Basic Information:

  VIRBase ID:  

HHID00061630

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-454-3p:  MIMAT0003885          PDE4B:  NM_001037340     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-454-3p	PDE4B
miRBase Accession/Entrez ID	MIMAT0003885	5142
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	DPDE4//PDEIVB

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-454-3p	rs1450965019 chr17:59137799    A/G rs377123764 chr17:59137788    C/G rs377123764 chr17:59137788    C/T rs771457463 chr17:59137792    A/G rs779514158 chr17:59137798    A/G rs1391884708 chr17:59137808    TACTCAGAACTATTTACAC/T rs555225543 chr17:59137803    T/G rs772555392 chr17:59137806    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PDE4B	chr1:66630108(+) A-I      intronic chr1:66630104(+) A-I      intronic chr1:66630040(+) A-I      intronic chr1:66630041(+) A-I      intronic chr1:66630042(+) A-I      intronic chr1:66630047(+) A-I      intronic chr1:66630088(+) A-I      intronic chr1:66630098(+) A-I      intronic chr1:66630099(+) A-I      intronic chr1:66630651(+) A-I      intronic chr1:66630229(+) A-I      intronic chr1:66630198(+) A-I      intronic chr1:66630184(+) A-I      intronic chr1:66602326(+) A-I      intronic chr1:66602313(+) A-I      intronic chr1:66750234(+) A-I      intronic chr1:66676145(+) A-I      intronic chr1:66734308(+) A-I      intronic chr1:66759746(+) A-I      intronic chr1:66640332(+) A-I      intronic chr1:66676070(+) A-I      intronic chr1:66613833(+) A-I      intronic chr1:66502765(+) A-I      intronic chr1:66454928(+) A-I      intronic chr1:66639569(+) A-I      intronic chr1:66630032(+) A-I      intronic chr1:66613767(+) A-I      intronic chr1:66602338(+) A-I      intronic chr1:66630018(+) A-I      intronic chr1:66274759(+) A-I      intronic chr1:66630241(+) A-I      intronic chr1:66612141(+) A-I      intronic chr1:66630205(+) A-I      intronic chr1:66745249(+) A-I      intronic chr1:66639675(+) A-I      intronic chr1:66401376(+) A-I      intronic chr1:66613885(+) A-I      intronic chr1:66602331(+) A-I      intronic chr1:66804199(+) A-I      intronic chr1:66611931(+) A-I      intronic chr1:66288823(+) A-I      intronic chr1:66639570(+) A-I      intronic chr1:66630031(+) A-I      intronic chr1:66630201(+) A-I      intronic chr1:66496468(+) A-I      intronic chr1:66630168(+) A-I      intronic chr1:66734339(+) A-I      intronic chr1:66632170(+) A-I      intronic chr1:66502695(+) A-I      intronic chr1:66496495(+) A-I      intronic chr1:66485143(+) A-I      intronic chr1:66602306(+) A-I      intronic chr1:66632951(+) A-I      intronic chr1:66630511(+) A-I      intronic chr1:66485118(+) A-I      intronic chr1:66743140(+) A-I      intronic chr1:66501464(+) A-I      intronic chr1:66519422(+) A-I      intronic chr1:66613725(+) A-I      intronic chr1:66694224(+) A-I      intronic chr1:66582270(+) A-I      intronic chr1:66630022(+) A-I      intronic chr1:66274750(+) A-I      intronic chr1:66630140(+) A-I      intronic chr1:66630479(+) A-I      intronic chr1:66753644(+) A-I      intronic chr1:66761212(+) A-I      intronic chr1:66835755(+) A-I      intronic chr1:66456847(+) A-I      intronic chr1:66485132(+) A-I      intronic chr1:66483938(+) A-I      intronic chr1:66734240(+) A-I      intronic chr1:66720791(+) A-I      intronic chr1:66467551(+) A-I      intronic chr1:66761170(+) A-I      intronic chr1:66639642(+) A-I      intronic chr1:66542076(+) A-I      intronic chr1:66270910(+) A-I      intronic chr1:66377951(+) A-I      intronic chr1:66406155(+) A-I      intronic chr1:66540622(+) A-I      intronic chr1:66502705(+) A-I      intronic chr1:66745201(+) A-I      intronic chr1:66483881(+) A-I      intronic chr1:66454929(+) A-I      intronic chr1:66485138(+) A-I      intronic chr1:66485219(+) A-I      intronic chr1:66639653(+) A-I      intronic chr1:66496547(+) A-I      intronic chr1:66630062(+) A-I      intronic chr1:66632928(+) A-I      intronic chr1:66612073(+) A-I      intronic chr1:66483934(+) A-I      intronic chr1:66406036(+) A-I      intronic chr1:66630203(+) A-I      intronic chr1:66542063(+) A-I      intronic chr1:66501453(+) A-I      intronic chr1:66743351(+) A-I      intronic chr1:66613832(+) A-I      intronic chr1:66694227(+) A-I      intronic chr1:66406221(+) A-I      intronic chr1:66613699(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PDE4B	chr1:66829350(+) C-T intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PDE4B	chr1:66458314-66458315(+) m6A 5'UTR//exon//intron       24981863 chr1:66458483-66458484(+) m6A 5'UTR//exon//intron       24981863 chr1:66458501-66458502(+) m6A 5'UTR//exon//intron       24981863 chr1:66458587-66458588(+) m6A 5'UTR//exon//intron       24981863//26404942 chr1:66458615-66458616(+) m6A CDS//exon//intron       24981863//26404942 chr1:66458630-66458631(+) m6A CDS//exon//intron       24981863//26404942 chr1:66458649-66458650(+) m6A CDS//exon//intron       24981863//26404942 chr1:66458675-66458676(+) m6A CDS//exon//intron       24981863//26404942 chr1:66458701-66458702(+) m6A CDS//exon//intron       24981863//26404942 chr1:66458746-66458747(+) m6A CDS//exon//intron       24981863 chr1:66797807-66797808(+) m6A 5'UTR//intron       - chr1:66797843-66797844(+) m6A 5'UTR//intron       24981863 chr1:66797874-66797875(+) m6A 5'UTR//intron       24981863 chr1:66797903-66797904(+) m6A 5'UTR//intron       24981863 chr1:66797984-66797985(+) m6A 5'UTR//intron       24981863 chr1:66798139-66798140(+) m6A CDS//intron       24981863 chr1:66798235-66798236(+) m6A CDS       24981863 chr1:66833820-66833821(+) m6A exon//intron       - chr1:66834497-66834498(+) m6A CDS       - chr1:66834541-66834542(+) m6A CDS       - chr1:66834578-66834579(+) m6A CDS       - chr1:66834624-66834625(+) m6A CDS       24981863 chr1:66838034-66838035(+) m6A CDS       25456834//24981863//26404942 chr1:66838068-66838069(+) m6A CDS       25456834//24981863//26404942//22608085 chr1:66838098-66838099(+) m6A CDS       25456834//24981863//26404942//22575960//22608085 chr1:66838152-66838153(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr1:66838158-66838159(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr1:66838192-66838193(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr1:66838222-66838223(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr1:66838243-66838244(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr1:66838293-66838294(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr1:66838313-66838314(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr1:66838323-66838324(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr1:66838338-66838339(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr1:66838384-66838385(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr1:66838446-66838447(+) m6A 3'UTR       24209618//25456834//24981863//26404942//22575960//22608085 chr1:66838457-66838458(+) m6A 3'UTR       24209618//25456834//24981863//26404942//22575960//22608085 chr1:66838508-66838509(+) m6A 3'UTR       24209618//25456834//24981863//26404942//22608085 chr1:66838613-66838614(+) m6A 3'UTR       25456834//24981863//26404942 chr1:66838635-66838636(+) m6A 3'UTR       25456834//24981863//26404942 chr1:66838642-66838643(+) m6A 3'UTR       25456834//24981863//26404942 chr1:66838674-66838675(+) m6A 3'UTR       25456834//24981863//26404942 chr1:66838696-66838697(+) m6A 3'UTR       25456834//24981863//26404942 chr1:66838774-66838775(+) m6A 3'UTR       24981863//26404942 chr1:66838948-66838949(+) m6A 3'UTR       24981863 chr1:66839028-66839029(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-454-3p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Serum     18589210 Exosome Saliva     19627513 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Primary dendritic cells|T cell line (J77)     21505438 Exosome Plasma     23663360 Exosome Endothelial cells     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Nucleolus HeLa cells     23940654 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	PDE4B	Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-454-3p	4-(2-Pyridylazo)-N,N-dimethylaniline 81528 Drug sensitive o-Aminoazotoluene 7340 Drug sensitive Piperidinium pentamethylenedithiocarbamate 72508 Drug sensitive Crotonoside 65085 Drug sensitive Trihydroxygermaeranolide isobutyrate 6436277 Drug sensitive (Z)-6-(2-(Pyridin-2-ylmethylene)hydrazinyl)-9H-purine 60147744 Drug sensitive Ketone, methyl 2-pyridyl, 4,4-dimethyl-3-thiosemicarbazone 5843399 Drug sensitive Incomptina B 54612584 Drug sensitive Selendale 54601159 Drug resistant Aspiculamycin hcl 54600418 Drug resistant Methyl (1R,4R,7E,9S,10R,11S)-9-acetyloxy-10-(2,3-dimethyloxirane-2-carbonyl)oxy-4-methyl-12-methylidene-13-oxo-3,14-dioxatricyclo[9.3.0.02,4]tetradec-7-ene-8-carboxylate 5458601 Drug sensitive 7-(3-Methoxyphenyl)-N-(pyridin-4-ylmethylideneamino)-5H-pyrrolo[3,2-d]pyrimidin-4-amine 53239944 Drug resistant Herbimycin 5311102 Drug sensitive Vorinostat 5311 Drug sensitive Amonafide 50515 Drug sensitive Fastigilin C 442242 Drug sensitive trans-Bis(acetato)amminepyridineplatinum(II) 405450 Drug sensitive Antineoplastic-690271 391308 Drug sensitive Idebenone 3686 Drug sensitive 2,7-Dicyanoxanthone 363841 Drug resistant 2-Hydroxy discorhabdin D 362391 Drug sensitive Maxima isoflavone D 343081 Drug resistant 6-[(7-Nitro-2,1,3-benzoxadiazol-4-yl)sulfanyl]-7H-purin-2-amine 3246652 Drug sensitive 1,4-Naphthalenedione, 5,8-dihydroxy-2,3-bis(hydroxymethyl)- 313371 Drug sensitive Razoxane 30623 Drug sensitive [(5Z)-1,7,7-Trimethyl-5-(nitromethylene)-6-oxo-norbornan-2-yl] acetate 3004516 Drug sensitive Salarin C 24867082 Drug resistant 2-(4-((Oxiran-2-yl)methoxy)styryl)-4,5-dihydrooxazole 24206038 Drug sensitive Haterumalide NA methyl esters 24204452 Drug resistant Pirarubicin hydrochloride 20846247 Drug sensitive 1,2:5,6-Dianhydrogalactitol 15942827 Drug sensitive 12-Iminodaunorubicin hcl 135539784 Drug sensitive 5-Hydroxypicolinaldehyde thiosemicarbazone 135453292 Drug sensitive Formycin b 135449281 Drug sensitive Kinamycin C 135430800 Drug sensitive Veracoquinazole 135416663 Drug sensitive Inosine dialdehyde 135400916 Drug sensitive 43-Dioxypectenotoxin 131751434 Drug resistant Epilactose 128037 Drug resistant Cytochalasin q 11970174 Drug sensitive (3S,6R,10R,13Z,16S)-10-[(4-Methoxyphenyl)methyl]-6-methyl-3-(2-methylpropyl)-16-[(1S)-1-[(2R,3R)-3-phenyloxiran-2-yl]ethyl]-1,4-dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone 101917006 Drug resistant Cyanocycline A 100158 Drug sensitive 1,3-diphenyl-4-(3-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1H-pyrazole - Drug resistant 9h-quino[4,3,2-de][1,10]phenanthrolin-9-one, 5-methoxy- - Drug resistant N-(4-{2-[(1R,6R,11aS,13S,14aR)-1,13-dihydroxy-4-oxo-1,6,7,8,9,11a,12,13,14,14a-decahydro-4H-cyclopenta[f]oxacyclotridecin-6-yl]ethyl}phenyl)acetamide - Drug resistant (1s,2e,4r,6r,7e,10r,11e)-2,7,11-cembratriene-4,6,10-triol - Drug sensitive (2r,3r)-(+)-methyl 3-phenyloxirane-carboxylate - Drug sensitive 1h-benzo[a]carbazole-1,4(11h)-dione, 11-phenyl- - Drug sensitive 2,6-bis(4-morpholinylmethyl)cyclohexanone,dihydrochloride - Drug sensitive 2-bromo-5,8-dihydroxy-3-methyl-1,4-naphthoquinone - Drug sensitive 4-(2-pyridinyl)-5h-1,2,3-dithiazole-5-thione - Drug sensitive 6h-purine-6-thione, 1,7-dihydro-, mercury complex (9ci) - Drug sensitive benzofurazan, 5-nitro-6-(1-piperidinyl)-, 1-oxide - Drug sensitive cyclohexanone, 2,6-bis(piperidinomethyl)- - Drug sensitive ethanone, 1-(2-pyrimidinyl)-, (2-benzoxazolyl)hydrazone - Drug sensitive (s)(-)-methyl perillate - Drug sensitive antineoplastic-654379 - Drug sensitive Camptothecin Derivative - Drug sensitive chlorobis(4-ethyltropolonato)bismuth(iii) - Drug sensitive cyclo [n-naphthoyl-d-lys-asn-gln-trp-ala-val-d-ala-his-leu] - Drug sensitive Indenoisoquinoline derivative - Drug sensitive n-acetyl-4-s-cystaminyl phenol - Drug sensitive o-linoleoyl-2-butoxy-1-desoamine - Drug sensitive Tetraplatin - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-454-3p	Formaldehyde 712 Drug interaction    RC00006668 Gemcitabine 60750 Drug interaction    RC00006676 Vincristine 5978 Drug interaction    RC00006673 Floxuridine 5790 Drug interaction    RC00006672 Prednisolone 5755 Drug interaction    RC00006671 Sunitinib 5329102 Drug interaction    RC00006681 4-Hydroxynonenal 5283344 Drug interaction    RC00006680 Diethylstilbestrol 448537 Drug interaction    RC00006679 5-Fluorouracil 3385 Drug interaction    RC00006670 Doxorubicin 31703 Drug interaction    RC00006675 Daunorubicin 30323 Drug interaction    RC00006674 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00006677 Verapamil 2520 Drug interaction    RC00006669 Docetaxel 148124 Drug interaction    RC00006678 Asparaginase Escherichia coli - Drug interaction    RC00006683 FdUMP[10] - Drug interaction    RC00006682

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-454-3p	Cisplatin 5702198       30099826

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-454-3p
Interactor2: PDE4B

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.