Basic Information:

  VIRBase ID:  

HHID00060741

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-579-3p:  MIMAT0003244          PLCE1:  NM_001165979     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-579-3p	PLCE1
miRBase Accession/Entrez ID	MIMAT0003244	51196
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	NPHS3//PLCE//PPLC

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-579-3p	rs1165224671 chr5:32394404    T/C rs1190752232 chr5:32394395    C/T rs1404190650 chr5:32394401    T/C rs1412824363 chr5:32394357    AAAGACCATAGACTGTAGTAAGTTGATGCAAAAATAATCGCGG/A rs1415619084 chr5:32394406    C/T rs376231726 chr5:32394397    C/T rs768681140 chr5:32394396    G/A rs939936972 chr5:32394398    G/A rs1487016067 chr5:32394410    A/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PLCE1	chr10:96021246(+) A-I      intronic chr10:96021267(+) A-I      intronic chr10:96021268(+) A-I      intronic chr10:96021212(+) A-I      intronic chr10:96021247(+) A-I      intronic chr10:95814609(+) A-I      intronic chr10:95814617(+) A-I      intronic chr10:95814592(+) A-I      intronic chr10:95814607(+) A-I      intronic chr10:96024703(+) A-I      intronic chr10:95767826(+) A-I      intronic chr10:95958542(+) A-I      intronic chr10:95892633(+) A-I      intronic chr10:96023151(+) A-I      intronic chr10:96065107(+) A-I      intronic chr10:96015996(+) A-I      intronic chr10:95829175(+) A-I      intronic chr10:95821348(+) A-I      intronic chr10:95821362(+) A-I      intronic chr10:95837261(+) A-I      intronic chr10:95837262(+) A-I      intronic chr10:95927624(+) A-I      intronic chr10:95941493(+) A-I      intronic chr10:96015827(+) A-I      intronic chr10:96023120(+) A-I      intronic chr10:96023156(+) A-I      intronic chr10:96024643(+) A-I      intronic chr10:96024647(+) A-I      intronic chr10:95957512(+) A-I      intronic chr10:96024652(+) A-I      intronic chr10:96057880(+) A-I      intronic chr10:96057881(+) A-I      intronic chr10:96057889(+) A-I      intronic chr10:96069143(+) A-I      intronic chr10:96065782(+) A-I      intronic chr10:96069167(+) A-I      intronic chr10:96076848(+) A-I      intronic chr10:96017961(+) A-I      intronic chr10:96078746(+) A-I      intronic chr10:95767802(+) A-I      intronic chr10:96015853(+) A-I      intronic chr10:96010208(+) A-I      intronic chr10:96078737(+) A-I      intronic chr10:96069192(+) A-I      intronic chr10:96078760(+) A-I      intronic chr10:95958572(+) A-I      intronic chr10:96078755(+) A-I      intronic chr10:96078775(+) A-I      intronic chr10:96023326(+) A-I      intronic chr10:96065101(+) A-I      intronic chr10:96015862(+) A-I      intronic chr10:96015840(+) A-I      intronic chr10:96069662(+) A-I      intronic chr10:96022812(+) A-I      intronic chr10:96078754(+) A-I      intronic chr10:95993545(+) A-I      intronic chr10:95768143(+) A-I      intronic chr10:96079707(+) A-I      intronic chr10:96017960(+) A-I      intronic chr10:96023186(+) A-I      intronic chr10:96015972(+) A-I      intronic chr10:95767799(+) A-I      intronic chr10:96078730(+) A-I      intronic chr10:96023110(+) A-I      intronic chr10:96023353(+) A-I      intronic chr10:96024379(+) A-I      intronic chr10:96079691(+) A-I      intronic chr10:96017984(+) A-I      intronic chr10:96013250(+) A-I      intronic chr10:95958571(+) A-I      intronic chr10:96069722(+) A-I      intronic chr10:96053631(+) A-I      intronic chr10:96053644(+) A-I      intronic chr10:96023118(+) A-I      intronic chr10:96069660(+) A-I      intronic chr10:95957730(+) A-I      intronic chr10:95767721(+) A-I      intronic chr10:96078762(+) A-I      intronic chr10:96017905(+) A-I      intronic chr10:95926937(+) A-I      intronic chr10:96016056(+) A-I      intronic chr10:96079696(+) A-I      intronic chr10:96021444(+) A-I      intronic chr10:96076007(+) A-I      intronic chr10:96074944(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PLCE1	chr10:96074944(+) A-I intron -    15342557 chr10:96076007(+) A-I intron -    15342557 chr10:96078730(+) A-I intron -    15342557 chr10:96078737(+) A-I intron -    15342557 chr10:96078746(+) A-I intron -    15342557 chr10:96078754(+) A-I intron -    15342557 chr10:96078755(+) A-I intron -    15342557 chr10:96078760(+) A-I intron -    15342557 chr10:96078762(+) A-I intron -    15342557 chr10:96078775(+) A-I intron -    15342557 chr10:96079691(+) A-I intron -    15342557 chr10:96079696(+) A-I intron -    15342557 chr10:96079707(+) A-I intron -    15342557 chr10:96085127(+) A-I intron -    15258596 chr10:96085151(+) A-I intron -    15258596 chr10:96085191(+) A-I intron -    15258596 chr10:96085241(+) A-I intron -    15258596

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PLCE1	chr10:95790694-95790695(+) m6A 5'UTR       24981863 chr10:95790739-95790740(+) m6A 5'UTR       24981863//22608085 chr10:95790784-95790785(+) m6A 5'UTR       24981863//22608085 chr10:95790906-95790907(+) m6A CDS       24981863//22608085 chr10:95790950-95790951(+) m6A CDS       24284625//24981863//22608085 chr10:95790975-95790976(+) m6A CDS       24284625//24981863//22608085 chr10:95790991-95790992(+) m6A CDS       24284625//24981863//22608085 chr10:95791056-95791057(+) m6A CDS       24284625//24981863//22608085 chr10:95791104-95791105(+) m6A CDS       24284625//24981863//22608085 chr10:95791137-95791138(+) m6A CDS       24284625//24981863//22608085 chr10:95791162-95791163(+) m6A CDS       24981863//22608085 chr10:95791200-95791201(+) m6A CDS       24981863//22608085 chr10:95791214-95791215(+) m6A CDS       24981863//22608085 chr10:95791267-95791268(+) m6A CDS       24209618//24981863//22608085 chr10:95791272-95791273(+) m6A CDS       24209618//24981863//22608085 chr10:95791325-95791326(+) m6A CDS       24209618//24981863//22608085 chr10:95791398-95791399(+) m6A CDS       24209618//24981863//22608085 chr10:95791422-95791423(+) m6A CDS       24209618//24981863//22608085 chr10:95791488-95791489(+) m6A CDS       24284625//24209618//24981863//22608085 chr10:95791510-95791511(+) m6A CDS       24284625//24209618//24981863//22608085 chr10:95791659-95791660(+) m6A CDS       24284625//24209618//24981863//22608085 chr10:95791685-95791686(+) m6A CDS       24284625//24209618//24981863//22608085 chr10:95791707-95791708(+) m6A CDS       24284625//24209618//24981863//22608085 chr10:95791832-95791833(+) m6A CDS       24284625//24209618//24981863//22608085 chr10:95791850-95791851(+) m6A CDS       24284625//24209618//24981863//22608085 chr10:95791942-95791943(+) m6A CDS       24209618//22608085 chr10:95931128-95931129(+) m6A CDS       24284625 chr10:96005782-96005783(+) m6A CDS       24981863 chr10:96005899-96005900(+) m6A CDS       24284625//24209618//24981863//22608085 chr10:96006002-96006003(+) m6A CDS       24284625//24209618//24981863//22608085 chr10:96006160-96006161(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22608085 chr10:96006164-96006165(+) m6A CDS       - chr10:96006189-96006190(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr10:96006219-96006220(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr10:96006226-96006227(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr10:96006293-96006294(+) m6A CDS       24284625//24209618//24981863//26404942//22608085 chr10:96006338-96006339(+) m6A CDS       24284625//24209618//24981863//22608085 chr10:96006356-96006357(+) m6A CDS       24284625//24209618//24981863//22608085 chr10:96012148-96012149(+) m6A CDS       24209618 chr10:96012162-96012163(+) m6A CDS       24209618 chr10:96012202-96012203(+) m6A CDS       24981863 chr10:96014040-96014041(+) m6A CDS       24981863 chr10:96014050-96014051(+) m6A CDS       24981863 chr10:96014676-96014677(+) m6A CDS       24981863 chr10:96081765-96081766(+) m6A CDS       22608085 chr10:96084905-96084906(+) m6A 3'UTR//intron       24981863 chr10:96087757-96087758(+) m6A 3'UTR       24209618//24981863//22608085 chr10:96087790-96087791(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr10:96087796-96087797(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr10:96087818-96087819(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr10:96087917-96087918(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr10:96088005-96088006(+) m6A 3'UTR       24284625//24981863//22608085 chr10:96088087-96088088(+) m6A 3'UTR       24981863 chr10:96088127-96088128(+) m6A 3'UTR       24981863 chr10:96088140-96088141(+) m6A 3'UTR       24981863 chr10:96088283-96088284(+) m6A 3'UTR       27773535 chr10:96088316-96088317(+) m6A 3'UTR       27773535 chr10:96088323-96088324(+) m6A 3'UTR       27773535 chr10:96088346-96088347(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-579-3p	Exosome Lung adenocarcinoma epithelial cell line (A549)     20615901 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Fibroblasts|Mesenchymal stem cells     -
	PLCE1	Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-579-3p
Interactor2: PLCE1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.