Detail Information

Basic Information:


  VIRBase ID:  

HHID00061068

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-590-5p:           NPTN:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-590-5p NPTN
miRBase
Accession/Entrez ID		 MIMAT0003258 27020
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - GP55//GP65//np55//np65//SDFR1//SDR1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-590-5p
rs1554709898 chr7:74191225    A/G
rs192756765 chr7:74191221    T/A
rs781995768 chr7:74191223    A/G
rs782101000 chr7:74191229    G/A
rs189727189 chr7:74191216    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR NPTN
chr15:73866949(-) A-I      intronic
chr15:73866902(-) A-I      intronic
chr15:73866918(-) A-I      intronic
chr15:73866950(-) A-I      intronic
chr15:73874422(-) A-I      intronic
chr15:73906138(-) A-I      intronic
chr15:73906119(-) A-I      intronic
chr15:73906094(-) A-I      intronic
chr15:73902572(-) A-I      intronic
chr15:73902566(-) A-I      intronic
chr15:73902524(-) A-I      intronic
chr15:73902506(-) A-I      intronic
chr15:73901950(-) A-I      intronic
chr15:73901889(-) A-I      intronic
chr15:73901872(-) A-I      intronic
chr15:73901860(-) A-I      intronic
chr15:73901850(-) A-I      intronic
chr15:73901807(-) A-I      intronic
chr15:73867027(-) A-I      intronic
chr15:73866886(-) A-I      intronic
chr15:73901728(-) A-I      intronic
chr15:73919525(-) A-I      intronic
chr15:73916022(-) A-I      intronic
chr15:73915952(-) A-I      intronic
chr15:73906623(-) A-I      intronic
chr15:73906195(-) A-I      intronic
chr15:73919428(-) A-I      intronic
chr15:73906617(-) A-I      intronic
chr15:73901824(-) A-I      intronic
chr15:73906566(-) A-I      intronic
chr15:73906253(-) A-I      intronic
chr15:73905077(-) A-I      intronic
chr15:73902525(-) A-I      intronic
chr15:73901800(-) A-I      intronic
chr15:73902551(-) A-I      intronic
chr15:73853897(-) A-I      intronic
chr15:73902611(-) A-I      intronic
chr15:73906545(-) A-I      intronic
chr15:73882284(-) A-I      intronic
chr15:73867543(-) A-I      intronic
chr15:73917811(-) A-I      intronic
chr15:73915946(-) A-I      intronic
chr15:73906592(-) A-I      intronic
chr15:73915880(-) A-I      intronic
chr15:73919407(-) A-I      intronic
chr15:73906164(-) A-I      intronic
chr15:73904729(-) A-I      intronic
chr15:73906585(-) A-I      intronic
chr15:73866882(-) A-I      intronic
chr15:73902592(-) A-I      intronic
chr15:73866908(-) A-I      intronic
chr15:73906159(-) A-I      intronic
chr15:73906577(-) A-I      intronic
chr15:73919464(-) A-I      intronic
chr15:73906660(-) A-I      intronic
chr15:73906628(-) A-I      intronic
chr15:73919494(-) A-I      intronic
chr15:73906615(-) A-I      intronic
chr15:73906539(-) A-I      intronic
chr15:73906579(-) A-I      intronic
chr15:73919413(-) A-I      intronic
chr15:73906254(-) A-I      intronic
chr15:73906549(-) A-I      intronic
chr15:73906299(-) A-I      intronic
chr15:73866892(-) A-I      intronic
chr15:73881555(-) A-I      intronic
chr15:73917801(-) A-I      intronic
chr15:73906306(-) A-I      intronic
chr15:73882342(-) A-I      intronic
chr15:73919393(-) A-I      intronic
chr15:73901750(-) A-I      intronic
chr15:73906165(-) A-I      intronic
chr15:73906220(-) A-I      intronic
chr15:73901936(-) A-I      intronic
chr15:73919319(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase NPTN
chr15:73852775-73852776(-) m6A 3'UTR       26404942
chr15:73852825-73852826(-) m6A 3'UTR       26404942
chr15:73853333-73853334(-) m6A 3'UTR//exon       26404942
chr15:73853371-73853372(-) m6A 3'UTR//exon       26404942
chr15:73854260-73854261(-) m6A 3'UTR//CDS//exon       24981863//26404942//27773535
chr15:73854275-73854276(-) m6A 3'UTR//CDS//exon       24981863//26404942//27773535
chr15:73854306-73854307(-) m6A CDS//exon       24981863//26404942//27773535
chr15:73855581-73855582(-) m6A CDS//exon       24981863//26404942//27773535
chr15:73855590-73855591(-) m6A CDS//exon//intron       24981863//26404942//27773535
chr15:73855608-73855609(-) m6A exon//intron       24981863//27773535
chr15:73855613-73855614(-) m6A exon//intron       24981863//27773535
chr15:73862675-73862676(-) m6A CDS//exon       26404942//27773535//27371828
chr15:73862688-73862689(-) Cm CDS//exon       -
chr15:73862693-73862694(-) m6A CDS//exon       26404942//27773535//27371828
chr15:73862702-73862703(-) m6A CDS//exon       26404942//27773535//27371828
chr15:73866039-73866040(-) m6A CDS//exon       26404942//27773535//22575960
chr15:73866099-73866100(-) m6A CDS//exon       27773535
chr15:73884347-73884348(-) m6A CDS//exon//intron       26404942//27773535
chr15:73884364-73884365(-) m6A CDS//exon//intron       26404942//27773535
chr15:73884438-73884439(-) m6A CDS//exon//intron       27773535
chr15:73889412-73889413(-) m6A CDS//intron       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-590-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome B cell line (Raji)|Primary dendritic cells|T cell line (J77)     21505438
Exosome Human mast cell line (HMC-1)     24009880
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Follicular fluid     23666971
Microvesicle Mesenchymal stem cells     -
Mitochondrion Skeletal muscle myoblasts     21637849
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Neural progenitor cells     21363885
NPTN
Chromatin K562 cells     -
Cytosol K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-590-5p
Sensorad 99342 Drug sensitive
Gardenin B 96539 Drug sensitive
2,5-Dimethyl-1,4-benzoquinone 8718 Drug sensitive
Acid Green 27 80837 Drug sensitive
Morpholine-N-dithiocarbamate 72675 Drug sensitive
Berberine iodide 72350 Drug sensitive
Sulbentine 67686 Drug sensitive
Laurolinium acetate 67354 Drug sensitive
Dihydroartemisinyl ether, stereoisomer of NSC-685989 6712439 Drug sensitive
Acnistin F 6712173 Drug sensitive
Verrucarin A 6326658 Drug sensitive
Verrucarin A, 3'-(acetyloxy)-7'-deoxo-2'-deoxy-4'-hydroxy-7'-(1-hydroxyethyl)- 5933240 Drug sensitive
8B-Hydroxy-9B,10B-epoxyverrucarin A 5477536 Drug sensitive
Caracemide 54747 Drug sensitive
Artelasticin 5471311 Drug sensitive
(Z)-1-Iodo-2-phenyl-1-penten-3-one 5468684 Drug sensitive
3,19-(4-Acetamido)benzylidineandrographolide 54612901 Drug sensitive
Herveline O 5459269 Drug sensitive
Cuspidatin C 5459164 Drug sensitive
Thiram 5455 Drug sensitive
(E)-1-(2,5-Dihydroxyphenyl)ethene-2-isonitrile 5388136 Drug sensitive
(1E,4E)-1,5-Dipyridin-3-ylpenta-1,4-dien-3-one 5382674 Drug sensitive
Ovatifolin acetate 5358419 Drug sensitive
Indanthren Corinth RK 5351878 Drug sensitive
Herbimycin 5311102 Drug sensitive
Vorinostat 5311 Drug sensitive
6-Methoxy-7-(2lambda(5)-1,2-triazadienyl)-5,8-quinolinedione 494043 Drug sensitive
Asimicinone 393461 Drug sensitive
2-(1-Propynyl)estradiol 388008 Drug sensitive
Acetic acid,4,7,10-tetraazacyclododecane-1,7-diyl]bis 387352 Drug sensitive
4-Phenacyloxychromen-2-one 386272 Drug resistant
(-)7,8-Dihydrocalanolide A 383107 Drug sensitive
1-Azido-2-phenyl-3-phenalenone 381891 Drug sensitive
(1R)-3,3-Dibromocamphor 376765 Drug sensitive
3,8-Dimethyl-1,2-naphthoquinone 373912 Drug sensitive
Antineoplastic-645804 371505 Drug sensitive
1-(4-Methoxy-2-methylphenyl)naphtho[1,2-c]furan-3(1H)-one 369148 Drug sensitive
Aplidazole C . TFA 362402 Drug sensitive
Thiosangivamycin 3580213 Drug sensitive
Bis(helenalinyl)glutarate 336831 Drug sensitive
6-(4-Chlorophenyl)sulfanylquinazoline-2,4-diamine 328131 Drug sensitive
2,3-Dimethoxy-5-naphthalen-2-ylsulfanylcyclohexa-2,5-diene-1,4-dione 314728 Drug sensitive
Antimycin A3 245869 Drug sensitive
(2-Methoxy-9,10-dihydrophenanthren-3-yl)methyl-dimethyl-(phenylsulfanylmethyl)azanium;bromide 24200489 Drug sensitive
[(4E,6Z,10Z)-20,22-Dihydroxy-13,14,17-trimethoxy-4,8,10,12,16-pentamethyl-3-oxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18(22),19-hexaen-9-yl] carbamate 24199492 Drug sensitive
Antibiotic U 29135 24196291 Drug sensitive
7-Fluoro-2-benzoyl-3-trifluoromethylquioxaline 1,4-dioxide 23635154 Drug sensitive
Drostanolone propionate 224004 Drug sensitive
Kinetin riboside 20345 Drug resistant
Methyl 1,6,8,14a-tetrahydroxy-11-[(4-hydroxy-3,5-dimethoxy-6-methyloxan-2-yl)amino]-6a-methoxy-3-methyl-7,9,12,14-tetraoxo-5,6-dihydrobenzo[a]tetracene-2-carboxylate 197261 Drug sensitive
4-Chloro-5-(pyridin-2-ylthio)-3H-1,2-dithiole-3-thione 16766538 Drug sensitive
4H-1,3,2-Benzodioxastannin-4-one, 7-amino-2,2-diphenyl- 16683127 Drug sensitive
Dihydroartemisinin (mixture of alpha and beta isomers) 16399850 Drug sensitive
Triethyltin chloride 13820 Drug sensitive
Astrazon Orange R 135747272 Drug sensitive
(1R,2S,5S,8S,9S,17R,18R,21S,24R,26S,27S)-14-Chloro-5,15-dihydroxy-2,9,26-trimethyl-3,19,23,28-tetraoxaoctacyclo[16.9.1.118,27.01,5.02,24.08,17.09,14.021,26]nonacos-11-ene-4,10,22,29-tetrone 134715214 Drug sensitive
Melampodinin 11953936 Drug sensitive
Unii-C616DV5Y11 117587576 Drug sensitive
Cyanoaminopyranopyridine derivatives 11494577 Drug resistant
Unii-9JU14BJ5QG 109374088 Drug sensitive
Cladospirone bisepoxide 10316810 Drug sensitive
Fusariotoxin T-2 102515111 Drug sensitive
15,16-Dihydrocuracin A 101683509 Drug sensitive
(1S,3R,6R,12S,14R,15S,18R,19E,21Z,25R,26S,27R)-6,15-Dihydroxy-18-[(1R)-1-hydroxyethyl]-5,14,26-trimethylspiro[2,10,13,17,24-pentaoxapentacyclo[23.2.1.03,8.08,26.012,14]octacosa-4,19,21-triene-27,2'-oxirane]-11,23-dione 101307863 Drug sensitive
Chimaphilin 101211 Drug sensitive
(3Z,4R)-4-Hydroxy-3-[2-[(1S,3R)-3-[2-[(1S,3S,3'R,4S)-1-hydroxy-4,6,6-trimethylspiro[2,5-dioxabicyclo[2.2.2]octane-3,6'-oxane]-3'-yl]ethyl]-2,2-dimethyl-6-methylidenecyclohexyl]ethylidene]oxolan-2-one 101206903 Drug sensitive
1,4-benzenediamine (9ci), n-butyl-n'-phenyl- - Drug sensitive
1h-1,4,7-triazonine-1,4,7-triacetic acid, octahydro- - Drug sensitive
1h-1,4,7-triazonine-1,4-diacetic acid, octahydro- - Drug sensitive
1-piperidinecarbodithioic acid, antimony complex - Drug sensitive
4'-deoxy-13',17-dinitro-3',4'-epoxy-vincaleukoblastine - Drug sensitive
4-morpholinecarbodithioic acid, antimony complex - Drug sensitive
4-thiomorpholinecarbodithioic acid, antimony complex - Drug sensitive
7-n,n-dimethylamino brefeldin a hydrochloride - Drug sensitive
9h-purine, 2-amino-6-(2,4-dichlorobenzylthio)-9-isobutyl- - Drug sensitive
anthracen-9-one, 10-[(2-methoxyphenyl)methylene]- - Drug sensitive
benzamide, 5-bromo-2-hydroxy-n-[3-(trifluoromethyl)phenyl]- - Drug sensitive
benzonitrile, 2-amino-3,5-dinitro- (9ci) - Drug sensitive
cyclohexanone, 2,6-bis(piperidinomethyl)- - Drug sensitive
geldanamycin, n,n'-dimethyl - Drug sensitive
gold(1+), bis(trimethylphosphine)-, chloride - Drug sensitive
iodonium, (4-methoxyphenyl)(3-methylphenyl)-, bromide - Drug sensitive
roridin a, 8-hydroxy-9b,10b-epoxy- - Drug sensitive
uridine, 5-isobutyl-2'-deoxy- - Drug sensitive
(Z)-6-chloro-3-((2-(4-methoxyphenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive
1-[(2-phenylethoxy)methyl]-5-ethyl-6-(phenylseleno)uracil - Drug sensitive
2-(4-hydroxy-benzylidene)-2-(2-pyridyl)acetonitrile - Drug sensitive
9-(3-fluorobenzyl)-7-(3-fluorobenzyloxy)-2-(4-fluorobenzyl)-1-methyl-9H-beta-carbolinium bromide - Drug sensitive
antineoplastic-615538 - Drug sensitive
antineoplastic-644916 - Drug sensitive
bavachyaone - Drug sensitive
geldanamycin analog - Drug sensitive
isatin dr - Drug sensitive
thiadiazines - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-590-5p
Nicotine 89594 Drug interaction    RC00006067
Formaldehyde 712 Drug interaction    RC00006061
Gemcitabine 60750 Drug interaction    RC00006066
5-Fluorouracil 3385 Drug interaction    RC00006064
Doxorubicin 31703 Drug interaction    RC00006065
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00006063
Verapamil 2520 Drug interaction    RC00006062
Docetaxel 148124 Drug interaction    RC00006069
Ginsenoside Rh2 119307 Drug interaction    RC00006068
SIOP treatment protocol - Drug interaction    RC00006070
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-590-5p
Cisplatin 5702198       27757042
Paclitaxel 36314       27757042
Doxorubicin 31703       30111512

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-590-5p
Interactor2: NPTN

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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