Basic Information:

  VIRBase ID:  

HHID00060744

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-579-3p:  MIMAT0003244          TET2:  NM_017628     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-579-3p	TET2
miRBase Accession/Entrez ID	MIMAT0003244	54790
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	IMD75//KIAA1546//MDS

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-579-3p	rs1165224671 chr5:32394404    T/C rs1190752232 chr5:32394395    C/T rs1404190650 chr5:32394401    T/C rs1412824363 chr5:32394357    AAAGACCATAGACTGTAGTAAGTTGATGCAAAAATAATCGCGG/A rs1415619084 chr5:32394406    C/T rs376231726 chr5:32394397    C/T rs768681140 chr5:32394396    G/A rs939936972 chr5:32394398    G/A rs1487016067 chr5:32394410    A/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TET2	chr4:106073085(+) A-I      intronic chr4:106075950(+) A-I      intronic chr4:106180333(+) A-I      intronic chr4:106135097(+) A-I      intronic chr4:106135081(+) A-I      intronic chr4:106134072(+) A-I      intronic chr4:106134068(+) A-I      intronic chr4:106082038(+) A-I      intronic chr4:106081957(+) A-I      intronic chr4:106081081(+) A-I      intronic chr4:106081059(+) A-I      intronic chr4:106081014(+) A-I      intronic chr4:106107266(+) A-I      intronic chr4:106107328(+) A-I      intronic chr4:106080985(+) A-I      intronic chr4:106080983(+) A-I      intronic chr4:106079077(+) A-I      intronic chr4:106079069(+) A-I      intronic chr4:106107746(+) A-I      intronic chr4:106078999(+) A-I      intronic chr4:106078979(+) A-I      intronic chr4:106078970(+) A-I      intronic chr4:106078963(+) A-I      intronic chr4:106076011(+) A-I      intronic chr4:106107664(+) A-I      intronic chr4:106107702(+) A-I      intronic chr4:106126906(+) A-I      intronic chr4:106126928(+) A-I      intronic chr4:106075975(+) A-I      intronic chr4:106074016(+) A-I      intronic chr4:106074015(+) A-I      intronic chr4:106073871(+) A-I      intronic chr4:106073854(+) A-I      intronic chr4:106086448(+) A-I      intronic chr4:106073774(+) A-I      intronic chr4:106073370(+) A-I      intronic chr4:106073345(+) A-I      intronic chr4:106073229(+) A-I      intronic chr4:106073188(+) A-I      intronic chr4:106073173(+) A-I      intronic chr4:106073125(+) A-I      intronic chr4:106073121(+) A-I      intronic chr4:106086426(+) A-I      intronic chr4:106107842(+) A-I      intronic chr4:106106842(+) A-I      intronic chr4:106086307(+) A-I      intronic chr4:106127012(+) A-I      intronic chr4:106082116(+) A-I      intronic chr4:106082072(+) A-I      intronic chr4:106106735(+) A-I      intronic chr4:106127000(+) A-I      intronic chr4:106073079(+) A-I      intronic chr4:106073074(+) A-I      intronic chr4:106073073(+) A-I      intronic chr4:106073036(+) A-I      intronic chr4:106127013(+) A-I      intronic chr4:106127019(+) A-I      intronic chr4:106127043(+) A-I      intronic chr4:106127053(+) A-I      intronic chr4:106133947(+) A-I      intronic chr4:106106783(+) A-I      intronic chr4:106134008(+) A-I      intronic chr4:106134016(+) A-I      intronic chr4:106106778(+) A-I      intronic chr4:106134026(+) A-I      intronic chr4:106073776(+) A-I      intronic chr4:106166726(+) A-I      intronic chr4:106106771(+) A-I      intronic chr4:106073273(+) A-I      intronic chr4:106171869(+) A-I      intronic chr4:106180318(+) A-I      intronic chr4:106107256(+) A-I      intronic chr4:106135133(+) A-I      intronic chr4:106107276(+) A-I      intronic chr4:106073988(+) A-I      intronic chr4:106180310(+) A-I      intronic chr4:106106774(+) A-I      intronic chr4:106167217(+) A-I      intronic chr4:106107164(+) A-I      intronic chr4:106106775(+) A-I      intronic chr4:106080586(+) A-I      intronic chr4:106078934(+) A-I      intronic chr4:106107909(+) A-I      intronic chr4:106080524(+) A-I      intronic chr4:106073056(+) A-I      intronic chr4:106171868(+) A-I      intronic chr4:106073177(+) A-I      intronic chr4:106107755(+) A-I      intronic chr4:106073969(+) A-I      intronic chr4:106082062(+) A-I      intronic chr4:106081145(+) A-I      intronic chr4:106080984(+) A-I      intronic chr4:106107758(+) A-I      intronic chr4:106127059(+) A-I      intronic chr4:106073963(+) A-I      intronic chr4:106073893(+) A-I      intronic chr4:106107768(+) A-I      intronic chr4:106073937(+) A-I      intronic chr4:106107849(+) A-I      intronic chr4:106079034(+) A-I      intronic chr4:106180341(+) A-I      intronic chr4:106107155(+) A-I      intronic chr4:106107876(+) A-I      intronic chr4:106107801(+) A-I      intronic chr4:106101891(+) A-I      intronic chr4:106151384(+) A-I      intronic chr4:106135191(+) A-I      intronic chr4:106107829(+) A-I      intronic chr4:106135070(+) A-I      intronic chr4:106189873(+) A-I      intronic chr4:106107809(+) A-I      intronic chr4:106106776(+) A-I      intronic chr4:106126889(+) A-I      intronic chr4:106079020(+) A-I      intronic chr4:106107850(+) A-I      intronic chr4:106169031(+) A-I      intronic chr4:106078933(+) A-I      intronic chr4:106080530(+) A-I      intronic chr4:106180361(+) A-I      intronic chr4:106135198(+) A-I      intronic chr4:106106816(+) A-I      intronic chr4:106171599(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	TET2	chr4:106180774(+) A-I intron -    22327324 chr4:106073855(+) A-G intron -    22484847 chr4:106073893(+) A-G intron -    22484847 chr4:106073963(+) A-G intron -    22484847 chr4:106073969(+) A-G intron -    22484847 chr4:106073988(+) A-G intron -    22484847 chr4:106076102(+) A-G intron -    22484847 chr4:106078913(+) A-G intron -    22484847 chr4:106078933(+) A-G intron -    22484847 chr4:106078934(+) A-G intron -    22484847 chr4:106079020(+) A-G intron -    22484847 chr4:106079034(+) A-G intron -    22484847 chr4:106080524(+) A-G intron -    22484847 chr4:106080530(+) A-G intron -    22484847 chr4:106080586(+) A-G intron -    22484847 chr4:106080996(+) G-A intron -    22484847 chr4:106081145(+) A-G intron -    22484847 chr4:106101891(+) A-G intron -    22484847 chr4:106106771(+) A-G intron -    22484847 chr4:106106774(+) A-G intron -    22484847 chr4:106106775(+) A-G intron -    22484847 chr4:106106776(+) A-G intron -    22484847 chr4:106106816(+) A-G intron -    22484847 chr4:106107122(+) A-G intron -    22484847 chr4:106107202(+) A-G intron -    22484847 chr4:106107256(+) A-G intron -    22484847 chr4:106107276(+) A-G intron -    22484847 chr4:106107758(+) A-G intron -    22484847 chr4:106107801(+) A-G intron -    22484847 chr4:106107803(+) A-G intron -    22484847 chr4:106107809(+) A-G intron -    22484847 chr4:106107829(+) A-G intron -    22484847 chr4:106107849(+) A-G intron -    22484847 chr4:106107850(+) A-G intron -    22484847 chr4:106107876(+) A-G intron -    22484847 chr4:106107909(+) A-G intron -    22484847 chr4:106123186(+) T-C intron -    22484847 chr4:106126889(+) A-G intron -    22484847 chr4:106127059(+) A-G intron -    22484847 chr4:106135070(+) A-G intron -    22484847 chr4:106135072(+) A-G intron -    22484847 chr4:106135133(+) A-G intron -    22484847 chr4:106135191(+) A-G intron -    22484847 chr4:106135194(+) A-G intron -    22484847 chr4:106135198(+) A-G intron -    22484847 chr4:106135628(+) A-T intron -    22484847 chr4:106172131(+) G-A intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TET2	chr4:106067520-106067521(+) m6A 5'UTR//intron       - chr4:106068087-106068088(+) m6A 5'UTR//exon//intron       24981863 chr4:106123696-106123697(+) m6A exon//intron       - chr4:106155137-106155138(+) m6A CDS       24981863//22608085 chr4:106155177-106155178(+) m6A CDS       22608085 chr4:106155182-106155183(+) m6A CDS       22608085 chr4:106155250-106155251(+) m6A CDS       24981863//22608085 chr4:106155398-106155399(+) m6A CDS       24981863//22608085 chr4:106155437-106155438(+) m6A CDS       24981863//22608085 chr4:106155442-106155443(+) m6A CDS       24981863//22608085 chr4:106155685-106155686(+) m6A CDS       24284625//24981863//22608085 chr4:106155703-106155704(+) m6A CDS       24284625//24981863//22608085 chr4:106155755-106155756(+) m6A CDS       24284625//24981863//22608085 chr4:106155770-106155771(+) m6A CDS       24284625//24981863//22608085 chr4:106155783-106155784(+) m6A CDS       24284625//24981863//22608085 chr4:106155831-106155832(+) m6A CDS       24284625//24981863//22608085 chr4:106156214-106156215(+) m6A CDS       24284625 chr4:106156460-106156461(+) m6A CDS       24284625//22575960//22608085 chr4:106156555-106156556(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr4:106156572-106156573(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr4:106156581-106156582(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr4:106156611-106156612(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr4:106156616-106156617(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr4:106156628-106156629(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr4:106156678-106156679(+) m6A CDS       24284625//24981863//22575960//22608085 chr4:106156702-106156703(+) m6A CDS       24284625//24981863//22575960//22608085 chr4:106156732-106156733(+) m6A CDS       24284625//24981863//22608085 chr4:106156743-106156744(+) m6A CDS       24284625//24981863//22608085 chr4:106156781-106156782(+) m6A CDS       24981863 chr4:106156968-106156969(+) m6A CDS       24284625//24981863//22608085 chr4:106157041-106157042(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085 chr4:106157063-106157064(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085 chr4:106157091-106157092(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22608085 chr4:106157169-106157170(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22608085 chr4:106157177-106157178(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22608085 chr4:106157198-106157199(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22608085 chr4:106157226-106157227(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22608085 chr4:106157242-106157243(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22608085 chr4:106157273-106157274(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085 chr4:106157286-106157287(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085 chr4:106157320-106157321(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085 chr4:106157373-106157374(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085 chr4:106157433-106157434(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085 chr4:106157493-106157494(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr4:106157513-106157514(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22575960//22608085 chr4:106157562-106157563(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22575960//22608085 chr4:106157605-106157606(+) m6A 3'UTR//CDS       24284625//24981863//22575960//22608085 chr4:106157636-106157637(+) m6A 3'UTR//CDS       24284625//24981863//22575960//22608085 chr4:106157654-106157655(+) m6A 3'UTR//CDS       24284625//24981863//22575960//22608085 chr4:106157668-106157669(+) m6A 3'UTR//CDS       24284625//24981863//22608085 chr4:106157673-106157674(+) m6A 3'UTR//CDS       24284625//24981863//22608085 chr4:106157680-106157681(+) m6A 3'UTR//CDS       24284625//24981863//22608085 chr4:106157753-106157754(+) m6A 3'UTR//CDS       24981863//22608085 chr4:106157806-106157807(+) m6A 3'UTR//CDS       24284625//24981863//22608085 chr4:106157916-106157917(+) m6A 3'UTR//CDS       24284625//24981863//22608085 chr4:106157932-106157933(+) m6A 3'UTR//CDS       24284625//24981863//22608085 chr4:106157981-106157982(+) m6A 3'UTR//CDS       24284625//24981863//22608085 chr4:106157991-106157992(+) m6A 3'UTR//CDS       24284625//24981863//22608085 chr4:106158006-106158007(+) m6A 3'UTR//CDS       24284625//24981863//22608085 chr4:106158050-106158051(+) m6A 3'UTR//CDS       24284625//24981863//22608085 chr4:106158097-106158098(+) m6A 3'UTR//CDS       24981863//22608085 chr4:106158102-106158103(+) m6A 3'UTR//CDS       24981863//22608085 chr4:106158177-106158178(+) m6A 3'UTR//CDS       24981863//22608085 chr4:106158299-106158300(+) m6A 3'UTR//CDS       24284625//24981863//22608085 chr4:106158317-106158318(+) m6A 3'UTR//CDS       24284625//24981863//22608085 chr4:106158351-106158352(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085 chr4:106158369-106158370(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085 chr4:106158384-106158385(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085 chr4:106158474-106158475(+) m6A 3'UTR//CDS       - chr4:106160021-106160022(+) m6A 3'UTR//intron       - chr4:106160040-106160041(+) m6A 3'UTR//intron       - chr4:106160068-106160069(+) m6A 3'UTR//intron       - chr4:106160136-106160137(+) m6A 3'UTR//intron       - chr4:106182923-106182924(+) m6A 3'UTR//CDS       24981863 chr4:106182943-106182944(+) m6A 3'UTR//CDS       24981863 chr4:106182977-106182978(+) m6A 3'UTR//CDS       24981863 chr4:106190777-106190778(+) m6A 3'UTR//CDS       24981863 chr4:106194037-106194038(+) m6A 3'UTR//CDS       24981863 chr4:106194064-106194065(+) m6A 3'UTR//CDS       24284625//24981863//22608085 chr4:106196223-106196224(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085 chr4:106196295-106196296(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085 chr4:106196326-106196327(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085 chr4:106196408-106196409(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085 chr4:106196453-106196454(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085 chr4:106196513-106196514(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085 chr4:106196573-106196574(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085 chr4:106196585-106196586(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085 chr4:106196660-106196661(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085 chr4:106196759-106196760(+) m6A 3'UTR//CDS       24981863//22608085 chr4:106196802-106196803(+) m6A 3'UTR//CDS       24981863//22608085 chr4:106196909-106196910(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085 chr4:106196915-106196916(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085 chr4:106196931-106196932(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085 chr4:106197017-106197018(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085 chr4:106197091-106197092(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr4:106197191-106197192(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22608085 chr4:106197212-106197213(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22608085 chr4:106197399-106197400(+) m6A 3'UTR//CDS       24284625//24981863//22608085 chr4:106197479-106197480(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//22608085 chr4:106197541-106197542(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr4:106197589-106197590(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr4:106197608-106197609(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr4:106197712-106197713(+) m6A 3'UTR       24284625//24981863//22608085 chr4:106197799-106197800(+) m6A 3'UTR       24981863//22608085 chr4:106197891-106197892(+) m6A 3'UTR       24981863//22608085 chr4:106197953-106197954(+) m6A 3'UTR       24981863//22608085 chr4:106198066-106198067(+) m6A 3'UTR       24981863//22608085 chr4:106198077-106198078(+) m6A 3'UTR       24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-579-3p	Exosome Lung adenocarcinoma epithelial cell line (A549)     20615901 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Fibroblasts|Mesenchymal stem cells     -
	TET2	Chromatin K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)     - Ribosome-free cytosol Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-579-3p
Interactor2: TET2

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.