Basic Information:

  VIRBase ID:  

HHID00061796

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-454-3p:  MIMAT0003885          ITSN2:  NM_001348182     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-454-3p	ITSN2
miRBase Accession/Entrez ID	MIMAT0003885	50618
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	PRO2015//SH3D1B//SH3P18//SWA//SWAP

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-454-3p	rs1450965019 chr17:59137799    A/G rs377123764 chr17:59137788    C/G rs377123764 chr17:59137788    C/T rs771457463 chr17:59137792    A/G rs779514158 chr17:59137798    A/G rs1391884708 chr17:59137808    TACTCAGAACTATTTACAC/T rs555225543 chr17:59137803    T/G rs772555392 chr17:59137806    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ITSN2	chr2:24479982(-) A-I      intronic chr2:24517173(-) A-I      intronic chr2:24517195(-) A-I      intronic chr2:24539246(-) A-I      intronic chr2:24480418(-) A-I      intronic chr2:24517233(-) A-I      intronic chr2:24517232(-) A-I      intronic chr2:24517208(-) A-I      intronic chr2:24539261(-) A-I      intronic chr2:24539278(-) A-I      intronic chr2:24539242(-) A-I      intronic chr2:24453574(-) A-I      intronic chr2:24539288(-) A-I      intronic chr2:24487231(-) A-I      intronic chr2:24489615(-) A-I      intronic chr2:24489746(-) A-I      intronic chr2:24490568(-) A-I      intronic chr2:24490595(-) A-I      intronic chr2:24490625(-) A-I      intronic chr2:24498168(-) A-I      intronic chr2:24517077(-) A-I      intronic chr2:24517219(-) A-I      intronic chr2:24518305(-) A-I      intronic chr2:24518386(-) A-I      intronic chr2:24518391(-) A-I      intronic chr2:24518405(-) A-I      intronic chr2:24528254(-) A-I      intronic chr2:24528259(-) A-I      intronic chr2:24528878(-) A-I      intronic chr2:24528911(-) A-I      intronic chr2:24528914(-) A-I      intronic chr2:24528921(-) A-I      intronic chr2:24529009(-) A-I      intronic chr2:24529115(-) A-I      intronic chr2:24550312(-) A-I      intronic chr2:24550341(-) A-I      intronic chr2:24550345(-) A-I      intronic chr2:24550346(-) A-I      intronic chr2:24550392(-) A-I      intronic chr2:24550395(-) A-I      intronic chr2:24479968(-) A-I      intronic chr2:24479981(-) A-I      intronic chr2:24480033(-) A-I      intronic chr2:24550423(-) A-I      intronic chr2:24554963(-) A-I      intronic chr2:24555003(-) A-I      intronic chr2:24556794(-) A-I      intronic chr2:24557035(-) A-I      intronic chr2:24480089(-) A-I      intronic chr2:24480106(-) A-I      intronic chr2:24564579(-) A-I      intronic chr2:24480184(-) A-I      intronic chr2:24480464(-) A-I      intronic chr2:24557110(-) A-I      intronic chr2:24480499(-) A-I      intronic chr2:24480502(-) A-I      intronic chr2:24480504(-) A-I      intronic chr2:24479942(-) A-I      intronic chr2:24557131(-) A-I      intronic chr2:24557183(-) A-I      intronic chr2:24557194(-) A-I      intronic chr2:24480505(-) A-I      intronic chr2:24480506(-) A-I      intronic chr2:24557217(-) A-I      intronic chr2:24558361(-) A-I      intronic chr2:24558702(-) A-I      intronic chr2:24558921(-) A-I      intronic chr2:24558929(-) A-I      intronic chr2:24558946(-) A-I      intronic chr2:24558952(-) A-I      intronic chr2:24558962(-) A-I      intronic chr2:24571314(-) A-I      intronic chr2:24576220(-) A-I      intronic chr2:24576451(-) A-I      intronic chr2:24564582(-) A-I      intronic chr2:24564654(-) A-I      intronic chr2:24565235(-) A-I      intronic chr2:24565897(-) A-I      intronic chr2:24518304(-) A-I      intronic chr2:24565938(-) A-I      intronic chr2:24569806(-) A-I      intronic chr2:24569810(-) A-I      intronic chr2:24569869(-) A-I      intronic chr2:24558989(-) A-I      intronic chr2:24569947(-) A-I      intronic chr2:24444997(-) A-I      intronic chr2:24445634(-) A-I      intronic chr2:24445673(-) A-I      intronic chr2:24445749(-) A-I      intronic chr2:24449417(-) A-I      intronic chr2:24449443(-) A-I      intronic chr2:24450712(-) A-I      intronic chr2:24453525(-) A-I      intronic chr2:24453528(-) A-I      intronic chr2:24453529(-) A-I      intronic chr2:24478357(-) A-I      intronic chr2:24478428(-) A-I      intronic chr2:24480182(-) A-I      intronic chr2:24559002(-) A-I      intronic chr2:24559003(-) A-I      intronic chr2:24559107(-) A-I      intronic chr2:24559109(-) A-I      intronic chr2:24560492(-) A-I      intronic chr2:24560639(-) A-I      intronic chr2:24560649(-) A-I      intronic chr2:24562652(-) A-I      intronic chr2:24562724(-) A-I      intronic chr2:24562725(-) A-I      intronic chr2:24562761(-) A-I      intronic chr2:24562878(-) A-I      intronic chr2:24563250(-) A-I      intronic chr2:24564536(-) A-I      intronic chr2:24570004(-) A-I      intronic chr2:24570455(-) A-I      intronic chr2:24570720(-) A-I      intronic chr2:24570758(-) A-I      intronic chr2:24570761(-) A-I      intronic chr2:24571159(-) A-I      intronic chr2:24480577(-) A-I      intronic chr2:24487058(-) A-I      intronic chr2:24558999(-) A-I      intronic chr2:24518382(-) A-I      intronic chr2:24445002(-) A-I      intronic chr2:24560439(-) A-I      intronic chr2:24560384(-) A-I      intronic chr2:24558646(-) A-I      intronic chr2:24560425(-) A-I      intronic chr2:24480029(-) A-I      intronic chr2:24480563(-) A-I      intronic chr2:24560448(-) A-I      intronic chr2:24459543(-) A-I      intronic chr2:24562780(-) A-I      intronic chr2:24518191(-) A-I      intronic chr2:24570472(-) A-I      intronic chr2:24560357(-) A-I      intronic chr2:24570833(-) A-I      intronic chr2:24541117(-) A-I      intronic chr2:24558287(-) A-I      intronic chr2:24489729(-) A-I      intronic chr2:24528307(-) A-I      intronic chr2:24444940(-) A-I      intronic chr2:24445617(-) A-I      intronic chr2:24560465(-) A-I      intronic chr2:24480508(-) A-I      intronic chr2:24554989(-) A-I      intronic chr2:24506098(-) A-I      intronic chr2:24550347(-) A-I      intronic chr2:24480493(-) A-I      intronic chr2:24446522(-) A-I      intronic chr2:24580921(-) A-I      intronic chr2:24480034(-) A-I      intronic chr2:24548265(-) A-I      intronic chr2:24556919(-) A-I      intronic chr2:24565267(-) A-I      intronic chr2:24529703(-) A-I      intronic chr2:24517209(-) A-I      intronic chr2:24580947(-) A-I      intronic chr2:24560486(-) A-I      intronic chr2:24563298(-) A-I      intronic chr2:24558640(-) A-I      intronic chr2:24569928(-) A-I      intronic chr2:24569953(-) A-I      intronic chr2:24565132(-) A-I      intronic chr2:24570473(-) A-I      intronic chr2:24558854(-) A-I      intronic chr2:24539331(-) A-I      intronic chr2:24466587(-) A-I      intronic chr2:24560461(-) A-I      intronic chr2:24560352(-) A-I      intronic chr2:24554078(-) A-I      intronic chr2:24495552(-) A-I      intronic chr2:24482944(-) A-I      intronic chr2:24554145(-) A-I      intronic chr2:24480393(-) A-I      intronic chr2:24452427(-) A-I      intronic chr2:24480599(-) A-I      intronic chr2:24478369(-) A-I      intronic chr2:24570431(-) A-I      intronic chr2:24560358(-) A-I      intronic chr2:24550400(-) A-I      intronic chr2:24489744(-) A-I      intronic chr2:24560491(-) A-I      intronic chr2:24558294(-) A-I      intronic chr2:24570503(-) A-I      intronic chr2:24560424(-) A-I      intronic chr2:24564588(-) A-I      intronic chr2:24558710(-) A-I      intronic chr2:24529012(-) A-I      intronic chr2:24542989(-) A-I      intronic chr2:24557688(-) A-I      intronic chr2:24569872(-) A-I      intronic chr2:24528399(-) A-I      intronic chr2:24539423(-) A-I      intronic chr2:24540153(-) A-I      intronic chr2:24518340(-) A-I      intronic chr2:24480581(-) A-I      intronic chr2:24570731(-) A-I      intronic chr2:24560633(-) A-I      intronic chr2:24562730(-) A-I      intronic chr2:24570516(-) A-I      intronic chr2:24517212(-) A-I      intronic chr2:24518374(-) A-I      intronic chr2:24490451(-) A-I      intronic chr2:24558299(-) A-I      intronic chr2:24550362(-) A-I      intronic chr2:24489539(-) A-I      intronic chr2:24561626(-) A-I      intronic chr2:24445630(-) A-I      intronic chr2:24565169(-) A-I      intronic chr2:24550305(-) A-I      intronic chr2:24478325(-) A-I      intronic chr2:24466591(-) A-I      intronic chr2:24558385(-) A-I      intronic chr2:24459677(-) A-I      intronic chr2:24550440(-) A-I      intronic chr2:24539422(-) A-I      intronic chr2:24569952(-) A-I      intronic chr2:24478445(-) A-I      intronic chr2:24487902(-) A-I      intronic chr2:24487132(-) A-I      intronic chr2:24569898(-) A-I      intronic chr2:24528214(-) A-I      intronic chr2:24570863(-) A-I      intronic chr2:24558711(-) A-I      intronic chr2:24517183(-) A-I      intronic chr2:24562191(-) A-I      intronic chr2:24449909(-) A-I      intronic chr2:24558340(-) A-I      intronic chr2:24528260(-) A-I      intronic chr2:24518261(-) A-I      intronic chr2:24570845(-) A-I      intronic chr2:24570823(-) A-I      intronic chr2:24550306(-) A-I      intronic chr2:24483065(-) A-I      intronic chr2:24552361(-) A-I      intronic chr2:24580880(-) A-I      intronic chr2:24569830(-) A-I      intronic chr2:24459815(-) A-I      intronic chr2:24558366(-) A-I      intronic chr2:24576389(-) A-I      intronic chr2:24550196(-) A-I      intronic chr2:24468476(-) A-I      intronic chr2:24487939(-) A-I      intronic chr2:24490705(-) A-I      intronic chr2:24576263(-) A-I      intronic chr2:24558655(-) A-I      intronic chr2:24557267(-) A-I      intronic chr2:24495461(-) A-I      intronic chr2:24529138(-) A-I      intronic chr2:24528881(-) A-I      intronic chr2:24480113(-) A-I      intronic chr2:24449403(-) A-I      intronic chr2:24570690(-) A-I      intronic chr2:24478397(-) A-I      intronic chr2:24490646(-) A-I      intronic chr2:24562859(-) A-I      intronic chr2:24565248(-) A-I      intronic chr2:24554141(-) A-I      intronic chr2:24452222(-) A-I      intronic chr2:24480519(-) A-I      intronic chr2:24529076(-) A-I      intronic chr2:24480120(-) A-I      intronic chr2:24478365(-) A-I      intronic chr2:24444999(-) A-I      intronic chr2:24565129(-) A-I      intronic chr2:24570862(-) A-I      intronic chr2:24480094(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ITSN2	chr2:24560352(-) A-I intron -    22028664 chr2:24560357(-) A-I intron -    22028664 chr2:24560358(-) A-I intron -    22028664 chr2:24560384(-) A-I intron -    22028664 chr2:24560424(-) A-I intron -    22028664 chr2:24560425(-) A-I intron -    22028664 chr2:24560439(-) A-I intron -    22028664 chr2:24560448(-) A-I intron -    22028664 chr2:24560461(-) A-I intron -    22028664 chr2:24560465(-) A-I intron -    22028664 chr2:24560486(-) A-I intron -    22028664 chr2:24560491(-) A-I intron -    22028664 chr2:24565231(-) A-I intron -    21960545 chr2:24565235(-) A-I intron -    21960545 chr2:24565601(-) A-I intron -    21960545 chr2:24566360(-) A-I intron -    21960545 chr2:24494638(-) A-C exon CDS    21725310 chr2:24444932(-) A-G intron -    22484847 chr2:24444940(-) A-G intron -    22484847 chr2:24444999(-) A-G intron -    22484847 chr2:24445002(-) A-G intron -    22484847 chr2:24445009(-) A-G intron -    22484847 chr2:24449909(-) A-G intron -    22484847 chr2:24474018(-) T-G intron -    22484847 chr2:24478325(-) A-G intron -    22484847 chr2:24478365(-) A-G intron -    22484847 chr2:24478369(-) A-G intron -    22484847 chr2:24478445(-) A-G intron -    22484847 chr2:24478754(-) C-T intron -    22484847 chr2:24479941(-) A-G intron -    22484847 chr2:24479983(-) A-G intron -    22484847 chr2:24480029(-) A-G intron -    22484847 chr2:24480034(-) A-G intron -    22484847 chr2:24480094(-) A-G intron -    22484847 chr2:24480113(-) A-G intron -    22484847 chr2:24480442(-) A-G intron -    22484847 chr2:24480503(-) A-G intron -    22484847 chr2:24480581(-) A-G intron -    22484847 chr2:24480599(-) A-G intron -    22484847 chr2:24483771(-) A-T intron -    22484847 chr2:24483772(-) G-T intron -    22484847 chr2:24487069(-) A-G intron -    22484847 chr2:24487868(-) G-A intron -    22484847 chr2:24487887(-) A-G intron -    22484847 chr2:24487902(-) A-G intron -    22484847 chr2:24487939(-) A-G intron -    22484847 chr2:24489678(-) A-G intron -    22484847 chr2:24489729(-) A-G intron -    22484847 chr2:24489734(-) A-G intron -    22484847 chr2:24489744(-) A-G intron -    22484847 chr2:24490629(-) A-G intron -    22484847 chr2:24490646(-) A-G intron -    22484847 chr2:24514625(-) T-C intron -    22484847 chr2:24517038(-) A-G intron -    22484847 chr2:24517183(-) A-G intron -    22484847 chr2:24517209(-) A-G intron -    22484847 chr2:24517212(-) A-G intron -    22484847 chr2:24518261(-) A-G intron -    22484847 chr2:24528260(-) A-G intron -    22484847 chr2:24528307(-) A-G intron -    22484847 chr2:24529012(-) A-G intron -    22484847 chr2:24529138(-) A-G intron -    22484847 chr2:24539422(-) A-G intron -    22484847 chr2:24539423(-) A-G intron -    22484847 chr2:24540153(-) A-G intron -    22484847 chr2:24540201(-) A-G intron -    22484847 chr2:24540253(-) A-G intron -    22484847 chr2:24540254(-) G-T intron -    22484847 chr2:24541117(-) A-G intron -    22484847 chr2:24543089(-) T-G intron -    22484847 chr2:24543090(-) G-A intron -    22484847 chr2:24543092(-) A-T intron -    22484847 chr2:24556919(-) A-G intron -    22484847 chr2:24557267(-) A-G intron -    22484847 chr2:24557688(-) A-G intron -    22484847 chr2:24558294(-) A-G intron -    22484847 chr2:24558299(-) A-G intron -    22484847 chr2:24558326(-) A-G intron -    22484847 chr2:24558366(-) A-G intron -    22484847 chr2:24558601(-) A-G intron -    22484847 chr2:24558646(-) A-G intron -    22484847 chr2:24558655(-) A-G intron -    22484847 chr2:24558710(-) A-G intron -    22484847 chr2:24558711(-) A-G intron -    22484847 chr2:24560633(-) A-G intron -    22484847 chr2:24562730(-) A-G intron -    22484847 chr2:24562780(-) A-G intron -    22484847 chr2:24562859(-) A-G intron -    22484847 chr2:24562883(-) A-G intron -    22484847 chr2:24563298(-) A-G intron -    22484847 chr2:24563354(-) T-C intron -    22484847 chr2:24564588(-) A-G intron -    22484847 chr2:24565958(-) A-T intron -    22484847 chr2:24565959(-) G-T intron -    22484847 chr2:24569953(-) A-G intron -    22484847 chr2:24569961(-) A-G intron -    22484847 chr2:24570465(-) T-C intron -    22484847 chr2:24570472(-) A-G intron -    22484847 chr2:24570473(-) A-G intron -    22484847 chr2:24570503(-) A-G intron -    22484847 chr2:24570516(-) A-G intron -    22484847 chr2:24570731(-) A-G intron -    22484847 chr2:24570823(-) A-G intron -    22484847 chr2:24570829(-) A-G intron -    22484847 chr2:24570845(-) A-G intron -    22484847 chr2:24570850(-) A-G intron -    22484847 chr2:24570862(-) A-G intron -    22484847 chr2:24570863(-) A-G intron -    22484847 chr2:24570936(-) A-G intron -    22484847 chr2:24571155(-) A-G intron -    22484847 chr2:24571331(-) A-G intron -    22484847 chr2:24579771(-) A-T intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ITSN2	chr2:24426300-24426301(-) m6A 3'UTR//exon       - chr2:24426305-24426306(-) m6A 3'UTR//exon       - chr2:24426324-24426325(-) m6A 3'UTR//exon       - chr2:24426434-24426435(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085 chr2:24426467-24426468(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085 chr2:24426481-24426482(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27371828//22608085 chr2:24426505-24426506(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27371828//22608085 chr2:24426605-24426606(-) m6A 3'UTR//CDS//exon       - chr2:24426610-24426611(-) m6A 3'UTR//CDS//exon       - chr2:24427220-24427221(-) m6A 3'UTR//CDS//exon       27773535 chr2:24427230-24427231(-) m6A 3'UTR//CDS//exon       27773535 chr2:24428089-24428090(-) m6A 3'UTR//CDS//exon       27773535 chr2:24428151-24428152(-) m6A 3'UTR//CDS//exon       27773535 chr2:24428186-24428187(-) m6A exon//intron       - chr2:24428413-24428414(-) m6A exon//intron       27773535 chr2:24428497-24428498(-) m6A exon//intron       27773535 chr2:24428520-24428521(-) m6A exon//intron       27773535 chr2:24439078-24439079(-) m6A CDS       27773535 chr2:24462177-24462178(-) m6A 3'UTR//intron       27773535 chr2:24462216-24462217(-) m6A 3'UTR//intron       27773535 chr2:24462292-24462293(-) m6A 3'UTR//intron       27773535 chr2:24475228-24475229(-) m6A CDS       24981863 chr2:24475238-24475239(-) m6A CDS       24981863 chr2:24475278-24475279(-) m6A CDS       24981863 chr2:24493579-24493580(-) m6A CDS       27773535 chr2:24493631-24493632(-) m6A CDS       24981863//28052920//27773535//27371828//22608085 chr2:24494677-24494678(-) m6A CDS       24981863//28052920//27773535//27371828//22608085 chr2:24494721-24494722(-) m6A CDS       24981863//28052920//27773535//27371828//22608085 chr2:24494746-24494747(-) m6A CDS       24981863//28052920//27773535//27371828//22608085 chr2:24494753-24494754(-) m1A CDS       26863196 chr2:24494786-24494787(-) m6A CDS       24981863//28052920//27773535//27371828//22608085 chr2:24498601-24498602(-) m6A CDS       24981863//27773535//22608085 chr2:24498619-24498620(-) m6A CDS       24981863//27773535//22608085 chr2:24498676-24498677(-) m6A CDS       24981863//27773535//22608085 chr2:24498705-24498706(-) m6A CDS       27773535//22608085 chr2:24498715-24498716(-) m6A CDS       27773535 chr2:24516579-24516580(-) m6A CDS//exon       24981863//27773535 chr2:24518538-24518539(-) m6A CDS//exon       24981863//27773535//27371828 chr2:24518606-24518607(-) m6A CDS       24981863//27773535//27371828 chr2:24518615-24518616(-) m6A CDS       24981863//27773535//27371828 chr2:24518643-24518644(-) m6A CDS       24981863//27773535//27371828 chr2:24518664-24518665(-) m6A CDS       24981863//27773535//27371828 chr2:24521573-24521574(-) m6A CDS       24981863//27773535//27371828//22608085 chr2:24521596-24521597(-) m6A CDS       24981863//28052920//27773535//27371828//22608085 chr2:24521668-24521669(-) m6A CDS       24209618//24981863//28052920//27773535//27371828//22608085 chr2:24521674-24521675(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828//22608085 chr2:24522793-24522794(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828//22608085 chr2:24522819-24522820(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828//22608085 chr2:24522867-24522868(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828//22608085 chr2:24522882-24522883(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828//22608085 chr2:24522900-24522901(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828//22608085 chr2:24522997-24522998(-) m6A CDS       24981863//27773535//27371828//22608085 chr2:24523027-24523028(-) m6A CDS       24981863//27773535//27371828//22608085 chr2:24533402-24533403(-) m6A CDS       27773535 chr2:24533474-24533475(-) m6A CDS       27773535 chr2:24550953-24550954(-) m6A 5'UTR//CDS//exon       27773536 chr2:24550960-24550961(-) m6A 5'UTR//CDS//exon       27773536 chr2:24583531-24583532(-) m6A 5'UTR       27371828//27773536 chr2:24583555-24583556(-) m6A 5'UTR       27371828//27773536 chr2:24583575-24583576(-) m6A 5'UTR       27371828//27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-454-3p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Serum     18589210 Exosome Saliva     19627513 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Primary dendritic cells|T cell line (J77)     21505438 Exosome Plasma     23663360 Exosome Endothelial cells     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Nucleolus HeLa cells     23940654 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	ITSN2	Cytosol HCC cell line (HepG2)|HeLa-S3 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Membrane HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome HEK-293 cells     22199352

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-454-3p	4-(2-Pyridylazo)-N,N-dimethylaniline 81528 Drug sensitive o-Aminoazotoluene 7340 Drug sensitive Piperidinium pentamethylenedithiocarbamate 72508 Drug sensitive Crotonoside 65085 Drug sensitive Trihydroxygermaeranolide isobutyrate 6436277 Drug sensitive (Z)-6-(2-(Pyridin-2-ylmethylene)hydrazinyl)-9H-purine 60147744 Drug sensitive Ketone, methyl 2-pyridyl, 4,4-dimethyl-3-thiosemicarbazone 5843399 Drug sensitive Incomptina B 54612584 Drug sensitive Selendale 54601159 Drug resistant Aspiculamycin hcl 54600418 Drug resistant Methyl (1R,4R,7E,9S,10R,11S)-9-acetyloxy-10-(2,3-dimethyloxirane-2-carbonyl)oxy-4-methyl-12-methylidene-13-oxo-3,14-dioxatricyclo[9.3.0.02,4]tetradec-7-ene-8-carboxylate 5458601 Drug sensitive 7-(3-Methoxyphenyl)-N-(pyridin-4-ylmethylideneamino)-5H-pyrrolo[3,2-d]pyrimidin-4-amine 53239944 Drug resistant Herbimycin 5311102 Drug sensitive Vorinostat 5311 Drug sensitive Amonafide 50515 Drug sensitive Fastigilin C 442242 Drug sensitive trans-Bis(acetato)amminepyridineplatinum(II) 405450 Drug sensitive Antineoplastic-690271 391308 Drug sensitive Idebenone 3686 Drug sensitive 2,7-Dicyanoxanthone 363841 Drug resistant 2-Hydroxy discorhabdin D 362391 Drug sensitive Maxima isoflavone D 343081 Drug resistant 6-[(7-Nitro-2,1,3-benzoxadiazol-4-yl)sulfanyl]-7H-purin-2-amine 3246652 Drug sensitive 1,4-Naphthalenedione, 5,8-dihydroxy-2,3-bis(hydroxymethyl)- 313371 Drug sensitive Razoxane 30623 Drug sensitive [(5Z)-1,7,7-Trimethyl-5-(nitromethylene)-6-oxo-norbornan-2-yl] acetate 3004516 Drug sensitive Salarin C 24867082 Drug resistant 2-(4-((Oxiran-2-yl)methoxy)styryl)-4,5-dihydrooxazole 24206038 Drug sensitive Haterumalide NA methyl esters 24204452 Drug resistant Pirarubicin hydrochloride 20846247 Drug sensitive 1,2:5,6-Dianhydrogalactitol 15942827 Drug sensitive 12-Iminodaunorubicin hcl 135539784 Drug sensitive 5-Hydroxypicolinaldehyde thiosemicarbazone 135453292 Drug sensitive Formycin b 135449281 Drug sensitive Kinamycin C 135430800 Drug sensitive Veracoquinazole 135416663 Drug sensitive Inosine dialdehyde 135400916 Drug sensitive 43-Dioxypectenotoxin 131751434 Drug resistant Epilactose 128037 Drug resistant Cytochalasin q 11970174 Drug sensitive (3S,6R,10R,13Z,16S)-10-[(4-Methoxyphenyl)methyl]-6-methyl-3-(2-methylpropyl)-16-[(1S)-1-[(2R,3R)-3-phenyloxiran-2-yl]ethyl]-1,4-dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone 101917006 Drug resistant Cyanocycline A 100158 Drug sensitive 1,3-diphenyl-4-(3-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1H-pyrazole - Drug resistant 9h-quino[4,3,2-de][1,10]phenanthrolin-9-one, 5-methoxy- - Drug resistant N-(4-{2-[(1R,6R,11aS,13S,14aR)-1,13-dihydroxy-4-oxo-1,6,7,8,9,11a,12,13,14,14a-decahydro-4H-cyclopenta[f]oxacyclotridecin-6-yl]ethyl}phenyl)acetamide - Drug resistant (1s,2e,4r,6r,7e,10r,11e)-2,7,11-cembratriene-4,6,10-triol - Drug sensitive (2r,3r)-(+)-methyl 3-phenyloxirane-carboxylate - Drug sensitive 1h-benzo[a]carbazole-1,4(11h)-dione, 11-phenyl- - Drug sensitive 2,6-bis(4-morpholinylmethyl)cyclohexanone,dihydrochloride - Drug sensitive 2-bromo-5,8-dihydroxy-3-methyl-1,4-naphthoquinone - Drug sensitive 4-(2-pyridinyl)-5h-1,2,3-dithiazole-5-thione - Drug sensitive 6h-purine-6-thione, 1,7-dihydro-, mercury complex (9ci) - Drug sensitive benzofurazan, 5-nitro-6-(1-piperidinyl)-, 1-oxide - Drug sensitive cyclohexanone, 2,6-bis(piperidinomethyl)- - Drug sensitive ethanone, 1-(2-pyrimidinyl)-, (2-benzoxazolyl)hydrazone - Drug sensitive (s)(-)-methyl perillate - Drug sensitive antineoplastic-654379 - Drug sensitive Camptothecin Derivative - Drug sensitive chlorobis(4-ethyltropolonato)bismuth(iii) - Drug sensitive cyclo [n-naphthoyl-d-lys-asn-gln-trp-ala-val-d-ala-his-leu] - Drug sensitive Indenoisoquinoline derivative - Drug sensitive n-acetyl-4-s-cystaminyl phenol - Drug sensitive o-linoleoyl-2-butoxy-1-desoamine - Drug sensitive Tetraplatin - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-454-3p	Formaldehyde 712 Drug interaction    RC00006668 Gemcitabine 60750 Drug interaction    RC00006676 Vincristine 5978 Drug interaction    RC00006673 Floxuridine 5790 Drug interaction    RC00006672 Prednisolone 5755 Drug interaction    RC00006671 Sunitinib 5329102 Drug interaction    RC00006681 4-Hydroxynonenal 5283344 Drug interaction    RC00006680 Diethylstilbestrol 448537 Drug interaction    RC00006679 5-Fluorouracil 3385 Drug interaction    RC00006670 Doxorubicin 31703 Drug interaction    RC00006675 Daunorubicin 30323 Drug interaction    RC00006674 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00006677 Verapamil 2520 Drug interaction    RC00006669 Docetaxel 148124 Drug interaction    RC00006678 Asparaginase Escherichia coli - Drug interaction    RC00006683 FdUMP[10] - Drug interaction    RC00006682

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-454-3p	Cisplatin 5702198       30099826

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-454-3p
Interactor2: ITSN2

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.