Detail Information

Basic Information:


  VIRBase ID:  

HHID00061156

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-624-5p:           BRWD3:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-624-5p BRWD3
miRBase
Accession/Entrez ID		 MIMAT0003293 254065
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - BRODL//MRX93

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-624-5p
rs1278140211 chr14:31014716    G/C
rs1340440431 chr14:31014712    CA/C
rs991440005 chr14:31014714    A/T
rs1281278674 chr14:31014726    T/C
rs1331954189 chr14:31014720    T/C
rs1339745262 chr14:31014723    T/C
rs1436307961 chr14:31014714    AGGTACT/A
rs778437262 chr14:31014725    C/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR BRWD3
chrX:80051727(-) A-I      intronic
chrX:80003650(-) A-I      intronic
chrX:80006207(-) A-I      intronic
chrX:80051892(-) A-I      intronic
chrX:80051900(-) A-I      intronic
chrX:80058360(-) A-I      intronic
chrX:80045147(-) A-I      intronic
chrX:80051722(-) A-I      intronic
chrX:80051416(-) A-I      intronic
chrX:80049421(-) A-I      intronic
chrX:80045687(-) A-I      intronic
chrX:80045486(-) A-I      intronic
chrX:80007676(-) A-I      intronic
chrX:80045139(-) A-I      intronic
chrX:80045104(-) A-I      intronic
chrX:80045090(-) A-I      intronic
chrX:80045071(-) A-I      intronic
chrX:80045042(-) A-I      intronic
chrX:80045023(-) A-I      intronic
chrX:80045013(-) A-I      intronic
chrX:80042290(-) A-I      intronic
chrX:80042282(-) A-I      intronic
chrX:80042276(-) A-I      intronic
chrX:80042193(-) A-I      intronic
chrX:80041447(-) A-I      intronic
chrX:80041420(-) A-I      intronic
chrX:80041405(-) A-I      intronic
chrX:80041361(-) A-I      intronic
chrX:80038278(-) A-I      intronic
chrX:80038210(-) A-I      intronic
chrX:80035017(-) A-I      intronic
chrX:80034596(-) A-I      intronic
chrX:80033374(-) A-I      intronic
chrX:80033056(-) A-I      intronic
chrX:80033016(-) A-I      intronic
chrX:80016501(-) A-I      intronic
chrX:80010460(-) A-I      intronic
chrX:80010375(-) A-I      intronic
chrX:80010358(-) A-I      intronic
chrX:80010326(-) A-I      intronic
chrX:80010303(-) A-I      intronic
chrX:80010271(-) A-I      intronic
chrX:80008946(-) A-I      intronic
chrX:80052462(-) A-I      intronic
chrX:80051809(-) A-I      intronic
chrX:80051732(-) A-I      intronic
chrX:80008907(-) A-I      intronic
chrX:80008906(-) A-I      intronic
chrX:80008829(-) A-I      intronic
chrX:80008301(-) A-I      intronic
chrX:80007729(-) A-I      intronic
chrX:80007712(-) A-I      intronic
chrX:80045654(-) A-I      intronic
chrX:80042207(-) A-I      intronic
chrX:80033422(-) A-I      intronic
chrX:80033080(-) A-I      intronic
chrX:80008302(-) A-I      intronic
chrX:79969823(-) A-I      intronic
chrX:80016544(-) A-I      intronic
chrX:80057326(-) A-I      intronic
chrX:80057094(-) A-I      intronic
chrX:80007681(-) A-I      intronic
chrX:79991050(-) A-I      intronic
chrX:80035065(-) A-I      intronic
chrX:79963859(-) A-I      intronic
chrX:80042152(-) A-I      intronic
chrX:80010340(-) A-I      intronic
chrX:80010424(-) A-I      intronic
chrX:80034479(-) A-I      intronic
chrX:80045039(-) A-I      intronic
chrX:80034620(-) A-I      intronic
chrX:80029820(-) A-I      intronic
chrX:80045601(-) A-I      intronic
chrX:80010348(-) A-I      intronic
chrX:80045639(-) A-I      intronic
chrX:80056987(-) A-I      intronic
chrX:80041522(-) A-I      intronic
chrX:80035090(-) A-I      intronic
chrX:80057234(-) A-I      intronic
chrX:80033130(-) A-I      intronic
chrX:80056910(-) A-I      intronic
chrX:80053405(-) A-I      intronic
chrX:80051901(-) A-I      intronic
chrX:80059797(-) A-I      intronic
chrX:80045602(-) A-I      intronic
chrX:80010288(-) A-I      intronic
chrX:80010407(-) A-I      intronic
chrX:80016540(-) A-I      intronic
chrX:80042281(-) A-I      intronic
chrX:80045553(-) A-I      intronic
chrX:80041446(-) A-I      intronic
chrX:80041344(-) A-I      intronic
chrX:80045070(-) A-I      intronic
chrX:80057743(-) A-I      intronic
chrX:80056843(-) A-I      intronic
chrX:80014282(-) A-I      intronic
chrX:80033064(-) A-I      intronic
chrX:80059822(-) A-I      intronic
chrX:80051335(-) A-I      intronic
chrX:80029854(-) A-I      intronic
chrX:80045515(-) A-I      intronic
chrX:80045561(-) A-I      intronic
chrX:80052425(-) A-I      intronic
chrX:79963843(-) A-I      intronic
chrX:80041417(-) A-I      intronic
chrX:79969829(-) A-I      intronic
chrX:80035066(-) A-I      intronic
chrX:80045080(-) A-I      intronic
chrX:80042196(-) A-I      intronic
chrX:80045573(-) A-I      intronic
chrX:80034315(-) A-I      intronic
chrX:80009042(-) A-I      intronic
chrX:80041276(-) A-I      intronic
chrX:80035092(-) A-I      intronic
chrX:80033135(-) A-I      intronic
chrX:80007660(-) A-I      intronic
chrX:80051741(-) A-I      intronic
chrX:80016519(-) A-I      intronic
chrX:80045641(-) A-I      intronic
chrX:80045512(-) A-I      intronic
chrX:80045557(-) A-I      intronic
chrX:80056816(-) A-I      intronic
chrX:80059901(-) A-I      intronic
chrX:80032941(-) A-I      intronic
chrX:80042151(-) A-I      intronic
chrX:80061241(-) A-I      intronic
chrX:80034970(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED BRWD3
chrX:80006320(-) A-G intron -    22484847
chrX:80007627(-) A-G intron -    22484847
chrX:80041429(-) A-G intron -    22484847
chrX:80042110(-) A-G intron -    22484847
chrX:80042111(-) A-G intron -    22484847
chrX:80042196(-) A-G intron -    22484847
chrX:80042281(-) A-G intron -    22484847
chrX:80045601(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase BRWD3
chrX:79931816-79931817(-) m6A 3'UTR       24981863//22608085
chrX:79931827-79931828(-) m6A 3'UTR       24981863//22608085
chrX:79931842-79931843(-) m6A 3'UTR       24284625//24981863//22608085
chrX:79931870-79931871(-) m6A 3'UTR       24284625//24981863//22608085
chrX:79931956-79931957(-) m6A 3'UTR       24284625//22608085
chrX:79932016-79932017(-) m6A 3'UTR       22608085
chrX:79932176-79932177(-) Cm CDS       -
chrX:79932250-79932251(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//22608085
chrX:79932264-79932265(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//22575960//22608085
chrX:79932271-79932272(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//22575960//22608085
chrX:79932287-79932288(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//22575960//22608085
chrX:79932517-79932518(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27371828//22608085
chrX:79932557-79932558(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27371828//22575960//22608085
chrX:79932569-79932570(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27371828//22575960//22608085
chrX:79932574-79932575(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27371828//22575960//22608085
chrX:79932600-79932601(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27371828//22575960//22608085
chrX:79932625-79932626(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27371828//22575960//22608085
chrX:79932733-79932734(-) m6A CDS       24284625//24981863//28052920//27371828//22575960//22608085
chrX:79932765-79932766(-) m6A CDS//exon       24284625//24981863//28052920//27371828//22608085
chrX:79932794-79932795(-) m6A CDS//exon       24284625//24981863//28052920//27371828//22608085
chrX:79932811-79932812(-) m6A CDS//exon       24284625//24981863//28052920//27371828//22608085
chrX:79932845-79932846(-) m6A CDS//exon       24284625//24981863//27371828//22608085
chrX:79936843-79936844(-) m6A CDS//exon       24981863//22608085
chrX:79959083-79959084(-) m6A CDS//exon       24981863
chrX:79960187-79960188(-) m6A CDS//exon       24981863
chrX:79960197-79960198(-) m6A CDS//exon       24981863
chrX:79960269-79960270(-) m6A CDS//exon       24981863
chrX:79960278-79960279(-) m6A CDS//exon       24981863
chrX:79960316-79960317(-) m6A CDS//exon       24981863
chrX:79971729-79971730(-) m6A CDS//exon       24981863
chrX:79975048-79975049(-) m6A CDS//exon       24981863
chrX:79975055-79975056(-) m6A CDS//exon       24981863
chrX:79975060-79975061(-) m6A CDS//exon       24981863
chrX:79980471-79980472(-) m6A CDS       -
chrX:79980486-79980487(-) m6A CDS       -
chrX:79980563-79980564(-) m6A CDS       -
chrX:79985459-79985460(-) Am CDS       -
chrX:80064765-80064766(-) m6A CDS//exon       27773536
chrX:80065068-80065069(-) m6A 5'UTR//exon       -
chrX:80065100-80065101(-) m6A 5'UTR//exon       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-624-5p
Exosome Jurkat-derived T cell line (J77cl20)     21505438
Exosome Plasma     23663360
Exosome Plasma     24683445
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     -
BRWD3
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome HeLa cells     24205503
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-624-5p
Iodine Green 9956454 Drug sensitive
Midostaurin 9829523 Drug resistant
L-2-Aminobutyric acid 80283 Drug sensitive
Indolo[2,1-b]quinazoline-6,12-dione 73549 Drug sensitive
Sulbentine 67686 Drug sensitive
Ixabepilone 6445540 Drug sensitive
Verrucarin A 6326658 Drug sensitive
Tributyrin 6050 Drug sensitive
1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug sensitive
Artelasticin 5471311 Drug sensitive
3,19-(4-Acetamido)benzylidineandrographolide 54612901 Drug sensitive
Herveline O 5459269 Drug sensitive
Cuspidatin C 5459164 Drug sensitive
Thiram 5455 Drug sensitive
Simvastatin 54454 Drug resistant
(1E,4E)-1,5-Dipyridin-3-ylpenta-1,4-dien-3-one 5382674 Drug sensitive
Rozex 5353923 Drug sensitive
Indanthren Corinth RK 5351878 Drug sensitive
Vorinostat 5311 Drug sensitive
Spiperone 5265 Drug resistant
Kekule 499328 Drug sensitive
10-Hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12-dodecahydro-1H-picene-4a-carboxylic acid 495604 Drug sensitive
Propyl gallate 4947 Drug resistant
Tiazofurin 457954 Drug sensitive
1-(4-(Benzyloxy)phenyl)-3-(3-(1-ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl)phenyl)urea 44587530 Drug sensitive
1-Benzyl-3-hexadecyl-2-methylimidazolium chloride 44219704 Drug sensitive
Di-n-octyl-secalonsaure A 430141 Drug sensitive
Cyano pyridine-P-CH3 406496 Drug sensitive
S-(Dimethylarsino)-3-mercapto-1,2-propyl dibenzoate 406481 Drug sensitive
Aminopyrimidine-CH3 406278 Drug sensitive
2-Amino-4-(2-hydroxy-4-methylphenyl)-5-phenylpyrimidine 392744 Drug sensitive
3-(4-Fluorophenyl)-3-(4-hydroxy-2-methylphenyl)-2-benzofuran-1(3H)-one 387973 Drug resistant
Acetic acid,4,7,10-tetraazacyclododecane-1,7-diyl]bis 387352 Drug sensitive
4-Phenacyloxychromen-2-one 386272 Drug resistant
2,7-Bis(methoxycarbonylmethyl)-10-methylphenothiazine 384444 Drug sensitive
2-Ethylaminoestradiol 384235 Drug sensitive
2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant
3,8-Dimethyl-1,2-naphthoquinone 373912 Drug sensitive
Naphtho[2,3-f]quinoxaline-7,12-dione, 3-hydroxy-2-methyl- 371563 Drug resistant
Maxima isoflavone D 343081 Drug sensitive
Antimycin A3 245869 Drug sensitive
5-Hydroxy-3-phenylpyrano[3,2-c]chromen-2(5H)-one 24205741 Drug sensitive
(2-Methoxy-9,10-dihydrophenanthren-3-yl)methyl-dimethyl-(phenylsulfanylmethyl)azanium;bromide 24200489 Drug sensitive
Prumycin HCl 24197905 Drug resistant
9H-Purine, 2-amino-6-(o-chlorobenzylthio)-9-propyl- 239486 Drug sensitive
Drostanolone propionate 224004 Drug sensitive
Sudan II 18386 Drug sensitive
Astrazon Orange R 135747272 Drug sensitive
C8, Carbonyl prodigiosine 135540857 Drug sensitive
(2S,4S,5R)-20-De(1-hydroxypropyl)-6-demethyl-2,6-diethyl-5-hydroxy-20-(1-hydroxybutyl)lysocellin 124081057 Drug sensitive
Fusariotoxin T-2 102515111 Drug sensitive
Chimaphilin 101211 Drug sensitive
6-phenyl-6h-indeno[1,2-c]isoquinoline-5,11-dione - Drug resistant
1-[(2-cyclohexymethoxy)methyl]-5-ethyl-6-iodouracil - Drug resistant
tp4ek - Drug resistant
tunicamycin - Drug resistant
(z) 3,3',4,5-tetramethoxystilbene - Drug sensitive
(z) 4-acetoxy-(3,4',5)-trimethoxystilbene - Drug sensitive
1,4-benzenediamine (9ci), n-butyl-n'-phenyl- - Drug sensitive
1h-benzimidazole, 5,5'-dithiobis[2-(trifluoromethyl)- (9ci) - Drug sensitive
2-[(3,4-dicloro)anilino]-3-phenyl-5,7-diamino quinoxaline - Drug sensitive
4-(2-pyridinyl)-5h-1,2,3-dithiazole-5-thione - Drug sensitive
4-[4-(3-Methoxy-phenyl)-piperazin-1 -yl]-5H-pyrrolo[3,2-d]pyrimidine - Drug sensitive
4-morpholinecarbodithioic acid, antimony complex - Drug sensitive
4-thiomorpholinecarbodithioic acid, antimony complex - Drug sensitive
7-n,n-dimethylamino brefeldin a hydrochloride - Drug sensitive
9-acridinamine, n-(4-ethoxyphenyl)-, monohydrochloride - Drug sensitive
benzamide, 5-bromo-2-hydroxy-n-[3-(trifluoromethyl)phenyl]- - Drug sensitive
benzofurazan, 4-nitro-7-(2-pyridinylthio)-, n-oxide - Drug sensitive
E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive
isoflavone, 5,7-dihydroxy-4'-nitro- - Drug sensitive
(Z)-3-((2-(4-(trifluoromethyl)phenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive
(Z)-6-chloro-3-((2-(4-methoxyphenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive
2-amino-5-chloro-6-(2-thiazolyloxy)-benzimidazole - Drug sensitive
9-(3-fluorobenzyl)-7-(3-fluorobenzyloxy)-2-(4-fluorobenzyl)-1-methyl-9H-beta-carbolinium bromide - Drug sensitive
arylmethylene-f - Drug sensitive
his 47-methyl ct - Drug sensitive
n-myristoyl-(s)-phenylalaninal diethylcetal - Drug sensitive

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-624-5p
Interactor2: BRWD3

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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