Detail Information

Basic Information:


  VIRBase ID:  

HHID00061034

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-550a-3p:           TMED7:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-550a-3p TMED7
miRBase
Accession/Entrez ID		 MIMAT0003257 51014
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CGI-109//p24g3//p24gamma3//p27

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-550a-3p
rs1317042321 chr7:30289866    T/G
rs752029293 chr7:30289865    C/A
rs752029293 chr7:30289865    C/T
rs753579908 chr7:30289854    T/C
rs753579908 chr7:30289854    T/G
rs754718902 chr7:30289863    C/T
rs757638598 chr7:30289867    C/A
rs758569467 chr7:30289864    C/T
rs1397804079 chr7:32733052    C/T
rs1480179700 chr7:32733041    T/G
rs753385000 chr7:32733050    C/A
rs753385000 chr7:32733050    C/T
rs754544327 chr7:32733054    C/A
rs754544327 chr7:32733054    C/T
rs1160138379 chr7:29680769    A/C
rs1215839225 chr7:29680759    G/A
rs1233742150 chr7:29680750    G/A
rs1243746933 chr7:29680751    T/C
rs1351185254 chr7:29680757    A/T
rs1438993790 chr7:29680755    T/G
rs748269356 chr7:29680760    G/A
rs748269356 chr7:29680760    G/T
rs1167859973 chr7:30289855    G/GC
rs1287422791 chr7:30289855    G/A
rs1355964080 chr7:30289857    C/A
rs1355964080 chr7:30289857    C/G
rs1170862899 chr7:32733042    G/GC
rs1284798696 chr7:29680764    A/G
rs1402487721 chr7:29680768    CA/C
rs1405896278 chr7:29680766    G/C
rs773402038 chr7:29680767    A/T

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TMED7
chr5:114950536-114950537(-) m6A 3'UTR       26404942
chr5:114951186-114951187(-) m6A 3'UTR       26404942//27773535
chr5:114951224-114951225(-) m6A 3'UTR       26404942//27773535
chr5:114951273-114951274(-) m6A 3'UTR       27773535
chr5:114951319-114951320(-) m6A 3'UTR       27773535
chr5:114951347-114951348(-) m6A 3'UTR       27773535
chr5:114951474-114951475(-) m6A 3'UTR       27773535
chr5:114951488-114951489(-) m6A 3'UTR       27773535
chr5:114951545-114951546(-) Y 3'UTR       25219674
chr5:114951554-114951555(-) m6A 3'UTR       27773535
chr5:114951588-114951589(-) m6A 3'UTR       24981863//26404942//27773535
chr5:114951622-114951623(-) m6A 3'UTR       24209618//24981863//26404942//27773535//22608085
chr5:114951708-114951709(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr5:114951716-114951717(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr5:114951746-114951747(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr5:114951758-114951759(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr5:114951831-114951832(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr5:114951931-114951932(-) m6A CDS//exon       24284625//24209618//24981863//26404942//22608085
chr5:114952084-114952085(-) m6A CDS//exon       24284625//24981863//26404942
chr5:114956153-114956154(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22608085
chr5:114956177-114956178(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr5:114956208-114956209(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr5:114956256-114956257(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr5:114956296-114956297(-) m6A CDS//exon       24284625//24981863//26404942//27773535//22608085
chr5:114961334-114961335(-) m6A CDS//intron       24284625//27773535
chr5:114961399-114961400(-) m6A CDS//intron       27773536
chr5:114961539-114961540(-) m6A 5'UTR//intron       27773536//22575960
chr5:114961609-114961610(-) m6A 5'UTR//exon       24284625//24981863//27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-550a-3p
Exosome Jurkat-derived T cell line (J77cl20)     21505438
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Colon cancer cell line (LIM1863)     -
TMED7
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Membrane K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-550a-3p
Formaldehyde 712 Drug interaction    RC00006058
Bromocriptine 31101 Drug interaction    RC00006059
Ginsenoside Rh2 119307 Drug interaction    RC00006060
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-550a-3p
5-Fluorouracil 3385       25356050

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-550a-3p
Interactor2: TMED7

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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