Basic Information:

  VIRBase ID:  

HHID00060225

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-545-3p:  MIMAT0003165          ZMAT3:  NR_164721     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-545-3p	ZMAT3
miRBase Accession/Entrez ID	MIMAT0003165	64393
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	PAG608//WIG-1//WIG1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-545-3p	rs1283564708 chrX:74287146    G/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ZMAT3	chr3:178748281(-) A-I      intronic chr3:178748303(-) A-I      intronic chr3:178748370(-) A-I      intronic chr3:178749576(-) A-I      intronic chr3:178749657(-) A-I      intronic chr3:178782333(-) A-I      intronic chr3:178782438(-) A-I      intronic chr3:178782514(-) A-I      intronic chr3:178746785(-) A-I      intronic chr3:178746826(-) A-I      intronic chr3:178746908(-) A-I      intronic chr3:178782498(-) A-I      intronic chr3:178782315(-) A-I      intronic chr3:178749529(-) A-I      intronic chr3:178749503(-) A-I      intronic chr3:178782320(-) A-I      intronic chr3:178748319(-) A-I      intronic chr3:178749515(-) A-I      intronic chr3:178749573(-) A-I      intronic chr3:178748414(-) A-I      intronic chr3:178749583(-) A-I      intronic chr3:178744351(-) A-I      intronic chr3:178762265(-) A-I      intronic chr3:178783601(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ZMAT3	chr3:178740951(-) G-A exon 3'UTR    22484847 chr3:178744455(-) G-C intron -    22484847 chr3:178748414(-) A-G intron -    22484847 chr3:178749503(-) A-G intron -    22484847 chr3:178749515(-) A-G intron -    22484847 chr3:178749529(-) A-G intron -    22484847 chr3:178749573(-) A-G intron -    22484847 chr3:178749583(-) A-G intron -    22484847 chr3:178765486(-) G-T intron -    22484847 chr3:178778367(-) T-C intron -    22484847 chr3:178782498(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZMAT3	chr3:178738549-178738550(-) m6A 3'UTR       - chr3:178738614-178738615(-) m6A 3'UTR       - chr3:178742341-178742342(-) m6A 3'UTR       - chr3:178748766-178748767(-) m6A CDS       24981863//27773535//22608085 chr3:178785301-178785302(-) m6A CDS       24284625//24981863//27773535//22575960//22608085 chr3:178785321-178785322(-) m6A CDS       24284625//24981863//27773535//22575960//22608085 chr3:178785361-178785362(-) m6A CDS       24284625//24981863//28052920//27773535//22575960//22608085 chr3:178785388-178785389(-) m1A CDS       26863196 chr3:178785452-178785453(-) m6A CDS       24284625//24981863//22575960 chr3:178785588-178785589(-) m6A 5'UTR       - chr3:178789557-178789558(-) m6A 5'UTR       25456834//24981863//27371828 chr3:178789819-178789820(-) m6A 5'UTR       27371828 chr3:178789857-178789858(-) m6A 5'UTR       27371828 chr3:178789948-178789949(-) m6A 5'UTR       24981863//27371828 chr3:178789957-178789958(-) m6A 5'UTR       24981863//27371828

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-545-3p	Exosome Brain tissue     23382797 Exosome Serum     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	ZMAT3	Chromatin K562 cells     - Exosome Blood     - Nucleoplasm K562 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-545-3p	Iodine Green 9956454 Drug sensitive Sensorad 99342 Drug sensitive Midostaurin 9829523 Drug resistant Hydrazinecarboximidamide, 2,2'-(carbonylbis(imino-3,1-phenyleneethylidyne))bis-, hydrochloride 9577144 Drug sensitive L-2-Aminobutyric acid 80283 Drug sensitive Sulbentine 67686 Drug sensitive Ixabepilone 6445540 Drug sensitive trans-1,2-Bis(propylsulfonyl)ethylene 5904452 Drug sensitive 1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug sensitive Artelasticin 5471311 Drug sensitive 2-(1,3-Benzodioxol-5-yl)-5-hydroxy-3,7-dimethoxy-4H-chromen-4-one 5466137 Drug sensitive 3,19-(4-Acetamido)benzylidineandrographolide 54612901 Drug sensitive Herveline O 5459269 Drug sensitive Cuspidatin C 5459164 Drug sensitive Thiram 5455 Drug sensitive Indanthren Corinth RK 5351878 Drug sensitive 5-Methyl-2-{[(2)-3-phenylprop-2-enoyl]amino}benzamide 53329052 Drug sensitive Vorinostat 5311 Drug sensitive 8-Hydroxymanzamine A 5270765 Drug sensitive Spiperone 5265 Drug resistant 10-Hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12-dodecahydro-1H-picene-4a-carboxylic acid 495604 Drug sensitive Propyl gallate 4947 Drug resistant Methyl (13S,15S,16R,18S)-13-[(10S,11R,12R,19R)-11-acetyloxy-12-ethyl-10-hydroxy-5-methoxy-10-methoxycarbonyl-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraen-4-yl]-18-ethyl-1-oxido-17-oxa-11-aza-1-azoniapentacyclo[13.4.1.04,12.05,10.016,18]icosa-4(12),5,7,9-tetraene-13-carboxylate 462173 Drug sensitive 1-(4-(Benzyloxy)phenyl)-3-(3-(1-ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl)phenyl)urea 44587530 Drug sensitive Triciribine phosphate 43860 Drug resistant Di-n-octyl-secalonsaure A 430141 Drug sensitive Phosphine, 1,2-ethanediylbis[bis[2-(methylthio)phenyl]- 397601 Drug sensitive 2-Amino-4-(2-hydroxy-4-methylphenyl)-5-phenylpyrimidine 392744 Drug sensitive Leflunomide 3899 Drug sensitive Acetic acid,4,7,10-tetraazacyclododecane-1,7-diyl]bis 387352 Drug sensitive 4-Phenacyloxychromen-2-one 386272 Drug resistant 4,5-Dimethyl-11H-pyrido[4,3-a]carbazole 382590 Drug sensitive 2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant Maxima isoflavone D 343081 Drug sensitive Predorine 333830 Drug sensitive Rustaiyan A 324967 Drug sensitive Bromocriptine 31101 Drug sensitive Antimycin A3 245869 Drug sensitive 5-Hydroxy-3-phenylpyrano[3,2-c]chromen-2(5H)-one 24205741 Drug sensitive Prumycin HCl 24197905 Drug resistant Drostanolone propionate 224004 Drug sensitive Kinetin riboside 20345 Drug resistant Sudan II 18386 Drug sensitive Butyltriphenylphosphonium bromide 159628 Drug sensitive Antineoplastic-633273 15954131 Drug sensitive Astrazon Orange R 135747272 Drug sensitive (2Z)-3-Ethyl-2-[(E)-3-(3-ethyl-1,3-benzothiazol-3-ium-2-yl)-2-methylprop-2-enylidene]-1,3-benzothiazole;hydroiodide 129893658 Drug sensitive (2S,4S,5R)-20-De(1-hydroxypropyl)-6-demethyl-2,6-diethyl-5-hydroxy-20-(1-hydroxybutyl)lysocellin 124081057 Drug sensitive Fusariotoxin T-2 102515111 Drug sensitive 1-[(2-cyclohexymethoxy)methyl]-5-ethyl-6-iodouracil - Drug resistant tp4ek - Drug resistant (z) 3,3',4,5-tetramethoxystilbene - Drug sensitive (z) 4-acetoxy-(3,4',5)-trimethoxystilbene - Drug sensitive 1h-1,4,7-triazonine-1,4-diacetic acid, octahydro- - Drug sensitive 1h-benzimidazole, 5,5'-dithiobis[2-(trifluoromethyl)- (9ci) - Drug sensitive 2-[(3,4-dicloro)anilino]-3-phenyl-5,7-diamino quinoxaline - Drug sensitive 4-[4-(3-Methoxy-phenyl)-piperazin-1 -yl]-5H-pyrrolo[3,2-d]pyrimidine - Drug sensitive 4-morpholinecarbodithioic acid, antimony complex - Drug sensitive 4-thiomorpholinecarbodithioic acid, antimony complex - Drug sensitive 7-n,n-dimethylamino brefeldin a hydrochloride - Drug sensitive 9h-purine, 2-amino-6-(2,4-dichlorobenzylthio)-9-isobutyl- - Drug sensitive benzamide, 5-bromo-2-hydroxy-n-[3-(trifluoromethyl)phenyl]- - Drug sensitive E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive isoflavone, 5,7-dihydroxy-4'-nitro- - Drug sensitive phosphonium, (3-bromopropyl)triphenyl- bromide - Drug sensitive (Z)-3-((2-(4-(trifluoromethyl)phenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive (Z)-6-chloro-3-((2-(4-methoxyphenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive 1-[(2-phenylethoxy)methyl]-5-ethyl-6-(phenylseleno)uracil - Drug sensitive 9-(3-fluorobenzyl)-7-(3-fluorobenzyloxy)-2-(4-fluorobenzyl)-1-methyl-9H-beta-carbolinium bromide - Drug sensitive antineoplastic-615538 - Drug sensitive antineoplastic-641296 - Drug sensitive dichlorobisoxinatotitanium(iv) - Drug sensitive isatin dr - Drug sensitive n-myristoyl-(s)-phenylalaninal diethylcetal - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-545-3p	D-Glucose 5793 Drug interaction    RC00005847 Doxorubicin 31703 Drug interaction    RC00005848 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00005846 Verapamil 2520 Drug interaction    RC00005845 Chemotherapy - Drug interaction    RC00008874

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-545-3p
Interactor2: ZMAT3

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.