Detail Information

Basic Information:


  VIRBase ID:  

HHID00061059

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-590-5p:           FUBP1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-590-5p FUBP1
miRBase
Accession/Entrez ID		 MIMAT0003258 8880
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - FBP//FUBP//hDH V

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-590-5p
rs1554709898 chr7:74191225    A/G
rs192756765 chr7:74191221    T/A
rs781995768 chr7:74191223    A/G
rs782101000 chr7:74191229    G/A
rs189727189 chr7:74191216    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR FUBP1
chr1:78417199(-) A-I      intronic
chr1:78439011(-) A-I      intronic
chr1:78438997(-) A-I      intronic
chr1:78438982(-) A-I      intronic
chr1:78438968(-) A-I      intronic
chr1:78419792(-) A-I      intronic
chr1:78419778(-) A-I      intronic
chr1:78417837(-) A-I      intronic
chr1:78417295(-) A-I      intronic
chr1:78415979(-) A-I      intronic
chr1:78419067(-) A-I      intronic
chr1:78419009(-) A-I      intronic
chr1:78439123(-) A-I      intronic
chr1:78419790(-) A-I      intronic
chr1:78419754(-) A-I      intronic
chr1:78436546(-) A-I      intronic
chr1:78436608(-) A-I      intronic
chr1:78438267(-) A-I      intronic
chr1:78438276(-) A-I      intronic
chr1:78438327(-) A-I      intronic
chr1:78438334(-) A-I      intronic
chr1:78439053(-) A-I      intronic
chr1:78439041(-) A-I      intronic
chr1:78439133(-) A-I      intronic
chr1:78439134(-) A-I      intronic
chr1:78440195(-) A-I      intronic
chr1:78438992(-) A-I      intronic
chr1:78415944(-) A-I      intronic
chr1:78415985(-) A-I      intronic
chr1:78415893(-) A-I      intronic
chr1:78438270(-) A-I      intronic
chr1:78439202(-) A-I      intronic
chr1:78436485(-) A-I      intronic
chr1:78438250(-) A-I      intronic
chr1:78418758(-) A-I      intronic
chr1:78439130(-) A-I      intronic
chr1:78438364(-) A-I      intronic
chr1:78436644(-) A-I      intronic
chr1:78438324(-) A-I      intronic
chr1:78439768(-) A-I      intronic
chr1:78439779(-) A-I      intronic
chr1:78439659(-) A-I      intronic
chr1:78415914(-) A-I      intronic
chr1:78419093(-) A-I      intronic
chr1:78418971(-) A-I      intronic
chr1:78418940(-) A-I      intronic
chr1:78438337(-) A-I      intronic
chr1:78439203(-) A-I      intronic
chr1:78419124(-) A-I      intronic
chr1:78419113(-) A-I      intronic
chr1:78417898(-) A-I      intronic
chr1:78439944(-) A-I      intronic
chr1:78419160(-) A-I      intronic
chr1:78417271(-) A-I      intronic
chr1:78436537(-) A-I      intronic
chr1:78439062(-) A-I      intronic
chr1:78416096(-) A-I      intronic
chr1:78436645(-) A-I      intronic
chr1:78418713(-) A-I      intronic
chr1:78418953(-) A-I      intronic
chr1:78438328(-) A-I      intronic
chr1:78438265(-) A-I      intronic
chr1:78438363(-) A-I      intronic
chr1:78418738(-) A-I      intronic
chr1:78417264(-) A-I      intronic
chr1:78416002(-) A-I      intronic
chr1:78417836(-) A-I      intronic
chr1:78439068(-) A-I      intronic
chr1:78416064(-) A-I      intronic
chr1:78442450(-) A-I      intronic
chr1:78436478(-) A-I      intronic
chr1:78438172(-) A-I      intronic
chr1:78419129(-) A-I      intronic
chr1:78419068(-) A-I      intronic
chr1:78419784(-) A-I      intronic
chr1:78415970(-) A-I      intronic
chr1:78436566(-) A-I      intronic
chr1:78439038(-) A-I      intronic
chr1:78442274(-) A-I      intronic
chr1:78439094(-) A-I      intronic
chr1:78438245(-) A-I      intronic
chr1:78438253(-) A-I      intronic
chr1:78436484(-) A-I      intronic
chr1:78442240(-) A-I      intronic
chr1:78418721(-) A-I      intronic
chr1:78418972(-) A-I      intronic
chr1:78442287(-) A-I      intronic
chr1:78442316(-) A-I      intronic
chr1:78419114(-) A-I      intronic
chr1:78418982(-) A-I      intronic
chr1:78423701(-) A-I      intronic
chr1:78437603(-) A-I      intronic
chr1:78416095(-) A-I      intronic
chr1:78416091(-) A-I      intronic
chr1:78415949(-) A-I      intronic
chr1:78419762(-) A-I      intronic
chr1:78439067(-) A-I      intronic
chr1:78442468(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED FUBP1
chr1:78415906(-) A-I intron -    22327324
chr1:78416096(-) A-I intron -    22327324
chr1:78416002(-) A-I intron -    21960545
chr1:78415944(-) A-G intron -    22484847
chr1:78415949(-) A-G intron -    22484847
chr1:78415970(-) A-G intron -    22484847
chr1:78416002(-) A-G intron -    22484847
chr1:78416064(-) A-G intron -    22484847
chr1:78416095(-) A-G intron -    22484847
chr1:78416096(-) A-G intron -    22484847
chr1:78417264(-) A-G intron -    22484847
chr1:78417273(-) C-T intron -    22484847
chr1:78417936(-) A-T intron -    22484847
chr1:78418721(-) A-G intron -    22484847
chr1:78418738(-) A-G intron -    22484847
chr1:78418940(-) A-G intron -    22484847
chr1:78418953(-) A-G intron -    22484847
chr1:78418972(-) A-G intron -    22484847
chr1:78418982(-) A-G intron -    22484847
chr1:78419068(-) A-G intron -    22484847
chr1:78419093(-) A-G intron -    22484847
chr1:78419114(-) A-G intron -    22484847
chr1:78419124(-) A-G intron -    22484847
chr1:78419160(-) A-G intron -    22484847
chr1:78436478(-) A-G intron -    22484847
chr1:78436644(-) A-G intron -    22484847
chr1:78436645(-) A-G intron -    22484847
chr1:78437600(-) T-C intron -    22484847
chr1:78437603(-) A-G intron -    22484847
chr1:78438245(-) A-G intron -    22484847
chr1:78438250(-) A-G intron -    22484847
chr1:78438253(-) A-G intron -    22484847
chr1:78438265(-) A-G intron -    22484847
chr1:78438270(-) A-G intron -    22484847
chr1:78438324(-) A-G intron -    22484847
chr1:78438328(-) A-G intron -    22484847
chr1:78438337(-) A-G intron -    22484847
chr1:78438364(-) A-G intron -    22484847
chr1:78439062(-) A-G intron -    22484847
chr1:78439067(-) A-G intron -    22484847
chr1:78439068(-) A-G intron -    22484847
chr1:78439094(-) A-G intron -    22484847
chr1:78439130(-) A-G intron -    22484847
chr1:78439202(-) A-G intron -    22484847
chr1:78439203(-) A-G intron -    22484847
chr1:78439838(-) C-A intron -    22484847
chr1:78439944(-) A-G intron -    22484847
chr1:78442316(-) A-G intron -    22484847
chr1:78443083(-) C-T intron -    22484847
chr1:78443132(-) C-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase FUBP1
chr1:78409873-78409874(-) m6A exon       27773535
chr1:78409900-78409901(-) m6A exon       27773535
chr1:78414402-78414403(-) m6A 3'UTR//intron       27773535
chr1:78414439-78414440(-) m6A 3'UTR//intron       27773535
chr1:78422260-78422261(-) m6A CDS//exon       27773535
chr1:78422268-78422269(-) m6A CDS//exon       27773535
chr1:78426048-78426049(-) m6A CDS//exon       27773535//22575960
chr1:78426078-78426079(-) m6A CDS//exon       27773535
chr1:78426089-78426090(-) m6A CDS//exon       27773535
chr1:78426153-78426154(-) Y CDS//exon       25219674
chr1:78428462-78428463(-) Am CDS       -
chr1:78428488-78428489(-) m6A CDS       26404942
chr1:78428565-78428566(-) m6A CDS       24981863//26404942
chr1:78428606-78428607(-) m6A CDS       24981863//26404942
chr1:78429279-78429280(-) m6A CDS       26404942//22575960
chr1:78429316-78429317(-) m6A CDS       22575960
chr1:78429328-78429329(-) m6A CDS       22575960
chr1:78429335-78429336(-) m6A CDS       22575960
chr1:78429376-78429377(-) m6A CDS       22575960
chr1:78429382-78429383(-) m6A CDS       22575960
chr1:78429765-78429766(-) m6A CDS       22575960
chr1:78429798-78429799(-) m6A CDS       24981863//22575960
chr1:78429806-78429807(-) m6A CDS       24981863//22575960
chr1:78429838-78429839(-) m6A CDS       24981863//22575960
chr1:78430570-78430571(-) m6A CDS       24981863//26404942//22575960
chr1:78430590-78430591(-) m6A CDS       24981863//26404942//27773535//22575960
chr1:78430606-78430607(-) m6A CDS       24981863//26404942//27773535//22575960
chr1:78430761-78430762(-) m6A CDS       24981863//27773535
chr1:78430769-78430770(-) m6A CDS       24981863//27773535
chr1:78430842-78430843(-) m6A CDS       27773535
chr1:78430872-78430873(-) m6A CDS       27773535
chr1:78430894-78430895(-) m6A CDS       27773535
chr1:78434756-78434757(-) m6A CDS//intron       24981863
chr1:78435624-78435625(-) m6A CDS       24981863
chr1:78435633-78435634(-) m6A CDS       24981863//27773535
chr1:78435668-78435669(-) m6A CDS       24284625//24981863//27773535//22575960
chr1:78444680-78444681(-) m6A CDS       24284625//24981863//27773535//22575960
chr1:78444717-78444718(-) m6A 5'UTR       24284625//24981863//27773535//22575960

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-590-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome B cell line (Raji)|Primary dendritic cells|T cell line (J77)     21505438
Exosome Human mast cell line (HMC-1)     24009880
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Follicular fluid     23666971
Microvesicle Mesenchymal stem cells     -
Mitochondrion Skeletal muscle myoblasts     21637849
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Neural progenitor cells     21363885
FUBP1
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome Blood     -
Membrane HCC cell line (HepG2)|K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus Colon cancer cells     24393600
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-590-5p
Sensorad 99342 Drug sensitive
Gardenin B 96539 Drug sensitive
2,5-Dimethyl-1,4-benzoquinone 8718 Drug sensitive
Acid Green 27 80837 Drug sensitive
Morpholine-N-dithiocarbamate 72675 Drug sensitive
Berberine iodide 72350 Drug sensitive
Sulbentine 67686 Drug sensitive
Laurolinium acetate 67354 Drug sensitive
Dihydroartemisinyl ether, stereoisomer of NSC-685989 6712439 Drug sensitive
Acnistin F 6712173 Drug sensitive
Verrucarin A 6326658 Drug sensitive
Verrucarin A, 3'-(acetyloxy)-7'-deoxo-2'-deoxy-4'-hydroxy-7'-(1-hydroxyethyl)- 5933240 Drug sensitive
8B-Hydroxy-9B,10B-epoxyverrucarin A 5477536 Drug sensitive
Caracemide 54747 Drug sensitive
Artelasticin 5471311 Drug sensitive
(Z)-1-Iodo-2-phenyl-1-penten-3-one 5468684 Drug sensitive
3,19-(4-Acetamido)benzylidineandrographolide 54612901 Drug sensitive
Herveline O 5459269 Drug sensitive
Cuspidatin C 5459164 Drug sensitive
Thiram 5455 Drug sensitive
(E)-1-(2,5-Dihydroxyphenyl)ethene-2-isonitrile 5388136 Drug sensitive
(1E,4E)-1,5-Dipyridin-3-ylpenta-1,4-dien-3-one 5382674 Drug sensitive
Ovatifolin acetate 5358419 Drug sensitive
Indanthren Corinth RK 5351878 Drug sensitive
Herbimycin 5311102 Drug sensitive
Vorinostat 5311 Drug sensitive
6-Methoxy-7-(2lambda(5)-1,2-triazadienyl)-5,8-quinolinedione 494043 Drug sensitive
Asimicinone 393461 Drug sensitive
2-(1-Propynyl)estradiol 388008 Drug sensitive
Acetic acid,4,7,10-tetraazacyclododecane-1,7-diyl]bis 387352 Drug sensitive
4-Phenacyloxychromen-2-one 386272 Drug resistant
(-)7,8-Dihydrocalanolide A 383107 Drug sensitive
1-Azido-2-phenyl-3-phenalenone 381891 Drug sensitive
(1R)-3,3-Dibromocamphor 376765 Drug sensitive
3,8-Dimethyl-1,2-naphthoquinone 373912 Drug sensitive
Antineoplastic-645804 371505 Drug sensitive
1-(4-Methoxy-2-methylphenyl)naphtho[1,2-c]furan-3(1H)-one 369148 Drug sensitive
Aplidazole C . TFA 362402 Drug sensitive
Thiosangivamycin 3580213 Drug sensitive
Bis(helenalinyl)glutarate 336831 Drug sensitive
6-(4-Chlorophenyl)sulfanylquinazoline-2,4-diamine 328131 Drug sensitive
2,3-Dimethoxy-5-naphthalen-2-ylsulfanylcyclohexa-2,5-diene-1,4-dione 314728 Drug sensitive
Antimycin A3 245869 Drug sensitive
(2-Methoxy-9,10-dihydrophenanthren-3-yl)methyl-dimethyl-(phenylsulfanylmethyl)azanium;bromide 24200489 Drug sensitive
[(4E,6Z,10Z)-20,22-Dihydroxy-13,14,17-trimethoxy-4,8,10,12,16-pentamethyl-3-oxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18(22),19-hexaen-9-yl] carbamate 24199492 Drug sensitive
Antibiotic U 29135 24196291 Drug sensitive
7-Fluoro-2-benzoyl-3-trifluoromethylquioxaline 1,4-dioxide 23635154 Drug sensitive
Drostanolone propionate 224004 Drug sensitive
Kinetin riboside 20345 Drug resistant
Methyl 1,6,8,14a-tetrahydroxy-11-[(4-hydroxy-3,5-dimethoxy-6-methyloxan-2-yl)amino]-6a-methoxy-3-methyl-7,9,12,14-tetraoxo-5,6-dihydrobenzo[a]tetracene-2-carboxylate 197261 Drug sensitive
4-Chloro-5-(pyridin-2-ylthio)-3H-1,2-dithiole-3-thione 16766538 Drug sensitive
4H-1,3,2-Benzodioxastannin-4-one, 7-amino-2,2-diphenyl- 16683127 Drug sensitive
Dihydroartemisinin (mixture of alpha and beta isomers) 16399850 Drug sensitive
Triethyltin chloride 13820 Drug sensitive
Astrazon Orange R 135747272 Drug sensitive
(1R,2S,5S,8S,9S,17R,18R,21S,24R,26S,27S)-14-Chloro-5,15-dihydroxy-2,9,26-trimethyl-3,19,23,28-tetraoxaoctacyclo[16.9.1.118,27.01,5.02,24.08,17.09,14.021,26]nonacos-11-ene-4,10,22,29-tetrone 134715214 Drug sensitive
Melampodinin 11953936 Drug sensitive
Unii-C616DV5Y11 117587576 Drug sensitive
Cyanoaminopyranopyridine derivatives 11494577 Drug resistant
Unii-9JU14BJ5QG 109374088 Drug sensitive
Cladospirone bisepoxide 10316810 Drug sensitive
Fusariotoxin T-2 102515111 Drug sensitive
15,16-Dihydrocuracin A 101683509 Drug sensitive
(1S,3R,6R,12S,14R,15S,18R,19E,21Z,25R,26S,27R)-6,15-Dihydroxy-18-[(1R)-1-hydroxyethyl]-5,14,26-trimethylspiro[2,10,13,17,24-pentaoxapentacyclo[23.2.1.03,8.08,26.012,14]octacosa-4,19,21-triene-27,2'-oxirane]-11,23-dione 101307863 Drug sensitive
Chimaphilin 101211 Drug sensitive
(3Z,4R)-4-Hydroxy-3-[2-[(1S,3R)-3-[2-[(1S,3S,3'R,4S)-1-hydroxy-4,6,6-trimethylspiro[2,5-dioxabicyclo[2.2.2]octane-3,6'-oxane]-3'-yl]ethyl]-2,2-dimethyl-6-methylidenecyclohexyl]ethylidene]oxolan-2-one 101206903 Drug sensitive
1,4-benzenediamine (9ci), n-butyl-n'-phenyl- - Drug sensitive
1h-1,4,7-triazonine-1,4,7-triacetic acid, octahydro- - Drug sensitive
1h-1,4,7-triazonine-1,4-diacetic acid, octahydro- - Drug sensitive
1-piperidinecarbodithioic acid, antimony complex - Drug sensitive
4'-deoxy-13',17-dinitro-3',4'-epoxy-vincaleukoblastine - Drug sensitive
4-morpholinecarbodithioic acid, antimony complex - Drug sensitive
4-thiomorpholinecarbodithioic acid, antimony complex - Drug sensitive
7-n,n-dimethylamino brefeldin a hydrochloride - Drug sensitive
9h-purine, 2-amino-6-(2,4-dichlorobenzylthio)-9-isobutyl- - Drug sensitive
anthracen-9-one, 10-[(2-methoxyphenyl)methylene]- - Drug sensitive
benzamide, 5-bromo-2-hydroxy-n-[3-(trifluoromethyl)phenyl]- - Drug sensitive
benzonitrile, 2-amino-3,5-dinitro- (9ci) - Drug sensitive
cyclohexanone, 2,6-bis(piperidinomethyl)- - Drug sensitive
geldanamycin, n,n'-dimethyl - Drug sensitive
gold(1+), bis(trimethylphosphine)-, chloride - Drug sensitive
iodonium, (4-methoxyphenyl)(3-methylphenyl)-, bromide - Drug sensitive
roridin a, 8-hydroxy-9b,10b-epoxy- - Drug sensitive
uridine, 5-isobutyl-2'-deoxy- - Drug sensitive
(Z)-6-chloro-3-((2-(4-methoxyphenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive
1-[(2-phenylethoxy)methyl]-5-ethyl-6-(phenylseleno)uracil - Drug sensitive
2-(4-hydroxy-benzylidene)-2-(2-pyridyl)acetonitrile - Drug sensitive
9-(3-fluorobenzyl)-7-(3-fluorobenzyloxy)-2-(4-fluorobenzyl)-1-methyl-9H-beta-carbolinium bromide - Drug sensitive
antineoplastic-615538 - Drug sensitive
antineoplastic-644916 - Drug sensitive
bavachyaone - Drug sensitive
geldanamycin analog - Drug sensitive
isatin dr - Drug sensitive
thiadiazines - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-590-5p
Nicotine 89594 Drug interaction    RC00006067
Formaldehyde 712 Drug interaction    RC00006061
Gemcitabine 60750 Drug interaction    RC00006066
5-Fluorouracil 3385 Drug interaction    RC00006064
Doxorubicin 31703 Drug interaction    RC00006065
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00006063
Verapamil 2520 Drug interaction    RC00006062
Docetaxel 148124 Drug interaction    RC00006069
Ginsenoside Rh2 119307 Drug interaction    RC00006068
SIOP treatment protocol - Drug interaction    RC00006070
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-590-5p
Cisplatin 5702198       27757042
Paclitaxel 36314       27757042
Doxorubicin 31703       30111512

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-590-5p
Interactor2: FUBP1

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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