Basic Information:

  VIRBase ID:  

HHID00061138

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-624-5p:  MIMAT0003293          RB1:  NM_000321     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-624-5p	RB1
miRBase Accession/Entrez ID	MIMAT0003293	5925
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	OSRC//p105-Rb//p110-RB1//pp110//PPP1R130//pRb//RB

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-624-5p	rs1278140211 chr14:31014716    G/C rs1340440431 chr14:31014712    CA/C rs991440005 chr14:31014714    A/T rs1281278674 chr14:31014726    T/C rs1331954189 chr14:31014720    T/C rs1339745262 chr14:31014723    T/C rs1436307961 chr14:31014714    AGGTACT/A rs778437262 chr14:31014725    C/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	RB1	chr13:48997124(+) A-I      intronic chr13:48997123(+) A-I      intronic chr13:48997139(+) A-I      intronic chr13:48997181(+) A-I      intronic chr13:48956188(+) A-I      intronic chr13:48978743(+) A-I      intronic chr13:48964140(+) A-I      intronic chr13:48988381(+) A-I      intronic chr13:48950557(+) A-I      intronic chr13:48950476(+) A-I      intronic chr13:48988376(+) A-I      intronic chr13:49034950(+) A-I      intronic chr13:49034887(+) A-I      intronic chr13:49034872(+) A-I      intronic chr13:49034825(+) A-I      intronic chr13:48988271(+) A-I      intronic chr13:48965708(+) A-I      intronic chr13:48978843(+) A-I      intronic chr13:49034389(+) A-I      intronic chr13:49034239(+) A-I      intronic chr13:49034206(+) A-I      intronic chr13:49034169(+) A-I      intronic chr13:49018532(+) A-I      intronic chr13:49018503(+) A-I      intronic chr13:48950580(+) A-I      intronic chr13:49008334(+) A-I      intronic chr13:48950548(+) A-I      intronic chr13:49008328(+) A-I      intronic chr13:48989662(+) A-I      intronic chr13:48989649(+) A-I      intronic chr13:48978066(+) A-I      intronic chr13:48989590(+) A-I      intronic chr13:48949792(+) A-I      intronic chr13:48950556(+) A-I      intronic chr13:48894987(+) A-I      intronic chr13:48989528(+) A-I      intronic chr13:48978039(+) A-I      intronic chr13:48965619(+) A-I      intronic chr13:48978016(+) A-I      intronic chr13:48950423(+) A-I      intronic chr13:48989667(+) A-I      intronic chr13:48950513(+) A-I      intronic chr13:48966524(+) A-I      intronic chr13:48989516(+) A-I      intronic chr13:48964138(+) A-I      intronic chr13:48966523(+) A-I      intronic chr13:48966444(+) A-I      intronic chr13:48978763(+) A-I      intronic chr13:48989509(+) A-I      intronic chr13:48880518(+) A-I      intronic chr13:48966537(+) A-I      intronic chr13:48988389(+) A-I      intronic chr13:48886111(+) A-I      intronic chr13:48966431(+) A-I      intronic chr13:48950424(+) A-I      intronic chr13:48989582(+) A-I      intronic chr13:48888750(+) A-I      intronic chr13:48966340(+) A-I      intronic chr13:48988220(+) A-I      intronic chr13:48965700(+) A-I      intronic chr13:48964139(+) A-I      intronic chr13:48965681(+) A-I      intronic chr13:48949935(+) A-I      intronic chr13:48965677(+) A-I      intronic chr13:48964143(+) A-I      intronic chr13:48989533(+) A-I      intronic chr13:48906578(+) A-I      intronic chr13:48888158(+) A-I      intronic chr13:48989596(+) A-I      intronic chr13:49034919(+) A-I      intronic chr13:49035055(+) A-I      intronic chr13:48888146(+) A-I      intronic chr13:48888092(+) A-I      intronic chr13:49034285(+) A-I      intronic chr13:48989605(+) A-I      intronic chr13:48965977(+) A-I      intronic chr13:48888067(+) A-I      intronic chr13:48950551(+) A-I      intronic chr13:49035053(+) A-I      intronic chr13:48888011(+) A-I      intronic chr13:49034386(+) A-I      intronic chr13:48950475(+) A-I      intronic chr13:48888888(+) A-I      intronic chr13:48989520(+) A-I      intronic chr13:48965613(+) A-I      intronic chr13:48989581(+) A-I      intronic chr13:48963208(+) A-I      intronic chr13:48950494(+) A-I      intronic chr13:49048387(+) A-I      intronic chr13:48965629(+) A-I      intronic chr13:48978764(+) A-I      intronic chr13:48950422(+) A-I      intronic chr13:48888848(+) A-I      intronic chr13:48965952(+) A-I      intronic chr13:48961733(+) A-I      intronic chr13:48978682(+) A-I      intronic chr13:48888790(+) A-I      intronic chr13:48989650(+) A-I      intronic chr13:49035022(+) A-I      intronic chr13:49034932(+) A-I      intronic chr13:48978719(+) A-I      intronic chr13:49034380(+) A-I      intronic chr13:48966412(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	RB1	chr13:48881835(+) C-A intron -    22484847 chr13:48882797(+) A-C intron -    22484847 chr13:48882798(+) C-A intron -    22484847 chr13:48888108(+) A-C intron -    22484847 chr13:48963208(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	RB1	chr13:48878060-48878061(+) m6A CDS//exon       24209618//24981863//27371828 chr13:48878104-48878105(+) m6A CDS//exon       24209618//27371828 chr13:48878142-48878143(+) m6A CDS//exon       24209618//27371828 chr13:48878154-48878155(+) m6A CDS//exon       24209618//27371828 chr13:48878169-48878170(+) m6A CDS//exon       24209618//27371828 chr13:48919310-48919311(+) Y CDS//exon//intron       26075521 chr13:49030412-49030413(+) m6A CDS//exon       24981863 chr13:49030436-49030437(+) m6A CDS//exon       24981863 chr13:49039177-49039178(+) Y CDS       26075521 chr13:49050836-49050837(+) m6A CDS//exon       24981863 chr13:49050925-49050926(+) m6A CDS//exon       24284625//24981863 chr13:49050937-49050938(+) m6A CDS//exon       24284625//24981863 chr13:49051493-49051494(+) m6A CDS//exon       24284625//24981863 chr13:49051526-49051527(+) m6A CDS//exon       24284625//24981863 chr13:49054144-49054145(+) m6A CDS//exon       24284625//24981863 chr13:49054190-49054191(+) m6A CDS//exon       24981863 chr13:49054217-49054218(+) m6A 3'UTR//exon       24981863 chr13:49054227-49054228(+) m6A 3'UTR//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-624-5p	Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     -
	RB1	Chromatin K562 cells     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-624-5p	Iodine Green 9956454 Drug sensitive Midostaurin 9829523 Drug resistant L-2-Aminobutyric acid 80283 Drug sensitive Indolo[2,1-b]quinazoline-6,12-dione 73549 Drug sensitive Sulbentine 67686 Drug sensitive Ixabepilone 6445540 Drug sensitive Verrucarin A 6326658 Drug sensitive Tributyrin 6050 Drug sensitive 1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug sensitive Artelasticin 5471311 Drug sensitive 3,19-(4-Acetamido)benzylidineandrographolide 54612901 Drug sensitive Herveline O 5459269 Drug sensitive Cuspidatin C 5459164 Drug sensitive Thiram 5455 Drug sensitive Simvastatin 54454 Drug resistant (1E,4E)-1,5-Dipyridin-3-ylpenta-1,4-dien-3-one 5382674 Drug sensitive Rozex 5353923 Drug sensitive Indanthren Corinth RK 5351878 Drug sensitive Vorinostat 5311 Drug sensitive Spiperone 5265 Drug resistant Kekule 499328 Drug sensitive 10-Hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12-dodecahydro-1H-picene-4a-carboxylic acid 495604 Drug sensitive Propyl gallate 4947 Drug resistant Tiazofurin 457954 Drug sensitive 1-(4-(Benzyloxy)phenyl)-3-(3-(1-ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl)phenyl)urea 44587530 Drug sensitive 1-Benzyl-3-hexadecyl-2-methylimidazolium chloride 44219704 Drug sensitive Di-n-octyl-secalonsaure A 430141 Drug sensitive Cyano pyridine-P-CH3 406496 Drug sensitive S-(Dimethylarsino)-3-mercapto-1,2-propyl dibenzoate 406481 Drug sensitive Aminopyrimidine-CH3 406278 Drug sensitive 2-Amino-4-(2-hydroxy-4-methylphenyl)-5-phenylpyrimidine 392744 Drug sensitive 3-(4-Fluorophenyl)-3-(4-hydroxy-2-methylphenyl)-2-benzofuran-1(3H)-one 387973 Drug resistant Acetic acid,4,7,10-tetraazacyclododecane-1,7-diyl]bis 387352 Drug sensitive 4-Phenacyloxychromen-2-one 386272 Drug resistant 2,7-Bis(methoxycarbonylmethyl)-10-methylphenothiazine 384444 Drug sensitive 2-Ethylaminoestradiol 384235 Drug sensitive 2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant 3,8-Dimethyl-1,2-naphthoquinone 373912 Drug sensitive Naphtho[2,3-f]quinoxaline-7,12-dione, 3-hydroxy-2-methyl- 371563 Drug resistant Maxima isoflavone D 343081 Drug sensitive Antimycin A3 245869 Drug sensitive 5-Hydroxy-3-phenylpyrano[3,2-c]chromen-2(5H)-one 24205741 Drug sensitive (2-Methoxy-9,10-dihydrophenanthren-3-yl)methyl-dimethyl-(phenylsulfanylmethyl)azanium;bromide 24200489 Drug sensitive Prumycin HCl 24197905 Drug resistant 9H-Purine, 2-amino-6-(o-chlorobenzylthio)-9-propyl- 239486 Drug sensitive Drostanolone propionate 224004 Drug sensitive Sudan II 18386 Drug sensitive Astrazon Orange R 135747272 Drug sensitive C8, Carbonyl prodigiosine 135540857 Drug sensitive (2S,4S,5R)-20-De(1-hydroxypropyl)-6-demethyl-2,6-diethyl-5-hydroxy-20-(1-hydroxybutyl)lysocellin 124081057 Drug sensitive Fusariotoxin T-2 102515111 Drug sensitive Chimaphilin 101211 Drug sensitive 6-phenyl-6h-indeno[1,2-c]isoquinoline-5,11-dione - Drug resistant 1-[(2-cyclohexymethoxy)methyl]-5-ethyl-6-iodouracil - Drug resistant tp4ek - Drug resistant tunicamycin - Drug resistant (z) 3,3',4,5-tetramethoxystilbene - Drug sensitive (z) 4-acetoxy-(3,4',5)-trimethoxystilbene - Drug sensitive 1,4-benzenediamine (9ci), n-butyl-n'-phenyl- - Drug sensitive 1h-benzimidazole, 5,5'-dithiobis[2-(trifluoromethyl)- (9ci) - Drug sensitive 2-[(3,4-dicloro)anilino]-3-phenyl-5,7-diamino quinoxaline - Drug sensitive 4-(2-pyridinyl)-5h-1,2,3-dithiazole-5-thione - Drug sensitive 4-[4-(3-Methoxy-phenyl)-piperazin-1 -yl]-5H-pyrrolo[3,2-d]pyrimidine - Drug sensitive 4-morpholinecarbodithioic acid, antimony complex - Drug sensitive 4-thiomorpholinecarbodithioic acid, antimony complex - Drug sensitive 7-n,n-dimethylamino brefeldin a hydrochloride - Drug sensitive 9-acridinamine, n-(4-ethoxyphenyl)-, monohydrochloride - Drug sensitive benzamide, 5-bromo-2-hydroxy-n-[3-(trifluoromethyl)phenyl]- - Drug sensitive benzofurazan, 4-nitro-7-(2-pyridinylthio)-, n-oxide - Drug sensitive E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive isoflavone, 5,7-dihydroxy-4'-nitro- - Drug sensitive (Z)-3-((2-(4-(trifluoromethyl)phenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive (Z)-6-chloro-3-((2-(4-methoxyphenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive 2-amino-5-chloro-6-(2-thiazolyloxy)-benzimidazole - Drug sensitive 9-(3-fluorobenzyl)-7-(3-fluorobenzyloxy)-2-(4-fluorobenzyl)-1-methyl-9H-beta-carbolinium bromide - Drug sensitive arylmethylene-f - Drug sensitive his 47-methyl ct - Drug sensitive n-myristoyl-(s)-phenylalaninal diethylcetal - Drug sensitive

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-624-5p
Interactor2: RB1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.