Basic Information:

  VIRBase ID:  

HHID00060675

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-573:  MIMAT0003238          NFKBIZ:  NM_001005474     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-573	NFKBIZ
miRBase Accession/Entrez ID	MIMAT0003238	64332
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	IKBZ//INAP//MAIL

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-573	rs1203521332 chr4:24520263    C/T rs1262008333 chr4:24520263    C/CACA rs1323507871 chr4:24520254    G/T rs373452545 chr4:24520267    T/C rs554771730 chr4:24520260    T/C rs562847917 chr4:24520264    A/G rs760302615 chr4:24520257    C/T rs776058506 chr4:24520265    C/T rs1371079024 chr4:24520270    C/T rs1447248378 chr4:24520261    TACACATC/T rs899607846 chr4:24520271    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	NFKBIZ	chr3:101570816(+) A-I      intronic chr3:101550992(+) A-I      intronic chr3:101550983(+) A-I      intronic chr3:101562097(+) A-I      intronic chr3:101564324(+) A-I      intronic chr3:101562069(+) A-I      intronic chr3:101564279(+) A-I      intronic chr3:101551005(+) A-I      intronic chr3:101564345(+) A-I      intronic chr3:101564354(+) A-I      intronic chr3:101564406(+) A-I      intronic chr3:101564407(+) A-I      intronic chr3:101563838(+) A-I      intronic chr3:101563991(+) A-I      intronic chr3:101563848(+) A-I      intronic chr3:101550988(+) A-I      intronic chr3:101564062(+) A-I      intronic chr3:101550967(+) A-I      intronic chr3:101564250(+) A-I      intronic chr3:101550510(+) A-I      intronic chr3:101579079(+) A-I      3'UTR chr3:101579149(+) A-I      3'UTR chr3:101562023(+) A-I      intronic chr3:101564408(+) A-I      intronic chr3:101562088(+) A-I      intronic chr3:101564380(+) A-I      intronic chr3:101562127(+) A-I      intronic chr3:101563934(+) A-I      intronic chr3:101564207(+) A-I      intronic chr3:101562176(+) A-I      intronic chr3:101563896(+) A-I      intronic chr3:101562024(+) A-I      intronic chr3:101550698(+) A-I      intronic chr3:101564347(+) A-I      intronic chr3:101564018(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	NFKBIZ	chr3:101550515(+) C-A intron -    22484847 chr3:101556353(+) G-A intron -    22484847 chr3:101563856(+) A-G intron -    22484847 chr3:101563896(+) A-G intron -    22484847 chr3:101564250(+) A-G intron -    22484847 chr3:101564304(+) A-G intron -    22484847 chr3:101564347(+) A-G intron -    22484847 chr3:101564408(+) A-G intron -    22484847 chr3:101579079(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	NFKBIZ	chr3:101571990-101571991(+) m6A CDS       24981863//26404942 chr3:101571996-101571997(+) m6A CDS       24981863//26404942 chr3:101572025-101572026(+) m6A CDS       24981863//26404942 chr3:101572214-101572215(+) m6A CDS//intron       27773535 chr3:101572247-101572248(+) m6A CDS//intron       27773535 chr3:101572284-101572285(+) m6A CDS//intron       24981863//27773535 chr3:101572338-101572339(+) m6A CDS//intron       24981863 chr3:101572343-101572344(+) m6A CDS//intron       24981863 chr3:101578506-101578507(+) m6A 3'UTR       26404942//27773535 chr3:101578526-101578527(+) m6A 3'UTR       26404942//27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-573	Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	NFKBIZ	Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-573
Interactor2: NFKBIZ

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.