G rs772555392 chr17:59137806    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	RC3H2	chr9:125657626(-) A-I      intronic chr9:125657625(-) A-I      intronic chr9:125638724(-) A-I      intronic chr9:125664879(-) A-I      intronic chr9:125664034(-) A-I      intronic chr9:125664009(-) A-I      intronic chr9:125663966(-) A-I      intronic chr9:125661514(-) A-I      intronic chr9:125661458(-) A-I      intronic chr9:125661454(-) A-I      intronic chr9:125648406(-) A-I      intronic chr9:125648396(-) A-I      intronic chr9:125648370(-) A-I      intronic chr9:125648363(-) A-I      intronic chr9:125648351(-) A-I      intronic chr9:125648344(-) A-I      intronic chr9:125615887(-) A-I      intronic chr9:125638905(-) A-I      intronic chr9:125665126(-) A-I      intronic chr9:125664482(-) A-I      intronic chr9:125664467(-) A-I      intronic chr9:125664466(-) A-I      intronic chr9:125664437(-) A-I      intronic chr9:125664105(-) A-I      intronic chr9:125664008(-) A-I      intronic chr9:125663992(-) A-I      intronic chr9:125661642(-) A-I      intronic chr9:125661619(-) A-I      intronic chr9:125661488(-) A-I      intronic chr9:125661450(-) A-I      intronic chr9:125661449(-) A-I      intronic chr9:125661442(-) A-I      intronic chr9:125661434(-) A-I      intronic chr9:125660971(-) A-I      intronic chr9:125660946(-) A-I      intronic chr9:125660826(-) A-I      intronic chr9:125660799(-) A-I      intronic chr9:125657726(-) A-I      intronic chr9:125657648(-) A-I      intronic chr9:125657640(-) A-I      intronic chr9:125657507(-) A-I      intronic chr9:125657491(-) A-I      intronic chr9:125655721(-) A-I      intronic chr9:125655657(-) A-I      intronic chr9:125655569(-) A-I      intronic chr9:125655561(-) A-I      intronic chr9:125647010(-) A-I      intronic chr9:125646151(-) A-I      intronic chr9:125646068(-) A-I      intronic chr9:125646067(-) A-I      intronic chr9:125641667(-) A-I      intronic chr9:125641560(-) A-I      intronic chr9:125641549(-) A-I      intronic chr9:125641544(-) A-I      intronic chr9:125641418(-) A-I      intronic chr9:125641136(-) A-I      intronic chr9:125641117(-) A-I      intronic chr9:125639473(-) A-I      intronic chr9:125638825(-) A-I      intronic chr9:125638820(-) A-I      intronic chr9:125638795(-) A-I      intronic chr9:125638735(-) A-I      intronic chr9:125638718(-) A-I      intronic chr9:125635749(-) A-I      intronic chr9:125635747(-) A-I      intronic chr9:125635116(-) A-I      intronic chr9:125635028(-) A-I      intronic chr9:125634314(-) A-I      intronic chr9:125634302(-) A-I      intronic chr9:125632491(-) A-I      intronic chr9:125626297(-) A-I      intronic chr9:125626289(-) A-I      intronic chr9:125626186(-) A-I      intronic chr9:125626127(-) A-I      intronic chr9:125626112(-) A-I      intronic chr9:125626092(-) A-I      intronic chr9:125626030(-) A-I      intronic chr9:125625117(-) A-I      intronic chr9:125625112(-) A-I      intronic chr9:125625091(-) A-I      intronic chr9:125625017(-) A-I      intronic chr9:125625008(-) A-I      intronic chr9:125623604(-) A-I      intronic chr9:125623526(-) A-I      intronic chr9:125622920(-) A-I      intronic chr9:125622919(-) A-I      intronic chr9:125622870(-) A-I      intronic chr9:125615903(-) A-I      intronic chr9:125615882(-) A-I      intronic chr9:125615814(-) A-I      intronic chr9:125661022(-) A-I      intronic chr9:125632099(-) A-I      intronic chr9:125639618(-) A-I      intronic chr9:125660981(-) A-I      intronic chr9:125635748(-) A-I      intronic chr9:125661484(-) A-I      intronic chr9:125635002(-) A-I      intronic chr9:125624972(-) A-I      intronic chr9:125664913(-) A-I      intronic chr9:125665049(-) A-I      intronic chr9:125624917(-) A-I      intronic chr9:125650201(-) A-I      intronic chr9:125657047(-) A-I      intronic chr9:125641573(-) A-I      intronic chr9:125657531(-) A-I      intronic chr9:125626177(-) A-I      intronic chr9:125615992(-) A-I      intronic chr9:125632896(-) A-I      intronic chr9:125639631(-) A-I      intronic chr9:125638824(-) A-I      intronic chr9:125641591(-) A-I      intronic chr9:125661636(-) A-I      intronic chr9:125635762(-) A-I      intronic chr9:125638663(-) A-I      intronic chr9:125634969(-) A-I      intronic chr9:125635916(-) A-I      intronic chr9:125641610(-) A-I      intronic chr9:125631309(-) A-I      intronic chr9:125664376(-) A-I      intronic chr9:125664053(-) A-I      intronic chr9:125622944(-) A-I      intronic chr9:125622831(-) A-I      intronic chr9:125664983(-) A-I      intronic chr9:125639464(-) A-I      intronic chr9:125657083(-) A-I      intronic chr9:125641152(-) A-I      intronic chr9:125652162(-) A-I      intronic chr9:125632497(-) A-I      intronic chr9:125656475(-) A-I      intronic chr9:125635868(-) A-I      intronic chr9:125641260(-) A-I      intronic chr9:125664922(-) A-I      intronic chr9:125655705(-) A-I      intronic chr9:125627093(-) A-I      intronic chr9:125622868(-) A-I      intronic chr9:125641611(-) A-I      intronic chr9:125641184(-) A-I      intronic chr9:125615883(-) A-I      intronic chr9:125622860(-) A-I      intronic chr9:125625052(-) A-I      intronic chr9:125615909(-) A-I      intronic chr9:125634226(-) A-I      intronic chr9:125622791(-) A-I      intronic chr9:125626971(-) A-I      intronic chr9:125635805(-) A-I      intronic chr9:125665086(-) A-I      intronic chr9:125632124(-) A-I      intronic chr9:125627175(-) A-I      intronic chr9:125664491(-) A-I      intronic chr9:125638823(-) A-I      intronic chr9:125657585(-) A-I      intronic chr9:125648304(-) A-I      intronic chr9:125665019(-) A-I      intronic chr9:125655710(-) A-I      intronic chr9:125626083(-) A-I      intronic chr9:125635757(-) A-I      intronic chr9:125641561(-) A-I      intronic chr9:125638662(-) A-I      intronic chr9:125665045(-) A-I      intronic chr9:125635001(-) A-I      intronic chr9:125665055(-) A-I      intronic chr9:125639526(-) A-I      intronic chr9:125656993(-) A-I      intronic chr9:125635880(-) A-I      intronic chr9:125661542(-) A-I      intronic chr9:125635833(-) A-I      intronic chr9:125660906(-) A-I      intronic chr9:125622875(-) A-I      intronic chr9:125633715(-) A-I      intronic chr9:125641263(-) A-I      intronic chr9:125632488(-) A-I      intronic chr9:125633869(-) A-I      intronic chr9:125664094(-) A-I      intronic chr9:125660928(-) A-I      intronic chr9:125627100(-) A-I      intronic chr9:125664939(-) A-I      intronic chr9:125648342(-) A-I      intronic chr9:125635910(-) A-I      intronic chr9:125641492(-) A-I      intronic chr9:125660945(-) A-I      intronic chr9:125660986(-) A-I      intronic chr9:125657097(-) A-I      intronic chr9:125638759(-) A-I      intronic chr9:125665048(-) A-I      intronic chr9:125664867(-) A-I      intronic chr9:125657623(-) A-I      intronic chr9:125641472(-) A-I      intronic chr9:125663976(-) A-I      intronic chr9:125625088(-) A-I      intronic chr9:125657506(-) A-I      intronic chr9:125623706(-) A-I      intronic chr9:125625065(-) A-I      intronic chr9:125638758(-) A-I      intronic chr9:125639463(-) A-I      intronic chr9:125665009(-) A-I      intronic chr9:125648881(-) A-I      intronic chr9:125638783(-) A-I      intronic chr9:125664926(-) A-I      intronic chr9:125635892(-) A-I      intronic chr9:125638690(-) A-I      intronic chr9:125661498(-) A-I      intronic chr9:125634256(-) A-I      intronic chr9:125615774(-) A-I      intronic chr9:125638702(-) A-I      intronic chr9:125660772(-) A-I      intronic chr9:125661510(-) A-I      intronic chr9:125618634(-) A-I      intronic chr9:125622900(-) A-I      intronic chr9:125656349(-) A-I      intronic chr9:125635822(-) A-I      intronic chr9:125622943(-) A-I      intronic chr9:125640824(-) A-I      intronic chr9:125623709(-) A-I      intronic chr9:125635905(-) A-I      intronic chr9:125641195(-) A-I      intronic chr9:125625074(-) A-I      intronic chr9:125650163(-) A-I      intronic chr9:125664035(-) A-I      intronic chr9:125638807(-) A-I      intronic chr9:125641651(-) A-I      intronic chr9:125639508(-) A-I      intronic chr9:125624956(-) A-I      intronic chr9:125660857(-) A-I      intronic chr9:125635870(-) A-I      intronic chr9:125648950(-) A-I      intronic chr9:125622790(-) A-I      intronic chr9:125664373(-) A-I      intronic chr9:125631319(-) A-I      intronic chr9:125647085(-) A-I      intronic chr9:125625111(-) A-I      intronic chr9:125661551(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	RC3H2	chr9:125636234(-) A-I intron -    15258596 chr9:125636235(-) A-I intron -    15258596 chr9:125636998(-) A-I intron -    15258596 chr9:125637072(-) A-I intron -    15258596 chr9:125622791(-) A-I intron -    22327324 chr9:125635870(-) A-I intron -    21960545   //22327324 chr9:125622791(-) A-G intron -    22484847 chr9:125622860(-) A-G intron -    22484847 chr9:125623794(-) C-T intron -    22484847 chr9:125624917(-) A-G intron -    22484847 chr9:125635002(-) A-G intron -    22484847 chr9:125635833(-) A-G intron -    22484847 chr9:125635870(-) A-G intron -    22484847 chr9:125636234(-) A-G intron -    22484847 chr9:125636235(-) A-G intron -    22484847 chr9:125636998(-) A-G intron -    22484847 chr9:125638662(-) A-G intron -    22484847 chr9:125638823(-) A-G intron -    22484847 chr9:125648950(-) A-G intron -    22484847 chr9:125664064(-) A-G intron -    22484847 chr9:125664867(-) A-G intron -    22484847 chr9:125664983(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	RC3H2	chr9:125607040-125607041(-) m6A 3'UTR       24981863 chr9:125607085-125607086(-) m6A 3'UTR       24981863 chr9:125608044-125608045(-) m6A 3'UTR       24981863 chr9:125608062-125608063(-) m6A 3'UTR       24981863 chr9:125608131-125608132(-) m6A 3'UTR       24981863//22608085 chr9:125608205-125608206(-) m6A 3'UTR       24981863//22608085 chr9:125608959-125608960(-) m6A 3'UTR       27773535//22608085 chr9:125609092-125609093(-) m6A 3'UTR       24284625//24981863//27773535//22608085 chr9:125611769-125611770(-) m6A 3'UTR       27773535//22608085 chr9:125611938-125611939(-) m6A 3'UTR//CDS       24284625//24981863//27773535//27371828//22608085 chr9:125611976-125611977(-) m6A 3'UTR//CDS       24284625//24981863//27773535//27371828//22608085 chr9:125612087-125612088(-) m6A 3'UTR//CDS//exon       24284625//24981863//27773535//27371828//22608085 chr9:125613371-125613372(-) m6A 3'UTR//CDS//exon//intron       24284625//24981863//27773535//27371828//22608085 chr9:125613388-125613389(-) m6A 3'UTR//CDS//exon       24284625//24981863//27773535//27371828//22608085 chr9:125613497-125613498(-) m6A 3'UTR//CDS//exon       24981863//27773535 chr9:125613610-125613611(-) m6A 3'UTR//CDS//exon       24981863//27773535 chr9:125613619-125613620(-) m6A 3'UTR//CDS//exon       27773535 chr9:125613628-125613629(-) m6A 3'UTR//CDS//exon       27773535 chr9:125616103-125616104(-) m6A 3'UTR//intron       27773535 chr9:125616472-125616473(-) m6A 3'UTR//CDS       - chr9:125616488-125616489(-) m6A 3'UTR//CDS       - chr9:125616542-125616543(-) m6A 3'UTR//CDS       - chr9:125620350-125620351(-) m6A 3'UTR//CDS       27773535 chr9:125620369-125620370(-) m6A 3'UTR//CDS       27773535 chr9:125620967-125620968(-) m6A 3'UTR//CDS       27773535 chr9:125621187-125621188(-) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085 chr9:125622198-125622199(-) m6A 3'UTR//CDS       27773535 chr9:125622234-125622235(-) m6A 3'UTR//CDS       27773535 chr9:125622260-125622261(-) m6A 3'UTR//CDS       27773535 chr9:125622336-125622337(-) m6A 3'UTR//CDS       27773535 chr9:125622387-125622388(-) m6A 3'UTR//CDS       27773535 chr9:125627703-125627704(-) m6A 3'UTR//CDS       27773535 chr9:125652658-125652659(-) m6A CDS//exon       27773535 chr9:125652678-125652679(-) m6A CDS//exon       27773535 chr9:125652689-125652690(-) m6A CDS//exon       27773535 chr9:125652736-125652737(-) Am CDS//exon       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-454-3p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Serum     18589210 Exosome Saliva     19627513 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Primary dendritic cells|T cell line (J77)     21505438 Exosome Plasma     23663360 Exosome Endothelial cells     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Nucleolus HeLa cells     23940654 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	RC3H2	Cytoplasm OSCC cell lines (Cal27|HN4)     32163895 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome HEK-293 cells     22199352

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-454-3p	4-(2-Pyridylazo)-N,N-dimethylaniline 81528 Drug sensitive o-Aminoazotoluene 7340 Drug sensitive Piperidinium pentamethylenedithiocarbamate 72508 Drug sensitive Crotonoside 65085 Drug sensitive Trihydroxygermaeranolide isobutyrate 6436277 Drug sensitive (Z)-6-(2-(Pyridin-2-ylmethylene)hydrazinyl)-9H-purine 60147744 Drug sensitive Ketone, methyl 2-pyridyl, 4,4-dimethyl-3-thiosemicarbazone 5843399 Drug sensitive Incomptina B 54612584 Drug sensitive Selendale 54601159 Drug resistant Aspiculamycin hcl 54600418 Drug resistant Methyl (1R,4R,7E,9S,10R,11S)-9-acetyloxy-10-(2,3-dimethyloxirane-2-carbonyl)oxy-4-methyl-12-methylidene-13-oxo-3,14-dioxatricyclo[9.3.0.02,4]tetradec-7-ene-8-carboxylate 5458601 Drug sensitive 7-(3-Methoxyphenyl)-N-(pyridin-4-ylmethylideneamino)-5H-pyrrolo[3,2-d]pyrimidin-4-amine 53239944 Drug resistant Herbimycin 5311102 Drug sensitive Vorinostat 5311 Drug sensitive Amonafide 50515 Drug sensitive Fastigilin C 442242 Drug sensitive trans-Bis(acetato)amminepyridineplatinum(II) 405450 Drug sensitive Antineoplastic-690271 391308 Drug sensitive Idebenone 3686 Drug sensitive 2,7-Dicyanoxanthone 363841 Drug resistant 2-Hydroxy discorhabdin D 362391 Drug sensitive Maxima isoflavone D 343081 Drug resistant 6-[(7-Nitro-2,1,3-benzoxadiazol-4-yl)sulfanyl]-7H-purin-2-amine 3246652 Drug sensitive 1,4-Naphthalenedione, 5,8-dihydroxy-2,3-bis(hydroxymethyl)- 313371 Drug sensitive Razoxane 30623 Drug sensitive [(5Z)-1,7,7-Trimethyl-5-(nitromethylene)-6-oxo-norbornan-2-yl] acetate 3004516 Drug sensitive Salarin C 24867082 Drug resistant 2-(4-((Oxiran-2-yl)methoxy)styryl)-4,5-dihydrooxazole 24206038 Drug sensitive Haterumalide NA methyl esters 24204452 Drug resistant Pirarubicin hydrochloride 20846247 Drug sensitive 1,2:5,6-Dianhydrogalactitol 15942827 Drug sensitive 12-Iminodaunorubicin hcl 135539784 Drug sensitive 5-Hydroxypicolinaldehyde thiosemicarbazone 135453292 Drug sensitive Formycin b 135449281 Drug sensitive Kinamycin C 135430800 Drug sensitive Veracoquinazole 135416663 Drug sensitive Inosine dialdehyde 135400916 Drug sensitive 43-Dioxypectenotoxin 131751434 Drug resistant Epilactose 128037 Drug resistant Cytochalasin q 11970174 Drug sensitive (3S,6R,10R,13Z,16S)-10-[(4-Methoxyphenyl)methyl]-6-methyl-3-(2-methylpropyl)-16-[(1S)-1-[(2R,3R)-3-phenyloxiran-2-yl]ethyl]-1,4-dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone 101917006 Drug resistant Cyanocycline A 100158 Drug sensitive 1,3-diphenyl-4-(3-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1H-pyrazole - Drug resistant 9h-quino[4,3,2-de][1,10]phenanthrolin-9-one, 5-methoxy- - Drug resistant N-(4-{2-[(1R,6R,11aS,13S,14aR)-1,13-dihydroxy-4-oxo-1,6,7,8,9,11a,12,13,14,14a-decahydro-4H-cyclopenta[f]oxacyclotridecin-6-yl]ethyl}phenyl)acetamide - Drug resistant (1s,2e,4r,6r,7e,10r,11e)-2,7,11-cembratriene-4,6,10-triol - Drug sensitive (2r,3r)-(+)-methyl 3-phenyloxirane-carboxylate - Drug sensitive 1h-benzo[a]carbazole-1,4(11h)-dione, 11-phenyl- - Drug sensitive 2,6-bis(4-morpholinylmethyl)cyclohexanone,dihydrochloride - Drug sensitive 2-bromo-5,8-dihydroxy-3-methyl-1,4-naphthoquinone - Drug sensitive 4-(2-pyridinyl)-5h-1,2,3-dithiazole-5-thione - Drug sensitive 6h-purine-6-thione, 1,7-dihydro-, mercury complex (9ci) - Drug sensitive benzofurazan, 5-nitro-6-(1-piperidinyl)-, 1-oxide - Drug sensitive cyclohexanone, 2,6-bis(piperidinomethyl)- - Drug sensitive ethanone, 1-(2-pyrimidinyl)-, (2-benzoxazolyl)hydrazone - Drug sensitive (s)(-)-methyl perillate - Drug sensitive antineoplastic-654379 - Drug sensitive Camptothecin Derivative - Drug sensitive chlorobis(4-ethyltropolonato)bismuth(iii) - Drug sensitive cyclo [n-naphthoyl-d-lys-asn-gln-trp-ala-val-d-ala-his-leu] - Drug sensitive Indenoisoquinoline derivative - Drug sensitive n-acetyl-4-s-cystaminyl phenol - Drug sensitive o-linoleoyl-2-butoxy-1-desoamine - Drug sensitive Tetraplatin - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-454-3p	Formaldehyde 712 Drug interaction    RC00006668 Gemcitabine 60750 Drug interaction    RC00006676 Vincristine 5978 Drug interaction    RC00006673 Floxuridine 5790 Drug interaction    RC00006672 Prednisolone 5755 Drug interaction    RC00006671 Sunitinib 5329102 Drug interaction    RC00006681 4-Hydroxynonenal 5283344 Drug interaction    RC00006680 Diethylstilbestrol 448537 Drug interaction    RC00006679 5-Fluorouracil 3385 Drug interaction    RC00006670 Doxorubicin 31703 Drug interaction    RC00006675 Daunorubicin 30323 Drug interaction    RC00006674 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00006677 Verapamil 2520 Drug interaction    RC00006669 Docetaxel 148124 Drug interaction    RC00006678 Asparaginase Escherichia coli - Drug interaction    RC00006683 FdUMP[10] - Drug interaction    RC00006682

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-454-3p	Cisplatin 5702198       30099826

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-454-3p
Interactor2: RC3H2

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.