Basic Information:

  VIRBase ID:  

HHID00061717

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-454-3p:  MIMAT0003885          PLXNC1:  NR_037687     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-454-3p	PLXNC1
miRBase Accession/Entrez ID	MIMAT0003885	10154
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CD232//PLXN-C1//VESPR

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-454-3p	rs1450965019 chr17:59137799    A/G rs377123764 chr17:59137788    C/G rs377123764 chr17:59137788    C/T rs771457463 chr17:59137792    A/G rs779514158 chr17:59137798    A/G rs1391884708 chr17:59137808    TACTCAGAACTATTTACAC/T rs555225543 chr17:59137803    T/G rs772555392 chr17:59137806    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PLXNC1	chr12:94587769(+) A-I      intronic chr12:94587762(+) A-I      intronic chr12:94584158(+) A-I      intronic chr12:94549929(+) A-I      intronic chr12:94549935(+) A-I      intronic chr12:94568078(+) A-I      intronic chr12:94584092(+) A-I      intronic chr12:94582192(+) A-I      intronic chr12:94582160(+) A-I      intronic chr12:94647562(+) A-I      intronic chr12:94647576(+) A-I      intronic chr12:94576151(+) A-I      intronic chr12:94576149(+) A-I      intronic chr12:94576114(+) A-I      intronic chr12:94576100(+) A-I      intronic chr12:94576456(+) A-I      intronic chr12:94607736(+) A-I      intronic chr12:94583325(+) A-I      intronic chr12:94608097(+) A-I      intronic chr12:94646734(+) A-I      intronic chr12:94609993(+) A-I      intronic chr12:94575018(+) A-I      intronic chr12:94608098(+) A-I      intronic chr12:94585331(+) A-I      intronic chr12:94672618(+) A-I      intronic chr12:94647702(+) A-I      intronic chr12:94585304(+) A-I      intronic chr12:94568035(+) A-I      intronic chr12:94550711(+) A-I      intronic chr12:94607782(+) A-I      intronic chr12:94585310(+) A-I      intronic chr12:94583433(+) A-I      intronic chr12:94645509(+) A-I      intronic chr12:94647472(+) A-I      intronic chr12:94645637(+) A-I      intronic chr12:94607776(+) A-I      intronic chr12:94647639(+) A-I      intronic chr12:94687556(+) A-I      intronic chr12:94672627(+) A-I      intronic chr12:94584037(+) A-I      intronic chr12:94646928(+) A-I      intronic chr12:94646880(+) A-I      intronic chr12:94607960(+) A-I      intronic chr12:94607743(+) A-I      intronic chr12:94568073(+) A-I      intronic chr12:94607742(+) A-I      intronic chr12:94585417(+) A-I      intronic chr12:94607973(+) A-I      intronic chr12:94646856(+) A-I      intronic chr12:94606589(+) A-I      intronic chr12:94606625(+) A-I      intronic chr12:94606707(+) A-I      intronic chr12:94576280(+) A-I      intronic chr12:94585374(+) A-I      intronic chr12:94653607(+) A-I      intronic chr12:94583191(+) A-I      intronic chr12:94647616(+) A-I      intronic chr12:94583223(+) A-I      intronic chr12:94609843(+) A-I      intronic chr12:94636108(+) A-I      intronic chr12:94575015(+) A-I      intronic chr12:94576079(+) A-I      intronic chr12:94593696(+) A-I      intronic chr12:94643386(+) A-I      intronic chr12:94576057(+) A-I      intronic chr12:94582280(+) A-I      intronic chr12:94583357(+) A-I      intronic chr12:94583440(+) A-I      intronic chr12:94644521(+) A-I      intronic chr12:94583388(+) A-I      intronic chr12:94583296(+) A-I      intronic chr12:94588455(+) A-I      intronic chr12:94574992(+) A-I      intronic chr12:94583197(+) A-I      intronic chr12:94575085(+) A-I      intronic chr12:94575043(+) A-I      intronic chr12:94576109(+) A-I      intronic chr12:94584193(+) A-I      intronic chr12:94584279(+) A-I      intronic chr12:94550675(+) A-I      intronic chr12:94575041(+) A-I      intronic chr12:94575076(+) A-I      intronic chr12:94646937(+) A-I      intronic chr12:94585469(+) A-I      intronic chr12:94575084(+) A-I      intronic chr12:94647675(+) A-I      intronic chr12:94654086(+) A-I      intronic chr12:94585305(+) A-I      intronic chr12:94585440(+) A-I      intronic chr12:94647683(+) A-I      intronic chr12:94647575(+) A-I      intronic chr12:94584041(+) A-I      intronic chr12:94576119(+) A-I      intronic chr12:94647729(+) A-I      intronic chr12:94584145(+) A-I      intronic chr12:94609963(+) A-I      intronic chr12:94584200(+) A-I      intronic chr12:94582229(+) A-I      intronic chr12:94645703(+) A-I      intronic chr12:94643193(+) A-I      intronic chr12:94575016(+) A-I      intronic chr12:94576344(+) A-I      intronic chr12:94645603(+) A-I      intronic chr12:94583297(+) A-I      intronic chr12:94610032(+) A-I      intronic chr12:94585481(+) A-I      intronic chr12:94585439(+) A-I      intronic chr12:94575003(+) A-I      intronic chr12:94574988(+) A-I      intronic chr12:94643356(+) A-I      intronic chr12:94590239(+) A-I      intronic chr12:94588014(+) A-I      intronic chr12:94607930(+) A-I      intronic chr12:94549958(+) A-I      intronic chr12:94587734(+) A-I      intronic chr12:94584148(+) A-I      intronic chr12:94584291(+) A-I      intronic chr12:94585351(+) A-I      intronic chr12:94607962(+) A-I      intronic chr12:94643366(+) A-I      intronic chr12:94583246(+) A-I      intronic chr12:94582118(+) A-I      intronic chr12:94584285(+) A-I      intronic chr12:94584252(+) A-I      intronic chr12:94609994(+) A-I      intronic chr12:94590297(+) A-I      intronic chr12:94568038(+) A-I      intronic chr12:94647615(+) A-I      intronic chr12:94609792(+) A-I      intronic chr12:94654036(+) A-I      intronic chr12:94576264(+) A-I      intronic chr12:94576372(+) A-I      intronic chr12:94587726(+) A-I      intronic chr12:94575053(+) A-I      intronic chr12:94645674(+) A-I      intronic chr12:94574998(+) A-I      intronic chr12:94575070(+) A-I      intronic chr12:94587875(+) A-I      intronic chr12:94647599(+) A-I      intronic chr12:94548152(+) A-I      intronic chr12:94583376(+) A-I      intronic chr12:94584144(+) A-I      intronic chr12:94590025(+) A-I      intronic chr12:94583309(+) A-I      intronic chr12:94590149(+) A-I      intronic chr12:94646733(+) A-I      intronic chr12:94584039(+) A-I      intronic chr12:94585340(+) A-I      intronic chr12:94675462(+) A-I      intronic chr12:94575014(+) A-I      intronic chr12:94593671(+) A-I      intronic chr12:94583419(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PLXNC1	chr12:94574988(+) A-I intron -    15342557 chr12:94574992(+) A-I intron -    15342557 chr12:94574998(+) A-I intron -    15342557 chr12:94575003(+) A-I intron -    15342557 chr12:94575014(+) A-I intron -    15342557 chr12:94575041(+) A-I intron -    15342557 chr12:94575043(+) A-I intron -    15342557 chr12:94575053(+) A-I intron -    15342557 chr12:94575070(+) A-I intron -    15342557 chr12:94575076(+) A-I intron -    15342557 chr12:94575085(+) A-I intron -    15342557 chr12:94576057(+) A-I intron -    15342557 chr12:94576079(+) A-I intron -    15342557 chr12:94576109(+) A-I intron -    15342557 chr12:94576119(+) A-I intron -    15342557 chr12:94587726(+) A-G intron -    22484847 chr12:94587734(+) A-G intron -    22484847 chr12:94583388(+) A-G intron -    22484847 chr12:94583419(+) A-G intron -    22484847 chr12:94585374(+) A-G intron -    22484847 chr12:94675476(+) T-C intron -    22484847 chr12:94675486(+) T-C intron -    22484847 chr12:94675488(+) T-C intron -    22484847 chr12:94568038(+) A-G intron -    22484847 chr12:94582280(+) A-G intron -    22484847 chr12:94584144(+) A-G intron -    22484847 chr12:94584145(+) A-G intron -    22484847 chr12:94584148(+) A-G intron -    22484847 chr12:94584279(+) A-G intron -    22484847 chr12:94585351(+) A-G intron -    22484847 chr12:94585439(+) A-G intron -    22484847 chr12:94585440(+) A-G intron -    22484847 chr12:94607962(+) A-G intron -    22484847 chr12:94609963(+) A-G intron -    22484847 chr12:94644521(+) A-G intron -    22484847 chr12:94647616(+) A-G intron -    22484847 chr12:94674850(+) T-C intron -    22484847 chr12:94674852(+) T-C intron -    22484847 chr12:94677668(+) T-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PLXNC1	chr12:94542943-94542944(+) m6A CDS       25456834//22608085 chr12:94542952-94542953(+) m6A CDS       25456834//22608085 chr12:94542991-94542992(+) m6A CDS       25456834//22608085 chr12:94543128-94543129(+) m6A CDS       - chr12:94543261-94543262(+) m6A CDS       - chr12:94543372-94543373(+) m6A CDS       25456834//24981863 chr12:94543783-94543784(+) m6A CDS       - chr12:94544612-94544613(+) m6A exon//intron       - chr12:94544638-94544639(+) m6A exon//intron       - chr12:94563022-94563023(+) m6A CDS//exon       - chr12:94563027-94563028(+) m6A CDS//exon       - chr12:94700314-94700315(+) m6A 3'UTR       27773535 chr12:94700328-94700329(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-454-3p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Serum     18589210 Exosome Saliva     19627513 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Primary dendritic cells|T cell line (J77)     21505438 Exosome Plasma     23663360 Exosome Endothelial cells     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Nucleolus HeLa cells     23940654 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	PLXNC1	Chromatin K562 cells     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-454-3p	4-(2-Pyridylazo)-N,N-dimethylaniline 81528 Drug sensitive o-Aminoazotoluene 7340 Drug sensitive Piperidinium pentamethylenedithiocarbamate 72508 Drug sensitive Crotonoside 65085 Drug sensitive Trihydroxygermaeranolide isobutyrate 6436277 Drug sensitive (Z)-6-(2-(Pyridin-2-ylmethylene)hydrazinyl)-9H-purine 60147744 Drug sensitive Ketone, methyl 2-pyridyl, 4,4-dimethyl-3-thiosemicarbazone 5843399 Drug sensitive Incomptina B 54612584 Drug sensitive Selendale 54601159 Drug resistant Aspiculamycin hcl 54600418 Drug resistant Methyl (1R,4R,7E,9S,10R,11S)-9-acetyloxy-10-(2,3-dimethyloxirane-2-carbonyl)oxy-4-methyl-12-methylidene-13-oxo-3,14-dioxatricyclo[9.3.0.02,4]tetradec-7-ene-8-carboxylate 5458601 Drug sensitive 7-(3-Methoxyphenyl)-N-(pyridin-4-ylmethylideneamino)-5H-pyrrolo[3,2-d]pyrimidin-4-amine 53239944 Drug resistant Herbimycin 5311102 Drug sensitive Vorinostat 5311 Drug sensitive Amonafide 50515 Drug sensitive Fastigilin C 442242 Drug sensitive trans-Bis(acetato)amminepyridineplatinum(II) 405450 Drug sensitive Antineoplastic-690271 391308 Drug sensitive Idebenone 3686 Drug sensitive 2,7-Dicyanoxanthone 363841 Drug resistant 2-Hydroxy discorhabdin D 362391 Drug sensitive Maxima isoflavone D 343081 Drug resistant 6-[(7-Nitro-2,1,3-benzoxadiazol-4-yl)sulfanyl]-7H-purin-2-amine 3246652 Drug sensitive 1,4-Naphthalenedione, 5,8-dihydroxy-2,3-bis(hydroxymethyl)- 313371 Drug sensitive Razoxane 30623 Drug sensitive [(5Z)-1,7,7-Trimethyl-5-(nitromethylene)-6-oxo-norbornan-2-yl] acetate 3004516 Drug sensitive Salarin C 24867082 Drug resistant 2-(4-((Oxiran-2-yl)methoxy)styryl)-4,5-dihydrooxazole 24206038 Drug sensitive Haterumalide NA methyl esters 24204452 Drug resistant Pirarubicin hydrochloride 20846247 Drug sensitive 1,2:5,6-Dianhydrogalactitol 15942827 Drug sensitive 12-Iminodaunorubicin hcl 135539784 Drug sensitive 5-Hydroxypicolinaldehyde thiosemicarbazone 135453292 Drug sensitive Formycin b 135449281 Drug sensitive Kinamycin C 135430800 Drug sensitive Veracoquinazole 135416663 Drug sensitive Inosine dialdehyde 135400916 Drug sensitive 43-Dioxypectenotoxin 131751434 Drug resistant Epilactose 128037 Drug resistant Cytochalasin q 11970174 Drug sensitive (3S,6R,10R,13Z,16S)-10-[(4-Methoxyphenyl)methyl]-6-methyl-3-(2-methylpropyl)-16-[(1S)-1-[(2R,3R)-3-phenyloxiran-2-yl]ethyl]-1,4-dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone 101917006 Drug resistant Cyanocycline A 100158 Drug sensitive 1,3-diphenyl-4-(3-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1H-pyrazole - Drug resistant 9h-quino[4,3,2-de][1,10]phenanthrolin-9-one, 5-methoxy- - Drug resistant N-(4-{2-[(1R,6R,11aS,13S,14aR)-1,13-dihydroxy-4-oxo-1,6,7,8,9,11a,12,13,14,14a-decahydro-4H-cyclopenta[f]oxacyclotridecin-6-yl]ethyl}phenyl)acetamide - Drug resistant (1s,2e,4r,6r,7e,10r,11e)-2,7,11-cembratriene-4,6,10-triol - Drug sensitive (2r,3r)-(+)-methyl 3-phenyloxirane-carboxylate - Drug sensitive 1h-benzo[a]carbazole-1,4(11h)-dione, 11-phenyl- - Drug sensitive 2,6-bis(4-morpholinylmethyl)cyclohexanone,dihydrochloride - Drug sensitive 2-bromo-5,8-dihydroxy-3-methyl-1,4-naphthoquinone - Drug sensitive 4-(2-pyridinyl)-5h-1,2,3-dithiazole-5-thione - Drug sensitive 6h-purine-6-thione, 1,7-dihydro-, mercury complex (9ci) - Drug sensitive benzofurazan, 5-nitro-6-(1-piperidinyl)-, 1-oxide - Drug sensitive cyclohexanone, 2,6-bis(piperidinomethyl)- - Drug sensitive ethanone, 1-(2-pyrimidinyl)-, (2-benzoxazolyl)hydrazone - Drug sensitive (s)(-)-methyl perillate - Drug sensitive antineoplastic-654379 - Drug sensitive Camptothecin Derivative - Drug sensitive chlorobis(4-ethyltropolonato)bismuth(iii) - Drug sensitive cyclo [n-naphthoyl-d-lys-asn-gln-trp-ala-val-d-ala-his-leu] - Drug sensitive Indenoisoquinoline derivative - Drug sensitive n-acetyl-4-s-cystaminyl phenol - Drug sensitive o-linoleoyl-2-butoxy-1-desoamine - Drug sensitive Tetraplatin - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-454-3p	Formaldehyde 712 Drug interaction    RC00006668 Gemcitabine 60750 Drug interaction    RC00006676 Vincristine 5978 Drug interaction    RC00006673 Floxuridine 5790 Drug interaction    RC00006672 Prednisolone 5755 Drug interaction    RC00006671 Sunitinib 5329102 Drug interaction    RC00006681 4-Hydroxynonenal 5283344 Drug interaction    RC00006680 Diethylstilbestrol 448537 Drug interaction    RC00006679 5-Fluorouracil 3385 Drug interaction    RC00006670 Doxorubicin 31703 Drug interaction    RC00006675 Daunorubicin 30323 Drug interaction    RC00006674 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00006677 Verapamil 2520 Drug interaction    RC00006669 Docetaxel 148124 Drug interaction    RC00006678 Asparaginase Escherichia coli - Drug interaction    RC00006683 FdUMP[10] - Drug interaction    RC00006682

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-454-3p	Cisplatin 5702198       30099826

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-454-3p
Interactor2: PLXNC1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.