Basic Information:

  VIRBase ID:  

HHID00061057

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-590-5p:  MIMAT0003258          SORL1:  NM_003105     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-590-5p	SORL1
miRBase Accession/Entrez ID	MIMAT0003258	6653
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	C11orf32//gp250//LR11//LRP9//SORLA//SorLA-1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-590-5p	rs1554709898 chr7:74191225    A/G rs192756765 chr7:74191221    T/A rs781995768 chr7:74191223    A/G rs782101000 chr7:74191229    G/A rs189727189 chr7:74191216    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SORL1	chr11:121432874(+) A-I      intronic chr11:121431708(+) A-I      intronic chr11:121431724(+) A-I      intronic chr11:121431692(+) A-I      intronic chr11:121431691(+) A-I      intronic chr11:121432894(+) A-I      intronic chr11:121364194(+) A-I      intronic chr11:121431730(+) A-I      intronic chr11:121431742(+) A-I      intronic chr11:121431778(+) A-I      intronic chr11:121432854(+) A-I      intronic chr11:121432866(+) A-I      intronic chr11:121432858(+) A-I      intronic chr11:121432862(+) A-I      intronic chr11:121365816(+) A-I      intronic chr11:121455324(+) A-I      intronic chr11:121355738(+) A-I      intronic chr11:121407302(+) A-I      intronic chr11:121362931(+) A-I      intronic chr11:121357549(+) A-I      intronic chr11:121362894(+) A-I      intronic chr11:121407203(+) A-I      intronic chr11:121362886(+) A-I      intronic chr11:121362884(+) A-I      intronic chr11:121357370(+) A-I      intronic chr11:121355486(+) A-I      intronic chr11:121407391(+) A-I      intronic chr11:121403654(+) A-I      intronic chr11:121412155(+) A-I      intronic chr11:121399070(+) A-I      intronic chr11:121347557(+) A-I      intronic chr11:121347710(+) A-I      intronic chr11:121412156(+) A-I      intronic chr11:121403607(+) A-I      intronic chr11:121364066(+) A-I      intronic chr11:121362972(+) A-I      intronic chr11:121456112(+) A-I      intronic chr11:121455937(+) A-I      intronic chr11:121399957(+) A-I      intronic chr11:121400043(+) A-I      intronic chr11:121482783(+) A-I      intronic chr11:121357106(+) A-I      intronic chr11:121386590(+) A-I      intronic chr11:121357093(+) A-I      intronic chr11:121355494(+) A-I      intronic chr11:121361330(+) A-I      intronic chr11:121399088(+) A-I      intronic chr11:121374386(+) A-I      intronic chr11:121456180(+) A-I      intronic chr11:121456014(+) A-I      intronic chr11:121455538(+) A-I      intronic chr11:121413773(+) A-I      intronic chr11:121413753(+) A-I      intronic chr11:121412193(+) A-I      intronic chr11:121413745(+) A-I      intronic chr11:121347763(+) A-I      intronic chr11:121412180(+) A-I      intronic chr11:121412199(+) A-I      intronic chr11:121412153(+) A-I      intronic chr11:121411930(+) A-I      intronic chr11:121411203(+) A-I      intronic chr11:121407257(+) A-I      intronic chr11:121407227(+) A-I      intronic chr11:121403636(+) A-I      intronic chr11:121403481(+) A-I      intronic chr11:121400026(+) A-I      intronic chr11:121400012(+) A-I      intronic chr11:121403593(+) A-I      intronic chr11:121399945(+) A-I      intronic chr11:121389802(+) A-I      intronic chr11:121389726(+) A-I      intronic chr11:121347762(+) A-I      intronic chr11:121387693(+) A-I      intronic chr11:121374251(+) A-I      intronic chr11:121362889(+) A-I      intronic chr11:121373052(+) A-I      intronic chr11:121347626(+) A-I      intronic chr11:121373010(+) A-I      intronic chr11:121364240(+) A-I      intronic chr11:121364227(+) A-I      intronic chr11:121364046(+) A-I      intronic chr11:121363707(+) A-I      intronic chr11:121362976(+) A-I      intronic chr11:121362955(+) A-I      intronic chr11:121361326(+) A-I      intronic chr11:121455332(+) A-I      intronic chr11:121362949(+) A-I      intronic chr11:121375000(+) A-I      intronic chr11:121413777(+) A-I      intronic chr11:121413631(+) A-I      intronic chr11:121373044(+) A-I      intronic chr11:121407222(+) A-I      intronic chr11:121363077(+) A-I      intronic chr11:121375019(+) A-I      intronic chr11:121357115(+) A-I      intronic chr11:121362823(+) A-I      intronic chr11:121364228(+) A-I      intronic chr11:121431675(+) A-I      intronic chr11:121374237(+) A-I      intronic chr11:121411108(+) A-I      intronic chr11:121362793(+) A-I      intronic chr11:121344348(+) A-I      intronic chr11:121347631(+) A-I      intronic chr11:121456049(+) A-I      intronic chr11:121391041(+) A-I      intronic chr11:121482788(+) A-I      intronic chr11:121456179(+) A-I      intronic chr11:121403538(+) A-I      intronic chr11:121411176(+) A-I      intronic chr11:121374956(+) A-I      intronic chr11:121374378(+) A-I      intronic chr11:121362815(+) A-I      intronic chr11:121348621(+) A-I      intronic chr11:121432908(+) A-I      intronic chr11:121431645(+) A-I      intronic chr11:121363872(+) A-I      intronic chr11:121399077(+) A-I      intronic chr11:121407379(+) A-I      intronic chr11:121374903(+) A-I      intronic chr11:121400391(+) A-I      intronic chr11:121361339(+) A-I      intronic chr11:121448269(+) A-I      intronic chr11:121343445(+) A-I      intronic chr11:121496787(+) A-I      intronic chr11:121373632(+) A-I      intronic chr11:121362923(+) A-I      intronic chr11:121432838(+) A-I      intronic chr11:121403576(+) A-I      intronic chr11:121403446(+) A-I      intronic chr11:121411929(+) A-I      intronic chr11:121364024(+) A-I      intronic chr11:121403534(+) A-I      intronic chr11:121364095(+) A-I      intronic chr11:121341526(+) A-I      intronic chr11:121431640(+) A-I      intronic chr11:121496780(+) A-I      intronic chr11:121403464(+) A-I      intronic chr11:121456028(+) A-I      intronic chr11:121362814(+) A-I      intronic chr11:121431641(+) A-I      intronic chr11:121374249(+) A-I      intronic chr11:121373779(+) A-I      intronic chr11:121347753(+) A-I      intronic chr11:121455951(+) A-I      intronic chr11:121411131(+) A-I      intronic chr11:121341581(+) A-I      intronic chr11:121364149(+) A-I      intronic chr11:121357149(+) A-I      intronic chr11:121412011(+) A-I      intronic chr11:121364146(+) A-I      intronic chr11:121448268(+) A-I      intronic chr11:121403573(+) A-I      intronic chr11:121413910(+) A-I      intronic chr11:121413779(+) A-I      intronic chr11:121361357(+) A-I      intronic chr11:121391034(+) A-I      intronic chr11:121470133(+) A-I      intronic chr11:121373036(+) A-I      intronic chr11:121374299(+) A-I      intronic chr11:121496779(+) A-I      intronic chr11:121362820(+) A-I      intronic chr11:121456011(+) A-I      intronic chr11:121391035(+) A-I      intronic chr11:121407308(+) A-I      intronic chr11:121403655(+) A-I      intronic chr11:121357306(+) A-I      intronic chr11:121448359(+) A-I      intronic chr11:121413632(+) A-I      intronic chr11:121398996(+) A-I      intronic chr11:121372876(+) A-I      intronic chr11:121363800(+) A-I      intronic chr11:121390900(+) A-I      intronic chr11:121374974(+) A-I      intronic chr11:121403532(+) A-I      intronic chr11:121434367(+) A-I      intronic chr11:121374868(+) A-I      intronic chr11:121411130(+) A-I      intronic chr11:121411166(+) A-I      intronic chr11:121347640(+) A-I      intronic chr11:121391112(+) A-I      intronic chr11:121407248(+) A-I      intronic chr11:121400385(+) A-I      intronic chr11:121347673(+) A-I      intronic chr11:121364157(+) A-I      intronic chr11:121347554(+) A-I      intronic chr11:121362860(+) A-I      intronic chr11:121403448(+) A-I      intronic chr11:121362959(+) A-I      intronic chr11:121446900(+) A-I      intronic chr11:121496784(+) A-I      intronic chr11:121363821(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SORL1	chr11:121496784(+) A-I intron -    22327324 chr11:121503149(+) A-I intron -    22327324 chr11:121391034(+) A-G intron -    22484847 chr11:121391035(+) A-G intron -    22484847 chr11:121448269(+) A-G intron -    22484847 chr11:121357549(+) A-G intron -    22484847 chr11:121403538(+) A-G intron -    22484847 chr11:121407308(+) A-G intron -    22484847 chr11:121412156(+) A-G intron -    22484847 chr11:121412180(+) A-G intron -    22484847 chr11:121482788(+) A-G intron -    22484847 chr11:121431641(+) A-G intron -    22484847 chr11:121496784(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SORL1	chr11:121323321-121323322(+) m6A CDS//exon       27371828 chr11:121448067-121448068(+) m6A CDS       - chr11:121448082-121448083(+) m6A CDS       - chr11:121483352-121483353(+) m6A exon//intron       - chr11:121483463-121483464(+) m6A CDS//exon       - chr11:121483504-121483505(+) m6A CDS//exon       - chr11:121483511-121483512(+) m6A CDS//exon       - chr11:121485629-121485630(+) m6A CDS//exon       - chr11:121485725-121485726(+) m6A CDS//exon       - chr11:121485746-121485747(+) m6A CDS//exon       - chr11:121500391-121500392(+) m6A 3'UTR//exon//intron       27773535 chr11:121500398-121500399(+) m6A 3'UTR//exon//intron       27773535 chr11:121500434-121500435(+) m6A 3'UTR//intron       27773535 chr11:121500456-121500457(+) m6A 3'UTR//intron       27773535 chr11:121500463-121500464(+) m6A 3'UTR//intron       27773535 chr11:121501392-121501393(+) m6A 3'UTR//intron       - chr11:121501440-121501441(+) m6A 3'UTR//intron       - chr11:121501503-121501504(+) m6A 3'UTR//intron       - chr11:121501554-121501555(+) m6A 3'UTR//intron       - chr11:121503878-121503879(+) m6A 3'UTR       26404942 chr11:121504073-121504074(+) m6A 3'UTR       26404942 chr11:121504114-121504115(+) m6A 3'UTR       24981863//26404942 chr11:121504127-121504128(+) m6A 3'UTR       24981863//26404942 chr11:121504137-121504138(+) m6A 3'UTR       24981863//26404942 chr11:121504203-121504204(+) m6A 3'UTR       26404942//27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-590-5p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome B cell line (Raji)|Primary dendritic cells|T cell line (J77)     21505438 Exosome Human mast cell line (HMC-1)     24009880 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Follicular fluid     23666971 Microvesicle Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Neural progenitor cells     21363885
	SORL1	Cytosol HCC cell line (HepG2)     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-590-5p	Sensorad 99342 Drug sensitive Gardenin B 96539 Drug sensitive 2,5-Dimethyl-1,4-benzoquinone 8718 Drug sensitive Acid Green 27 80837 Drug sensitive Morpholine-N-dithiocarbamate 72675 Drug sensitive Berberine iodide 72350 Drug sensitive Sulbentine 67686 Drug sensitive Laurolinium acetate 67354 Drug sensitive Dihydroartemisinyl ether, stereoisomer of NSC-685989 6712439 Drug sensitive Acnistin F 6712173 Drug sensitive Verrucarin A 6326658 Drug sensitive Verrucarin A, 3'-(acetyloxy)-7'-deoxo-2'-deoxy-4'-hydroxy-7'-(1-hydroxyethyl)- 5933240 Drug sensitive 8B-Hydroxy-9B,10B-epoxyverrucarin A 5477536 Drug sensitive Caracemide 54747 Drug sensitive Artelasticin 5471311 Drug sensitive (Z)-1-Iodo-2-phenyl-1-penten-3-one 5468684 Drug sensitive 3,19-(4-Acetamido)benzylidineandrographolide 54612901 Drug sensitive Herveline O 5459269 Drug sensitive Cuspidatin C 5459164 Drug sensitive Thiram 5455 Drug sensitive (E)-1-(2,5-Dihydroxyphenyl)ethene-2-isonitrile 5388136 Drug sensitive (1E,4E)-1,5-Dipyridin-3-ylpenta-1,4-dien-3-one 5382674 Drug sensitive Ovatifolin acetate 5358419 Drug sensitive Indanthren Corinth RK 5351878 Drug sensitive Herbimycin 5311102 Drug sensitive Vorinostat 5311 Drug sensitive 6-Methoxy-7-(2lambda(5)-1,2-triazadienyl)-5,8-quinolinedione 494043 Drug sensitive Asimicinone 393461 Drug sensitive 2-(1-Propynyl)estradiol 388008 Drug sensitive Acetic acid,4,7,10-tetraazacyclododecane-1,7-diyl]bis 387352 Drug sensitive 4-Phenacyloxychromen-2-one 386272 Drug resistant (-)7,8-Dihydrocalanolide A 383107 Drug sensitive 1-Azido-2-phenyl-3-phenalenone 381891 Drug sensitive (1R)-3,3-Dibromocamphor 376765 Drug sensitive 3,8-Dimethyl-1,2-naphthoquinone 373912 Drug sensitive Antineoplastic-645804 371505 Drug sensitive 1-(4-Methoxy-2-methylphenyl)naphtho[1,2-c]furan-3(1H)-one 369148 Drug sensitive Aplidazole C . TFA 362402 Drug sensitive Thiosangivamycin 3580213 Drug sensitive Bis(helenalinyl)glutarate 336831 Drug sensitive 6-(4-Chlorophenyl)sulfanylquinazoline-2,4-diamine 328131 Drug sensitive 2,3-Dimethoxy-5-naphthalen-2-ylsulfanylcyclohexa-2,5-diene-1,4-dione 314728 Drug sensitive Antimycin A3 245869 Drug sensitive (2-Methoxy-9,10-dihydrophenanthren-3-yl)methyl-dimethyl-(phenylsulfanylmethyl)azanium;bromide 24200489 Drug sensitive [(4E,6Z,10Z)-20,22-Dihydroxy-13,14,17-trimethoxy-4,8,10,12,16-pentamethyl-3-oxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18(22),19-hexaen-9-yl] carbamate 24199492 Drug sensitive Antibiotic U 29135 24196291 Drug sensitive 7-Fluoro-2-benzoyl-3-trifluoromethylquioxaline 1,4-dioxide 23635154 Drug sensitive Drostanolone propionate 224004 Drug sensitive Kinetin riboside 20345 Drug resistant Methyl 1,6,8,14a-tetrahydroxy-11-[(4-hydroxy-3,5-dimethoxy-6-methyloxan-2-yl)amino]-6a-methoxy-3-methyl-7,9,12,14-tetraoxo-5,6-dihydrobenzo[a]tetracene-2-carboxylate 197261 Drug sensitive 4-Chloro-5-(pyridin-2-ylthio)-3H-1,2-dithiole-3-thione 16766538 Drug sensitive 4H-1,3,2-Benzodioxastannin-4-one, 7-amino-2,2-diphenyl- 16683127 Drug sensitive Dihydroartemisinin (mixture of alpha and beta isomers) 16399850 Drug sensitive Triethyltin chloride 13820 Drug sensitive Astrazon Orange R 135747272 Drug sensitive (1R,2S,5S,8S,9S,17R,18R,21S,24R,26S,27S)-14-Chloro-5,15-dihydroxy-2,9,26-trimethyl-3,19,23,28-tetraoxaoctacyclo[16.9.1.118,27.01,5.02,24.08,17.09,14.021,26]nonacos-11-ene-4,10,22,29-tetrone 134715214 Drug sensitive Melampodinin 11953936 Drug sensitive Unii-C616DV5Y11 117587576 Drug sensitive Cyanoaminopyranopyridine derivatives 11494577 Drug resistant Unii-9JU14BJ5QG 109374088 Drug sensitive Cladospirone bisepoxide 10316810 Drug sensitive Fusariotoxin T-2 102515111 Drug sensitive 15,16-Dihydrocuracin A 101683509 Drug sensitive (1S,3R,6R,12S,14R,15S,18R,19E,21Z,25R,26S,27R)-6,15-Dihydroxy-18-[(1R)-1-hydroxyethyl]-5,14,26-trimethylspiro[2,10,13,17,24-pentaoxapentacyclo[23.2.1.03,8.08,26.012,14]octacosa-4,19,21-triene-27,2'-oxirane]-11,23-dione 101307863 Drug sensitive Chimaphilin 101211 Drug sensitive (3Z,4R)-4-Hydroxy-3-[2-[(1S,3R)-3-[2-[(1S,3S,3'R,4S)-1-hydroxy-4,6,6-trimethylspiro[2,5-dioxabicyclo[2.2.2]octane-3,6'-oxane]-3'-yl]ethyl]-2,2-dimethyl-6-methylidenecyclohexyl]ethylidene]oxolan-2-one 101206903 Drug sensitive 1,4-benzenediamine (9ci), n-butyl-n'-phenyl- - Drug sensitive 1h-1,4,7-triazonine-1,4,7-triacetic acid, octahydro- - Drug sensitive 1h-1,4,7-triazonine-1,4-diacetic acid, octahydro- - Drug sensitive 1-piperidinecarbodithioic acid, antimony complex - Drug sensitive 4'-deoxy-13',17-dinitro-3',4'-epoxy-vincaleukoblastine - Drug sensitive 4-morpholinecarbodithioic acid, antimony complex - Drug sensitive 4-thiomorpholinecarbodithioic acid, antimony complex - Drug sensitive 7-n,n-dimethylamino brefeldin a hydrochloride - Drug sensitive 9h-purine, 2-amino-6-(2,4-dichlorobenzylthio)-9-isobutyl- - Drug sensitive anthracen-9-one, 10-[(2-methoxyphenyl)methylene]- - Drug sensitive benzamide, 5-bromo-2-hydroxy-n-[3-(trifluoromethyl)phenyl]- - Drug sensitive benzonitrile, 2-amino-3,5-dinitro- (9ci) - Drug sensitive cyclohexanone, 2,6-bis(piperidinomethyl)- - Drug sensitive geldanamycin, n,n'-dimethyl - Drug sensitive gold(1+), bis(trimethylphosphine)-, chloride - Drug sensitive iodonium, (4-methoxyphenyl)(3-methylphenyl)-, bromide - Drug sensitive roridin a, 8-hydroxy-9b,10b-epoxy- - Drug sensitive uridine, 5-isobutyl-2'-deoxy- - Drug sensitive (Z)-6-chloro-3-((2-(4-methoxyphenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive 1-[(2-phenylethoxy)methyl]-5-ethyl-6-(phenylseleno)uracil - Drug sensitive 2-(4-hydroxy-benzylidene)-2-(2-pyridyl)acetonitrile - Drug sensitive 9-(3-fluorobenzyl)-7-(3-fluorobenzyloxy)-2-(4-fluorobenzyl)-1-methyl-9H-beta-carbolinium bromide - Drug sensitive antineoplastic-615538 - Drug sensitive antineoplastic-644916 - Drug sensitive bavachyaone - Drug sensitive geldanamycin analog - Drug sensitive isatin dr - Drug sensitive thiadiazines - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-590-5p	Nicotine 89594 Drug interaction    RC00006067 Formaldehyde 712 Drug interaction    RC00006061 Gemcitabine 60750 Drug interaction    RC00006066 5-Fluorouracil 3385 Drug interaction    RC00006064 Doxorubicin 31703 Drug interaction    RC00006065 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00006063 Verapamil 2520 Drug interaction    RC00006062 Docetaxel 148124 Drug interaction    RC00006069 Ginsenoside Rh2 119307 Drug interaction    RC00006068 SIOP treatment protocol - Drug interaction    RC00006070

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-590-5p	Cisplatin 5702198       27757042 Paclitaxel 36314       27757042 Doxorubicin 31703       30111512

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-590-5p
Interactor2: SORL1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.