Basic Information:

  VIRBase ID:  

HHID00060219

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-545-3p:  MIMAT0003165          ZRANB1:  NM_017580     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-545-3p	ZRANB1
miRBase Accession/Entrez ID	MIMAT0003165	54764
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	TRABID

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-545-3p	rs1283564708 chrX:74287146    G/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ZRANB1	chr10:126640379(+) A-I      intronic chr10:126634937(+) A-I      intronic chr10:126634601(+) A-I      intronic chr10:126640406(+) A-I      intronic chr10:126641236(+) A-I      intronic chr10:126666137(+) A-I      intronic chr10:126640370(+) A-I      intronic chr10:126638955(+) A-I      intronic chr10:126641393(+) A-I      intronic chr10:126638806(+) A-I      intronic chr10:126634430(+) A-I      intronic chr10:126634456(+) A-I      intronic chr10:126641363(+) A-I      intronic chr10:126634520(+) A-I      intronic chr10:126638312(+) A-I      intronic chr10:126638203(+) A-I      intronic chr10:126640405(+) A-I      intronic chr10:126641345(+) A-I      intronic chr10:126641280(+) A-I      intronic chr10:126634545(+) A-I      intronic chr10:126634495(+) A-I      intronic chr10:126634473(+) A-I      intronic chr10:126634455(+) A-I      intronic chr10:126634450(+) A-I      intronic chr10:126634435(+) A-I      intronic chr10:126634373(+) A-I      intronic chr10:126643551(+) A-I      intronic chr10:126634423(+) A-I      intronic chr10:126664315(+) A-I      intronic chr10:126664428(+) A-I      intronic chr10:126643086(+) A-I      intronic chr10:126666235(+) A-I      intronic chr10:126638146(+) A-I      intronic chr10:126665588(+) A-I      intronic chr10:126643511(+) A-I      intronic chr10:126643519(+) A-I      intronic chr10:126642629(+) A-I      intronic chr10:126666103(+) A-I      intronic chr10:126651674(+) A-I      intronic chr10:126643532(+) A-I      intronic chr10:126664364(+) A-I      intronic chr10:126665663(+) A-I      intronic chr10:126634641(+) A-I      intronic chr10:126666281(+) A-I      intronic chr10:126666133(+) A-I      intronic chr10:126666097(+) A-I      intronic chr10:126666083(+) A-I      intronic chr10:126643567(+) A-I      intronic chr10:126665802(+) A-I      intronic chr10:126665751(+) A-I      intronic chr10:126651579(+) A-I      intronic chr10:126638967(+) A-I      intronic chr10:126634592(+) A-I      intronic chr10:126665706(+) A-I      intronic chr10:126634723(+) A-I      intronic chr10:126634732(+) A-I      intronic chr10:126665695(+) A-I      intronic chr10:126634755(+) A-I      intronic chr10:126665637(+) A-I      intronic chr10:126665586(+) A-I      intronic chr10:126664473(+) A-I      intronic chr10:126664464(+) A-I      intronic chr10:126638740(+) A-I      intronic chr10:126664316(+) A-I      intronic chr10:126664395(+) A-I      intronic chr10:126641319(+) A-I      intronic chr10:126634866(+) A-I      intronic chr10:126634893(+) A-I      intronic chr10:126634908(+) A-I      intronic chr10:126638830(+) A-I      intronic chr10:126664361(+) A-I      intronic chr10:126638954(+) A-I      intronic chr10:126663466(+) A-I      intronic chr10:126667216(+) A-I      intronic chr10:126639290(+) A-I      intronic chr10:126643118(+) A-I      intronic chr10:126651659(+) A-I      intronic chr10:126643214(+) A-I      intronic chr10:126643217(+) A-I      intronic chr10:126664346(+) A-I      intronic chr10:126643226(+) A-I      intronic chr10:126643238(+) A-I      intronic chr10:126643255(+) A-I      intronic chr10:126651673(+) A-I      intronic chr10:126643256(+) A-I      intronic chr10:126664419(+) A-I      intronic chr10:126666165(+) A-I      intronic chr10:126664356(+) A-I      intronic chr10:126638876(+) A-I      intronic chr10:126634733(+) A-I      intronic chr10:126634593(+) A-I      intronic chr10:126642654(+) A-I      intronic chr10:126665611(+) A-I      intronic chr10:126663441(+) A-I      intronic chr10:126634468(+) A-I      intronic chr10:126643134(+) A-I      intronic chr10:126665267(+) A-I      intronic chr10:126643291(+) A-I      intronic chr10:126634738(+) A-I      intronic chr10:126634626(+) A-I      intronic chr10:126643548(+) A-I      intronic chr10:126665739(+) A-I      intronic chr10:126664490(+) A-I      intronic chr10:126643444(+) A-I      intronic chr10:126639350(+) A-I      intronic chr10:126634832(+) A-I      intronic chr10:126632059(+) A-I      intronic chr10:126641426(+) A-I      intronic chr10:126643158(+) A-I      intronic chr10:126667300(+) A-I      intronic chr10:126643443(+) A-I      intronic chr10:126643700(+) A-I      intronic chr10:126638914(+) A-I      intronic chr10:126643577(+) A-I      intronic chr10:126639403(+) A-I      intronic chr10:126665681(+) A-I      intronic chr10:126665280(+) A-I      intronic chr10:126666159(+) A-I      intronic chr10:126634610(+) A-I      intronic chr10:126663500(+) A-I      intronic chr10:126666146(+) A-I      intronic chr10:126646959(+) A-I      intronic chr10:126639444(+) A-I      intronic chr10:126643828(+) A-I      intronic chr10:126669446(+) A-I      intronic chr10:126639282(+) A-I      intronic chr10:126665724(+) A-I      intronic chr10:126639349(+) A-I      intronic chr10:126638794(+) A-I      intronic chr10:126639347(+) A-I      intronic chr10:126639406(+) A-I      intronic chr10:126634420(+) A-I      intronic chr10:126643121(+) A-I      intronic chr10:126666169(+) A-I      intronic chr10:126663467(+) A-I      intronic chr10:126646911(+) A-I      intronic chr10:126666255(+) A-I      intronic chr10:126664451(+) A-I      intronic chr10:126651744(+) A-I      intronic chr10:126643643(+) A-I      intronic chr10:126665315(+) A-I      intronic chr10:126666230(+) A-I      intronic chr10:126643541(+) A-I      intronic chr10:126665705(+) A-I      intronic chr10:126638913(+) A-I      intronic chr10:126664519(+) A-I      intronic chr10:126646425(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ZRANB1	chr10:126674880(+) A-I intron -    21960545 chr10:126639403(+) A-G intron -    22484847 chr10:126639406(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZRANB1	chr10:126631111-126631112(+) m6A CDS       24209618//24981863//22575960//22608085 chr10:126631154-126631155(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr10:126631164-126631165(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr10:126631267-126631268(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085 chr10:126631280-126631281(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085 chr10:126631351-126631352(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085 chr10:126631398-126631399(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr10:126631445-126631446(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr10:126631496-126631497(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr10:126631501-126631502(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr10:126631509-126631510(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr10:126631521-126631522(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr10:126631546-126631547(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr10:126631589-126631590(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr10:126631623-126631624(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr10:126631657-126631658(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr10:126631729-126631730(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr10:126631793-126631794(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr10:126631804-126631805(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr10:126631814-126631815(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr10:126631831-126631832(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr10:126631845-126631846(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr10:126655216-126655217(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr10:126655265-126655266(+) Y CDS       26075521 chr10:126662849-126662850(+) m6A CDS       24981863 chr10:126662854-126662855(+) m6A CDS       24981863 chr10:126662864-126662865(+) m6A CDS       24981863 chr10:126662915-126662916(+) m6A CDS       24981863 chr10:126670352-126670353(+) m6A CDS//exon       - chr10:126670366-126670367(+) m6A CDS//exon       - chr10:126671848-126671849(+) m6A CDS//exon       - chr10:126671857-126671858(+) Y CDS//exon       26075521 chr10:126673356-126673357(+) m6A CDS       24981863 chr10:126673368-126673369(+) m6A CDS       24981863 chr10:126673388-126673389(+) m6A CDS       24981863//27773535 chr10:126673574-126673575(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr10:126673584-126673585(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr10:126673656-126673657(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr10:126673697-126673698(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr10:126673741-126673742(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr10:126673748-126673749(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr10:126673759-126673760(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr10:126673778-126673779(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr10:126673793-126673794(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22575960//22608085 chr10:126673798-126673799(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22575960//22608085 chr10:126673858-126673859(+) m6A 3'UTR       24981863//26404942//22608085 chr10:126674695-126674696(+) Y 3'UTR       26075521 chr10:126676230-126676231(+) m6A 3'UTR       - chr10:126676283-126676284(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-545-3p	Exosome Brain tissue     23382797 Exosome Serum     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	ZRANB1	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells     - Ribosome HEK-293 cells     22199352

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-545-3p	Iodine Green 9956454 Drug sensitive Sensorad 99342 Drug sensitive Midostaurin 9829523 Drug resistant Hydrazinecarboximidamide, 2,2'-(carbonylbis(imino-3,1-phenyleneethylidyne))bis-, hydrochloride 9577144 Drug sensitive L-2-Aminobutyric acid 80283 Drug sensitive Sulbentine 67686 Drug sensitive Ixabepilone 6445540 Drug sensitive trans-1,2-Bis(propylsulfonyl)ethylene 5904452 Drug sensitive 1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug sensitive Artelasticin 5471311 Drug sensitive 2-(1,3-Benzodioxol-5-yl)-5-hydroxy-3,7-dimethoxy-4H-chromen-4-one 5466137 Drug sensitive 3,19-(4-Acetamido)benzylidineandrographolide 54612901 Drug sensitive Herveline O 5459269 Drug sensitive Cuspidatin C 5459164 Drug sensitive Thiram 5455 Drug sensitive Indanthren Corinth RK 5351878 Drug sensitive 5-Methyl-2-{[(2)-3-phenylprop-2-enoyl]amino}benzamide 53329052 Drug sensitive Vorinostat 5311 Drug sensitive 8-Hydroxymanzamine A 5270765 Drug sensitive Spiperone 5265 Drug resistant 10-Hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12-dodecahydro-1H-picene-4a-carboxylic acid 495604 Drug sensitive Propyl gallate 4947 Drug resistant Methyl (13S,15S,16R,18S)-13-[(10S,11R,12R,19R)-11-acetyloxy-12-ethyl-10-hydroxy-5-methoxy-10-methoxycarbonyl-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraen-4-yl]-18-ethyl-1-oxido-17-oxa-11-aza-1-azoniapentacyclo[13.4.1.04,12.05,10.016,18]icosa-4(12),5,7,9-tetraene-13-carboxylate 462173 Drug sensitive 1-(4-(Benzyloxy)phenyl)-3-(3-(1-ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl)phenyl)urea 44587530 Drug sensitive Triciribine phosphate 43860 Drug resistant Di-n-octyl-secalonsaure A 430141 Drug sensitive Phosphine, 1,2-ethanediylbis[bis[2-(methylthio)phenyl]- 397601 Drug sensitive 2-Amino-4-(2-hydroxy-4-methylphenyl)-5-phenylpyrimidine 392744 Drug sensitive Leflunomide 3899 Drug sensitive Acetic acid,4,7,10-tetraazacyclododecane-1,7-diyl]bis 387352 Drug sensitive 4-Phenacyloxychromen-2-one 386272 Drug resistant 4,5-Dimethyl-11H-pyrido[4,3-a]carbazole 382590 Drug sensitive 2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant Maxima isoflavone D 343081 Drug sensitive Predorine 333830 Drug sensitive Rustaiyan A 324967 Drug sensitive Bromocriptine 31101 Drug sensitive Antimycin A3 245869 Drug sensitive 5-Hydroxy-3-phenylpyrano[3,2-c]chromen-2(5H)-one 24205741 Drug sensitive Prumycin HCl 24197905 Drug resistant Drostanolone propionate 224004 Drug sensitive Kinetin riboside 20345 Drug resistant Sudan II 18386 Drug sensitive Butyltriphenylphosphonium bromide 159628 Drug sensitive Antineoplastic-633273 15954131 Drug sensitive Astrazon Orange R 135747272 Drug sensitive (2Z)-3-Ethyl-2-[(E)-3-(3-ethyl-1,3-benzothiazol-3-ium-2-yl)-2-methylprop-2-enylidene]-1,3-benzothiazole;hydroiodide 129893658 Drug sensitive (2S,4S,5R)-20-De(1-hydroxypropyl)-6-demethyl-2,6-diethyl-5-hydroxy-20-(1-hydroxybutyl)lysocellin 124081057 Drug sensitive Fusariotoxin T-2 102515111 Drug sensitive 1-[(2-cyclohexymethoxy)methyl]-5-ethyl-6-iodouracil - Drug resistant tp4ek - Drug resistant (z) 3,3',4,5-tetramethoxystilbene - Drug sensitive (z) 4-acetoxy-(3,4',5)-trimethoxystilbene - Drug sensitive 1h-1,4,7-triazonine-1,4-diacetic acid, octahydro- - Drug sensitive 1h-benzimidazole, 5,5'-dithiobis[2-(trifluoromethyl)- (9ci) - Drug sensitive 2-[(3,4-dicloro)anilino]-3-phenyl-5,7-diamino quinoxaline - Drug sensitive 4-[4-(3-Methoxy-phenyl)-piperazin-1 -yl]-5H-pyrrolo[3,2-d]pyrimidine - Drug sensitive 4-morpholinecarbodithioic acid, antimony complex - Drug sensitive 4-thiomorpholinecarbodithioic acid, antimony complex - Drug sensitive 7-n,n-dimethylamino brefeldin a hydrochloride - Drug sensitive 9h-purine, 2-amino-6-(2,4-dichlorobenzylthio)-9-isobutyl- - Drug sensitive benzamide, 5-bromo-2-hydroxy-n-[3-(trifluoromethyl)phenyl]- - Drug sensitive E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive isoflavone, 5,7-dihydroxy-4'-nitro- - Drug sensitive phosphonium, (3-bromopropyl)triphenyl- bromide - Drug sensitive (Z)-3-((2-(4-(trifluoromethyl)phenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive (Z)-6-chloro-3-((2-(4-methoxyphenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive 1-[(2-phenylethoxy)methyl]-5-ethyl-6-(phenylseleno)uracil - Drug sensitive 9-(3-fluorobenzyl)-7-(3-fluorobenzyloxy)-2-(4-fluorobenzyl)-1-methyl-9H-beta-carbolinium bromide - Drug sensitive antineoplastic-615538 - Drug sensitive antineoplastic-641296 - Drug sensitive dichlorobisoxinatotitanium(iv) - Drug sensitive isatin dr - Drug sensitive n-myristoyl-(s)-phenylalaninal diethylcetal - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-545-3p	D-Glucose 5793 Drug interaction    RC00005847 Doxorubicin 31703 Drug interaction    RC00005848 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00005846 Verapamil 2520 Drug interaction    RC00005845 Chemotherapy - Drug interaction    RC00008874

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-545-3p
Interactor2: ZRANB1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.