Detail Information

Basic Information:


  VIRBase ID:  

HHID00060216

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-545-3p:           KMT5B:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-545-3p KMT5B
miRBase
Accession/Entrez ID		 MIMAT0003165 51111
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CGI-85//CGI85//MRD51//SUV420H1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-545-3p
rs1283564708 chrX:74287146    G/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR KMT5B
chr11:67935543(-) A-I      intronic
chr11:67943614(-) A-I      intronic
chr11:67966364(-) A-I      intronic
chr11:67966386(-) A-I      intronic
chr11:67966392(-) A-I      intronic
chr11:67943599(-) A-I      intronic
chr11:67965804(-) A-I      intronic
chr11:67969288(-) A-I      intronic
chr11:67966371(-) A-I      intronic
chr11:67973226(-) A-I      intronic
chr11:67973262(-) A-I      intronic
chr11:67975244(-) A-I      intronic
chr11:67933077(-) A-I      intronic
chr11:67935380(-) A-I      intronic
chr11:67935574(-) A-I      intronic
chr11:67964712(-) A-I      intronic
chr11:67935998(-) A-I      intronic
chr11:67936006(-) A-I      intronic
chr11:67936007(-) A-I      intronic
chr11:67936049(-) A-I      intronic
chr11:67936053(-) A-I      intronic
chr11:67963484(-) A-I      intronic
chr11:67936059(-) A-I      intronic
chr11:67942116(-) A-I      intronic
chr11:67943417(-) A-I      intronic
chr11:67975392(-) A-I      intronic
chr11:67943444(-) A-I      intronic
chr11:67975417(-) A-I      intronic
chr11:67943447(-) A-I      intronic
chr11:67975482(-) A-I      intronic
chr11:67943449(-) A-I      intronic
chr11:67958396(-) A-I      intronic
chr11:67951739(-) A-I      intronic
chr11:67970591(-) A-I      intronic
chr11:67963622(-) A-I      intronic
chr11:67962524(-) A-I      intronic
chr11:67943478(-) A-I      intronic
chr11:67943484(-) A-I      intronic
chr11:67943510(-) A-I      intronic
chr11:67943519(-) A-I      intronic
chr11:67965646(-) A-I      intronic
chr11:67943546(-) A-I      intronic
chr11:67958194(-) A-I      intronic
chr11:67958386(-) A-I      intronic
chr11:67943591(-) A-I      intronic
chr11:67944143(-) A-I      intronic
chr11:67951194(-) A-I      intronic
chr11:67951265(-) A-I      intronic
chr11:67951294(-) A-I      intronic
chr11:67944244(-) A-I      intronic
chr11:67943604(-) A-I      intronic
chr11:67951377(-) A-I      intronic
chr11:67951650(-) A-I      intronic
chr11:67963524(-) A-I      intronic
chr11:67951825(-) A-I      intronic
chr11:67951695(-) A-I      intronic
chr11:67972793(-) A-I      intronic
chr11:67975479(-) A-I      intronic
chr11:67951717(-) A-I      intronic
chr11:67963458(-) A-I      intronic
chr11:67935557(-) A-I      intronic
chr11:67951770(-) A-I      intronic
chr11:67942081(-) A-I      intronic
chr11:67951801(-) A-I      intronic
chr11:67972161(-) A-I      intronic
chr11:67958234(-) A-I      intronic
chr11:67951811(-) A-I      intronic
chr11:67964576(-) A-I      intronic
chr11:67951321(-) A-I      intronic
chr11:67975412(-) A-I      intronic
chr11:67958293(-) A-I      intronic
chr11:67958338(-) A-I      intronic
chr11:67963380(-) A-I      intronic
chr11:67975089(-) A-I      intronic
chr11:67936076(-) A-I      intronic
chr11:67935104(-) A-I      intronic
chr11:67975444(-) A-I      intronic
chr11:67935459(-) A-I      intronic
chr11:67972728(-) A-I      intronic
chr11:67958706(-) A-I      intronic
chr11:67958782(-) A-I      intronic
chr11:67958233(-) A-I      intronic
chr11:67972723(-) A-I      intronic
chr11:67966361(-) A-I      intronic
chr11:67961879(-) A-I      intronic
chr11:67959052(-) A-I      intronic
chr11:67966308(-) A-I      intronic
chr11:67966293(-) A-I      intronic
chr11:67965788(-) A-I      intronic
chr11:67970580(-) A-I      intronic
chr11:67972310(-) A-I      intronic
chr11:67973282(-) A-I      intronic
chr11:67964713(-) A-I      intronic
chr11:67963379(-) A-I      intronic
chr11:67970687(-) A-I      intronic
chr11:67935409(-) A-I      intronic
chr11:67944219(-) A-I      intronic
chr11:67951271(-) A-I      intronic
chr11:67935895(-) A-I      intronic
chr11:67969431(-) A-I      intronic
chr11:67935927(-) A-I      intronic
chr11:67970242(-) A-I      intronic
chr11:67970217(-) A-I      intronic
chr11:67958720(-) A-I      intronic
chr11:67969428(-) A-I      intronic
chr11:67975851(-) A-I      intronic
chr11:67962526(-) A-I      intronic
chr11:67958601(-) A-I      intronic
chr11:67975906(-) A-I      intronic
chr11:67969411(-) A-I      intronic
chr11:67972647(-) A-I      intronic
chr11:67951757(-) A-I      intronic
chr11:67935167(-) A-I      intronic
chr11:67958838(-) A-I      intronic
chr11:67958836(-) A-I      intronic
chr11:67972224(-) A-I      intronic
chr11:67935014(-) A-I      intronic
chr11:67935531(-) A-I      intronic
chr11:67963505(-) A-I      intronic
chr11:67970554(-) A-I      intronic
chr11:67963349(-) A-I      intronic
chr11:67975473(-) A-I      intronic
chr11:67961376(-) A-I      intronic
chr11:67935113(-) A-I      intronic
chr11:67973209(-) A-I      intronic
chr11:67966335(-) A-I      intronic
chr11:67970153(-) A-I      intronic
chr11:67951300(-) A-I      intronic
chr11:67976235(-) A-I      intronic
chr11:67943651(-) A-I      intronic
chr11:67963421(-) A-I      intronic
chr11:67965729(-) A-I      intronic
chr11:67936088(-) A-I      intronic
chr11:67961755(-) A-I      intronic
chr11:67962605(-) A-I      intronic
chr11:67952948(-) A-I      intronic
chr11:67964646(-) A-I      intronic
chr11:67943514(-) A-I      intronic
chr11:67951291(-) A-I      intronic
chr11:67951690(-) A-I      intronic
chr11:67936078(-) A-I      intronic
chr11:67951730(-) A-I      intronic
chr11:67935999(-) A-I      intronic
chr11:67935062(-) A-I      intronic
chr11:67969434(-) A-I      intronic
chr11:67958737(-) A-I      intronic
chr11:67973360(-) A-I      intronic
chr11:67951297(-) A-I      intronic
chr11:67935105(-) A-I      intronic
chr11:67943492(-) A-I      intronic
chr11:67963444(-) A-I      intronic
chr11:67951378(-) A-I      intronic
chr11:67975576(-) A-I      intronic
chr11:67944130(-) A-I      intronic
chr11:67951756(-) A-I      intronic
chr11:67963512(-) A-I      intronic
chr11:67943551(-) A-I      intronic
chr11:67935404(-) A-I      intronic
chr11:67969290(-) A-I      intronic
chr11:67970287(-) A-I      intronic
chr11:67951251(-) A-I      intronic
chr11:67935943(-) A-I      intronic
chr11:67935940(-) A-I      intronic
chr11:67950907(-) A-I      intronic
chr11:67975443(-) A-I      intronic
chr11:67964624(-) A-I      intronic
chr11:67935590(-) A-I      intronic
chr11:67964643(-) A-I      intronic
chr11:67963618(-) A-I      intronic
chr11:67970713(-) A-I      intronic
chr11:67972221(-) A-I      intronic
chr11:67935476(-) A-I      intronic
chr11:67950963(-) A-I      intronic
chr11:67936075(-) A-I      intronic
chr11:67958760(-) A-I      intronic
chr11:67950995(-) A-I      intronic
chr11:67969515(-) A-I      intronic
chr11:67951305(-) A-I      intronic
chr11:67975481(-) A-I      intronic
chr11:67972179(-) A-I      intronic
chr11:67944165(-) A-I      intronic
chr11:67932966(-) A-I      intronic
chr11:67958692(-) A-I      intronic
chr11:67935196(-) A-I      intronic
chr11:67959076(-) A-I      intronic
chr11:67951296(-) A-I      intronic
chr11:67975792(-) A-I      intronic
chr11:67935124(-) A-I      intronic
chr11:67944169(-) A-I      intronic
chr11:67959009(-) A-I      intronic
chr11:67935382(-) A-I      intronic
chr11:67935519(-) A-I      intronic
chr11:67963500(-) A-I      intronic
chr11:67951224(-) A-I      intronic
chr11:67961724(-) A-I      intronic
chr11:67935046(-) A-I      intronic
chr11:67958380(-) A-I      intronic
chr11:67969512(-) A-I      intronic
chr11:67951223(-) A-I      intronic
chr11:67944136(-) A-I      intronic
chr11:67943590(-) A-I      intronic
chr11:67944175(-) A-I      intronic
chr11:67951837(-) A-I      intronic
chr11:67942159(-) A-I      intronic
chr11:67972334(-) A-I      intronic
chr11:67958258(-) A-I      intronic
chr11:67958591(-) A-I      intronic
chr11:67951195(-) A-I      intronic
chr11:67966463(-) A-I      intronic
chr11:67951727(-) A-I      intronic
chr11:67958766(-) A-I      intronic
chr11:67944218(-) A-I      intronic
chr11:67951248(-) A-I      intronic
chr11:67951676(-) A-I      intronic
chr11:67969503(-) A-I      intronic
chr11:67958530(-) A-I      intronic
chr11:67966209(-) A-I      intronic
chr11:67951731(-) A-I      intronic
chr11:67964621(-) A-I      intronic
chr11:67975914(-) A-I      intronic
chr11:67943555(-) A-I      intronic
chr11:67963502(-) A-I      intronic
chr11:67973359(-) A-I      intronic
chr11:67970714(-) A-I      intronic
chr11:67961823(-) A-I      intronic
chr11:67935206(-) A-I      intronic
chr11:67964582(-) A-I      intronic
chr11:67975474(-) A-I      intronic
chr11:67972195(-) A-I      intronic
chr11:67972180(-) A-I      intronic
chr11:67975659(-) A-I      intronic
chr11:67935941(-) A-I      intronic
chr11:67935567(-) A-I      intronic
chr11:67944166(-) A-I      intronic
chr11:67963441(-) A-I      intronic
chr11:67943549(-) A-I      intronic
chr11:67965805(-) A-I      intronic
chr11:67969461(-) A-I      intronic
chr11:67961878(-) A-I      intronic
chr11:67951361(-) A-I      intronic
chr11:67952775(-) A-I      intronic
chr11:67951112(-) A-I      intronic
chr11:67944170(-) A-I      intronic
chr11:67950862(-) A-I      intronic
chr11:67951603(-) A-I      intronic
chr11:67973252(-) A-I      intronic
chr11:67933031(-) A-I      intronic
chr11:67951787(-) A-I      intronic
chr11:67951666(-) A-I      intronic
chr11:67959051(-) A-I      intronic
chr11:67935556(-) A-I      intronic
chr11:67966210(-) A-I      intronic
chr11:67961826(-) A-I      intronic
chr11:67935580(-) A-I      intronic
chr11:67977518(-) A-I      intronic
chr11:67935996(-) A-I      intronic
chr11:67963687(-) A-I      intronic

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-545-3p
Exosome Brain tissue     23382797
Exosome Serum     24683445
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
KMT5B
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-545-3p
Iodine Green 9956454 Drug sensitive
Sensorad 99342 Drug sensitive
Midostaurin 9829523 Drug resistant
Hydrazinecarboximidamide, 2,2'-(carbonylbis(imino-3,1-phenyleneethylidyne))bis-, hydrochloride 9577144 Drug sensitive
L-2-Aminobutyric acid 80283 Drug sensitive
Sulbentine 67686 Drug sensitive
Ixabepilone 6445540 Drug sensitive
trans-1,2-Bis(propylsulfonyl)ethylene 5904452 Drug sensitive
1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug sensitive
Artelasticin 5471311 Drug sensitive
2-(1,3-Benzodioxol-5-yl)-5-hydroxy-3,7-dimethoxy-4H-chromen-4-one 5466137 Drug sensitive
3,19-(4-Acetamido)benzylidineandrographolide 54612901 Drug sensitive
Herveline O 5459269 Drug sensitive
Cuspidatin C 5459164 Drug sensitive
Thiram 5455 Drug sensitive
Indanthren Corinth RK 5351878 Drug sensitive
5-Methyl-2-{[(2)-3-phenylprop-2-enoyl]amino}benzamide 53329052 Drug sensitive
Vorinostat 5311 Drug sensitive
8-Hydroxymanzamine A 5270765 Drug sensitive
Spiperone 5265 Drug resistant
10-Hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12-dodecahydro-1H-picene-4a-carboxylic acid 495604 Drug sensitive
Propyl gallate 4947 Drug resistant
Methyl (13S,15S,16R,18S)-13-[(10S,11R,12R,19R)-11-acetyloxy-12-ethyl-10-hydroxy-5-methoxy-10-methoxycarbonyl-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraen-4-yl]-18-ethyl-1-oxido-17-oxa-11-aza-1-azoniapentacyclo[13.4.1.04,12.05,10.016,18]icosa-4(12),5,7,9-tetraene-13-carboxylate 462173 Drug sensitive
1-(4-(Benzyloxy)phenyl)-3-(3-(1-ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl)phenyl)urea 44587530 Drug sensitive
Triciribine phosphate 43860 Drug resistant
Di-n-octyl-secalonsaure A 430141 Drug sensitive
Phosphine, 1,2-ethanediylbis[bis[2-(methylthio)phenyl]- 397601 Drug sensitive
2-Amino-4-(2-hydroxy-4-methylphenyl)-5-phenylpyrimidine 392744 Drug sensitive
Leflunomide 3899 Drug sensitive
Acetic acid,4,7,10-tetraazacyclododecane-1,7-diyl]bis 387352 Drug sensitive
4-Phenacyloxychromen-2-one 386272 Drug resistant
4,5-Dimethyl-11H-pyrido[4,3-a]carbazole 382590 Drug sensitive
2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant
Maxima isoflavone D 343081 Drug sensitive
Predorine 333830 Drug sensitive
Rustaiyan A 324967 Drug sensitive
Bromocriptine 31101 Drug sensitive
Antimycin A3 245869 Drug sensitive
5-Hydroxy-3-phenylpyrano[3,2-c]chromen-2(5H)-one 24205741 Drug sensitive
Prumycin HCl 24197905 Drug resistant
Drostanolone propionate 224004 Drug sensitive
Kinetin riboside 20345 Drug resistant
Sudan II 18386 Drug sensitive
Butyltriphenylphosphonium bromide 159628 Drug sensitive
Antineoplastic-633273 15954131 Drug sensitive
Astrazon Orange R 135747272 Drug sensitive
(2Z)-3-Ethyl-2-[(E)-3-(3-ethyl-1,3-benzothiazol-3-ium-2-yl)-2-methylprop-2-enylidene]-1,3-benzothiazole;hydroiodide 129893658 Drug sensitive
(2S,4S,5R)-20-De(1-hydroxypropyl)-6-demethyl-2,6-diethyl-5-hydroxy-20-(1-hydroxybutyl)lysocellin 124081057 Drug sensitive
Fusariotoxin T-2 102515111 Drug sensitive
1-[(2-cyclohexymethoxy)methyl]-5-ethyl-6-iodouracil - Drug resistant
tp4ek - Drug resistant
(z) 3,3',4,5-tetramethoxystilbene - Drug sensitive
(z) 4-acetoxy-(3,4',5)-trimethoxystilbene - Drug sensitive
1h-1,4,7-triazonine-1,4-diacetic acid, octahydro- - Drug sensitive
1h-benzimidazole, 5,5'-dithiobis[2-(trifluoromethyl)- (9ci) - Drug sensitive
2-[(3,4-dicloro)anilino]-3-phenyl-5,7-diamino quinoxaline - Drug sensitive
4-[4-(3-Methoxy-phenyl)-piperazin-1 -yl]-5H-pyrrolo[3,2-d]pyrimidine - Drug sensitive
4-morpholinecarbodithioic acid, antimony complex - Drug sensitive
4-thiomorpholinecarbodithioic acid, antimony complex - Drug sensitive
7-n,n-dimethylamino brefeldin a hydrochloride - Drug sensitive
9h-purine, 2-amino-6-(2,4-dichlorobenzylthio)-9-isobutyl- - Drug sensitive
benzamide, 5-bromo-2-hydroxy-n-[3-(trifluoromethyl)phenyl]- - Drug sensitive
E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive
isoflavone, 5,7-dihydroxy-4'-nitro- - Drug sensitive
phosphonium, (3-bromopropyl)triphenyl- bromide - Drug sensitive
(Z)-3-((2-(4-(trifluoromethyl)phenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive
(Z)-6-chloro-3-((2-(4-methoxyphenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive
1-[(2-phenylethoxy)methyl]-5-ethyl-6-(phenylseleno)uracil - Drug sensitive
9-(3-fluorobenzyl)-7-(3-fluorobenzyloxy)-2-(4-fluorobenzyl)-1-methyl-9H-beta-carbolinium bromide - Drug sensitive
antineoplastic-615538 - Drug sensitive
antineoplastic-641296 - Drug sensitive
dichlorobisoxinatotitanium(iv) - Drug sensitive
isatin dr - Drug sensitive
n-myristoyl-(s)-phenylalaninal diethylcetal - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-545-3p
D-Glucose 5793 Drug interaction    RC00005847
Doxorubicin 31703 Drug interaction    RC00005848
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00005846
Verapamil 2520 Drug interaction    RC00005845
Chemotherapy - Drug interaction    RC00008874

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-545-3p
Interactor2: KMT5B

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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