Detail Information

Basic Information:


  VIRBase ID:  

HHID00061523

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-542-3p:           UBP1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-542-3p UBP1
miRBase
Accession/Entrez ID		 MIMAT0003389 7342
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - LBP-1a//LBP-1B//LBP1A//LBP1B

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-542-3p
rs1040134213 chrX:134541375    A/T
rs772278520 chrX:134541372    A/G
rs773120200 chrX:134541373    T/C
rs1328624194 chrX:134541383    A/C
rs1446280034 chrX:134541384    C/A
rs759552858 chrX:134541378    C/T
rs765130012 chrX:134541381    T/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR UBP1
chr3:33462105(-) A-I      intronic
chr3:33468552(-) A-I      intronic
chr3:33468562(-) A-I      intronic
chr3:33468724(-) A-I      intronic
chr3:33469454(-) A-I      intronic
chr3:33475069(-) A-I      intronic
chr3:33462119(-) A-I      intronic
chr3:33469458(-) A-I      intronic
chr3:33473633(-) A-I      intronic
chr3:33470843(-) A-I      intronic
chr3:33462135(-) A-I      intronic
chr3:33462154(-) A-I      intronic
chr3:33462158(-) A-I      intronic
chr3:33462861(-) A-I      intronic
chr3:33462113(-) A-I      intronic
chr3:33460304(-) A-I      intronic
chr3:33461926(-) A-I      intronic
chr3:33461885(-) A-I      intronic
chr3:33461875(-) A-I      intronic
chr3:33462897(-) A-I      intronic
chr3:33463034(-) A-I      intronic
chr3:33463373(-) A-I      intronic
chr3:33470870(-) A-I      intronic
chr3:33463379(-) A-I      intronic
chr3:33470982(-) A-I      intronic
chr3:33473599(-) A-I      intronic
chr3:33473678(-) A-I      intronic
chr3:33473784(-) A-I      intronic
chr3:33474658(-) A-I      intronic
chr3:33474713(-) A-I      intronic
chr3:33474731(-) A-I      intronic
chr3:33460289(-) A-I      intronic
chr3:33460227(-) A-I      intronic
chr3:33474732(-) A-I      intronic
chr3:33474746(-) A-I      intronic
chr3:33471038(-) A-I      intronic
chr3:33473734(-) A-I      intronic
chr3:33477081(-) A-I      intronic
chr3:33477003(-) A-I      intronic
chr3:33464643(-) A-I      intronic
chr3:33476405(-) A-I      intronic
chr3:33476354(-) A-I      intronic
chr3:33476276(-) A-I      intronic
chr3:33476255(-) A-I      intronic
chr3:33476246(-) A-I      intronic
chr3:33475123(-) A-I      intronic
chr3:33475093(-) A-I      intronic
chr3:33469508(-) A-I      intronic
chr3:33475082(-) A-I      intronic
chr3:33470957(-) A-I      intronic
chr3:33473603(-) A-I      intronic
chr3:33473625(-) A-I      intronic
chr3:33464647(-) A-I      intronic
chr3:33464648(-) A-I      intronic
chr3:33464656(-) A-I      intronic
chr3:33464795(-) A-I      intronic
chr3:33464711(-) A-I      intronic
chr3:33477069(-) A-I      intronic
chr3:33477124(-) A-I      intronic
chr3:33474717(-) A-I      intronic
chr3:33475896(-) A-I      intronic
chr3:33469530(-) A-I      intronic
chr3:33476963(-) A-I      intronic
chr3:33475112(-) A-I      intronic
chr3:33468494(-) A-I      intronic
chr3:33464135(-) A-I      intronic
chr3:33464700(-) A-I      intronic
chr3:33474747(-) A-I      intronic
chr3:33468650(-) A-I      intronic
chr3:33461856(-) A-I      intronic
chr3:33472986(-) A-I      intronic
chr3:33473120(-) A-I      intronic
chr3:33473707(-) A-I      intronic
chr3:33461894(-) A-I      intronic
chr3:33468651(-) A-I      intronic
chr3:33464782(-) A-I      intronic
chr3:33463323(-) A-I      intronic
chr3:33473740(-) A-I      intronic
chr3:33477013(-) A-I      intronic
chr3:33473691(-) A-I      intronic
chr3:33475416(-) A-I      intronic
chr3:33459933(-) A-I      intronic
chr3:33471094(-) A-I      intronic
chr3:33464122(-) A-I      intronic
chr3:33471093(-) A-I      intronic
chr3:33475954(-) A-I      intronic
chr3:33469562(-) A-I      intronic
chr3:33464173(-) A-I      intronic
chr3:33472985(-) A-I      intronic
chr3:33476275(-) A-I      intronic
chr3:33475902(-) A-I      intronic
chr3:33476383(-) A-I      intronic
chr3:33462929(-) A-I      intronic
chr3:33464171(-) A-I      intronic
chr3:33460871(-) A-I      intronic
chr3:33469449(-) A-I      intronic
chr3:33476953(-) A-I      intronic
chr3:33469439(-) A-I      intronic
chr3:33474620(-) A-I      intronic
chr3:33463436(-) A-I      intronic
chr3:33460299(-) A-I      intronic
chr3:33469517(-) A-I      intronic
chr3:33473156(-) A-I      intronic
chr3:33472995(-) A-I      intronic
chr3:33474691(-) A-I      intronic
chr3:33473704(-) A-I      intronic
chr3:33473602(-) A-I      intronic
chr3:33466293(-) A-I      intronic
chr3:33473185(-) A-I      intronic
chr3:33461929(-) A-I      intronic
chr3:33475957(-) A-I      intronic
chr3:33461890(-) A-I      intronic
chr3:33460251(-) A-I      intronic
chr3:33469587(-) A-I      intronic
chr3:33468597(-) A-I      intronic
chr3:33477009(-) A-I      intronic
chr3:33463453(-) A-I      intronic
chr3:33474965(-) A-I      intronic
chr3:33463370(-) A-I      intronic
chr3:33477095(-) A-I      intronic
chr3:33469598(-) A-I      intronic
chr3:33464705(-) A-I      intronic
chr3:33473062(-) A-I      intronic
chr3:33463284(-) A-I      intronic
chr3:33473668(-) A-I      intronic
chr3:33461878(-) A-I      intronic
chr3:33470959(-) A-I      intronic
chr3:33471080(-) A-I      intronic
chr3:33464714(-) A-I      intronic
chr3:33469425(-) A-I      intronic
chr3:33460736(-) A-I      intronic
chr3:33475997(-) A-I      intronic
chr3:33474625(-) A-I      intronic
chr3:33476443(-) A-I      intronic
chr3:33473056(-) A-I      intronic
chr3:33464601(-) A-I      intronic
chr3:33470903(-) A-I      intronic
chr3:33476051(-) A-I      intronic
chr3:33460134(-) A-I      intronic
chr3:33470967(-) A-I      intronic
chr3:33473218(-) A-I      intronic
chr3:33475928(-) A-I      intronic
chr3:33463493(-) A-I      intronic
chr3:33468565(-) A-I      intronic
chr3:33475101(-) A-I      intronic
chr3:33462980(-) A-I      intronic
chr3:33474982(-) A-I      intronic
chr3:33473106(-) A-I      intronic
chr3:33460188(-) A-I      intronic
chr3:33475345(-) A-I      intronic
chr3:33463454(-) A-I      intronic
chr3:33473699(-) A-I      intronic
chr3:33470954(-) A-I      intronic
chr3:33463521(-) A-I      intronic
chr3:33469511(-) A-I      intronic
chr3:33463420(-) A-I      intronic
chr3:33476343(-) A-I      intronic
chr3:33472973(-) A-I      intronic
chr3:33471022(-) A-I      intronic
chr3:33473113(-) A-I      intronic
chr3:33475941(-) A-I      intronic
chr3:33473043(-) A-I      intronic
chr3:33466321(-) A-I      intronic
chr3:33459930(-) A-I      intronic
chr3:33475410(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED UBP1
chr3:33477095(-) A-I intron -    21960545
chr3:33459930(-) A-G intron -    22484847
chr3:33459933(-) A-G intron -    22484847
chr3:33460134(-) A-G intron -    22484847
chr3:33460188(-) A-G intron -    22484847
chr3:33460229(-) A-G intron -    22484847
chr3:33460251(-) A-G intron -    22484847
chr3:33460299(-) A-G intron -    22484847
chr3:33461037(-) A-G intron -    22484847
chr3:33461081(-) A-G intron -    22484847
chr3:33462098(-) T-C intron -    22484847
chr3:33463420(-) A-G intron -    22484847
chr3:33463454(-) A-G intron -    22484847
chr3:33463521(-) A-G intron -    22484847
chr3:33464117(-) A-G intron -    22484847
chr3:33464122(-) A-G intron -    22484847
chr3:33464542(-) A-C intron -    22484847
chr3:33464700(-) A-G intron -    22484847
chr3:33464705(-) A-G intron -    22484847
chr3:33464711(-) A-G intron -    22484847
chr3:33464714(-) A-G intron -    22484847
chr3:33464781(-) A-G intron -    22484847
chr3:33464782(-) A-G intron -    22484847
chr3:33468494(-) A-G intron -    22484847
chr3:33468658(-) A-G intron -    22484847
chr3:33469587(-) A-G intron -    22484847
chr3:33470903(-) A-G intron -    22484847
chr3:33470906(-) A-G intron -    22484847
chr3:33470959(-) A-G intron -    22484847
chr3:33470960(-) A-G intron -    22484847
chr3:33470967(-) A-G intron -    22484847
chr3:33471022(-) A-G intron -    22484847
chr3:33471080(-) A-G intron -    22484847
chr3:33473056(-) A-G intron -    22484847
chr3:33473106(-) A-G intron -    22484847
chr3:33473110(-) A-G intron -    22484847
chr3:33473113(-) A-G intron -    22484847
chr3:33473120(-) A-G intron -    22484847
chr3:33473156(-) A-G intron -    22484847
chr3:33473185(-) A-G intron -    22484847
chr3:33473186(-) A-G intron -    22484847
chr3:33473235(-) C-T intron -    22484847
chr3:33473691(-) A-G intron -    22484847
chr3:33473704(-) A-G intron -    22484847
chr3:33474691(-) A-G intron -    22484847
chr3:33474717(-) A-G intron -    22484847
chr3:33474721(-) A-G intron -    22484847
chr3:33474747(-) A-G intron -    22484847
chr3:33475101(-) A-G intron -    22484847
chr3:33475410(-) A-G intron -    22484847
chr3:33475416(-) A-G intron -    22484847
chr3:33475927(-) A-G intron -    22484847
chr3:33475941(-) A-G intron -    22484847
chr3:33476382(-) A-G intron -    22484847
chr3:33476443(-) A-G intron -    22484847
chr3:33477009(-) A-G intron -    22484847
chr3:33477044(-) A-G intron -    22484847
chr3:33477069(-) A-G intron -    22484847
chr3:33477095(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase UBP1
chr3:33430563-33430564(-) m6A 3'UTR//exon       27773535
chr3:33430648-33430649(-) m6A 3'UTR//exon       27773535
chr3:33430726-33430727(-) m6A 3'UTR//exon       27773535
chr3:33430794-33430795(-) m6A 3'UTR//exon       27773535
chr3:33430815-33430816(-) m6A 3'UTR//exon       27773535
chr3:33430838-33430839(-) m6A 3'UTR//exon       27773535
chr3:33430923-33430924(-) m6A 3'UTR//exon       27773535
chr3:33430946-33430947(-) m6A 3'UTR//exon       24284625//26404942//27773535
chr3:33431034-33431035(-) m6A 3'UTR//exon       24284625//24981863//27773535//22608085
chr3:33431108-33431109(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22608085
chr3:33431146-33431147(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//27773535//22608085
chr3:33431205-33431206(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//27773535//22608085
chr3:33431389-33431390(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr3:33431420-33431421(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr3:33431471-33431472(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr3:33431703-33431704(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//27371828//22608085
chr3:33431761-33431762(-) m6A 3'UTR//exon       24284625//24981863//26404942//27773535//27371828//22608085
chr3:33431804-33431805(-) m6A 3'UTR//exon       24284625//24981863//26404942//27773535//22608085
chr3:33431809-33431810(-) m6A 3'UTR//exon       24284625//24981863//26404942//27773535//22608085
chr3:33432886-33432887(-) m6A exon//intron       27773535
chr3:33432965-33432966(-) m6A exon//intron       27773535
chr3:33433491-33433492(-) m6A exon//intron       27773535
chr3:33433612-33433613(-) m6A exon//intron       27773535
chr3:33433670-33433671(-) m6A exon//intron       27773535
chr3:33441699-33441700(-) m6A CDS//exon       27773535
chr3:33441721-33441722(-) m6A CDS//exon       24284625//27773535
chr3:33441743-33441744(-) m6A CDS//exon       24284625//27773535
chr3:33442464-33442465(-) m6A CDS//exon       24284625//27773535
chr3:33444295-33444296(-) m6A CDS//exon       24284625//24981863//27773535
chr3:33450212-33450213(-) m6A CDS//exon//intron       24284625//24981863//27773535//27371828
chr3:33450225-33450226(-) m6A CDS//exon//intron       24981863//27773535//27371828
chr3:33450253-33450254(-) m6A CDS//exon//intron       24981863//27773535//27371828
chr3:33450783-33450784(-) m6A CDS//exon       24981863
chr3:33450810-33450811(-) m6A 5'UTR//CDS//exon       24981863
chr3:33450817-33450818(-) m6A 5'UTR//CDS//exon       24981863
chr3:33450824-33450825(-) m6A 5'UTR//CDS//exon       24981863
chr3:33457528-33457529(-) m6A exon//intron       24981863
chr3:33481881-33481882(-) m6A 5'UTR//intron       25456834//24981863//27773536
chr3:33482008-33482009(-) m6A 5'UTR//intron       25456834

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-542-3p
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Breast cell line|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
UBP1
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome Blood     -
Insoluble cytoplasm HCC cell line (HepG2)|K562 cells     -
Membrane HCC cell line (HepG2)     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-542-3p
Hydrazinecarboximidamide, 2,2'-(carbonylbis(imino-3,1-phenyleneethylidyne))bis-, hydrochloride 9577144 Drug sensitive
Ambrosin 92119 Drug resistant
Venenatine 73061 Drug sensitive
1,3,5-Triacryloylhexahydro-1,3,5-triazine 70397 Drug resistant
3,6-Diamino-10-methylacridinium chloride 6842 Drug sensitive
2-[(5Z)-5-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylidene]-4-methoxypyrrol-2-ylidene]indole 66751253 Drug resistant
2-Azaadenine 5480214 Drug resistant
Biantrazole 54607781 Drug sensitive
Betuletol 5459196 Drug sensitive
Xestin A 5352066 Drug resistant
Hydroxy AT 125 5351254 Drug resistant
1-Piperidineethanol, alpha-[p-(p-chlorostyryl)phenyl]- 5351150 Drug resistant
Proscillaridin 5284613 Drug sensitive
10-Hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12-dodecahydro-1H-picene-4a-carboxylic acid 495604 Drug sensitive
6-Bromosangivamycin 470030 Drug resistant
CID 44581723 44581723 Drug resistant
Di-n-octyl-secalonsaure A 430141 Drug sensitive
Mitoxantrone 4212 Drug sensitive
Mauve 407617 Drug sensitive
Fagaronine chloride 40304 Drug sensitive
Phosphine, 1,2-ethanediylbis[bis[2-(methylthio)phenyl]- 397601 Drug sensitive
1H-Purine, 6-[(1-methyl-4-nitro-1H-imidazol-5-yl)seleno]- 3879067 Drug resistant
ARQ monoacetate 385441 Drug sensitive
2-(2-(Dimethylamino)ethylamino)naphthazarin 376950 Drug resistant
2-N-Methyl-6-thiaellipticinum iodide 367888 Drug sensitive
2,7-Dicyanoxanthone 363841 Drug sensitive
Ellipticine 3213 Drug sensitive
SMA-491 (free base of NSC D742838) 302576 Drug resistant
Pirarubicin hydrochloride 20846247 Drug sensitive
(p-Nitrophenyl)phenyliodonium bromide 19992 Drug sensitive
(R)-(2,8-Bis(trifluoromethyl)quinolin-4-yl)((S)-piperidin-2-yl)methanol hydrochloride 18660697 Drug resistant
3,6-Diamino-10-methylacridinium chloride hydrochloride 15558347 Drug sensitive
Methyl (3'R)-3,4',9',10-tetrahydroxy-3'-[(2S,4R,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-7'-methoxy-5',8',9-trioxospiro[3,4-dihydropyrano[4,3-g]chromene-2,2'-3H-benzo[f][1]benzofuran]-7-carboxylate 137326876 Drug sensitive
Methyl ester prodigiosene 136040158 Drug resistant
(2S,4S,5R)-20-De(1-hydroxypropyl)-6-demethyl-2,6-diethyl-5-hydroxy-20-(1-hydroxybutyl)lysocellin 124081057 Drug sensitive
2,9-Dimethylellipticinium acetate 10472068 Drug sensitive
inosine, 6-thio-, 2',3',5'-tripentanoate - Drug resistant
bafilomycin antibiotic - Drug resistant
bafilomycin deriv - Drug resistant
(3-(4-bromophenyl)-5-(1,3-diphenyl-1H-pyrazol-4-yl)-4,5-dihydropyrazol-1-yl)(4-methoxyphenyl)methanone - Drug sensitive
(z) 4-acetoxy-(3,4',5)-trimethoxystilbene - Drug sensitive
5.alpha.,25d-spirostan-3.beta.-ol glycoside - Drug sensitive
phosphinic acid, bis(1-aziridinyl)-, 2-naphthyl ester - Drug sensitive
2-methylellpticinium - Drug sensitive
Camptothecin Derivative - Drug sensitive
from cephalodiscus gilchristi - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-542-3p
Ethanol 702 Drug interaction    RC00006449
Medroxyprogesterone acetate 6279 Drug interaction    RC00006453
Gemcitabine 60750 Drug interaction    RC00006456
Estradiol 5757 Drug interaction    RC00006452
Vorinostat 5311 Drug interaction    RC00006451
Etoposide 36462 Drug interaction    RC00006455
Doxorubicin 31703 Drug interaction    RC00006454
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00006450
Proanthocyanidin 108065 Drug interaction    RC00006457
Trastuzumab - Drug interaction    RC00006458
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-542-3p
Cisplatin 5702198       21939554
Etoposide 36462       23028896
Trastuzumab -       25586125

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-542-3p
Interactor2: UBP1

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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