Basic Information:

  VIRBase ID:  

HHID00061091

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-590-5p:  MIMAT0003258          GLCCI1:  NM_138426     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-590-5p	GLCCI1
miRBase Accession/Entrez ID	MIMAT0003258	113263
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	FAM117C//GCTR//GIG18//TSSN1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-590-5p	rs1554709898 chr7:74191225    A/G rs192756765 chr7:74191221    T/A rs781995768 chr7:74191223    A/G rs782101000 chr7:74191229    G/A rs189727189 chr7:74191216    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	GLCCI1	chr7:8056044(+) A-I      intronic chr7:8055988(+) A-I      intronic chr7:8055984(+) A-I      intronic chr7:8055978(+) A-I      intronic chr7:8055952(+) A-I      intronic chr7:8053905(+) A-I      intronic chr7:8048019(+) A-I      intronic chr7:8038057(+) A-I      intronic chr7:8027282(+) A-I      intronic chr7:8027269(+) A-I      intronic chr7:8027264(+) A-I      intronic chr7:8019705(+) A-I      intronic chr7:8081433(+) A-I      intronic chr7:8016405(+) A-I      intronic chr7:8016393(+) A-I      intronic chr7:8020672(+) A-I      intronic chr7:8020643(+) A-I      intronic chr7:8079493(+) A-I      intronic chr7:8079507(+) A-I      intronic chr7:8081498(+) A-I      intronic chr7:8100937(+) A-I      intronic chr7:8082194(+) A-I      intronic chr7:8084269(+) A-I      intronic chr7:8082275(+) A-I      intronic chr7:8102894(+) A-I      intronic chr7:8081362(+) A-I      intronic chr7:8081333(+) A-I      intronic chr7:8084153(+) A-I      intronic chr7:8084156(+) A-I      intronic chr7:8084158(+) A-I      intronic chr7:8084270(+) A-I      intronic chr7:8107808(+) A-I      intronic chr7:8107859(+) A-I      intronic chr7:8107873(+) A-I      intronic chr7:8107940(+) A-I      intronic chr7:8081278(+) A-I      intronic chr7:8080012(+) A-I      intronic chr7:8081370(+) A-I      intronic chr7:8102965(+) A-I      intronic chr7:8066932(+) A-I      intronic chr7:8037926(+) A-I      intronic chr7:8107860(+) A-I      intronic chr7:8080085(+) A-I      intronic chr7:8048053(+) A-I      intronic chr7:8079934(+) A-I      intronic chr7:8037951(+) A-I      intronic chr7:8050709(+) A-I      intronic chr7:8079977(+) A-I      intronic chr7:8053694(+) A-I      intronic chr7:8082185(+) A-I      intronic chr7:8015963(+) A-I      intronic chr7:8015990(+) A-I      intronic chr7:8019617(+) A-I      intronic chr7:8079914(+) A-I      intronic chr7:8102868(+) A-I      intronic chr7:8082187(+) A-I      intronic chr7:8053719(+) A-I      intronic chr7:8019714(+) A-I      intronic chr7:8081422(+) A-I      intronic chr7:8015989(+) A-I      intronic chr7:8079572(+) A-I      intronic chr7:8082217(+) A-I      intronic chr7:8027244(+) A-I      intronic chr7:8035007(+) A-I      intronic chr7:8082247(+) A-I      intronic chr7:8107784(+) A-I      intronic chr7:8081346(+) A-I      intronic chr7:8080035(+) A-I      intronic chr7:8104621(+) A-I      intronic chr7:8066862(+) A-I      intronic chr7:8023771(+) A-I      intronic chr7:8103350(+) A-I      intronic chr7:8079577(+) A-I      intronic chr7:8016423(+) A-I      intronic chr7:8103487(+) A-I      intronic chr7:8107724(+) A-I      intronic chr7:8081411(+) A-I      intronic chr7:8107771(+) A-I      intronic chr7:8107769(+) A-I      intronic chr7:8039118(+) A-I      intronic chr7:8083837(+) A-I      intronic chr7:8081412(+) A-I      intronic chr7:8102985(+) A-I      intronic chr7:8081431(+) A-I      intronic chr7:8081499(+) A-I      intronic chr7:8053720(+) A-I      intronic chr7:8079873(+) A-I      intronic chr7:8081378(+) A-I      intronic chr7:8037912(+) A-I      intronic chr7:8053681(+) A-I      intronic chr7:8081249(+) A-I      intronic chr7:8016396(+) A-I      intronic chr7:8047939(+) A-I      intronic chr7:8026049(+) A-I      intronic chr7:8027280(+) A-I      intronic chr7:8103461(+) A-I      intronic chr7:8053759(+) A-I      intronic chr7:8095699(+) A-I      intronic chr7:8050615(+) A-I      intronic chr7:8016305(+) A-I      intronic chr7:8107793(+) A-I      intronic chr7:8101397(+) A-I      intronic chr7:8107727(+) A-I      intronic chr7:8053676(+) A-I      intronic chr7:8081350(+) A-I      intronic chr7:8055946(+) A-I      intronic chr7:8083849(+) A-I      intronic chr7:8027299(+) A-I      intronic chr7:8107823(+) A-I      intronic chr7:8107857(+) A-I      intronic chr7:8107869(+) A-I      intronic chr7:8081321(+) A-I      intronic chr7:8037473(+) A-I      intronic chr7:8027275(+) A-I      intronic chr7:8103050(+) A-I      intronic chr7:8100749(+) A-I      intronic chr7:8037377(+) A-I      intronic chr7:8027352(+) A-I      intronic chr7:8023766(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	GLCCI1	chr7:8020298(+) A-I intron -    22327324 chr7:8020305(+) A-I intron -    22327324 chr7:8020324(+) A-I intron -    22327324 chr7:8020441(+) A-I intron -    22327324 chr7:8020673(+) A-I intron -    22327324 chr7:8020689(+) A-I intron -    22327324 chr7:8020697(+) A-I intron -    22327324 chr7:8034485(+) A-I intron -    22327324 chr7:8081412(+) A-I intron -    22327324 chr7:8081499(+) A-I intron -    22327324 chr7:8082185(+) A-I intron -    22327324 chr7:8082247(+) A-I intron -    22327324 chr7:8103461(+) A-I intron -    21960545 chr7:8046880(+) T-C intron -    22484847 chr7:8015897(+) A-G intron -    22484847 chr7:8016058(+) T-C intron -    22484847 chr7:8016107(+) T-A intron -    22484847 chr7:8016108(+) C-A intron -    22484847 chr7:8016109(+) T-A intron -    22484847 chr7:8016110(+) C-A intron -    22484847 chr7:8016396(+) A-G intron -    22484847 chr7:8019620(+) A-G intron -    22484847 chr7:8025881(+) T-C intron -    22484847 chr7:8026049(+) A-G intron -    22484847 chr7:8027275(+) A-G intron -    22484847 chr7:8027280(+) A-G intron -    22484847 chr7:8027299(+) A-G intron -    22484847 chr7:8027319(+) A-G intron -    22484847 chr7:8033722(+) A-T intron -    22484847 chr7:8033807(+) T-C intron -    22484847 chr7:8037377(+) A-G intron -    22484847 chr7:8037473(+) A-G intron -    22484847 chr7:8037951(+) A-G intron -    22484847 chr7:8047939(+) A-G intron -    22484847 chr7:8048009(+) A-G intron -    22484847 chr7:8048015(+) A-G intron -    22484847 chr7:8048016(+) A-G intron -    22484847 chr7:8053676(+) A-G intron -    22484847 chr7:8053681(+) A-G intron -    22484847 chr7:8053694(+) A-G intron -    22484847 chr7:8053719(+) A-G intron -    22484847 chr7:8053720(+) A-G intron -    22484847 chr7:8053749(+) A-G intron -    22484847 chr7:8053759(+) A-G intron -    22484847 chr7:8055946(+) A-G intron -    22484847 chr7:8061167(+) T-C intron -    22484847 chr7:8062869(+) T-C intron -    22484847 chr7:8064920(+) A-G intron -    22484847 chr7:8079873(+) A-G intron -    22484847 chr7:8079934(+) A-G intron -    22484847 chr7:8079969(+) A-G intron -    22484847 chr7:8080005(+) A-G intron -    22484847 chr7:8080009(+) A-G intron -    22484847 chr7:8080035(+) A-G intron -    22484847 chr7:8080085(+) A-G intron -    22484847 chr7:8081249(+) A-G intron -    22484847 chr7:8081321(+) A-G intron -    22484847 chr7:8081346(+) A-G intron -    22484847 chr7:8081347(+) A-G intron -    22484847 chr7:8081350(+) A-G intron -    22484847 chr7:8081378(+) A-G intron -    22484847 chr7:8081411(+) A-G intron -    22484847 chr7:8081412(+) A-G intron -    22484847 chr7:8081422(+) A-G intron -    22484847 chr7:8081499(+) A-G intron -    22484847 chr7:8082171(+) A-G intron -    22484847 chr7:8082185(+) A-G intron -    22484847 chr7:8082187(+) A-G intron -    22484847 chr7:8082217(+) A-G intron -    22484847 chr7:8082247(+) A-G intron -    22484847 chr7:8083837(+) A-G intron -    22484847 chr7:8083849(+) A-G intron -    22484847 chr7:8084111(+) A-G intron -    22484847 chr7:8092974(+) G-T intron -    22484847 chr7:8101396(+) A-G intron -    22484847 chr7:8101397(+) A-G intron -    22484847 chr7:8102814(+) T-C intron -    22484847 chr7:8102865(+) C-T intron -    22484847 chr7:8103360(+) C-T intron -    22484847 chr7:8103361(+) A-C intron -    22484847 chr7:8103427(+) A-T intron -    22484847 chr7:8103487(+) A-G intron -    22484847 chr7:8104453(+) A-T intron -    22484847 chr7:8107704(+) A-G intron -    22484847 chr7:8107724(+) A-G intron -    22484847 chr7:8107769(+) A-G intron -    22484847 chr7:8107771(+) A-G intron -    22484847 chr7:8107777(+) A-G intron -    22484847 chr7:8107793(+) A-G intron -    22484847 chr7:8107857(+) A-G intron -    22484847 chr7:8107860(+) A-G intron -    22484847 chr7:8107912(+) G-A intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	GLCCI1	chr7:8008493-8008494(+) m6A 5'UTR       - chr7:8008842-8008843(+) m6A 5'UTR       - chr7:8010106-8010107(+) m6A exon//intron       - chr7:8021692-8021693(+) m6A intron       22608085 chr7:8021697-8021698(+) m6A intron       22608085 chr7:8021704-8021705(+) m6A intron       22608085 chr7:8021772-8021773(+) m6A intron       22608085 chr7:8021805-8021806(+) m6A intron       22608085 chr7:8095097-8095098(+) Y CDS//exon       26075521 chr7:8125869-8125870(+) m6A CDS//exon//intron       24284625//24209618//22608085 chr7:8125915-8125916(+) m6A CDS//exon//intron       24284625//24209618//24981863//22608085 chr7:8125959-8125960(+) m6A CDS//exon//intron       24284625//24209618//24981863//22608085 chr7:8126119-8126120(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr7:8126133-8126134(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr7:8126151-8126152(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr7:8126211-8126212(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr7:8126223-8126224(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr7:8126242-8126243(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr7:8126251-8126252(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr7:8126300-8126301(+) m6A 3'UTR//exon//intron       24284625//24209618//24981863//22575960//22608085 chr7:8126323-8126324(+) m6A 3'UTR//exon//intron       24284625//24209618//24981863//22575960//22608085 chr7:8126398-8126399(+) m6A 3'UTR//exon//intron       24284625//24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-590-5p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome B cell line (Raji)|Primary dendritic cells|T cell line (J77)     21505438 Exosome Human mast cell line (HMC-1)     24009880 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Follicular fluid     23666971 Microvesicle Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Neural progenitor cells     21363885
	GLCCI1	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-590-5p	Sensorad 99342 Drug sensitive Gardenin B 96539 Drug sensitive 2,5-Dimethyl-1,4-benzoquinone 8718 Drug sensitive Acid Green 27 80837 Drug sensitive Morpholine-N-dithiocarbamate 72675 Drug sensitive Berberine iodide 72350 Drug sensitive Sulbentine 67686 Drug sensitive Laurolinium acetate 67354 Drug sensitive Dihydroartemisinyl ether, stereoisomer of NSC-685989 6712439 Drug sensitive Acnistin F 6712173 Drug sensitive Verrucarin A 6326658 Drug sensitive Verrucarin A, 3'-(acetyloxy)-7'-deoxo-2'-deoxy-4'-hydroxy-7'-(1-hydroxyethyl)- 5933240 Drug sensitive 8B-Hydroxy-9B,10B-epoxyverrucarin A 5477536 Drug sensitive Caracemide 54747 Drug sensitive Artelasticin 5471311 Drug sensitive (Z)-1-Iodo-2-phenyl-1-penten-3-one 5468684 Drug sensitive 3,19-(4-Acetamido)benzylidineandrographolide 54612901 Drug sensitive Herveline O 5459269 Drug sensitive Cuspidatin C 5459164 Drug sensitive Thiram 5455 Drug sensitive (E)-1-(2,5-Dihydroxyphenyl)ethene-2-isonitrile 5388136 Drug sensitive (1E,4E)-1,5-Dipyridin-3-ylpenta-1,4-dien-3-one 5382674 Drug sensitive Ovatifolin acetate 5358419 Drug sensitive Indanthren Corinth RK 5351878 Drug sensitive Herbimycin 5311102 Drug sensitive Vorinostat 5311 Drug sensitive 6-Methoxy-7-(2lambda(5)-1,2-triazadienyl)-5,8-quinolinedione 494043 Drug sensitive Asimicinone 393461 Drug sensitive 2-(1-Propynyl)estradiol 388008 Drug sensitive Acetic acid,4,7,10-tetraazacyclododecane-1,7-diyl]bis 387352 Drug sensitive 4-Phenacyloxychromen-2-one 386272 Drug resistant (-)7,8-Dihydrocalanolide A 383107 Drug sensitive 1-Azido-2-phenyl-3-phenalenone 381891 Drug sensitive (1R)-3,3-Dibromocamphor 376765 Drug sensitive 3,8-Dimethyl-1,2-naphthoquinone 373912 Drug sensitive Antineoplastic-645804 371505 Drug sensitive 1-(4-Methoxy-2-methylphenyl)naphtho[1,2-c]furan-3(1H)-one 369148 Drug sensitive Aplidazole C . TFA 362402 Drug sensitive Thiosangivamycin 3580213 Drug sensitive Bis(helenalinyl)glutarate 336831 Drug sensitive 6-(4-Chlorophenyl)sulfanylquinazoline-2,4-diamine 328131 Drug sensitive 2,3-Dimethoxy-5-naphthalen-2-ylsulfanylcyclohexa-2,5-diene-1,4-dione 314728 Drug sensitive Antimycin A3 245869 Drug sensitive (2-Methoxy-9,10-dihydrophenanthren-3-yl)methyl-dimethyl-(phenylsulfanylmethyl)azanium;bromide 24200489 Drug sensitive [(4E,6Z,10Z)-20,22-Dihydroxy-13,14,17-trimethoxy-4,8,10,12,16-pentamethyl-3-oxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18(22),19-hexaen-9-yl] carbamate 24199492 Drug sensitive Antibiotic U 29135 24196291 Drug sensitive 7-Fluoro-2-benzoyl-3-trifluoromethylquioxaline 1,4-dioxide 23635154 Drug sensitive Drostanolone propionate 224004 Drug sensitive Kinetin riboside 20345 Drug resistant Methyl 1,6,8,14a-tetrahydroxy-11-[(4-hydroxy-3,5-dimethoxy-6-methyloxan-2-yl)amino]-6a-methoxy-3-methyl-7,9,12,14-tetraoxo-5,6-dihydrobenzo[a]tetracene-2-carboxylate 197261 Drug sensitive 4-Chloro-5-(pyridin-2-ylthio)-3H-1,2-dithiole-3-thione 16766538 Drug sensitive 4H-1,3,2-Benzodioxastannin-4-one, 7-amino-2,2-diphenyl- 16683127 Drug sensitive Dihydroartemisinin (mixture of alpha and beta isomers) 16399850 Drug sensitive Triethyltin chloride 13820 Drug sensitive Astrazon Orange R 135747272 Drug sensitive (1R,2S,5S,8S,9S,17R,18R,21S,24R,26S,27S)-14-Chloro-5,15-dihydroxy-2,9,26-trimethyl-3,19,23,28-tetraoxaoctacyclo[16.9.1.118,27.01,5.02,24.08,17.09,14.021,26]nonacos-11-ene-4,10,22,29-tetrone 134715214 Drug sensitive Melampodinin 11953936 Drug sensitive Unii-C616DV5Y11 117587576 Drug sensitive Cyanoaminopyranopyridine derivatives 11494577 Drug resistant Unii-9JU14BJ5QG 109374088 Drug sensitive Cladospirone bisepoxide 10316810 Drug sensitive Fusariotoxin T-2 102515111 Drug sensitive 15,16-Dihydrocuracin A 101683509 Drug sensitive (1S,3R,6R,12S,14R,15S,18R,19E,21Z,25R,26S,27R)-6,15-Dihydroxy-18-[(1R)-1-hydroxyethyl]-5,14,26-trimethylspiro[2,10,13,17,24-pentaoxapentacyclo[23.2.1.03,8.08,26.012,14]octacosa-4,19,21-triene-27,2'-oxirane]-11,23-dione 101307863 Drug sensitive Chimaphilin 101211 Drug sensitive (3Z,4R)-4-Hydroxy-3-[2-[(1S,3R)-3-[2-[(1S,3S,3'R,4S)-1-hydroxy-4,6,6-trimethylspiro[2,5-dioxabicyclo[2.2.2]octane-3,6'-oxane]-3'-yl]ethyl]-2,2-dimethyl-6-methylidenecyclohexyl]ethylidene]oxolan-2-one 101206903 Drug sensitive 1,4-benzenediamine (9ci), n-butyl-n'-phenyl- - Drug sensitive 1h-1,4,7-triazonine-1,4,7-triacetic acid, octahydro- - Drug sensitive 1h-1,4,7-triazonine-1,4-diacetic acid, octahydro- - Drug sensitive 1-piperidinecarbodithioic acid, antimony complex - Drug sensitive 4'-deoxy-13',17-dinitro-3',4'-epoxy-vincaleukoblastine - Drug sensitive 4-morpholinecarbodithioic acid, antimony complex - Drug sensitive 4-thiomorpholinecarbodithioic acid, antimony complex - Drug sensitive 7-n,n-dimethylamino brefeldin a hydrochloride - Drug sensitive 9h-purine, 2-amino-6-(2,4-dichlorobenzylthio)-9-isobutyl- - Drug sensitive anthracen-9-one, 10-[(2-methoxyphenyl)methylene]- - Drug sensitive benzamide, 5-bromo-2-hydroxy-n-[3-(trifluoromethyl)phenyl]- - Drug sensitive benzonitrile, 2-amino-3,5-dinitro- (9ci) - Drug sensitive cyclohexanone, 2,6-bis(piperidinomethyl)- - Drug sensitive geldanamycin, n,n'-dimethyl - Drug sensitive gold(1+), bis(trimethylphosphine)-, chloride - Drug sensitive iodonium, (4-methoxyphenyl)(3-methylphenyl)-, bromide - Drug sensitive roridin a, 8-hydroxy-9b,10b-epoxy- - Drug sensitive uridine, 5-isobutyl-2'-deoxy- - Drug sensitive (Z)-6-chloro-3-((2-(4-methoxyphenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive 1-[(2-phenylethoxy)methyl]-5-ethyl-6-(phenylseleno)uracil - Drug sensitive 2-(4-hydroxy-benzylidene)-2-(2-pyridyl)acetonitrile - Drug sensitive 9-(3-fluorobenzyl)-7-(3-fluorobenzyloxy)-2-(4-fluorobenzyl)-1-methyl-9H-beta-carbolinium bromide - Drug sensitive antineoplastic-615538 - Drug sensitive antineoplastic-644916 - Drug sensitive bavachyaone - Drug sensitive geldanamycin analog - Drug sensitive isatin dr - Drug sensitive thiadiazines - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-590-5p	Nicotine 89594 Drug interaction    RC00006067 Formaldehyde 712 Drug interaction    RC00006061 Gemcitabine 60750 Drug interaction    RC00006066 5-Fluorouracil 3385 Drug interaction    RC00006064 Doxorubicin 31703 Drug interaction    RC00006065 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00006063 Verapamil 2520 Drug interaction    RC00006062 Docetaxel 148124 Drug interaction    RC00006069 Ginsenoside Rh2 119307 Drug interaction    RC00006068 SIOP treatment protocol - Drug interaction    RC00006070

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-590-5p	Cisplatin 5702198       27757042 Paclitaxel 36314       27757042 Doxorubicin 31703       30111512

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-590-5p
Interactor2: GLCCI1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.