Detail Information

Basic Information:


  VIRBase ID:  

HHID00061197

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-625-5p:           CRTC2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-625-5p CRTC2
miRBase
Accession/Entrez ID		 MIMAT0003294 200186
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - TORC-2//TORC2

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-625-5p
rs1042448922 chr14:65471127    T/C
rs1322999280 chr14:65471116    A/AG
rs1448815981 chr14:65471133    GTCCTGTAA/G
rs376464832 chr14:65471130    A/G
rs747900219 chr14:65471135    C/T
rs1310485565 chr14:65471123    A/C
rs1310485565 chr14:65471123    A/T
rs1413575999 chr14:65471121    GA/G
rs372863864 chr14:65471117    G/A
rs944057908 chr14:65471119    G/A
rs944057908 chr14:65471119    G/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR CRTC2
chr1:153922573(-) A-I      intronic
chr1:153922324(-) A-I      intronic
chr1:153922684(-) A-I      intronic
chr1:153922662(-) A-I      intronic
chr1:153922661(-) A-I      intronic
chr1:153922216(-) A-I      intronic
chr1:153922225(-) A-I      intronic
chr1:153922517(-) A-I      intronic
chr1:153922569(-) A-I      intronic
chr1:153922547(-) A-I      intronic
chr1:153922238(-) A-I      intronic
chr1:153922157(-) A-I      intronic
chr1:153922625(-) A-I      intronic
chr1:153922530(-) A-I      intronic
chr1:153922263(-) A-I      intronic
chr1:153922067(-) A-I      intronic
chr1:153922487(-) A-I      intronic
chr1:153922243(-) A-I      intronic
chr1:153922670(-) A-I      intronic
chr1:153922145(-) A-I      intronic
chr1:153922079(-) A-I      intronic
chr1:153922159(-) A-I      intronic
chr1:153922603(-) A-I      intronic
chr1:153922581(-) A-I      intronic
chr1:153922120(-) A-I      intronic
chr1:153922511(-) A-I      intronic
chr1:153922242(-) A-I      intronic
chr1:153922626(-) A-I      intronic
chr1:153922444(-) A-I      intronic
chr1:153922203(-) A-I      intronic
chr1:153922464(-) A-I      intronic
chr1:153922080(-) A-I      intronic
chr1:153922133(-) A-I      intronic
chr1:153922627(-) A-I      intronic
chr1:153922239(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED CRTC2
chr1:153922079(-) A-G intron -    22484847
chr1:153922145(-) A-G intron -    22484847
chr1:153922157(-) A-G intron -    22484847
chr1:153922159(-) A-G intron -    22484847
chr1:153922225(-) A-G intron -    22484847
chr1:153922238(-) A-G intron -    22484847
chr1:153922239(-) A-G intron -    22484847
chr1:153922242(-) A-G intron -    22484847
chr1:153922243(-) A-G intron -    22484847
chr1:153922263(-) A-G intron -    22484847
chr1:153922511(-) A-G intron -    22484847
chr1:153922627(-) A-G intron -    22484847
chr1:153925631(-) G-C intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CRTC2
chr1:153920150-153920151(-) m6A 3'UTR       27773535
chr1:153920349-153920350(-) m6A 3'UTR//exon       24284625//25456834//28052920//27773535//27371828
chr1:153920384-153920385(-) m6A 3'UTR//exon       24284625//25456834//28052920//27773535//27371828//22575960
chr1:153920504-153920505(-) m6A 3'UTR//exon       24284625//25456834//24981863//28052920//27773535//27371828//22608085
chr1:153920660-153920661(-) m6A 3'UTR//CDS//exon       24284625//27773535//27371828
chr1:153920983-153920984(-) m6A 3'UTR//CDS//exon       27773535
chr1:153921667-153921668(-) m6A 3'UTR//CDS//exon       27773535
chr1:153921836-153921837(-) m6A 3'UTR//CDS//exon       24284625//27773535
chr1:153923780-153923781(-) m6A 3'UTR//CDS//exon//intron       24284625//27773535
chr1:153924140-153924141(-) m6A 3'UTR//CDS//exon//intron       24284625//24981863//27773535//27371828
chr1:153924604-153924605(-) m6A 3'UTR//CDS//exon//intron       24284625//24209618//24981863//28052920//27773535//27371828
chr1:153924615-153924616(-) m6A 3'UTR//CDS//exon//intron       24284625//24981863//28052920//27773535//27371828
chr1:153924681-153924682(-) m6A 3'UTR//CDS//exon//intron       24284625//24981863//27773535
chr1:153925806-153925807(-) m6A 3'UTR//CDS//exon//intron       27773535
chr1:153927627-153927628(-) m6A CDS//exon//intron       -
chr1:153930631-153930632(-) m6A exon//intron       -
chr1:153930637-153930638(-) m6A exon//intron       -
chr1:153930656-153930657(-) m1A exon//intron       26863196
chr1:153930836-153930837(-) m6A CDS//exon//intron       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-625-5p
Exosome Jurkat-derived T cell line (J77cl20)     21505438
Exosome Plasma     23663360
Exosome Breast cancer cell lines (MCF-7|MDA-MB-231)     24468161
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
CRTC2
Chromatin K562 cells     -
Cytosol K562 cells     -
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-625-5p
(7S,13E,16S,18R,19E,21R)-21-(Acetyloxy)-7,18-dihydroxy-16,18-dimethyl-10-phenyl[11]cytochalasa-6(12),13,19-triene-1,17-dione 98137101 Drug resistant
2,5-Bis(1-aziridinyl)hydroquinone 94797 Drug resistant
2-(Benzyloxy)-4-methoxybenzaldehyde 820527 Drug resistant
1,5-Methano-11H-furo(3,2-g)pyrano(3,2-b)xanthene-3a(4H)-crotonaldehyde, 1,2,5,7-tetrahydro-8-hydroxy-alpha,2,2,11,11-pentamethyl-13-(3-methyl-2-butenyl)-4,7-dioxo-, trans- 78358492 Drug sensitive
Thioinosine 676166 Drug sensitive
Simvastatin 54454 Drug resistant
Reumycin 5351216 Drug resistant
Lovastatin 53232 Drug resistant
Streptonigrin 5298 Drug resistant
(7S,9S)-7-[(2R,4S,5S,6S)-4-(Dimethylamino)-5-hydroxy-6-methyl-tetrahydropyran-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione 474312 Drug resistant
Aphidicolin 457964 Drug resistant
2-S-Dimethylarsino-2-thiobenzoic acid 404813 Drug resistant
Massoia lactone 39914 Drug sensitive
Free base of NSC 610966 355990 Drug sensitive
12-Hydroxyindolo[2,1-b]quinazoline-6(12H)-one 324952 Drug resistant
1-(2-(Dimethylamino)ethyl)-3-(((2R,4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methyl)urea 23634407 Drug sensitive
1H-Indole-3-methanol, 1-[(4-chlorophenyl)methyl]- 11821732 Drug resistant
1-[bis(4,4'-aminophenyl)methylidenyl]-[3]ferrocenophane - Drug resistant
naphthalene, 2,3-dimethoxy-6-(2-nitroethenyl)- - Drug resistant
.alpha.-sarcin - Drug resistant
1-[(4-aminophenyl)-(4-hydroxyphenyl)methylidene]-[3]ferrocenophane - Drug resistant
2-(n-d-glysoyl)aminobenzothiazole - Drug resistant
Camptothecin Derivative - Drug resistant
crotoxin cd - Drug resistant
protein toxin a 23 - mw approx. 6700 - Drug resistant
protein: pahiv4 - Drug resistant
sphinxolide e - Drug resistant
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-625-5p
Vincristine 5978 Drug interaction    RC00006177
Prednisone 5865 Drug interaction    RC00006176
Prednisolone 5755 Drug interaction    RC00006175
Eloxatine 5310940 Drug interaction    RC00006183
Diethylstilbestrol 448537 Drug interaction    RC00006181
Paroxetine 43815 Drug interaction    RC00006180
Paclitaxel 36314 Drug interaction    RC00006179
Daunorubicin 30323 Drug interaction    RC00006178
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00006174
Tamoxifen 2733526 Drug interaction    RC00006182
Asparaginase Escherichia coli - Drug interaction    RC00006184
Chemotherapy - Drug interaction    RC00008878

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-625-5p
Interactor2: CRTC2

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region CDS
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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