Detail Information

Basic Information:


  VIRBase ID:  

HHID00061004

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-548a-3p:           SESN1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-548a-3p SESN1
miRBase
Accession/Entrez ID		 MIMAT0003251 27244
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - PA26//SEST1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-548a-3p
rs1164461265 chr6:18571854    A/G
rs1165672383 chr6:18571864    G/C
rs1367516995 chr6:18571852    G/A
rs1452081761 chr6:18571844    C/T
rs1456125774 chr6:18571853    C/A
rs371324260 chr6:18571856    T/TTAC
rs745784846 chr6:18571855    AT/A
rs753232100 chr6:18571865    C/T
rs765730274 chr6:18571860    T/G
rs1029034755 chr6:135239228    G/T
rs1178036684 chr6:135239234    A/T
rs1395774538 chr6:135239235    C/T
rs373439066 chr6:135239231    A/C
rs373439066 chr6:135239231    A/G
rs1181589874 chr8:104484390    G/T
rs1328816266 chr8:104484397    C/T
rs552025667 chr8:104484394    T/C
rs746672467 chr8:104484389    A/T
rs766393197 chr8:104484388    A/G
rs769687902 chr8:104484405    G/A
rs769687902 chr8:104484405    G/T
rs1177955102 chr6:18571847    A/G
rs1178800173 chr6:18571851    G/C
rs1236087532 chr6:18571849    C/A
rs1236087532 chr6:18571849    C/T
rs1441316829 chr6:18571850    T/C
rs1441316829 chr6:18571850    T/G
rs970024181 chr6:18571848    A/T
rs1252922886 chr6:135239223    A/T
rs1309130208 chr8:104484401    T/A
rs1375898875 chr8:104484398    C/G
rs745714043 chr8:104484402    T/A
rs776399840 chr8:104484399    A/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR SESN1
chr6:109395385(-) A-I      intronic
chr6:109395346(-) A-I      intronic
chr6:109395341(-) A-I      intronic
chr6:109395324(-) A-I      intronic
chr6:109316953(-) A-I      intronic
chr6:109316901(-) A-I      intronic
chr6:109395414(-) A-I      intronic
chr6:109395406(-) A-I      intronic
chr6:109395403(-) A-I      intronic
chr6:109402463(-) A-I      intronic
chr6:109342844(-) A-I      intronic
chr6:109342824(-) A-I      intronic
chr6:109383325(-) A-I      intronic
chr6:109333096(-) A-I      intronic
chr6:109412097(-) A-I      intronic
chr6:109406665(-) A-I      intronic
chr6:109405638(-) A-I      intronic
chr6:109333083(-) A-I      intronic
chr6:109316902(-) A-I      intronic
chr6:109353375(-) A-I      intronic
chr6:109342815(-) A-I      intronic
chr6:109339199(-) A-I      intronic
chr6:109338761(-) A-I      intronic
chr6:109338666(-) A-I      intronic
chr6:109338660(-) A-I      intronic
chr6:109338659(-) A-I      intronic
chr6:109338627(-) A-I      intronic
chr6:109402464(-) A-I      intronic
chr6:109333105(-) A-I      intronic
chr6:109342838(-) A-I      intronic
chr6:109383343(-) A-I      intronic
chr6:109402396(-) A-I      intronic
chr6:109312717(-) A-I      intronic
chr6:109362127(-) A-I      intronic
chr6:109333082(-) A-I      intronic
chr6:109407426(-) A-I      intronic
chr6:109353353(-) A-I      intronic
chr6:109316951(-) A-I      intronic
chr6:109361980(-) A-I      intronic
chr6:109332934(-) A-I      intronic
chr6:109334219(-) A-I      intronic
chr6:109316943(-) A-I      intronic
chr6:109316935(-) A-I      intronic
chr6:109407432(-) A-I      intronic
chr6:109357006(-) A-I      intronic
chr6:109356993(-) A-I      intronic
chr6:109356942(-) A-I      intronic
chr6:109353374(-) A-I      intronic
chr6:109353363(-) A-I      intronic
chr6:109407396(-) A-I      intronic
chr6:109350930(-) A-I      intronic
chr6:109350911(-) A-I      intronic
chr6:109350909(-) A-I      intronic
chr6:109350906(-) A-I      intronic
chr6:109348219(-) A-I      intronic
chr6:109348181(-) A-I      intronic
chr6:109348163(-) A-I      intronic
chr6:109338669(-) A-I      intronic
chr6:109366114(-) A-I      intronic
chr6:109382998(-) A-I      intronic
chr6:109390860(-) A-I      intronic
chr6:109412137(-) A-I      intronic
chr6:109350901(-) A-I      intronic
chr6:109333111(-) A-I      intronic
chr6:109350855(-) A-I      intronic
chr6:109361952(-) A-I      intronic
chr6:109315973(-) A-I      intronic
chr6:109365261(-) A-I      intronic
chr6:109365418(-) A-I      intronic
chr6:109377525(-) A-I      intronic
chr6:109408287(-) A-I      intronic
chr6:109412161(-) A-I      intronic
chr6:109412062(-) A-I      intronic
chr6:109350885(-) A-I      intronic
chr6:109315243(-) A-I      intronic
chr6:109412089(-) A-I      intronic
chr6:109343659(-) A-I      intronic
chr6:109334160(-) A-I      intronic
chr6:109348111(-) A-I      intronic
chr6:109347846(-) A-I      intronic
chr6:109347836(-) A-I      intronic
chr6:109383339(-) A-I      intronic
chr6:109338760(-) A-I      intronic
chr6:109343782(-) A-I      intronic
chr6:109362503(-) A-I      intronic
chr6:109412000(-) A-I      intronic
chr6:109316954(-) A-I      intronic
chr6:109342895(-) A-I      intronic
chr6:109350984(-) A-I      intronic
chr6:109316846(-) A-I      intronic
chr6:109334073(-) A-I      intronic
chr6:109357057(-) A-I      intronic
chr6:109366104(-) A-I      intronic
chr6:109407454(-) A-I      intronic
chr6:109342288(-) A-I      intronic
chr6:109334197(-) A-I      intronic
chr6:109343781(-) A-I      intronic
chr6:109412257(-) A-I      intronic
chr6:109362332(-) A-I      intronic
chr6:109362335(-) A-I      intronic
chr6:109412064(-) A-I      intronic
chr6:109316980(-) A-I      intronic
chr6:109365275(-) A-I      intronic
chr6:109312610(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED SESN1
chr6:109316980(-) A-I intron -    21960545
chr6:109395321(-) A-G intron -    22484847
chr6:109398227(-) A-G intron -    22484847
chr6:109316104(-) G-T intron -    22484847
chr6:109338669(-) A-G intron -    22484847
chr6:109338760(-) A-G intron -    22484847
chr6:109347836(-) A-G intron -    22484847
chr6:109348108(-) C-T intron -    22484847
chr6:109348111(-) A-G intron -    22484847
chr6:109362483(-) A-G intron -    22484847
chr6:109362503(-) A-G intron -    22484847
chr6:109382998(-) A-G intron -    22484847
chr6:109383339(-) A-G intron -    22484847
chr6:109402448(-) A-G intron -    22484847
chr6:109407344(-) A-G intron -    22484847
chr6:109407454(-) A-G intron -    22484847
chr6:109412137(-) A-G intron -    22484847
chr6:109412161(-) A-G intron -    22484847
chr6:109412177(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SESN1
chr6:109307751-109307752(-) m6A 3'UTR       27773535
chr6:109308277-109308278(-) m6A 3'UTR       27773535//22608085
chr6:109308395-109308396(-) m6A 3'UTR       24981863//27773535//22608085
chr6:109308537-109308538(-) m6A 3'UTR       22608085
chr6:109308593-109308594(-) m6A 3'UTR       24284625//22608085
chr6:109308657-109308658(-) m6A 3'UTR       27773535//22608085
chr6:109308668-109308669(-) m6A 3'UTR       27773535//22608085
chr6:109308788-109308789(-) m6A CDS       27773535
chr6:109311874-109311875(-) m6A CDS//exon       26404942
chr6:109315788-109315789(-) Y CDS//exon       26075521
chr6:109321330-109321331(-) m6A exon//intron       27773535
chr6:109415143-109415144(-) m6A CDS//exon       24981863//27773535//22608085
chr6:109415170-109415171(-) m6A CDS//exon       24981863//27773535//22608085
chr6:109415185-109415186(-) m6A CDS       25456834//24981863//27773535//27371828//22608085
chr6:109415196-109415197(-) m6A CDS       25456834//24981863//27773535//27371828//22608085
chr6:109415209-109415210(-) m6A CDS       25456834//24981863//27773535//27371828//22608085
chr6:109415240-109415241(-) m6A CDS       24284625//25456834//24981863//27773535//27371828//22608085
chr6:109415284-109415285(-) m6A 5'UTR       24209618//24981863//27773535//27371828//22608085
chr6:109415298-109415299(-) m6A 5'UTR       24209618//24981863//27773535//27371828//22608085
chr6:109415490-109415491(-) m6A 5'UTR       25456834//24981863//27371828//22608085
chr6:109415512-109415513(-) m6A 5'UTR       25456834//24981863//27371828//22608085
chr6:109415688-109415689(-) m6A 5'UTR       25456834//27371828//27773536//22608085
chr6:109415705-109415706(-) m6A 5'UTR       25456834//27371828//27773536//22608085
chr6:109415746-109415747(-) m6A 5'UTR       25456834//27371828//27773536//22608085
chr6:109415870-109415871(-) m6A 5'UTR       27773536
chr6:109415886-109415887(-) m6A 5'UTR       27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-548a-3p
Exosome Pooled sera     27278097
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Follicular fluid     23666971
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
SESN1
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Membrane HCC cell line (HepG2)|K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-548a-3p
Interactor2: SESN1

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region CDS
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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