Detail Information

Basic Information:


  VIRBase ID:  

HHID00060224

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-545-3p:           USP31:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-545-3p USP31
miRBase
Accession/Entrez ID		 MIMAT0003165 57478
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - -

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-545-3p
rs1283564708 chrX:74287146    G/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR USP31
chr16:23148858(-) A-I      intronic
chr16:23138876(-) A-I      intronic
chr16:23076024(-) A-I      3'UTR
chr16:23138881(-) A-I      intronic
chr16:23074911(-) A-I      3'UTR
chr16:23138899(-) A-I      intronic
chr16:23138886(-) A-I      intronic
chr16:23138895(-) A-I      intronic
chr16:23148863(-) A-I      intronic
chr16:23148879(-) A-I      intronic
chr16:23138880(-) A-I      intronic
chr16:23155938(-) A-I      intronic
chr16:23158502(-) A-I      intronic
chr16:23155893(-) A-I      intronic
chr16:23156029(-) A-I      intronic
chr16:23158433(-) A-I      intronic
chr16:23157762(-) A-I      intronic
chr16:23158461(-) A-I      intronic
chr16:23158567(-) A-I      intronic
chr16:23158605(-) A-I      intronic
chr16:23159248(-) A-I      intronic
chr16:23156027(-) A-I      intronic
chr16:23130211(-) A-I      intronic
chr16:23130212(-) A-I      intronic
chr16:23130492(-) A-I      intronic
chr16:23130557(-) A-I      intronic
chr16:23130694(-) A-I      intronic
chr16:23130710(-) A-I      intronic
chr16:23138490(-) A-I      intronic
chr16:23138629(-) A-I      intronic
chr16:23138636(-) A-I      intronic
chr16:23138677(-) A-I      intronic
chr16:23138734(-) A-I      intronic
chr16:23138738(-) A-I      intronic
chr16:23138806(-) A-I      intronic
chr16:23138838(-) A-I      intronic
chr16:23150640(-) A-I      intronic
chr16:23155848(-) A-I      intronic
chr16:23137496(-) A-I      intronic
chr16:23159258(-) A-I      intronic
chr16:23158432(-) A-I      intronic
chr16:23130516(-) A-I      intronic
chr16:23158703(-) A-I      intronic
chr16:23158455(-) A-I      intronic
chr16:23159250(-) A-I      intronic
chr16:23159263(-) A-I      intronic
chr16:23158636(-) A-I      intronic
chr16:23155960(-) A-I      intronic
chr16:23130485(-) A-I      intronic
chr16:23152791(-) A-I      intronic
chr16:23157737(-) A-I      intronic
chr16:23159252(-) A-I      intronic
chr16:23130314(-) A-I      intronic
chr16:23130154(-) A-I      intronic
chr16:23138932(-) A-I      intronic
chr16:23159183(-) A-I      intronic
chr16:23138922(-) A-I      intronic
chr16:23130232(-) A-I      intronic
chr16:23159130(-) A-I      intronic
chr16:23150467(-) A-I      intronic
chr16:23129341(-) A-I      intronic
chr16:23152917(-) A-I      intronic
chr16:23158541(-) A-I      intronic
chr16:23158991(-) A-I      intronic
chr16:23159031(-) A-I      intronic
chr16:23139071(-) A-I      intronic
chr16:23129176(-) A-I      intronic
chr16:23158526(-) A-I      intronic
chr16:23130487(-) A-I      intronic
chr16:23159246(-) A-I      intronic
chr16:23159003(-) A-I      intronic
chr16:23156075(-) A-I      intronic
chr16:23138672(-) A-I      intronic
chr16:23157758(-) A-I      intronic
chr16:23156076(-) A-I      intronic
chr16:23129248(-) A-I      intronic
chr16:23158702(-) A-I      intronic
chr16:23159134(-) A-I      intronic
chr16:23090761(-) A-I      intronic
chr16:23158465(-) A-I      intronic
chr16:23159269(-) A-I      intronic
chr16:23129389(-) A-I      intronic
chr16:23158554(-) A-I      intronic
chr16:23155897(-) A-I      intronic
chr16:23129217(-) A-I      intronic
chr16:23139072(-) A-I      intronic
chr16:23159136(-) A-I      intronic
chr16:23159179(-) A-I      intronic
chr16:23158594(-) A-I      intronic
chr16:23159057(-) A-I      intronic
chr16:23149166(-) A-I      intronic
chr16:23149200(-) A-I      intronic
chr16:23155102(-) A-I      intronic
chr16:23159182(-) A-I      intronic
chr16:23130517(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED USP31
chr16:23129389(-) A-G intron -    22484847
chr16:23158703(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase USP31
chr16:23072818-23072819(-) m6A 3'UTR       27773535
chr16:23075426-23075427(-) m6A 3'UTR       27773535
chr16:23075450-23075451(-) m6A 3'UTR       27773535
chr16:23075570-23075571(-) m6A 3'UTR       24981863//27773535//22608085
chr16:23075582-23075583(-) m6A 3'UTR       24981863//27773535//22608085
chr16:23075655-23075656(-) m6A 3'UTR       27773535//22608085
chr16:23075703-23075704(-) m6A 3'UTR       27773535//22608085
chr16:23075761-23075762(-) m6A 3'UTR       24981863//27773535//22608085
chr16:23075869-23075870(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr16:23075898-23075899(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085
chr16:23075924-23075925(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085
chr16:23076102-23076103(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085
chr16:23076248-23076249(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr16:23076274-23076275(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr16:23076320-23076321(-) m6A 3'UTR       27773535
chr16:23076344-23076345(-) m6A 3'UTR       27773535
chr16:23078692-23078693(-) m6A 3'UTR       27773535
chr16:23078869-23078870(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr16:23078885-23078886(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr16:23078905-23078906(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr16:23078950-23078951(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr16:23079015-23079016(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr16:23079023-23079024(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr16:23079059-23079060(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr16:23079143-23079144(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr16:23079166-23079167(-) m6A 3'UTR       24209618//27773535//22608085
chr16:23079315-23079316(-) m6A 3'UTR       24981863//27773535
chr16:23079375-23079376(-) m6A CDS       24284625//24981863//27773535
chr16:23079398-23079399(-) m6A CDS       24284625//24981863//27773535
chr16:23079475-23079476(-) m6A CDS       24284625//25456834//24981863//27773535//27371828//22608085
chr16:23079519-23079520(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr16:23079535-23079536(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr16:23079631-23079632(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr16:23079686-23079687(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr16:23079713-23079714(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr16:23079723-23079724(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr16:23079757-23079758(-) m6A CDS       24284625//25456834//24981863//27371828//27773536//22608085
chr16:23079772-23079773(-) m6A CDS       24284625//25456834//24981863//27371828//27773536//22608085
chr16:23079900-23079901(-) m6A CDS       24284625//25456834//24981863//27773535//27371828//27773536//22608085
chr16:23079945-23079946(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr16:23079973-23079974(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr16:23079980-23079981(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr16:23080111-23080112(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr16:23080296-23080297(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22608085
chr16:23080371-23080372(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr16:23080429-23080430(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr16:23080504-23080505(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr16:23080521-23080522(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr16:23080549-23080550(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr16:23080564-23080565(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr16:23080653-23080654(-) m6A CDS       24284625//25456834//24981863//27371828//22575960//22608085
chr16:23080675-23080676(-) m6A CDS       24284625//25456834//24981863//27371828//22575960//22608085
chr16:23091098-23091099(-) m6A CDS//intron       24981863
chr16:23091331-23091332(-) m6A CDS       24209618//24981863//27773535//22608085
chr16:23091340-23091341(-) m6A CDS       24209618//24981863//27773535//22608085
chr16:23091351-23091352(-) m6A CDS       24209618//24981863//27371828//22608085
chr16:23091433-23091434(-) m6A CDS       24209618//24981863//22608085
chr16:23091463-23091464(-) m6A CDS       24209618//24981863//22608085
chr16:23091471-23091472(-) m6A CDS       24209618
chr16:23091484-23091485(-) m6A CDS       24209618
chr16:23096964-23096965(-) m6A CDS       27773535
chr16:23099149-23099150(-) m6A CDS       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-545-3p
Exosome Brain tissue     23382797
Exosome Serum     24683445
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
USP31
Chromatin K562 cells     -
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Ribosome HEK-293 cells     22199352

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-545-3p
Iodine Green 9956454 Drug sensitive
Sensorad 99342 Drug sensitive
Midostaurin 9829523 Drug resistant
Hydrazinecarboximidamide, 2,2'-(carbonylbis(imino-3,1-phenyleneethylidyne))bis-, hydrochloride 9577144 Drug sensitive
L-2-Aminobutyric acid 80283 Drug sensitive
Sulbentine 67686 Drug sensitive
Ixabepilone 6445540 Drug sensitive
trans-1,2-Bis(propylsulfonyl)ethylene 5904452 Drug sensitive
1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug sensitive
Artelasticin 5471311 Drug sensitive
2-(1,3-Benzodioxol-5-yl)-5-hydroxy-3,7-dimethoxy-4H-chromen-4-one 5466137 Drug sensitive
3,19-(4-Acetamido)benzylidineandrographolide 54612901 Drug sensitive
Herveline O 5459269 Drug sensitive
Cuspidatin C 5459164 Drug sensitive
Thiram 5455 Drug sensitive
Indanthren Corinth RK 5351878 Drug sensitive
5-Methyl-2-{[(2)-3-phenylprop-2-enoyl]amino}benzamide 53329052 Drug sensitive
Vorinostat 5311 Drug sensitive
8-Hydroxymanzamine A 5270765 Drug sensitive
Spiperone 5265 Drug resistant
10-Hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12-dodecahydro-1H-picene-4a-carboxylic acid 495604 Drug sensitive
Propyl gallate 4947 Drug resistant
Methyl (13S,15S,16R,18S)-13-[(10S,11R,12R,19R)-11-acetyloxy-12-ethyl-10-hydroxy-5-methoxy-10-methoxycarbonyl-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraen-4-yl]-18-ethyl-1-oxido-17-oxa-11-aza-1-azoniapentacyclo[13.4.1.04,12.05,10.016,18]icosa-4(12),5,7,9-tetraene-13-carboxylate 462173 Drug sensitive
1-(4-(Benzyloxy)phenyl)-3-(3-(1-ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl)phenyl)urea 44587530 Drug sensitive
Triciribine phosphate 43860 Drug resistant
Di-n-octyl-secalonsaure A 430141 Drug sensitive
Phosphine, 1,2-ethanediylbis[bis[2-(methylthio)phenyl]- 397601 Drug sensitive
2-Amino-4-(2-hydroxy-4-methylphenyl)-5-phenylpyrimidine 392744 Drug sensitive
Leflunomide 3899 Drug sensitive
Acetic acid,4,7,10-tetraazacyclododecane-1,7-diyl]bis 387352 Drug sensitive
4-Phenacyloxychromen-2-one 386272 Drug resistant
4,5-Dimethyl-11H-pyrido[4,3-a]carbazole 382590 Drug sensitive
2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant
Maxima isoflavone D 343081 Drug sensitive
Predorine 333830 Drug sensitive
Rustaiyan A 324967 Drug sensitive
Bromocriptine 31101 Drug sensitive
Antimycin A3 245869 Drug sensitive
5-Hydroxy-3-phenylpyrano[3,2-c]chromen-2(5H)-one 24205741 Drug sensitive
Prumycin HCl 24197905 Drug resistant
Drostanolone propionate 224004 Drug sensitive
Kinetin riboside 20345 Drug resistant
Sudan II 18386 Drug sensitive
Butyltriphenylphosphonium bromide 159628 Drug sensitive
Antineoplastic-633273 15954131 Drug sensitive
Astrazon Orange R 135747272 Drug sensitive
(2Z)-3-Ethyl-2-[(E)-3-(3-ethyl-1,3-benzothiazol-3-ium-2-yl)-2-methylprop-2-enylidene]-1,3-benzothiazole;hydroiodide 129893658 Drug sensitive
(2S,4S,5R)-20-De(1-hydroxypropyl)-6-demethyl-2,6-diethyl-5-hydroxy-20-(1-hydroxybutyl)lysocellin 124081057 Drug sensitive
Fusariotoxin T-2 102515111 Drug sensitive
1-[(2-cyclohexymethoxy)methyl]-5-ethyl-6-iodouracil - Drug resistant
tp4ek - Drug resistant
(z) 3,3',4,5-tetramethoxystilbene - Drug sensitive
(z) 4-acetoxy-(3,4',5)-trimethoxystilbene - Drug sensitive
1h-1,4,7-triazonine-1,4-diacetic acid, octahydro- - Drug sensitive
1h-benzimidazole, 5,5'-dithiobis[2-(trifluoromethyl)- (9ci) - Drug sensitive
2-[(3,4-dicloro)anilino]-3-phenyl-5,7-diamino quinoxaline - Drug sensitive
4-[4-(3-Methoxy-phenyl)-piperazin-1 -yl]-5H-pyrrolo[3,2-d]pyrimidine - Drug sensitive
4-morpholinecarbodithioic acid, antimony complex - Drug sensitive
4-thiomorpholinecarbodithioic acid, antimony complex - Drug sensitive
7-n,n-dimethylamino brefeldin a hydrochloride - Drug sensitive
9h-purine, 2-amino-6-(2,4-dichlorobenzylthio)-9-isobutyl- - Drug sensitive
benzamide, 5-bromo-2-hydroxy-n-[3-(trifluoromethyl)phenyl]- - Drug sensitive
E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive
isoflavone, 5,7-dihydroxy-4'-nitro- - Drug sensitive
phosphonium, (3-bromopropyl)triphenyl- bromide - Drug sensitive
(Z)-3-((2-(4-(trifluoromethyl)phenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive
(Z)-6-chloro-3-((2-(4-methoxyphenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive
1-[(2-phenylethoxy)methyl]-5-ethyl-6-(phenylseleno)uracil - Drug sensitive
9-(3-fluorobenzyl)-7-(3-fluorobenzyloxy)-2-(4-fluorobenzyl)-1-methyl-9H-beta-carbolinium bromide - Drug sensitive
antineoplastic-615538 - Drug sensitive
antineoplastic-641296 - Drug sensitive
dichlorobisoxinatotitanium(iv) - Drug sensitive
isatin dr - Drug sensitive
n-myristoyl-(s)-phenylalaninal diethylcetal - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-545-3p
D-Glucose 5793 Drug interaction    RC00005847
Doxorubicin 31703 Drug interaction    RC00005848
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00005846
Verapamil 2520 Drug interaction    RC00005845
Chemotherapy - Drug interaction    RC00008874

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-545-3p
Interactor2: USP31

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

Starting a new search, please wait ...