Detail Information

Basic Information:


  VIRBase ID:  

HHID00061333

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-642a-5p:           NRAS:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-642a-5p NRAS
miRBase
Accession/Entrez ID		 MIMAT0003312 4893
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - ALPS4//CMNS//N-ras//NCMS//NRAS1//NS6

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-642a-5p
rs1187651627 chr19:45674964    G/GATCCCCCACCCCAA
rs1441411829 chr19:45674963    TGGGGTGGGG/T
rs775648115 chr19:45674943    G/T
rs374751972 chr19:45674950    T/A
rs78902025 chr19:45674948    T/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR NRAS
chr1:115255950(-) A-I      intronic
chr1:115255947(-) A-I      intronic
chr1:115253742(-) A-I      intronic
chr1:115253691(-) A-I      intronic
chr1:115255952(-) A-I      intronic
chr1:115255951(-) A-I      intronic
chr1:115253647(-) A-I      intronic
chr1:115253759(-) A-I      intronic
chr1:115256022(-) A-I      intronic
chr1:115255983(-) A-I      intronic
chr1:115255985(-) A-I      intronic
chr1:115255987(-) A-I      intronic
chr1:115256074(-) A-I      intronic
chr1:115256080(-) A-I      intronic
chr1:115252414(-) A-I      intronic
chr1:115255979(-) A-I      intronic
chr1:115256011(-) A-I      intronic
chr1:115255840(-) A-I      intronic
chr1:115253675(-) A-I      intronic
chr1:115256036(-) A-I      intronic
chr1:115256035(-) A-I      intronic
chr1:115256085(-) A-I      intronic
chr1:115256117(-) A-I      intronic
chr1:115256064(-) A-I      intronic
chr1:115252774(-) A-I      intronic
chr1:115253708(-) A-I      intronic
chr1:115256191(-) A-I      intronic
chr1:115253844(-) A-I      intronic
chr1:115256156(-) A-I      intronic
chr1:115253055(-) A-I      intronic
chr1:115253815(-) A-I      intronic
chr1:115255980(-) A-I      intronic
chr1:115253756(-) A-I      intronic
chr1:115256052(-) A-I      intronic
chr1:115252433(-) A-I      intronic
chr1:115253752(-) A-I      intronic
chr1:115253714(-) A-I      intronic
chr1:115253922(-) A-I      intronic
chr1:115253745(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED NRAS
chr1:115248402(-) C-T exon 3'UTR    22484847
chr1:115253714(-) A-G intron -    22484847
chr1:115253752(-) A-G intron -    22484847
chr1:115253756(-) A-G intron -    22484847
chr1:115255980(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase NRAS
chr1:115248444-115248445(-) m6A 3'UTR       -
chr1:115251193-115251194(-) m6A CDS       27371828
chr1:115251215-115251216(-) m6A CDS       24981863//27371828
chr1:115252192-115252193(-) m6A CDS       24981863//27371828
chr1:115252197-115252198(-) m6A CDS       24981863//27371828
chr1:115252209-115252210(-) m6A CDS       24981863//27371828
chr1:115252243-115252244(-) m6A CDS       24981863//27371828
chr1:115252255-115252256(-) m6A CDS       24981863//27371828
chr1:115252269-115252270(-) m6A CDS       24981863//27371828
chr1:115252292-115252293(-) m6A CDS       24981863//27371828
chr1:115252325-115252326(-) m6A CDS       -
chr1:115256490-115256491(-) m6A CDS       -
chr1:115256504-115256505(-) m6A CDS       -
chr1:115256530-115256531(-) m6A CDS       -
chr1:115256549-115256550(-) m6A CDS       -
chr1:115256562-115256563(-) m6A CDS       -
chr1:115256584-115256585(-) m6A CDS       -
chr1:115258704-115258705(-) m6A CDS       -
chr1:115258766-115258767(-) m6A CDS       22575960

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-642a-5p
Exosome Primary ovarian tumor cells|Serum     18589210
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Mesenchymal stem cells     -
NRAS
Cytosol K562 cells     -
Exosome Blood     -
Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-642a-5p
Interactor2: NRAS

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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