Basic Information:

  VIRBase ID:  

HHID00061455

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-659-3p:  MIMAT0003337          FOCAD:  NM_001375567     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-659-3p	FOCAD
miRBase Accession/Entrez ID	MIMAT0003337	54914
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	KIAA1797

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-659-3p	rs1410527784 chr22:37847714    G/GGAAGA rs1462192916 chr22:37847696    G/C rs1462513707 chr22:37847699    C/A rs760935985 chr22:37847705    C/A rs1472675095 chr22:37847711    C/T rs766475100 chr22:37847712    A/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	FOCAD	chr9:20735648(+) A-I      intronic chr9:20735657(+) A-I      intronic chr9:20815233(+) A-I      intronic chr9:20815237(+) A-I      intronic chr9:20815258(+) A-I      intronic chr9:20730996(+) A-I      intronic chr9:20730979(+) A-I      intronic chr9:20730971(+) A-I      intronic chr9:20712861(+) A-I      intronic chr9:20712395(+) A-I      intronic chr9:20815344(+) A-I      intronic chr9:20696648(+) A-I      intronic chr9:20696645(+) A-I      intronic chr9:20734743(+) A-I      intronic chr9:20731158(+) A-I      intronic chr9:20686220(+) A-I      intronic chr9:20733877(+) A-I      intronic chr9:20733843(+) A-I      intronic chr9:20733841(+) A-I      intronic chr9:20693773(+) A-I      intronic chr9:20734770(+) A-I      intronic chr9:20777929(+) A-I      intronic chr9:20733787(+) A-I      intronic chr9:20731845(+) A-I      intronic chr9:20731783(+) A-I      intronic chr9:20693790(+) A-I      intronic chr9:20731782(+) A-I      intronic chr9:20731721(+) A-I      intronic chr9:20693827(+) A-I      intronic chr9:20731064(+) A-I      intronic chr9:20936564(+) A-I      intronic chr9:20777930(+) A-I      intronic chr9:20983326(+) A-I      intronic chr9:20795662(+) A-I      intronic chr9:20795672(+) A-I      intronic chr9:20696657(+) A-I      intronic chr9:20985063(+) A-I      intronic chr9:20696759(+) A-I      intronic chr9:20698411(+) A-I      intronic chr9:20795521(+) A-I      intronic chr9:20795689(+) A-I      intronic chr9:20777942(+) A-I      intronic chr9:20795530(+) A-I      intronic chr9:20801424(+) A-I      intronic chr9:20807785(+) A-I      intronic chr9:20807794(+) A-I      intronic chr9:20807867(+) A-I      intronic chr9:20807975(+) A-I      intronic chr9:20808000(+) A-I      intronic chr9:20795538(+) A-I      intronic chr9:20698474(+) A-I      intronic chr9:20795511(+) A-I      intronic chr9:20790655(+) A-I      intronic chr9:20795636(+) A-I      intronic chr9:20669554(+) A-I      intronic chr9:20680784(+) A-I      intronic chr9:20731059(+) A-I      intronic chr9:20699555(+) A-I      intronic chr9:20702241(+) A-I      intronic chr9:20696638(+) A-I      intronic chr9:20884367(+) A-I      intronic chr9:20933411(+) A-I      intronic chr9:20696652(+) A-I      intronic chr9:20884476(+) A-I      intronic chr9:20884502(+) A-I      intronic chr9:20884849(+) A-I      intronic chr9:20884947(+) A-I      intronic chr9:20939005(+) A-I      intronic chr9:20964715(+) A-I      intronic chr9:20983418(+) A-I      intronic chr9:20983477(+) A-I      intronic chr9:20984941(+) A-I      intronic chr9:20665874(+) A-I      intronic chr9:20662641(+) A-I      intronic chr9:20680708(+) A-I      intronic chr9:20859119(+) A-I      intronic chr9:20658963(+) A-I      intronic chr9:20721602(+) A-I      intronic chr9:20819325(+) A-I      intronic chr9:20790623(+) A-I      intronic chr9:20815378(+) A-I      intronic chr9:20721446(+) A-I      intronic chr9:20696676(+) A-I      intronic chr9:20699626(+) A-I      intronic chr9:20778450(+) A-I      intronic chr9:20983395(+) A-I      intronic chr9:20712426(+) A-I      intronic chr9:20939077(+) A-I      intronic chr9:20731187(+) A-I      intronic chr9:20698635(+) A-I      intronic chr9:20693849(+) A-I      intronic chr9:20673695(+) A-I      intronic chr9:20712403(+) A-I      intronic chr9:20778481(+) A-I      intronic chr9:20815383(+) A-I      intronic chr9:20698422(+) A-I      intronic chr9:20819451(+) A-I      intronic chr9:20939028(+) A-I      intronic chr9:20659406(+) A-I      intronic chr9:20991710(+) A-I      intronic chr9:20755952(+) A-I      intronic chr9:20884437(+) A-I      intronic chr9:20702277(+) A-I      intronic chr9:20815341(+) A-I      intronic chr9:20698435(+) A-I      intronic chr9:20801443(+) A-I      intronic chr9:20693876(+) A-I      intronic chr9:20733997(+) A-I      intronic chr9:20659027(+) A-I      intronic chr9:20790720(+) A-I      intronic chr9:20731717(+) A-I      intronic chr9:20733842(+) A-I      intronic chr9:20731850(+) A-I      intronic chr9:20819402(+) A-I      intronic chr9:20985000(+) A-I      intronic chr9:20985075(+) A-I      intronic chr9:20686256(+) A-I      intronic chr9:20984880(+) A-I      intronic chr9:20819223(+) A-I      intronic chr9:20984851(+) A-I      intronic chr9:20819236(+) A-I      intronic chr9:20722159(+) A-I      intronic chr9:20940522(+) A-I      intronic chr9:20712862(+) A-I      intronic chr9:20778462(+) A-I      intronic chr9:20680923(+) A-I      intronic chr9:20971623(+) A-I      intronic chr9:20698529(+) A-I      intronic chr9:20984972(+) A-I      intronic chr9:20984983(+) A-I      intronic chr9:20699562(+) A-I      intronic chr9:20778393(+) A-I      intronic chr9:20721581(+) A-I      intronic chr9:20964342(+) A-I      intronic chr9:20790585(+) A-I      intronic chr9:20814494(+) A-I      intronic chr9:20699472(+) A-I      intronic chr9:20690680(+) A-I      intronic chr9:20698500(+) A-I      intronic chr9:20659138(+) A-I      intronic chr9:20807793(+) A-I      intronic chr9:20819352(+) A-I      intronic chr9:20696714(+) A-I      intronic chr9:20731091(+) A-I      intronic chr9:20662717(+) A-I      intronic chr9:20814484(+) A-I      intronic chr9:20669617(+) A-I      intronic chr9:20807939(+) A-I      intronic chr9:20691899(+) A-I      intronic chr9:20815272(+) A-I      intronic chr9:20984989(+) A-I      intronic chr9:20662723(+) A-I      intronic chr9:20819396(+) A-I      intronic chr9:20735724(+) A-I      intronic chr9:20807907(+) A-I      intronic chr9:20721710(+) A-I      intronic chr9:20983406(+) A-I      intronic chr9:20739455(+) A-I      intronic chr9:20731162(+) A-I      intronic chr9:20669695(+) A-I      intronic chr9:20983411(+) A-I      intronic chr9:20790551(+) A-I      intronic chr9:20664713(+) A-I      intronic chr9:20712961(+) A-I      intronic chr9:20957208(+) A-I      intronic chr9:20693945(+) A-I      intronic chr9:20731716(+) A-I      intronic chr9:20807996(+) A-I      intronic chr9:20819422(+) A-I      intronic chr9:20712616(+) A-I      intronic chr9:20731799(+) A-I      intronic chr9:20790516(+) A-I      intronic chr9:20698503(+) A-I      intronic chr9:20699557(+) A-I      intronic chr9:20691953(+) A-I      intronic chr9:20884951(+) A-I      intronic chr9:20940523(+) A-I      intronic chr9:20819338(+) A-I      intronic chr9:20940547(+) A-I      intronic chr9:20698534(+) A-I      intronic chr9:20731691(+) A-I      intronic chr9:20708653(+) A-I      intronic chr9:20819269(+) A-I      intronic chr9:20733926(+) A-I      intronic chr9:20698649(+) A-I      intronic chr9:20790663(+) A-I      intronic chr9:20710485(+) A-I      intronic chr9:20712404(+) A-I      intronic chr9:20964223(+) A-I      intronic chr9:20983295(+) A-I      intronic chr9:20983450(+) A-I      intronic chr9:20807935(+) A-I      intronic chr9:20710502(+) A-I      intronic chr9:20985061(+) A-I      intronic chr9:20702303(+) A-I      intronic chr9:20698530(+) A-I      intronic chr9:20702364(+) A-I      intronic chr9:20698501(+) A-I      intronic chr9:20819475(+) A-I      intronic chr9:20778361(+) A-I      intronic chr9:20819330(+) A-I      intronic chr9:20698582(+) A-I      intronic chr9:20940559(+) A-I      intronic chr9:20712647(+) A-I      intronic chr9:20985062(+) A-I      intronic chr9:20698647(+) A-I      intronic chr9:20659285(+) A-I      intronic chr9:20712984(+) A-I      intronic chr9:20699553(+) A-I      intronic chr9:20984917(+) A-I      intronic chr9:20819487(+) A-I      intronic chr9:20666448(+) A-I      intronic chr9:20706046(+) A-I      intronic chr9:20819354(+) A-I      intronic chr9:20723408(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	FOCAD	chr9:20903105(+) C-T intron -    22484847 chr9:20662661(+) A-G intron -    22484847 chr9:20936653(+) C-T intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	FOCAD	chr9:20658404-20658405(+) m6A 5'UTR       24981863 chr9:20885159-20885160(+) m6A CDS//exon       - chr9:20885167-20885168(+) m6A CDS//exon       - chr9:20885205-20885206(+) m6A CDS//exon       - chr9:20912869-20912870(+) m6A CDS//exon       24981863 chr9:20912896-20912897(+) m6A CDS//exon       24981863 chr9:20912911-20912912(+) m6A CDS       24981863 chr9:20995628-20995629(+) m6A 3'UTR       24284625//27773535//22608085 chr9:20995672-20995673(+) m6A 3'UTR       24284625//27773535//22608085 chr9:20995722-20995723(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr9:20995830-20995831(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr9:20995836-20995837(+) m6A 3'UTR       24284625//25456834//24981863//27773535//22575960//22608085 chr9:20995842-20995843(+) m6A 3'UTR       24284625//25456834//24981863//27773535//22575960//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-659-3p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	FOCAD	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-659-3p
Interactor2: FOCAD

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.