Basic Information:

  VIRBase ID:  

HHID00060476

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-92b-3p:  MIMAT0003218          KLHL42:  NM_020782     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-92b-3p	KLHL42
miRBase Accession/Entrez ID	MIMAT0003218	57542
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	Ctb9//KLHDC5

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-92b-3p	rs1235528450 chr1:155195237    T/C rs12759620 chr1:155195253    G/C rs1350664926 chr1:155195246    C/T rs1355214420 chr1:155195256    T/TCCGGCCCCC

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	KLHL42	chr12:27938207(+) A-I      intronic chr12:27938200(+) A-I      intronic chr12:27940377(+) A-I      intronic chr12:27938203(+) A-I      intronic chr12:27949805(+) A-I      intronic chr12:27946289(+) A-I      intronic chr12:27945636(+) A-I      intronic chr12:27949721(+) A-I      intronic chr12:27949753(+) A-I      intronic chr12:27949767(+) A-I      intronic chr12:27949791(+) A-I      intronic chr12:27949670(+) A-I      intronic chr12:27949742(+) A-I      intronic chr12:27949708(+) A-I      intronic chr12:27949698(+) A-I      intronic chr12:27947492(+) A-I      intronic chr12:27947486(+) A-I      intronic chr12:27946382(+) A-I      intronic chr12:27946372(+) A-I      intronic chr12:27946324(+) A-I      intronic chr12:27946320(+) A-I      intronic chr12:27946153(+) A-I      intronic chr12:27946114(+) A-I      intronic chr12:27945653(+) A-I      intronic chr12:27945608(+) A-I      intronic chr12:27937418(+) A-I      intronic chr12:27945582(+) A-I      intronic chr12:27945496(+) A-I      intronic chr12:27940232(+) A-I      intronic chr12:27940173(+) A-I      intronic chr12:27939857(+) A-I      intronic chr12:27939797(+) A-I      intronic chr12:27938237(+) A-I      intronic chr12:27937467(+) A-I      intronic chr12:27937426(+) A-I      intronic chr12:27946291(+) A-I      intronic chr12:27946294(+) A-I      intronic chr12:27938202(+) A-I      intronic chr12:27940252(+) A-I      intronic chr12:27946355(+) A-I      intronic chr12:27938153(+) A-I      intronic chr12:27946317(+) A-I      intronic chr12:27946416(+) A-I      intronic chr12:27939773(+) A-I      intronic chr12:27946258(+) A-I      intronic chr12:27945717(+) A-I      intronic chr12:27939785(+) A-I      intronic chr12:27940378(+) A-I      intronic chr12:27946179(+) A-I      intronic chr12:27939795(+) A-I      intronic chr12:27945639(+) A-I      intronic chr12:27937348(+) A-I      intronic chr12:27945557(+) A-I      intronic chr12:27946086(+) A-I      intronic chr12:27946085(+) A-I      intronic chr12:27945641(+) A-I      intronic chr12:27940385(+) A-I      intronic chr12:27943867(+) A-I      intronic chr12:27945973(+) A-I      intronic chr12:27945965(+) A-I      intronic chr12:27946244(+) A-I      intronic chr12:27940307(+) A-I      intronic chr12:27946234(+) A-I      intronic chr12:27949665(+) A-I      intronic chr12:27946253(+) A-I      intronic chr12:27945918(+) A-I      intronic chr12:27946178(+) A-I      intronic chr12:27943873(+) A-I      intronic chr12:27945560(+) A-I      intronic chr12:27947563(+) A-I      intronic chr12:27938236(+) A-I      intronic chr12:27937449(+) A-I      intronic chr12:27953654(+) A-I      3'UTR chr12:27943863(+) A-I      intronic chr12:27939865(+) A-I      intronic chr12:27940242(+) A-I      intronic chr12:27938347(+) A-I      intronic chr12:27949617(+) A-I      intronic chr12:27939719(+) A-I      intronic chr12:27946162(+) A-I      intronic chr12:27945574(+) A-I      intronic chr12:27946361(+) A-I      intronic chr12:27947550(+) A-I      intronic chr12:27946158(+) A-I      intronic chr12:27945656(+) A-I      intronic chr12:27939720(+) A-I      intronic chr12:27945464(+) A-I      intronic chr12:27946247(+) A-I      intronic chr12:27949621(+) A-I      intronic chr12:27949664(+) A-I      intronic chr12:27947536(+) A-I      intronic chr12:27949597(+) A-I      intronic chr12:27945482(+) A-I      intronic chr12:27946487(+) A-I      intronic chr12:27945596(+) A-I      intronic chr12:27940317(+) A-I      intronic chr12:27949589(+) A-I      intronic chr12:27938233(+) A-I      intronic chr12:27939789(+) A-I      intronic chr12:27937411(+) A-I      intronic chr12:27938152(+) A-I      intronic chr12:27946365(+) A-I      intronic chr12:27946385(+) A-I      intronic chr12:27945583(+) A-I      intronic chr12:27949832(+) A-I      intronic chr12:27945957(+) A-I      intronic chr12:27946154(+) A-I      intronic chr12:27939920(+) A-I      intronic chr12:27946271(+) A-I      intronic chr12:27945945(+) A-I      intronic chr12:27945586(+) A-I      intronic chr12:27940213(+) A-I      intronic chr12:27946069(+) A-I      intronic chr12:27949751(+) A-I      intronic chr12:27949822(+) A-I      intronic chr12:27947494(+) A-I      intronic chr12:27949678(+) A-I      intronic chr12:27949772(+) A-I      intronic chr12:27949635(+) A-I      intronic chr12:27946175(+) A-I      intronic chr12:27938329(+) A-I      intronic chr12:27945917(+) A-I      intronic chr12:27949592(+) A-I      intronic chr12:27947400(+) A-I      intronic chr12:27940241(+) A-I      intronic chr12:27947461(+) A-I      intronic chr12:27943938(+) A-I      intronic chr12:27940313(+) A-I      intronic chr12:27946191(+) A-I      intronic chr12:27946133(+) A-I      intronic chr12:27943879(+) A-I      intronic chr12:27946345(+) A-I      intronic chr12:27946272(+) A-I      intronic chr12:27947551(+) A-I      intronic chr12:27946576(+) A-I      intronic chr12:27946295(+) A-I      intronic chr12:27940383(+) A-I      intronic chr12:27946424(+) A-I      intronic chr12:27946176(+) A-I      intronic chr12:27945556(+) A-I      intronic chr12:27946207(+) A-I      intronic chr12:27946111(+) A-I      intronic chr12:27946090(+) A-I      intronic chr12:27945460(+) A-I      intronic chr12:27946101(+) A-I      intronic chr12:27946177(+) A-I      intronic chr12:27945944(+) A-I      intronic chr12:27945690(+) A-I      intronic chr12:27946131(+) A-I      intronic chr12:27949718(+) A-I      intronic chr12:27946400(+) A-I      intronic chr12:27943750(+) A-I      intronic chr12:27946329(+) A-I      intronic chr12:27946409(+) A-I      intronic chr12:27945695(+) A-I      intronic chr12:27946459(+) A-I      intronic chr12:27946138(+) A-I      intronic chr12:27946223(+) A-I      intronic chr12:27945893(+) A-I      intronic chr12:27949779(+) A-I      intronic chr12:27946326(+) A-I      intronic chr12:27946217(+) A-I      intronic chr12:27946240(+) A-I      intronic chr12:27946318(+) A-I      intronic chr12:27947524(+) A-I      intronic chr12:27953856(+) A-I      3'UTR

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	KLHL42	chr12:27933187-27933188(+) m6A 5'UTR       24209618//27773536 chr12:27933300-27933301(+) m6A CDS       24284625//24209618 chr12:27933462-27933463(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr12:27933839-27933840(+) m6A CDS       24284625//24209618//25456834//24981863//27773536//22608085 chr12:27933864-27933865(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr12:27933877-27933878(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr12:27934017-27934018(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr12:27934125-27934126(+) m6A CDS       - chr12:27944846-27944847(+) m6A 3'UTR//exon//intron       24981863 chr12:27950653-27950654(+) m6A 3'UTR//CDS       24284625//24981863 chr12:27950659-27950660(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085 chr12:27950706-27950707(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085 chr12:27950754-27950755(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22608085 chr12:27950821-27950822(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr12:27950881-27950882(+) m6A 3'UTR//CDS       24284625//24209618//24981863//26404942//22575960//22608085 chr12:27950975-27950976(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22575960//22608085 chr12:27951047-27951048(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22575960//22608085 chr12:27951093-27951094(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr12:27951125-27951126(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085 chr12:27951172-27951173(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085 chr12:27951248-27951249(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr12:27951263-27951264(+) m6A 3'UTR       24284625//24981863//22608085 chr12:27951280-27951281(+) m6A 3'UTR       24284625//24981863//22608085 chr12:27951341-27951342(+) m6A 3'UTR       24284625//24981863//22608085 chr12:27951426-27951427(+) m6A 3'UTR       22608085 chr12:27951819-27951820(+) m6A 3'UTR       22608085 chr12:27951885-27951886(+) m6A 3'UTR       24981863//22608085 chr12:27954406-27954407(+) m6A 3'UTR       24981863 chr12:27954703-27954704(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-92b-3p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Peripheral blood     31746410 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Cerebrospinal fluid     25420022 Exosome Blood|B lymphoblastoid cells|Breast tissue|Endothelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Tongue tissue     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Seminal plasma     23539611 Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	KLHL42	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-92b-3p	Iodine Green 9956454 Drug sensitive Sensorad 99342 Drug sensitive 8-Aminoadenosine 96851 Drug resistant Gardenin B 96539 Drug sensitive Hydrazinecarboximidamide, 2,2'-(carbonylbis(imino-3,1-phenyleneethylidyne))bis-, hydrochloride 9577144 Drug sensitive Actinomycin X4357G methoxime 9573583 Drug sensitive (3Z,8S,11Z,16S)-8,16-Bis(2-oxopropyl)-1,9-dioxacyclohexadeca-3,11-diene-2,5,10,13-tetrone 92973777 Drug sensitive L-2-Aminobutyric acid 80283 Drug sensitive Vancide 26 79411 Drug sensitive Cinerubin B 73593 Drug sensitive 4-(2-Naphthylamino)phenol 7141 Drug sensitive Sulbentine 67686 Drug sensitive Ixabepilone 6445540 Drug sensitive Piriqualone 6015423 Drug sensitive trans-1,2-Bis(propylsulfonyl)ethylene 5904452 Drug sensitive 1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug sensitive Artelasticin 5471311 Drug sensitive 2-(1,3-Benzodioxol-5-yl)-5-hydroxy-3,7-dimethoxy-4H-chromen-4-one 5466137 Drug sensitive 6-(4-Ethylphenyl)-2-benzenesulfonamidepyridazine-3(2H)-one 54612980 Drug sensitive Herveline O 5459269 Drug sensitive Cuspidatin C 5459164 Drug sensitive Thiram 5455 Drug sensitive (1E,4E)-1,5-Dipyridin-3-ylpenta-1,4-dien-3-one 5382674 Drug sensitive Indanthren Corinth RK 5351878 Drug sensitive 5-Phenyl-N-(3,4,5-trimethoxyphenyl)-1,3-oxazol-2-amine 5329854 Drug sensitive 1-[3-(Propylamino)phenyl]-N-(pyridin-4-ylmethylideneamino)pyrazolo[3,4-d]pyrimidin-4-amine 53239979 Drug sensitive Vorinostat 5311 Drug sensitive Spiperone 5265 Drug resistant Kekule 499328 Drug sensitive 10-Hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12-dodecahydro-1H-picene-4a-carboxylic acid 495604 Drug sensitive 6-Methoxy-7-(2lambda(5)-1,2-triazadienyl)-5,8-quinolinedione 494043 Drug sensitive Methyl (13S,15S,16R,18S)-13-[(10S,11R,12R,19R)-11-acetyloxy-12-ethyl-10-hydroxy-5-methoxy-10-methoxycarbonyl-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraen-4-yl]-18-ethyl-1-oxido-17-oxa-11-aza-1-azoniapentacyclo[13.4.1.04,12.05,10.016,18]icosa-4(12),5,7,9-tetraene-13-carboxylate 462173 Drug sensitive BAS100 Monohydrate 45028404 Drug sensitive 1-(4-(Benzyloxy)phenyl)-3-(3-(1-ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl)phenyl)urea 44587530 Drug sensitive Isopinnatal 44558939 Drug sensitive 1-Benzyl-3-hexadecyl-2-methylimidazolium chloride 44219704 Drug sensitive 2,6-Epoxy-2H-1-benzoxocin-5(6H)-one, 6,8-dimethyl- 434882 Drug sensitive Di-n-octyl-secalonsaure A 430141 Drug sensitive 2-Amino-4-(2-hydroxy-4-methylphenyl)-5-phenylpyrimidine 392744 Drug sensitive beta-Lapachone 3885 Drug sensitive Acetic acid,4,7,10-tetraazacyclododecane-1,7-diyl]bis 387352 Drug sensitive L-LYS-L-p-NO2Phe-L-Ala-L-p-NO2PheNH2 386384 Drug sensitive 4-Phenacyloxychromen-2-one 386272 Drug resistant 2-Ethylaminoestradiol 384235 Drug sensitive (-)7,8-Dihydrocalanolide A 383107 Drug sensitive 2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant 4-Methylthio-N-(3,4,5-trimethoxybenzyl)aniline 373808 Drug sensitive Sanguilutine pseudobase 371258 Drug sensitive 1-(4-Methoxy-2-methylphenyl)naphtho[1,2-c]furan-3(1H)-one 369148 Drug sensitive 1-Chloro-3-(3-chloropropylsulfonylsulfanyl)propane 355643 Drug sensitive Maxima isoflavone D 343081 Drug sensitive Bis(helenalinyl)glutarate 336831 Drug sensitive Rustaiyan A 324967 Drug sensitive (15S)-15-Ethyl-1,11-diazapentacyclo[9.6.2.02,7.08,18.015,19]nonadeca-2,4,6,8(18)-tetraen-17-one 2724040 Drug sensitive Antineoplastic-92915 261051 Drug sensitive 5-Hydroxy-3-phenylpyrano[3,2-c]chromen-2(5H)-one 24205741 Drug sensitive (2-Methoxy-9,10-dihydrophenanthren-3-yl)methyl-dimethyl-(phenylsulfanylmethyl)azanium;bromide 24200489 Drug sensitive Prumycin HCl 24197905 Drug resistant 9H-Purine, 2-amino-6-(o-chlorobenzylthio)-9-propyl- 239486 Drug sensitive 4,5-Bis(4-methoxyphenyl)-1,5-dihydroimidazol-2-one 231112 Drug sensitive 3-Amino-N-(2-fluorophenyl)-5-oxo-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide 1856915 Drug sensitive Sudan II 18386 Drug sensitive (2R)-2-[(3S,6R)-6-[[(2S,4R,5R,6R,7R,9R)-2-[(5S)-5-[(3S)-5-[(2S,3S,5R,6R)-6-Hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]-5-methyloxolan-2-yl]-7-methoxy-2,4,6-trimethyl-1,10-dioxaspiro[4.5]decan-9-yl]methyl]-3-methyloxan-2-yl]propanoic acid 152743331 Drug sensitive Arsenic trioxide 14888 Drug sensitive Astrazon Orange R 135747272 Drug sensitive C8, Carbonyl prodigiosine 135540857 Drug sensitive (2S,4S,5R)-20-De(1-hydroxypropyl)-6-demethyl-2,6-diethyl-5-hydroxy-20-(1-hydroxybutyl)lysocellin 124081057 Drug sensitive Melampodinin 11953936 Drug sensitive 2,2'-Bioxirane 11254 Drug sensitive Perillyl alcohol 10819 Drug sensitive Cladospirone bisepoxide 10316810 Drug sensitive Chimaphilin 101211 Drug sensitive 6-phenyl-6h-indeno[1,2-c]isoquinoline-5,11-dione - Drug resistant 1-[(2-cyclohexymethoxy)methyl]-5-ethyl-6-iodouracil - Drug resistant tgf.alpha.-pe40 - Drug resistant tp4ek - Drug resistant tunicamycin - Drug resistant (z) 3,3',4,5-tetramethoxystilbene - Drug sensitive (z) 4-acetoxy-(3,4',5)-trimethoxystilbene - Drug sensitive (Z)-N-phenyl-3-(3,4,5-trimethoxystyryl)pyridin-2-amine - Drug sensitive 1h-benzimidazole, 5,5'-dithiobis[2-(trifluoromethyl)- (9ci) - Drug sensitive 2-(4-(methylsulfonyl)phenyl)-6-p-tolyl-4,5-dihydropyridazin-3(2H)-one - Drug sensitive 2,4-diethoxyestra-1,3,5(10)trien-3,17.beta.-diol - Drug sensitive 2-[(3,4-dicloro)anilino]-3-phenyl-5,7-diamino quinoxaline - Drug sensitive 4-[4-(3-Methoxy-phenyl)-piperazin-1 -yl]-5H-pyrrolo[3,2-d]pyrimidine - Drug sensitive 4-morpholinecarbodithioic acid, antimony complex - Drug sensitive 4-thiomorpholinecarbodithioic acid, antimony complex - Drug sensitive 5-[2-(4-methoxyphenyl)ethyl]-1,2,3-dimethoxy benzene - Drug sensitive 7-n,n-dimethylamino brefeldin a hydrochloride - Drug sensitive 9-acridinamine, n-(4-ethoxyphenyl)-, monohydrochloride - Drug sensitive anthracen-9-one, 10-[(2-methoxyphenyl)methylene]- - Drug sensitive benzamide, 5-bromo-2-hydroxy-n-[3-(trifluoromethyl)phenyl]- - Drug sensitive benzo[1,2-c:4,5-c']dipyrrole-1,3,5,7(2h,6h)-tetraimine - Drug sensitive E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive inosine, 6-thio-, 2',3',5'-tris(4-methoxybenzoate) - Drug sensitive isoflavone, 5,7-dihydroxy-4'-nitro- - Drug sensitive phosphonium, (3-bromopropyl)triphenyl- bromide - Drug sensitive (Z)-3-((2-(4-(trifluoromethyl)phenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive (Z)-6-chloro-3-((2-(4-methoxyphenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive 1-[(2-phenylethoxy)methyl]-5-ethyl-6-(phenylseleno)uracil - Drug sensitive 2-amino-5-chloro-6-(2-thiazolyloxy)-benzimidazole - Drug sensitive 4-carbo-1-thiazolidine-3-o-gluconyl-.gamma.-lactone - Drug sensitive 9-(3-fluorobenzyl)-7-(3-fluorobenzyloxy)-2-(4-fluorobenzyl)-1-methyl-9H-beta-carbolinium bromide - Drug sensitive antineoplastic-615538 - Drug sensitive antineoplastic-d665837 - Drug sensitive arylmethylene-f - Drug sensitive carzinostatin - Drug sensitive cyclo [n-naphthoyl-d-lys-asn-gln-trp-ala-val-d-ala-his-leu] - Drug sensitive geldanamycin-11-hexadecanic acid ester - Drug sensitive his 47-methyl ct - Drug sensitive n-myristoyl-(s)-phenylalaninal diethylcetal - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-92b-3p	(S)-N-[1-(3-Morpholin-4-yl-phenyl)-ethyl]-3-phenyl-acrylamide 9949648 Drug interaction    RC00005944 Gemcitabine 60750 Drug interaction    RC00005940 Vincristine 5978 Drug interaction    RC00005938 Eloxatine 5310940 Drug interaction    RC00005943 Diethylstilbestrol 448537 Drug interaction    RC00005942 Bortezomib 387447 Drug interaction    RC00005941 5-Fluorouracil 3385 Drug interaction    RC00005937 Doxorubicin 31703 Drug interaction    RC00005939 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00005936 Trastuzumab - Drug interaction    RC00005945

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-92b-3p	Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-92b-3p
Interactor2: KLHL42

Evidence Support:

Weak-Evidence	HITS-CLIP
Support Database	ViRBase

References:

PMID	22473208	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Jijoye cells	Interactor2 expression	None
Description	Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).