Basic Information:

  VIRBase ID:  

HHID00060748

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-579-3p:  MIMAT0003244          MBD6:  NM_052897     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-579-3p	MBD6
miRBase Accession/Entrez ID	MIMAT0003244	114785
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-579-3p	rs1165224671 chr5:32394404    T/C rs1190752232 chr5:32394395    C/T rs1404190650 chr5:32394401    T/C rs1412824363 chr5:32394357    AAAGACCATAGACTGTAGTAAGTTGATGCAAAAATAATCGCGG/A rs1415619084 chr5:32394406    C/T rs376231726 chr5:32394397    C/T rs768681140 chr5:32394396    G/A rs939936972 chr5:32394398    G/A rs1487016067 chr5:32394410    A/T

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MBD6	chr12:57916781-57916782(+) m6A 5'UTR//intron       24284625 chr12:57917842-57917843(+) m6A 5'UTR//exon//intron       - chr12:57917847-57917848(+) m6A 5'UTR//exon//intron       - chr12:57917899-57917900(+) m6A 5'UTR//intron       - chr12:57919251-57919252(+) m6A CDS//intron       24981863 chr12:57919520-57919521(+) m6A CDS//intron       24284625//24209618//24981863 chr12:57919854-57919855(+) m6A CDS//intron       24284625 chr12:57919897-57919898(+) m6A CDS//intron       24284625 chr12:57920001-57920002(+) m6A CDS//intron       24284625 chr12:57920140-57920141(+) m6A CDS       - chr12:57921991-57921992(+) m6A CDS       24284625 chr12:57922114-57922115(+) m6A CDS       24284625//24981863 chr12:57922205-57922206(+) m6A CDS       - chr12:57922225-57922226(+) m6A CDS       - chr12:57922250-57922251(+) m6A CDS       - chr12:57922335-57922336(+) m6A CDS       - chr12:57922739-57922740(+) m6A CDS       24284625 chr12:57922760-57922761(+) m6A CDS       24284625 chr12:57922773-57922774(+) m6A CDS       24284625 chr12:57922991-57922992(+) m6A CDS       24284625 chr12:57923004-57923005(+) m6A CDS       24284625 chr12:57923105-57923106(+) m6A 3'UTR       24284625//24209618//25456834//24981863 chr12:57923264-57923265(+) Y 3'UTR//intron       26075521 chr12:57923413-57923414(+) m6A 3'UTR//intron       27773535 chr12:57923569-57923570(+) m6A 3'UTR//intron       - chr12:57923820-57923821(+) m6A 3'UTR       27773535 chr12:57923825-57923826(+) m6A 3'UTR       27773535 chr12:57923891-57923892(+) m6A 3'UTR       27773535 chr12:57923925-57923926(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-579-3p	Exosome Lung adenocarcinoma epithelial cell line (A549)     20615901 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Fibroblasts|Mesenchymal stem cells     -
	MBD6	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-579-3p
Interactor2: MBD6

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.