Basic Information:

  VIRBase ID:  

HHID00061243

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-33b-5p:  MIMAT0003301          LDHA:  NR_028500     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-33b-5p	LDHA
miRBase Accession/Entrez ID	MIMAT0003301	3939
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	GSD11//HEL-S-133P//LDHM//PIG19

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-33b-5p	rs1302588645 chr17:17813903    C/T rs1202893363 chr17:17813909    C/T rs1423321551 chr17:17813912    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	LDHA	chr11:18419235(+) A-I      intronic chr11:18426267(+) A-I      intronic chr11:18427630(+) A-I      intronic chr11:18427710(+) A-I      intronic chr11:18427735(+) A-I      intronic chr11:18428068(+) A-I      intronic chr11:18428077(+) A-I      intronic chr11:18428103(+) A-I      intronic chr11:18428152(+) A-I      intronic chr11:18428188(+) A-I      intronic chr11:18425890(+) A-I      intronic chr11:18428352(+) A-I      intronic chr11:18425850(+) A-I      intronic chr11:18420336(+) A-I      intronic chr11:18427587(+) A-I      intronic chr11:18419186(+) A-I      intronic chr11:18428062(+) A-I      intronic chr11:18427696(+) A-I      intronic chr11:18425791(+) A-I      intronic chr11:18425643(+) A-I      intronic chr11:18426192(+) A-I      intronic chr11:18428120(+) A-I      intronic chr11:18428414(+) A-I      intronic chr11:18428088(+) A-I      intronic chr11:18426193(+) A-I      intronic chr11:18426189(+) A-I      intronic chr11:18426178(+) A-I      intronic chr11:18425897(+) A-I      intronic chr11:18425796(+) A-I      intronic chr11:18428418(+) A-I      intronic chr11:18425577(+) A-I      intronic chr11:18425541(+) A-I      intronic chr11:18426195(+) A-I      intronic chr11:18420363(+) A-I      intronic chr11:18419104(+) A-I      intronic chr11:18425497(+) A-I      intronic chr11:18419192(+) A-I      intronic chr11:18426208(+) A-I      intronic chr11:18419966(+) A-I      intronic chr11:18420326(+) A-I      intronic chr11:18420287(+) A-I      intronic chr11:18420278(+) A-I      intronic chr11:18428419(+) A-I      intronic chr11:18419315(+) A-I      intronic chr11:18428102(+) A-I      intronic chr11:18419278(+) A-I      intronic chr11:18427612(+) A-I      intronic chr11:18419179(+) A-I      intronic chr11:18419142(+) A-I      intronic chr11:18420327(+) A-I      intronic chr11:18425659(+) A-I      intronic chr11:18425617(+) A-I      intronic chr11:18425595(+) A-I      intronic chr11:18428078(+) A-I      intronic chr11:18428143(+) A-I      intronic chr11:18425542(+) A-I      intronic chr11:18420346(+) A-I      intronic chr11:18419117(+) A-I      intronic chr11:18420262(+) A-I      intronic chr11:18420422(+) A-I      intronic chr11:18425794(+) A-I      intronic chr11:18419087(+) A-I      intronic chr11:18425501(+) A-I      intronic chr11:18427613(+) A-I      intronic chr11:18420423(+) A-I      intronic chr11:18428456(+) A-I      intronic chr11:18427933(+) A-I      intronic chr11:18428080(+) A-I      intronic chr11:18419283(+) A-I      intronic chr11:18419181(+) A-I      intronic chr11:18427606(+) A-I      intronic chr11:18428108(+) A-I      intronic chr11:18427687(+) A-I      intronic chr11:18419201(+) A-I      intronic chr11:18427693(+) A-I      intronic chr11:18420368(+) A-I      intronic chr11:18425797(+) A-I      intronic chr11:18425662(+) A-I      intronic chr11:18420530(+) A-I      intronic chr11:18419312(+) A-I      intronic chr11:18421206(+) A-I      intronic chr11:18427642(+) A-I      intronic chr11:18421177(+) A-I      intronic chr11:18421150(+) A-I      intronic chr11:18425813(+) A-I      intronic chr11:18427553(+) A-I      intronic chr11:18428410(+) A-I      intronic chr11:18427895(+) A-I      intronic chr11:18428468(+) A-I      intronic chr11:18425644(+) A-I      intronic chr11:18427997(+) A-I      intronic chr11:18425619(+) A-I      intronic chr11:18425800(+) A-I      intronic chr11:18419120(+) A-I      intronic chr11:18427652(+) A-I      intronic chr11:18420518(+) A-I      intronic chr11:18428366(+) A-I      intronic chr11:18425582(+) A-I      intronic chr11:18427535(+) A-I      intronic chr11:18427715(+) A-I      intronic chr11:18428449(+) A-I      intronic chr11:18425902(+) A-I      intronic chr11:18425499(+) A-I      intronic chr11:18428945(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	LDHA	chr11:18428945(+) A-I intron -    21960545 chr11:18419117(+) A-G intron -    22484847 chr11:18419201(+) A-G intron -    22484847 chr11:18425791(+) A-G intron -    22484847 chr11:18426093(+) T-C intron -    22484847 chr11:18427652(+) A-G intron -    22484847 chr11:18428143(+) A-G intron -    22484847 chr11:18428366(+) A-G intron -    22484847 chr11:18428414(+) A-G intron -    22484847 chr11:18428418(+) A-G intron -    22484847 chr11:18428456(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	LDHA	chr11:18418320-18418321(+) m6A 5'UTR//intron       24981863 chr11:18418436-18418437(+) m6A CDS//exon       27773535 chr11:18418586-18418587(+) m6A exon//intron       22575960 chr11:18421070-18421071(+) m6A 3'UTR//CDS//exon//intron       27773535 chr11:18422077-18422078(+) Gm exon//intron       - chr11:18422482-18422483(+) m6A 3'UTR//CDS//exon//intron       27773535 chr11:18422527-18422528(+) m6A 3'UTR//CDS//exon//intron       27773535 chr11:18424434-18424435(+) m6A 3'UTR//CDS//exon//intron       22575960 chr11:18424543-18424544(+) m6A 3'UTR//CDS//exon//intron       27773535//22575960 chr11:18425284-18425285(+) m6A 3'UTR//CDS//exon       27773535//22575960 chr11:18425305-18425306(+) m6A 3'UTR//CDS//exon       27773535//22575960 chr11:18425322-18425323(+) m6A 3'UTR//CDS//exon       27773535//22575960 chr11:18427013-18427014(+) m6A 3'UTR//CDS//exon//intron       27773535//22575960 chr11:18427043-18427044(+) m6A 3'UTR//CDS//exon//intron       27773535//22575960 chr11:18428716-18428717(+) m6A 3'UTR//CDS//exon//intron       27773535 chr11:18428733-18428734(+) m6A 3'UTR//CDS//exon//intron       27773535 chr11:18428944-18428945(+) m6A 3'UTR//exon       27773535 chr11:18428954-18428955(+) m6A 3'UTR//exon       27773535 chr11:18429172-18429173(+) m6A 3'UTR//exon       27773535//22575960 chr11:18429280-18429281(+) m6A 3'UTR//exon       27773535 chr11:18429331-18429332(+) m6A 3'UTR       27773535 chr11:18429369-18429370(+) m6A 3'UTR       27773535 chr11:18429380-18429381(+) m6A 3'UTR       27773535 chr11:18429387-18429388(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-33b-5p	Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Plasma     23663360 Exosome Breast milk     - Microvesicle Cerebrospinal fluid     24797360 Microvesicle Colon cancer cell line (LIM1863)     -
	LDHA	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-33b-5p	Iodine Green 9956454 Drug sensitive 2-(2,4-Difluorophenyl)-4,5,6,7-tetrafluoro-1H-isoindole-1,3(2H)-dione 9905583 Drug sensitive Actinomycin X4357G methoxime 9573583 Drug sensitive (3Z,8S,11Z,16S)-8,16-Bis(2-oxopropyl)-1,9-dioxacyclohexadeca-3,11-diene-2,5,10,13-tetrone 92973777 Drug sensitive 2,5-Dimethyl-1,4-benzoquinone 8718 Drug sensitive 4-(2-Pyridylazo)-N,N-dimethylaniline 81528 Drug sensitive L-2-Aminobutyric acid 80283 Drug sensitive Indolo[2,1-b]quinazoline-6,12-dione 73549 Drug sensitive Secalonic acid D 73431 Drug sensitive Venenatine 73061 Drug sensitive Redoxal 72571 Drug sensitive Azure B 68275 Drug sensitive Sulbentine 67686 Drug sensitive Reactive Blue 2 656725 Drug sensitive Ixabepilone 6445540 Drug sensitive Vicenistatin 6438888 Drug sensitive Verrucarin A 6326658 Drug sensitive 1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug sensitive Liatris laevigata lactone #2 5477810 Drug sensitive Caracemide 54747 Drug sensitive Tetrocarcin A, sodium salt 54724658 Drug sensitive Artelasticin 5471311 Drug sensitive Antineoplastic-690266 5469577 Drug sensitive 3,19-(4-Acetamido)benzylidineandrographolide 54612901 Drug sensitive p-Chloranilinum[bis(p-chloraniline)dioxalatoruthenate(III)] 54608061 Drug sensitive Herveline O 5459269 Drug sensitive Cuspidatin C 5459164 Drug sensitive Thiram 5455 Drug sensitive (1E,4E)-1,5-Dipyridin-3-ylpenta-1,4-dien-3-one 5382674 Drug sensitive Rozex 5353923 Drug sensitive Indanthren Corinth RK 5351878 Drug sensitive Vorinostat 5311 Drug sensitive Spiperone 5265 Drug resistant Kekule 499328 Drug sensitive Pyrimethamine 4993 Drug sensitive Lychnopholide 49767028 Drug sensitive Propyl gallate 4947 Drug resistant L-Cysteine analog 457392 Drug sensitive Aclarubicin 451415 Drug sensitive BAS100 Monohydrate 45028404 Drug sensitive 1-(4-(Benzyloxy)phenyl)-3-(3-(1-ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl)phenyl)urea 44587530 Drug sensitive Isopinnatal 44558939 Drug sensitive 1-Benzyl-3-hexadecyl-2-methylimidazolium chloride 44219704 Drug sensitive Iproplatin 44214 Drug sensitive 2,6-Epoxy-2H-1-benzoxocin-5(6H)-one, 6,8-dimethyl- 434882 Drug sensitive Di-n-octyl-secalonsaure A 430141 Drug sensitive S-(Dimethylarsino)-3-mercapto-1,2-propyl dibenzoate 406481 Drug sensitive Aminopyrimidine-CH3 406278 Drug sensitive 11-Hydroxyusambarine Chlorhydrate 401426 Drug sensitive Artelastin 399488 Drug sensitive Loratadine 3957 Drug sensitive Sjg-136 393111 Drug sensitive 2-Amino-4-(2-hydroxy-4-methylphenyl)-5-phenylpyrimidine 392744 Drug sensitive Lapachol 3884 Drug sensitive Acetic acid,4,7,10-tetraazacyclododecane-1,7-diyl]bis 387352 Drug sensitive Pyrimidin-2-amine, 4-(2-hydroxy-4-methoxyphenyl)-6-phenyl- 386505 Drug sensitive L-LYS-L-p-NO2Phe-L-Ala-L-p-NO2PheNH2 386384 Drug sensitive ARQ monoacetate 385441 Drug sensitive 2,7-Bis(methoxycarbonylmethyl)-10-methylphenothiazine 384444 Drug sensitive (-)7,8-Dihydrocalanolide A 383107 Drug sensitive 2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant 2-[[4-[1-(2,4-Diaminopteridin-6-yl)butan-2-yl]benzoyl]amino]-4-methylidenepentanedioic acid 375312 Drug sensitive 4-Methylthio-N-(3,4,5-trimethoxybenzyl)aniline 373808 Drug sensitive Sanguilutine pseudobase 371258 Drug sensitive 1,2-Dimethyl-phenothiazone 369387 Drug sensitive 4-Nitro-6-(trifluoromethyl)-2,1,3-benzoselenadiazole 362897 Drug sensitive Aplidazole C . TFA 362402 Drug sensitive 1-Chloro-3-(3-chloropropylsulfonylsulfanyl)propane 355643 Drug sensitive Maxima isoflavone D 343081 Drug sensitive Bis(helenalinyl)glutarate 336831 Drug sensitive Predorine 333830 Drug sensitive Helenin 327378 Drug sensitive 2,3-Dimethoxy-5-naphthalen-2-ylsulfanylcyclohexa-2,5-diene-1,4-dione 314728 Drug sensitive Flurocitabine 3034016 Drug sensitive 1,1-Dimethyl-5-(2-naphthalenyl)dithiobiuret 3004012 Drug sensitive Phenanthrene-9,10-diimine 2981 Drug sensitive 2-Chloro-5-[4-[2-chloro-4-(4,6-diamino-2,2-dimethyl-1,3,5-triazin-1-yl)phenyl]butyl]benzenesulfonyl fluoride;ethanesulfonic acid 278692 Drug sensitive Dichloroallyl lawsone 277767 Drug sensitive (15S)-15-Ethyl-1,11-diazapentacyclo[9.6.2.02,7.08,18.015,19]nonadeca-2,4,6,8(18)-tetraen-17-one 2724040 Drug sensitive 2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-N-[2-(methylamino)ethyl]-1H-imidazo[4,5-c]pyridine-7-carboxamide 25023715 Drug resistant Hydrazine sulfate 24842 Drug sensitive 9H-Purine, 6-(benzylthio)-9-(2-chloroethyl)- 246230 Drug sensitive Antimycin A3 245869 Drug sensitive (2-Methoxy-9,10-dihydrophenanthren-3-yl)methyl-dimethyl-(phenylsulfanylmethyl)azanium;bromide 24200489 Drug sensitive Prumycin HCl 24197905 Drug resistant 9H-Purine, 2-amino-6-(o-chlorobenzylthio)-9-propyl- 239486 Drug sensitive [(1S,2Z,4R,8R,9R,11R,13S)-13-Acetyloxy-1-hydroxy-2,11-dimethyl-7-methylidene-6-oxo-5,14-dioxatricyclo[9.2.1.04,8]tetradec-2-en-9-yl] 2-methylpropanoate 23255746 Drug sensitive Drostanolone propionate 224004 Drug sensitive (1S,3R,7Z,9R,12S,13R,15R)-13-Hydroxy-3,7,12-trimethyl-13-prop-1-en-2-yl-10,14,16-trioxatetracyclo[7.5.1.13,6.012,15]hexadeca-5,7-diene-4,11-dione 20835084 Drug sensitive Methyl 1,6,8,14a-tetrahydroxy-11-[(4-hydroxy-3,5-dimethoxy-6-methyloxan-2-yl)amino]-6a-methoxy-3-methyl-7,9,12,14-tetraoxo-5,6-dihydrobenzo[a]tetracene-2-carboxylate 197261 Drug sensitive 7,8-Dihydroxyflavone 1880 Drug sensitive Sudan II 18386 Drug sensitive P-Dioxane,5-bis[(benzoyloxymercuri)methyl]- 16683647 Drug sensitive Dihydrotriazine derivative 160202 Drug sensitive (3As,3bR)-3b-hydroxy-3a,5,5-trimethyl-3-methylidene-4H-cyclopenta[a]pentalene-2,6-dione 15699597 Drug sensitive (2Z,9E,13Z,15E)-4',11-Dihydroxy-2,4',9-trimethylspiro[3-aza-1(2,4)-thiazolacyclohexadecaphanene-6,3'-[1,2]dithiolane]-9,13,15-triene-4,5',12-trione 2'-oxide 154730760 Drug sensitive 1H-2,10a-Ethanophenanthrene, kaur-16-en-15-one deriv. 146156727 Drug sensitive Astrazon Orange R 135747272 Drug sensitive C8, Carbonyl prodigiosine 135540857 Drug sensitive 5-[(E)-[Amino(methyl)amino]azo]-1H-imidazole-4-carboxamide 135493930 Drug sensitive Emofolin sodium 135475347 Drug sensitive 2-Chloro-3-(2-butoxyethoxy)naphthazarin 135406263 Drug sensitive Raltitrexed 135400182 Drug sensitive DTIC-Dome 135398738 Drug sensitive (2S,4S,5R)-20-De(1-hydroxypropyl)-6-demethyl-2,6-diethyl-5-hydroxy-20-(1-hydroxybutyl)lysocellin 124081057 Drug sensitive Melampodinin 11953936 Drug sensitive 2,2'-Bioxirane 11254 Drug sensitive Gentian violet 11057 Drug sensitive Acetylenedicarboxamide 10971 Drug sensitive Fusariotoxin T-2 102515111 Drug sensitive Withajardin C 102469053 Drug sensitive 2,3-dihydro-1,2-syn-3-[phenylseleno]brefeldin a - Drug resistant 6-phenyl-6h-indeno[1,2-c]isoquinoline-5,11-dione - Drug resistant 9-methoxy-5-hydroxycamptothecin - Drug resistant tgf.alpha.-pe40 - Drug resistant tp4ek - Drug resistant vernonioside c - Drug resistant (z) 4-acetoxy-(3,4',5)-trimethoxystilbene - Drug sensitive 1,4-benzenediamine (9ci), n-butyl-n'-phenyl- - Drug sensitive 1,8-naphthyridin-4(1h)-one, 2-(3-chlorophenyl)-5-methyl- - Drug sensitive 1h-benzimidazole, 5,5'-dithiobis[2-(trifluoromethyl)- (9ci) - Drug sensitive 1h-benzo[a]carbazole-1,4(11h)-dione, 11-phenyl- - Drug sensitive 2-(n,n-diethyl)acetyl-1,2-dihydroellipticine - Drug sensitive 2-[(3,4-dicloro)anilino]-3-phenyl-5,7-diamino quinoxaline - Drug sensitive 4'-deoxy-13',17-dinitro-3',4'-epoxy-vincaleukoblastine - Drug sensitive 4-morpholinecarbodithioic acid, antimony complex - Drug sensitive 4-thiomorpholinecarbodithioic acid, antimony complex - Drug sensitive 7h-5,6-dithioleno[4,3-d]uracil - Drug sensitive 7-n,n-dimethylamino brefeldin a hydrochloride - Drug sensitive benzamide, 5-bromo-2-hydroxy-n-[3-(trifluoromethyl)phenyl]- - Drug sensitive benzene, 1,1'-[(1,3-butadiene-1,4-diyl)sulfonyl]bis - Drug sensitive benzo[1,2-c:4,5-c']dipyrrole-1,3,5,7(2h,6h)-tetraimine - Drug sensitive benzofurazan, 4-nitro-7-(2-pyridinylthio)-, n-oxide - Drug sensitive bersaldegenin 1,3,5-orthoacetate - Drug sensitive cis-2-hydroxymethyl-4-(5'-bromocytosin-1'-yl)-1,3-dioxolane - Drug sensitive E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive isoflavone, 5,7-dihydroxy-4'-nitro- - Drug sensitive mercury, tetrakis(acetato)(2,3,4,5-thiophenetetrayl)tetra- - Drug sensitive propan-1-one, 2,3-dichloro-1,3-bis(4-methylphenyl)- - Drug sensitive salicylaldehyde, 5-bromo- (8ci) - Drug sensitive tellurium, trichloro[1,2-hexanedioato(2-)-o,o']-, ammonium - Drug sensitive thiourea, n-(1-ethylpropyl)-n'-[(2-thienyl)thioxomethyl]- - Drug sensitive (Z)-3-((2-(4-(trifluoromethyl)phenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive (Z)-6-chloro-3-((2-(4-methoxyphenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive [bis(aminomethyl)diethylsilane]dichloroplatinum (ii) - Drug sensitive 4-carbo-1-thiazolidine-3-o-gluconyl-.gamma.-lactone - Drug sensitive 7-propanoyltaxol - Drug sensitive aromoline - Drug sensitive Carboxyphthalatoplatinum - Drug sensitive hymenialdisine - Drug sensitive methyl 3-farnesylthioacetate - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-33b-5p	Gemcitabine 60750 Drug interaction    RC00006226 Cholesterol 5997 Drug interaction    RC00006223 Lovastatin 53232 Drug interaction    RC00006225 Eloxatine 5310940 Drug interaction    RC00006228 Bortezomib 387447 Drug interaction    RC00006227 Doxorubicin 31703 Drug interaction    RC00006224 Verapamil 2520 Drug interaction    RC00006222 Chemotherapy - Drug interaction    RC00008880

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-33b-5p	Cisplatin 5702198       28436711 Docetaxel 148124       28436711

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-33b-5p
Interactor2: LDHA

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.