Detail Information

Basic Information:


  VIRBase ID:  

HHID00060456

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-92b-3p:           ZNF770:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-92b-3p ZNF770
miRBase
Accession/Entrez ID		 MIMAT0003218 54989
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - PRO1914

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-92b-3p
rs1235528450 chr1:155195237    T/C
rs12759620 chr1:155195253    G/C
rs1350664926 chr1:155195246    C/T
rs1355214420 chr1:155195256    T/TCCGGCCCCC

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ZNF770
chr15:35272815(-) A-I      3'UTR
chr15:35272821(-) A-I      3'UTR
chr15:35272786(-) A-I      3'UTR
chr15:35272812(-) A-I      3'UTR
chr15:35272794(-) A-I      3'UTR
chr15:35272969(-) A-I      3'UTR

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ZNF770
chr15:35270763-35270764(-) m6A 3'UTR       27773535
chr15:35271583-35271584(-) m6A 3'UTR       24981863
chr15:35271594-35271595(-) m6A 3'UTR       24981863
chr15:35271674-35271675(-) m6A 3'UTR       24981863
chr15:35274013-35274014(-) m6A CDS       22608085
chr15:35274069-35274070(-) m6A CDS       22608085
chr15:35274075-35274076(-) m6A CDS       22608085
chr15:35274096-35274097(-) m6A CDS       22608085
chr15:35274138-35274139(-) m6A CDS       22608085
chr15:35274159-35274160(-) m6A CDS       22608085
chr15:35274168-35274169(-) m6A CDS       22608085
chr15:35274222-35274223(-) m6A CDS       22608085
chr15:35274235-35274236(-) m6A CDS       22608085
chr15:35274319-35274320(-) m6A CDS       24981863//22608085
chr15:35274355-35274356(-) m6A CDS       24284625//24981863//27773535//22608085
chr15:35274422-35274423(-) m6A CDS       24284625//24981863//27773535//22608085
chr15:35274446-35274447(-) m6A CDS       24284625//24981863//27773535//27371828//22608085
chr15:35274455-35274456(-) m6A CDS       24284625//24981863//27773535//27371828//22608085
chr15:35274462-35274463(-) m6A CDS       24284625//24981863//27773535//27371828//22608085
chr15:35274485-35274486(-) m6A CDS       24284625//24981863//27773535//22608085
chr15:35274498-35274499(-) m6A CDS       24284625//24981863//27773535//22608085
chr15:35274635-35274636(-) m6A CDS       24981863
chr15:35274930-35274931(-) m6A CDS       24284625//24981863//27773535//22608085
chr15:35274945-35274946(-) m6A CDS       24284625//24981863//27773535//22575960//22608085
chr15:35274993-35274994(-) m6A CDS       24284625//24981863//28052920//27773535//22575960//22608085
chr15:35275113-35275114(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr15:35275299-35275300(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828//22575960//22608085
chr15:35275319-35275320(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828//22575960//22608085
chr15:35275352-35275353(-) m6A CDS       24284625//24981863//28052920//27773535//22575960//22608085
chr15:35275440-35275441(-) m6A CDS       24284625//24981863//27773535//22575960//22608085
chr15:35275448-35275449(-) m6A CDS       24284625//24981863//27773535//22575960//22608085
chr15:35275523-35275524(-) m6A CDS       24284625//24981863//27773535//22608085
chr15:35275564-35275565(-) m6A CDS       24284625//24981863//27773535//22608085
chr15:35275575-35275576(-) m6A CDS       24284625//24981863//27773535//22608085
chr15:35275621-35275622(-) m6A CDS       24284625//24981863//27773535//22608085
chr15:35275671-35275672(-) m6A 5'UTR       24284625//24981863//27773535//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-92b-3p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Peripheral blood     31746410
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Cerebrospinal fluid     25420022
Exosome Blood|B lymphoblastoid cells|Breast tissue|Endothelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Tongue tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Seminal plasma     23539611
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
ZNF770
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-92b-3p
Iodine Green 9956454 Drug sensitive
Sensorad 99342 Drug sensitive
8-Aminoadenosine 96851 Drug resistant
Gardenin B 96539 Drug sensitive
Hydrazinecarboximidamide, 2,2'-(carbonylbis(imino-3,1-phenyleneethylidyne))bis-, hydrochloride 9577144 Drug sensitive
Actinomycin X4357G methoxime 9573583 Drug sensitive
(3Z,8S,11Z,16S)-8,16-Bis(2-oxopropyl)-1,9-dioxacyclohexadeca-3,11-diene-2,5,10,13-tetrone 92973777 Drug sensitive
L-2-Aminobutyric acid 80283 Drug sensitive
Vancide 26 79411 Drug sensitive
Cinerubin B 73593 Drug sensitive
4-(2-Naphthylamino)phenol 7141 Drug sensitive
Sulbentine 67686 Drug sensitive
Ixabepilone 6445540 Drug sensitive
Piriqualone 6015423 Drug sensitive
trans-1,2-Bis(propylsulfonyl)ethylene 5904452 Drug sensitive
1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug sensitive
Artelasticin 5471311 Drug sensitive
2-(1,3-Benzodioxol-5-yl)-5-hydroxy-3,7-dimethoxy-4H-chromen-4-one 5466137 Drug sensitive
6-(4-Ethylphenyl)-2-benzenesulfonamidepyridazine-3(2H)-one 54612980 Drug sensitive
Herveline O 5459269 Drug sensitive
Cuspidatin C 5459164 Drug sensitive
Thiram 5455 Drug sensitive
(1E,4E)-1,5-Dipyridin-3-ylpenta-1,4-dien-3-one 5382674 Drug sensitive
Indanthren Corinth RK 5351878 Drug sensitive
5-Phenyl-N-(3,4,5-trimethoxyphenyl)-1,3-oxazol-2-amine 5329854 Drug sensitive
1-[3-(Propylamino)phenyl]-N-(pyridin-4-ylmethylideneamino)pyrazolo[3,4-d]pyrimidin-4-amine 53239979 Drug sensitive
Vorinostat 5311 Drug sensitive
Spiperone 5265 Drug resistant
Kekule 499328 Drug sensitive
10-Hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12-dodecahydro-1H-picene-4a-carboxylic acid 495604 Drug sensitive
6-Methoxy-7-(2lambda(5)-1,2-triazadienyl)-5,8-quinolinedione 494043 Drug sensitive
Methyl (13S,15S,16R,18S)-13-[(10S,11R,12R,19R)-11-acetyloxy-12-ethyl-10-hydroxy-5-methoxy-10-methoxycarbonyl-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraen-4-yl]-18-ethyl-1-oxido-17-oxa-11-aza-1-azoniapentacyclo[13.4.1.04,12.05,10.016,18]icosa-4(12),5,7,9-tetraene-13-carboxylate 462173 Drug sensitive
BAS100 Monohydrate 45028404 Drug sensitive
1-(4-(Benzyloxy)phenyl)-3-(3-(1-ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl)phenyl)urea 44587530 Drug sensitive
Isopinnatal 44558939 Drug sensitive
1-Benzyl-3-hexadecyl-2-methylimidazolium chloride 44219704 Drug sensitive
2,6-Epoxy-2H-1-benzoxocin-5(6H)-one, 6,8-dimethyl- 434882 Drug sensitive
Di-n-octyl-secalonsaure A 430141 Drug sensitive
2-Amino-4-(2-hydroxy-4-methylphenyl)-5-phenylpyrimidine 392744 Drug sensitive
beta-Lapachone 3885 Drug sensitive
Acetic acid,4,7,10-tetraazacyclododecane-1,7-diyl]bis 387352 Drug sensitive
L-LYS-L-p-NO2Phe-L-Ala-L-p-NO2PheNH2 386384 Drug sensitive
4-Phenacyloxychromen-2-one 386272 Drug resistant
2-Ethylaminoestradiol 384235 Drug sensitive
(-)7,8-Dihydrocalanolide A 383107 Drug sensitive
2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant
4-Methylthio-N-(3,4,5-trimethoxybenzyl)aniline 373808 Drug sensitive
Sanguilutine pseudobase 371258 Drug sensitive
1-(4-Methoxy-2-methylphenyl)naphtho[1,2-c]furan-3(1H)-one 369148 Drug sensitive
1-Chloro-3-(3-chloropropylsulfonylsulfanyl)propane 355643 Drug sensitive
Maxima isoflavone D 343081 Drug sensitive
Bis(helenalinyl)glutarate 336831 Drug sensitive
Rustaiyan A 324967 Drug sensitive
(15S)-15-Ethyl-1,11-diazapentacyclo[9.6.2.02,7.08,18.015,19]nonadeca-2,4,6,8(18)-tetraen-17-one 2724040 Drug sensitive
Antineoplastic-92915 261051 Drug sensitive
5-Hydroxy-3-phenylpyrano[3,2-c]chromen-2(5H)-one 24205741 Drug sensitive
(2-Methoxy-9,10-dihydrophenanthren-3-yl)methyl-dimethyl-(phenylsulfanylmethyl)azanium;bromide 24200489 Drug sensitive
Prumycin HCl 24197905 Drug resistant
9H-Purine, 2-amino-6-(o-chlorobenzylthio)-9-propyl- 239486 Drug sensitive
4,5-Bis(4-methoxyphenyl)-1,5-dihydroimidazol-2-one 231112 Drug sensitive
3-Amino-N-(2-fluorophenyl)-5-oxo-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide 1856915 Drug sensitive
Sudan II 18386 Drug sensitive
(2R)-2-[(3S,6R)-6-[[(2S,4R,5R,6R,7R,9R)-2-[(5S)-5-[(3S)-5-[(2S,3S,5R,6R)-6-Hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]-5-methyloxolan-2-yl]-7-methoxy-2,4,6-trimethyl-1,10-dioxaspiro[4.5]decan-9-yl]methyl]-3-methyloxan-2-yl]propanoic acid 152743331 Drug sensitive
Arsenic trioxide 14888 Drug sensitive
Astrazon Orange R 135747272 Drug sensitive
C8, Carbonyl prodigiosine 135540857 Drug sensitive
(2S,4S,5R)-20-De(1-hydroxypropyl)-6-demethyl-2,6-diethyl-5-hydroxy-20-(1-hydroxybutyl)lysocellin 124081057 Drug sensitive
Melampodinin 11953936 Drug sensitive
2,2'-Bioxirane 11254 Drug sensitive
Perillyl alcohol 10819 Drug sensitive
Cladospirone bisepoxide 10316810 Drug sensitive
Chimaphilin 101211 Drug sensitive
6-phenyl-6h-indeno[1,2-c]isoquinoline-5,11-dione - Drug resistant
1-[(2-cyclohexymethoxy)methyl]-5-ethyl-6-iodouracil - Drug resistant
tgf.alpha.-pe40 - Drug resistant
tp4ek - Drug resistant
tunicamycin - Drug resistant
(z) 3,3',4,5-tetramethoxystilbene - Drug sensitive
(z) 4-acetoxy-(3,4',5)-trimethoxystilbene - Drug sensitive
(Z)-N-phenyl-3-(3,4,5-trimethoxystyryl)pyridin-2-amine - Drug sensitive
1h-benzimidazole, 5,5'-dithiobis[2-(trifluoromethyl)- (9ci) - Drug sensitive
2-(4-(methylsulfonyl)phenyl)-6-p-tolyl-4,5-dihydropyridazin-3(2H)-one - Drug sensitive
2,4-diethoxyestra-1,3,5(10)trien-3,17.beta.-diol - Drug sensitive
2-[(3,4-dicloro)anilino]-3-phenyl-5,7-diamino quinoxaline - Drug sensitive
4-[4-(3-Methoxy-phenyl)-piperazin-1 -yl]-5H-pyrrolo[3,2-d]pyrimidine - Drug sensitive
4-morpholinecarbodithioic acid, antimony complex - Drug sensitive
4-thiomorpholinecarbodithioic acid, antimony complex - Drug sensitive
5-[2-(4-methoxyphenyl)ethyl]-1,2,3-dimethoxy benzene - Drug sensitive
7-n,n-dimethylamino brefeldin a hydrochloride - Drug sensitive
9-acridinamine, n-(4-ethoxyphenyl)-, monohydrochloride - Drug sensitive
anthracen-9-one, 10-[(2-methoxyphenyl)methylene]- - Drug sensitive
benzamide, 5-bromo-2-hydroxy-n-[3-(trifluoromethyl)phenyl]- - Drug sensitive
benzo[1,2-c:4,5-c']dipyrrole-1,3,5,7(2h,6h)-tetraimine - Drug sensitive
E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive
inosine, 6-thio-, 2',3',5'-tris(4-methoxybenzoate) - Drug sensitive
isoflavone, 5,7-dihydroxy-4'-nitro- - Drug sensitive
phosphonium, (3-bromopropyl)triphenyl- bromide - Drug sensitive
(Z)-3-((2-(4-(trifluoromethyl)phenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive
(Z)-6-chloro-3-((2-(4-methoxyphenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive
1-[(2-phenylethoxy)methyl]-5-ethyl-6-(phenylseleno)uracil - Drug sensitive
2-amino-5-chloro-6-(2-thiazolyloxy)-benzimidazole - Drug sensitive
4-carbo-1-thiazolidine-3-o-gluconyl-.gamma.-lactone - Drug sensitive
9-(3-fluorobenzyl)-7-(3-fluorobenzyloxy)-2-(4-fluorobenzyl)-1-methyl-9H-beta-carbolinium bromide - Drug sensitive
antineoplastic-615538 - Drug sensitive
antineoplastic-d665837 - Drug sensitive
arylmethylene-f - Drug sensitive
carzinostatin - Drug sensitive
cyclo [n-naphthoyl-d-lys-asn-gln-trp-ala-val-d-ala-his-leu] - Drug sensitive
geldanamycin-11-hexadecanic acid ester - Drug sensitive
his 47-methyl ct - Drug sensitive
n-myristoyl-(s)-phenylalaninal diethylcetal - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-92b-3p
(S)-N-[1-(3-Morpholin-4-yl-phenyl)-ethyl]-3-phenyl-acrylamide 9949648 Drug interaction    RC00005944
Gemcitabine 60750 Drug interaction    RC00005940
Vincristine 5978 Drug interaction    RC00005938
Eloxatine 5310940 Drug interaction    RC00005943
Diethylstilbestrol 448537 Drug interaction    RC00005942
Bortezomib 387447 Drug interaction    RC00005941
5-Fluorouracil 3385 Drug interaction    RC00005937
Doxorubicin 31703 Drug interaction    RC00005939
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00005936
Trastuzumab - Drug interaction    RC00005945
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-92b-3p
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-92b-3p
Interactor2: ZNF770

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region CDS
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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