Basic Information:

  VIRBase ID:  

HHID00061426

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-651-5p:  MIMAT0003321          BROX:  NR_109927     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-651-5p	BROX
miRBase Accession/Entrez ID	MIMAT0003321	148362
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	C1orf58

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-651-5p	rs111336920 chrX:8126995    A/G rs1166654464 chrX:8126990    G/A rs1450152007 chrX:8127000    T/C rs780175385 chrX:8127001    G/A rs758413295 chrX:8126982    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	BROX	chr1:222888156(+) A-I      intronic chr1:222888801(+) A-I      intronic chr1:222888840(+) A-I      intronic chr1:222899197(+) A-I      intronic chr1:222888841(+) A-I      intronic chr1:222888144(+) A-I      intronic chr1:222893934(+) A-I      intronic chr1:222893953(+) A-I      intronic chr1:222899089(+) A-I      intronic chr1:222899173(+) A-I      intronic chr1:222888169(+) A-I      intronic chr1:222895784(+) A-I      NonSyn:Glu->Gly chr1:222894035(+) A-I      intronic chr1:222888132(+) A-I      intronic chr1:222897162(+) A-I      intronic chr1:222899148(+) A-I      intronic chr1:222888136(+) A-I      intronic chr1:222894032(+) A-I      intronic chr1:222888157(+) A-I      intronic chr1:222897269(+) A-I      intronic chr1:222897239(+) A-I      intronic chr1:222897222(+) A-I      intronic chr1:222900029(+) A-I      intronic chr1:222897150(+) A-I      intronic chr1:222897160(+) A-I      intronic chr1:222897223(+) A-I      intronic chr1:222888830(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	BROX	chr1:222888136(+) A-I intron -    21960545   //22327324 chr1:222888157(+) A-I intron -    21960545 chr1:222888132(+) A-G intron -    22484847 chr1:222888136(+) A-G intron -    22484847 chr1:222888157(+) A-G intron -    22484847 chr1:222888830(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	BROX	chr1:222885993-222885994(+) m6A 5'UTR//exon       24284625//24981863 chr1:222886060-222886061(+) m6A 5'UTR//exon       24284625//24981863 chr1:222886257-222886258(+) m6A 5'UTR//exon       24981863 chr1:222886265-222886266(+) m6A 5'UTR//exon       24981863 chr1:222886719-222886720(+) m6A 5'UTR//exon//intron       24981863 chr1:222886931-222886932(+) m6A exon//intron       24981863 chr1:222886941-222886942(+) m6A exon//intron       24981863 chr1:222886948-222886949(+) m6A exon//intron       24981863 chr1:222886991-222886992(+) m6A exon//intron       24981863 chr1:222897496-222897497(+) m6A CDS//exon       24981863 chr1:222898808-222898809(+) m6A CDS//exon       24981863 chr1:222900531-222900532(+) m6A CDS//exon       24981863 chr1:222904804-222904805(+) m6A CDS//intron       22608085 chr1:222904813-222904814(+) m6A CDS//intron       22608085 chr1:222904842-222904843(+) m6A CDS//intron       24981863//27773535//22608085 chr1:222905974-222905975(+) m6A CDS       24981863//27773535//22608085 chr1:222905980-222905981(+) m6A CDS       24981863//27773535//22608085 chr1:222905998-222905999(+) m6A 3'UTR//CDS       24981863//22608085 chr1:222906010-222906011(+) m6A 3'UTR//CDS       24981863//22608085 chr1:222906015-222906016(+) m6A 3'UTR//CDS       24981863//22608085 chr1:222906022-222906023(+) m6A 3'UTR//CDS       24981863//22608085 chr1:222906033-222906034(+) m6A 3'UTR//CDS       24981863//22608085 chr1:222906100-222906101(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-651-5p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	BROX	Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-651-5p
Interactor2: BROX

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.