Detail Information

Basic Information:


  VIRBase ID:  

HHID00061628

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-454-3p:           OSBP:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-454-3p OSBP
miRBase
Accession/Entrez ID		 MIMAT0003885 5007
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - OSBP1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-454-3p
rs1450965019 chr17:59137799    A/G
rs377123764 chr17:59137788    C/G
rs377123764 chr17:59137788    C/T
rs771457463 chr17:59137792    A/G
rs779514158 chr17:59137798    A/G
rs1391884708 chr17:59137808    TACTCAGAACTATTTACAC/T
rs555225543 chr17:59137803    T/G
rs772555392 chr17:59137806    A/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR OSBP
chr11:59351503(-) A-I      intronic
chr11:59351490(-) A-I      intronic
chr11:59351289(-) A-I      intronic
chr11:59354906(-) A-I      intronic
chr11:59356852(-) A-I      intronic
chr11:59357276(-) A-I      intronic
chr11:59350666(-) A-I      intronic
chr11:59356911(-) A-I      intronic
chr11:59351283(-) A-I      intronic
chr11:59356660(-) A-I      intronic
chr11:59350641(-) A-I      intronic
chr11:59350723(-) A-I      intronic
chr11:59351214(-) A-I      intronic
chr11:59356930(-) A-I      intronic
chr11:59360543(-) A-I      intronic
chr11:59371265(-) A-I      intronic
chr11:59356919(-) A-I      intronic
chr11:59351225(-) A-I      intronic
chr11:59351242(-) A-I      intronic
chr11:59360377(-) A-I      intronic
chr11:59357253(-) A-I      intronic
chr11:59360329(-) A-I      intronic
chr11:59347322(-) A-I      intronic
chr11:59351246(-) A-I      intronic
chr11:59351286(-) A-I      intronic
chr11:59356220(-) A-I      intronic
chr11:59351306(-) A-I      intronic
chr11:59370272(-) A-I      intronic
chr11:59360397(-) A-I      intronic
chr11:59351326(-) A-I      intronic
chr11:59351516(-) A-I      intronic
chr11:59370335(-) A-I      intronic
chr11:59370330(-) A-I      intronic
chr11:59351521(-) A-I      intronic
chr11:59365387(-) A-I      intronic
chr11:59364750(-) A-I      intronic
chr11:59351534(-) A-I      intronic
chr11:59364702(-) A-I      intronic
chr11:59351557(-) A-I      intronic
chr11:59363247(-) A-I      intronic
chr11:59355952(-) A-I      intronic
chr11:59364700(-) A-I      intronic
chr11:59360366(-) A-I      intronic
chr11:59360273(-) A-I      intronic
chr11:59356711(-) A-I      intronic
chr11:59351597(-) A-I      intronic
chr11:59371174(-) A-I      intronic
chr11:59363334(-) A-I      intronic
chr11:59356253(-) A-I      intronic
chr11:59350722(-) A-I      intronic
chr11:59360270(-) A-I      intronic
chr11:59359361(-) A-I      intronic
chr11:59355887(-) A-I      intronic
chr11:59356359(-) A-I      intronic
chr11:59351565(-) A-I      intronic
chr11:59363287(-) A-I      intronic
chr11:59363210(-) A-I      intronic
chr11:59355841(-) A-I      intronic
chr11:59359205(-) A-I      intronic
chr11:59363153(-) A-I      intronic
chr11:59356891(-) A-I      intronic
chr11:59363140(-) A-I      intronic
chr11:59363138(-) A-I      intronic
chr11:59359167(-) A-I      intronic
chr11:59360522(-) A-I      intronic
chr11:59359166(-) A-I      intronic
chr11:59356490(-) A-I      intronic
chr11:59355844(-) A-I      intronic
chr11:59356707(-) A-I      intronic
chr11:59360513(-) A-I      intronic
chr11:59350566(-) A-I      intronic
chr11:59360489(-) A-I      intronic
chr11:59360560(-) A-I      intronic
chr11:59360487(-) A-I      intronic
chr11:59351132(-) A-I      intronic
chr11:59356829(-) A-I      intronic
chr11:59359156(-) A-I      intronic
chr11:59351693(-) A-I      intronic
chr11:59351619(-) A-I      intronic
chr11:59355965(-) A-I      intronic
chr11:59357410(-) A-I      intronic
chr11:59355885(-) A-I      intronic
chr11:59356952(-) A-I      intronic
chr11:59360474(-) A-I      intronic
chr11:59360447(-) A-I      intronic
chr11:59360437(-) A-I      intronic
chr11:59360415(-) A-I      intronic
chr11:59363309(-) A-I      intronic
chr11:59351281(-) A-I      intronic
chr11:59351639(-) A-I      intronic
chr11:59356908(-) A-I      intronic
chr11:59356366(-) A-I      intronic
chr11:59356882(-) A-I      intronic
chr11:59364669(-) A-I      intronic
chr11:59360490(-) A-I      intronic
chr11:59360450(-) A-I      intronic
chr11:59364755(-) A-I      intronic
chr11:59364670(-) A-I      intronic
chr11:59356378(-) A-I      intronic
chr11:59351202(-) A-I      intronic
chr11:59350690(-) A-I      intronic
chr11:59371192(-) A-I      intronic
chr11:59357228(-) A-I      intronic
chr11:59351273(-) A-I      intronic
chr11:59351277(-) A-I      intronic
chr11:59363245(-) A-I      intronic
chr11:59360297(-) A-I      intronic
chr11:59355881(-) A-I      intronic
chr11:59356727(-) A-I      intronic
chr11:59351316(-) A-I      intronic
chr11:59356222(-) A-I      intronic
chr11:59355824(-) A-I      intronic
chr11:59360449(-) A-I      intronic
chr11:59356356(-) A-I      intronic
chr11:59357213(-) A-I      intronic
chr11:59365233(-) A-I      intronic
chr11:59357393(-) A-I      intronic
chr11:59356734(-) A-I      intronic
chr11:59357284(-) A-I      intronic
chr11:59350618(-) A-I      intronic
chr11:59351288(-) A-I      intronic
chr11:59351628(-) A-I      intronic
chr11:59351598(-) A-I      intronic
chr11:59356313(-) A-I      intronic
chr11:59360341(-) A-I      intronic
chr11:59351383(-) A-I      intronic
chr11:59351419(-) A-I      intronic
chr11:59356656(-) A-I      intronic
chr11:59350703(-) A-I      intronic
chr11:59363295(-) A-I      intronic
chr11:59357425(-) A-I      intronic
chr11:59350702(-) A-I      intronic
chr11:59357409(-) A-I      intronic
chr11:59356669(-) A-I      intronic
chr11:59356687(-) A-I      intronic
chr11:59373132(-) A-I      intronic
chr11:59356236(-) A-I      intronic
chr11:59357067(-) A-I      intronic
chr11:59360503(-) A-I      intronic
chr11:59356257(-) A-I      intronic
chr11:59356725(-) A-I      intronic
chr11:59363335(-) A-I      intronic
chr11:59363360(-) A-I      intronic
chr11:59363304(-) A-I      intronic
chr11:59351307(-) A-I      intronic
chr11:59363191(-) A-I      intronic
chr11:59351337(-) A-I      intronic
chr11:59356906(-) A-I      intronic
chr11:59351559(-) A-I      intronic
chr11:59360475(-) A-I      intronic
chr11:59359190(-) A-I      intronic
chr11:59360544(-) A-I      intronic
chr11:59360433(-) A-I      intronic
chr11:59351213(-) A-I      intronic
chr11:59355933(-) A-I      intronic
chr11:59351340(-) A-I      intronic
chr11:59357201(-) A-I      intronic
chr11:59356261(-) A-I      intronic
chr11:59351257(-) A-I      intronic
chr11:59351252(-) A-I      intronic
chr11:59350779(-) A-I      intronic
chr11:59357399(-) A-I      intronic
chr11:59357027(-) A-I      intronic
chr11:59345981(-) A-I      intronic
chr11:59351353(-) A-I      intronic
chr11:59350621(-) A-I      intronic
chr11:59357334(-) A-I      intronic
chr11:59365460(-) A-I      intronic
chr11:59363300(-) A-I      intronic
chr11:59364696(-) A-I      intronic
chr11:59354929(-) A-I      intronic
chr11:59360407(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED OSBP
chr11:59351692(-) A-I intron -    21960545
chr11:59350566(-) A-G intron -    22484847
chr11:59351213(-) A-G intron -    22484847
chr11:59351597(-) A-G intron -    22484847
chr11:59351619(-) A-G intron -    22484847
chr11:59356222(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase OSBP
chr11:59343046-59343047(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr11:59343079-59343080(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr11:59343136-59343137(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr11:59343251-59343252(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr11:59343272-59343273(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr11:59343299-59343300(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr11:59343353-59343354(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr11:59343396-59343397(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr11:59343477-59343478(-) m6A 3'UTR       24284625//24209618//27773535//22608085
chr11:59343597-59343598(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr11:59343606-59343607(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr11:59343730-59343731(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr11:59343856-59343857(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr11:59343898-59343899(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr11:59344006-59344007(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr11:59344059-59344060(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr11:59344077-59344078(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr11:59344082-59344083(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr11:59344143-59344144(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr11:59344326-59344327(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr11:59344332-59344333(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr11:59344392-59344393(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22608085
chr11:59344417-59344418(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22608085
chr11:59344483-59344484(-) m6A 3'UTR//CDS       24209618//24981863//27371828//22608085
chr11:59347704-59347705(-) m6A 3'UTR//CDS       -
chr11:59347711-59347712(-) m6A 3'UTR//CDS       -
chr11:59361212-59361213(-) m6A exon//intron       -
chr11:59368005-59368006(-) m6A CDS//exon       27773535
chr11:59368038-59368039(-) m6A CDS//exon       27773535
chr11:59368060-59368061(-) m6A CDS//exon       27773535
chr11:59368078-59368079(-) m6A CDS       27773535
chr11:59368294-59368295(-) m6A CDS       27773535
chr11:59368833-59368834(-) m6A CDS       27773535
chr11:59369141-59369142(-) m6A CDS       27773535
chr11:59376010-59376011(-) m6A CDS       27371828
chr11:59376119-59376120(-) m6A CDS       27371828
chr11:59376141-59376142(-) m6A CDS       27371828
chr11:59376165-59376166(-) m6A CDS       27371828
chr11:59376174-59376175(-) m6A CDS       27371828
chr11:59377893-59377894(-) m6A CDS       22575960
chr11:59377952-59377953(-) m6A CDS       24209618//27773535//22575960
chr11:59377990-59377991(-) m6A CDS       24209618//27773535
chr11:59378043-59378044(-) m6A CDS       24209618//27773535
chr11:59382777-59382778(-) Cm CDS       -
chr11:59382842-59382843(-) m6A CDS       24209618//27773535
chr11:59383430-59383431(-) m6A 5'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-454-3p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Serum     18589210
Exosome Saliva     19627513
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Plasma     23663360
Exosome Endothelial cells     -
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Nucleolus HeLa cells     23940654
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
OSBP
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus Colon cancer cells     24393600
Nucleus HeLa-S3 cells|K562 cells     -
Ribosome HEK-293 cells     22199352

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-454-3p
4-(2-Pyridylazo)-N,N-dimethylaniline 81528 Drug sensitive
o-Aminoazotoluene 7340 Drug sensitive
Piperidinium pentamethylenedithiocarbamate 72508 Drug sensitive
Crotonoside 65085 Drug sensitive
Trihydroxygermaeranolide isobutyrate 6436277 Drug sensitive
(Z)-6-(2-(Pyridin-2-ylmethylene)hydrazinyl)-9H-purine 60147744 Drug sensitive
Ketone, methyl 2-pyridyl, 4,4-dimethyl-3-thiosemicarbazone 5843399 Drug sensitive
Incomptina B 54612584 Drug sensitive
Selendale 54601159 Drug resistant
Aspiculamycin hcl 54600418 Drug resistant
Methyl (1R,4R,7E,9S,10R,11S)-9-acetyloxy-10-(2,3-dimethyloxirane-2-carbonyl)oxy-4-methyl-12-methylidene-13-oxo-3,14-dioxatricyclo[9.3.0.02,4]tetradec-7-ene-8-carboxylate 5458601 Drug sensitive
7-(3-Methoxyphenyl)-N-(pyridin-4-ylmethylideneamino)-5H-pyrrolo[3,2-d]pyrimidin-4-amine 53239944 Drug resistant
Herbimycin 5311102 Drug sensitive
Vorinostat 5311 Drug sensitive
Amonafide 50515 Drug sensitive
Fastigilin C 442242 Drug sensitive
trans-Bis(acetato)amminepyridineplatinum(II) 405450 Drug sensitive
Antineoplastic-690271 391308 Drug sensitive
Idebenone 3686 Drug sensitive
2,7-Dicyanoxanthone 363841 Drug resistant
2-Hydroxy discorhabdin D 362391 Drug sensitive
Maxima isoflavone D 343081 Drug resistant
6-[(7-Nitro-2,1,3-benzoxadiazol-4-yl)sulfanyl]-7H-purin-2-amine 3246652 Drug sensitive
1,4-Naphthalenedione, 5,8-dihydroxy-2,3-bis(hydroxymethyl)- 313371 Drug sensitive
Razoxane 30623 Drug sensitive
[(5Z)-1,7,7-Trimethyl-5-(nitromethylene)-6-oxo-norbornan-2-yl] acetate 3004516 Drug sensitive
Salarin C 24867082 Drug resistant
2-(4-((Oxiran-2-yl)methoxy)styryl)-4,5-dihydrooxazole 24206038 Drug sensitive
Haterumalide NA methyl esters 24204452 Drug resistant
Pirarubicin hydrochloride 20846247 Drug sensitive
1,2:5,6-Dianhydrogalactitol 15942827 Drug sensitive
12-Iminodaunorubicin hcl 135539784 Drug sensitive
5-Hydroxypicolinaldehyde thiosemicarbazone 135453292 Drug sensitive
Formycin b 135449281 Drug sensitive
Kinamycin C 135430800 Drug sensitive
Veracoquinazole 135416663 Drug sensitive
Inosine dialdehyde 135400916 Drug sensitive
43-Dioxypectenotoxin 131751434 Drug resistant
Epilactose 128037 Drug resistant
Cytochalasin q 11970174 Drug sensitive
(3S,6R,10R,13Z,16S)-10-[(4-Methoxyphenyl)methyl]-6-methyl-3-(2-methylpropyl)-16-[(1S)-1-[(2R,3R)-3-phenyloxiran-2-yl]ethyl]-1,4-dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone 101917006 Drug resistant
Cyanocycline A 100158 Drug sensitive
1,3-diphenyl-4-(3-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1H-pyrazole - Drug resistant
9h-quino[4,3,2-de][1,10]phenanthrolin-9-one, 5-methoxy- - Drug resistant
N-(4-{2-[(1R,6R,11aS,13S,14aR)-1,13-dihydroxy-4-oxo-1,6,7,8,9,11a,12,13,14,14a-decahydro-4H-cyclopenta[f]oxacyclotridecin-6-yl]ethyl}phenyl)acetamide - Drug resistant
(1s,2e,4r,6r,7e,10r,11e)-2,7,11-cembratriene-4,6,10-triol - Drug sensitive
(2r,3r)-(+)-methyl 3-phenyloxirane-carboxylate - Drug sensitive
1h-benzo[a]carbazole-1,4(11h)-dione, 11-phenyl- - Drug sensitive
2,6-bis(4-morpholinylmethyl)cyclohexanone,dihydrochloride - Drug sensitive
2-bromo-5,8-dihydroxy-3-methyl-1,4-naphthoquinone - Drug sensitive
4-(2-pyridinyl)-5h-1,2,3-dithiazole-5-thione - Drug sensitive
6h-purine-6-thione, 1,7-dihydro-, mercury complex (9ci) - Drug sensitive
benzofurazan, 5-nitro-6-(1-piperidinyl)-, 1-oxide - Drug sensitive
cyclohexanone, 2,6-bis(piperidinomethyl)- - Drug sensitive
ethanone, 1-(2-pyrimidinyl)-, (2-benzoxazolyl)hydrazone - Drug sensitive
(s)(-)-methyl perillate - Drug sensitive
antineoplastic-654379 - Drug sensitive
Camptothecin Derivative - Drug sensitive
chlorobis(4-ethyltropolonato)bismuth(iii) - Drug sensitive
cyclo [n-naphthoyl-d-lys-asn-gln-trp-ala-val-d-ala-his-leu] - Drug sensitive
Indenoisoquinoline derivative - Drug sensitive
n-acetyl-4-s-cystaminyl phenol - Drug sensitive
o-linoleoyl-2-butoxy-1-desoamine - Drug sensitive
Tetraplatin - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-454-3p
Formaldehyde 712 Drug interaction    RC00006668
Gemcitabine 60750 Drug interaction    RC00006676
Vincristine 5978 Drug interaction    RC00006673
Floxuridine 5790 Drug interaction    RC00006672
Prednisolone 5755 Drug interaction    RC00006671
Sunitinib 5329102 Drug interaction    RC00006681
4-Hydroxynonenal 5283344 Drug interaction    RC00006680
Diethylstilbestrol 448537 Drug interaction    RC00006679
5-Fluorouracil 3385 Drug interaction    RC00006670
Doxorubicin 31703 Drug interaction    RC00006675
Daunorubicin 30323 Drug interaction    RC00006674
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00006677
Verapamil 2520 Drug interaction    RC00006669
Docetaxel 148124 Drug interaction    RC00006678
Asparaginase Escherichia coli - Drug interaction    RC00006683
FdUMP[10] - Drug interaction    RC00006682
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-454-3p
Cisplatin 5702198       30099826

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-454-3p
Interactor2: OSBP

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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