Basic Information:

  VIRBase ID:  

HHID00061020

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-548a-3p:  MIMAT0003251          SFT2D2:  NM_199344     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-548a-3p	SFT2D2
miRBase Accession/Entrez ID	MIMAT0003251	375035
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	dJ747L4.C1.2//UNQ512

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-548a-3p	rs1164461265 chr6:18571854    A/G rs1165672383 chr6:18571864    G/C rs1367516995 chr6:18571852    G/A rs1452081761 chr6:18571844    C/T rs1456125774 chr6:18571853    C/A rs371324260 chr6:18571856    T/TTAC rs745784846 chr6:18571855    AT/A rs753232100 chr6:18571865    C/T rs765730274 chr6:18571860    T/G rs1029034755 chr6:135239228    G/T rs1178036684 chr6:135239234    A/T rs1395774538 chr6:135239235    C/T rs373439066 chr6:135239231    A/C rs373439066 chr6:135239231    A/G rs1181589874 chr8:104484390    G/T rs1328816266 chr8:104484397    C/T rs552025667 chr8:104484394    T/C rs746672467 chr8:104484389    A/T rs766393197 chr8:104484388    A/G rs769687902 chr8:104484405    G/A rs769687902 chr8:104484405    G/T rs1177955102 chr6:18571847    A/G rs1178800173 chr6:18571851    G/C rs1236087532 chr6:18571849    C/A rs1236087532 chr6:18571849    C/T rs1441316829 chr6:18571850    T/C rs1441316829 chr6:18571850    T/G rs970024181 chr6:18571848    A/T rs1252922886 chr6:135239223    A/T rs1309130208 chr8:104484401    T/A rs1375898875 chr8:104484398    C/G rs745714043 chr8:104484402    T/A rs776399840 chr8:104484399    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SFT2D2	chr1:168209989(+) A-I      intronic chr1:168209897(+) A-I      intronic chr1:168209990(+) A-I      intronic chr1:168209896(+) A-I      intronic chr1:168209948(+) A-I      intronic chr1:168209964(+) A-I      intronic chr1:168209991(+) A-I      intronic chr1:168210515(+) A-I      intronic chr1:168209889(+) A-I      intronic chr1:168209230(+) A-I      intronic chr1:168209260(+) A-I      intronic chr1:168196157(+) A-I      intronic chr1:168209894(+) A-I      intronic chr1:168209256(+) A-I      intronic chr1:168209158(+) A-I      intronic chr1:168196184(+) A-I      intronic chr1:168196170(+) A-I      intronic chr1:168196158(+) A-I      intronic chr1:168209254(+) A-I      intronic chr1:168207645(+) A-I      intronic chr1:168209998(+) A-I      intronic chr1:168209259(+) A-I      intronic chr1:168209253(+) A-I      intronic chr1:168209994(+) A-I      intronic chr1:168209992(+) A-I      intronic chr1:168210000(+) A-I      intronic chr1:168209427(+) A-I      intronic chr1:168209884(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SFT2D2	chr1:168196066(+) C-T intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SFT2D2	chr1:168195306-168195307(+) m6A 5'UTR//exon       24284625//25456834//24981863//22608085 chr1:168195321-168195322(+) m6A CDS//exon       24284625//25456834//24981863//22608085 chr1:168195332-168195333(+) m1A CDS//exon       26863196 chr1:168195351-168195352(+) m6A CDS//exon       24284625//25456834//24981863//22608085 chr1:168195360-168195361(+) m6A CDS//exon       24284625//25456834//24981863//22608085 chr1:168205963-168205964(+) m6A CDS//exon       24284625 chr1:168211817-168211818(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085 chr1:168211831-168211832(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085 chr1:168211854-168211855(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085 chr1:168211869-168211870(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085 chr1:168211913-168211914(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr1:168211954-168211955(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr1:168212070-168212071(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr1:168212164-168212165(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085 chr1:168212255-168212256(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085 chr1:168212274-168212275(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085 chr1:168214406-168214407(+) m6A 3'UTR       24981863 chr1:168214442-168214443(+) m6A 3'UTR       24981863 chr1:168221522-168221523(+) m6A 3'UTR       24981863//26404942 chr1:168221532-168221533(+) m6A 3'UTR       24981863//26404942 chr1:168221543-168221544(+) m6A 3'UTR       24981863//26404942 chr1:168221567-168221568(+) m6A 3'UTR       24284625//24981863//26404942 chr1:168221580-168221581(+) m6A 3'UTR       24284625//24981863//26404942 chr1:168221611-168221612(+) m6A 3'UTR       24284625//24981863//26404942

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-548a-3p	Exosome Pooled sera     27278097 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Follicular fluid     23666971 Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	SFT2D2	Cytosol K562 cells     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-548a-3p
Interactor2: SFT2D2

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.