Basic Information:

  VIRBase ID:  

HHID00061101

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-597-5p:  MIMAT0003265          PCNA:  NM_182649     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-597-5p	PCNA
miRBase Accession/Entrez ID	MIMAT0003265	5111
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ATLD2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-597-5p	rs112056940 chr8:9741702    C/T rs1283691183 chr8:9741699    TG/T rs1313744079 chr8:9741704    A/G rs1322031493 chr8:9741703    C/T rs1435460970 chr8:9741705    C/T rs769103445 chr8:9741706    T/A rs769103445 chr8:9741706    T/C rs878949867 chr8:9741683    CGTGT/C rs908032273 chr8:9741707    G/A rs908032273 chr8:9741707    G/C rs908032273 chr8:9741707    G/T rs960242475 chr8:9741696    C/T rs780763708 chr8:9741690    G/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PCNA	chr20:5096916(-) A-I      intronic chr20:5104258(-) A-I      intronic chr20:5102792(-) A-I      intronic chr20:5102788(-) A-I      intronic chr20:5102824(-) A-I      intronic chr20:5104254(-) A-I      intronic chr20:5104294(-) A-I      intronic chr20:5102515(-) A-I      intronic chr20:5102436(-) A-I      intronic chr20:5102472(-) A-I      intronic chr20:5101591(-) A-I      intronic chr20:5105800(-) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PCNA	chr20:5095885-5095886(-) m6A 3'UTR       26404942 chr20:5095901-5095902(-) m6A 3'UTR       26404942 chr20:5095979-5095980(-) m6A CDS       26404942 chr20:5096162-5096163(-) m6A CDS       26404942 chr20:5096197-5096198(-) m6A CDS       26404942 chr20:5098144-5098145(-) m6A CDS       26404942//22575960 chr20:5098161-5098162(-) m6A CDS       26404942//22575960 chr20:5098175-5098176(-) m6A CDS       26404942//22575960 chr20:5098307-5098308(-) m6A CDS       22575960 chr20:5099270-5099271(-) m6A CDS       22575960 chr20:5099304-5099305(-) m6A CDS       26404942//22575960 chr20:5100232-5100233(-) m6A CDS       26404942 chr20:5100322-5100323(-) m6A CDS       24284625//24981863//26404942//27773535//22575960 chr20:5100337-5100338(-) m6A CDS       24284625//24981863//26404942//27773535//22575960 chr20:5100382-5100383(-) m6A CDS       24284625//24981863//26404942//27773535//22575960 chr20:5100494-5100495(-) m6A 5'UTR       24284625//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr20:5100503-5100504(-) m6A 5'UTR       24284625//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr20:5100664-5100665(-) m6A 5'UTR//intron       25456834//24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-597-5p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	PCNA	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Nucleus HCC cell line (HepG2)     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-597-5p
Interactor2: PCNA

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.