Basic Information:

  VIRBase ID:  

HHID00060197

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-545-3p:  MIMAT0003165          FUBP3:  NM_003934     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-545-3p	FUBP3
miRBase Accession/Entrez ID	MIMAT0003165	8939
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	FBP3

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-545-3p	rs1283564708 chrX:74287146    G/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	FUBP3	chr9:133476242(+) A-I      intronic chr9:133469935(+) A-I      intronic chr9:133469895(+) A-I      intronic chr9:133469741(+) A-I      intronic chr9:133468092(+) A-I      intronic chr9:133468031(+) A-I      intronic chr9:133467970(+) A-I      intronic chr9:133467601(+) A-I      intronic chr9:133467512(+) A-I      intronic chr9:133460027(+) A-I      intronic chr9:133460069(+) A-I      intronic chr9:133460070(+) A-I      intronic chr9:133460077(+) A-I      intronic chr9:133460177(+) A-I      intronic chr9:133466715(+) A-I      intronic chr9:133476127(+) A-I      intronic chr9:133462398(+) A-I      intronic chr9:133460181(+) A-I      intronic chr9:133465337(+) A-I      intronic chr9:133461485(+) A-I      intronic chr9:133461503(+) A-I      intronic chr9:133461852(+) A-I      intronic chr9:133466668(+) A-I      intronic chr9:133465363(+) A-I      intronic chr9:133465338(+) A-I      intronic chr9:133462266(+) A-I      intronic chr9:133464914(+) A-I      intronic chr9:133464911(+) A-I      intronic chr9:133482493(+) A-I      intronic chr9:133462712(+) A-I      intronic chr9:133486808(+) A-I      intronic chr9:133465376(+) A-I      intronic chr9:133482511(+) A-I      intronic chr9:133465324(+) A-I      intronic chr9:133459744(+) A-I      intronic chr9:133465325(+) A-I      intronic chr9:133465350(+) A-I      intronic chr9:133459682(+) A-I      intronic chr9:133462693(+) A-I      intronic chr9:133462681(+) A-I      intronic chr9:133462686(+) A-I      intronic chr9:133475902(+) A-I      intronic chr9:133469958(+) A-I      intronic chr9:133469949(+) A-I      intronic chr9:133459371(+) A-I      intronic chr9:133462672(+) A-I      intronic chr9:133462652(+) A-I      intronic chr9:133467460(+) A-I      intronic chr9:133468080(+) A-I      intronic chr9:133462404(+) A-I      intronic chr9:133476178(+) A-I      intronic chr9:133481115(+) A-I      intronic chr9:133482491(+) A-I      intronic chr9:133482639(+) A-I      intronic chr9:133482438(+) A-I      intronic chr9:133482419(+) A-I      intronic chr9:133482087(+) A-I      intronic chr9:133482086(+) A-I      intronic chr9:133482070(+) A-I      intronic chr9:133482052(+) A-I      intronic chr9:133482024(+) A-I      intronic chr9:133482007(+) A-I      intronic chr9:133481953(+) A-I      intronic chr9:133465392(+) A-I      intronic chr9:133469940(+) A-I      intronic chr9:133459762(+) A-I      intronic chr9:133459763(+) A-I      intronic chr9:133459808(+) A-I      intronic chr9:133459836(+) A-I      intronic chr9:133460006(+) A-I      intronic chr9:133482548(+) A-I      intronic chr9:133462649(+) A-I      intronic chr9:133478655(+) A-I      intronic chr9:133476216(+) A-I      intronic chr9:133465339(+) A-I      intronic chr9:133464860(+) A-I      intronic chr9:133478646(+) A-I      intronic chr9:133467404(+) A-I      intronic chr9:133480033(+) A-I      intronic chr9:133469866(+) A-I      intronic chr9:133459668(+) A-I      intronic chr9:133482505(+) A-I      intronic chr9:133482479(+) A-I      intronic chr9:133482633(+) A-I      intronic chr9:133469784(+) A-I      intronic chr9:133482444(+) A-I      intronic chr9:133482499(+) A-I      intronic chr9:133500313(+) A-I      intronic chr9:133459376(+) A-I      intronic chr9:133459653(+) A-I      intronic chr9:133470399(+) A-I      intronic chr9:133477282(+) A-I      intronic chr9:133459695(+) A-I      intronic chr9:133477289(+) A-I      intronic chr9:133481390(+) A-I      intronic chr9:133476198(+) A-I      intronic chr9:133476000(+) A-I      intronic chr9:133457599(+) A-I      intronic chr9:133467461(+) A-I      intronic chr9:133474532(+) A-I      intronic chr9:133469977(+) A-I      intronic chr9:133457814(+) A-I      intronic chr9:133467504(+) A-I      intronic chr9:133460100(+) A-I      intronic chr9:133461863(+) A-I      intronic chr9:133475916(+) A-I      intronic chr9:133477328(+) A-I      intronic chr9:133466659(+) A-I      intronic chr9:133482594(+) A-I      intronic chr9:133461407(+) A-I      intronic chr9:133476252(+) A-I      intronic chr9:133467513(+) A-I      intronic chr9:133461888(+) A-I      intronic chr9:133482139(+) A-I      intronic chr9:133478613(+) A-I      intronic chr9:133468150(+) A-I      intronic chr9:133462312(+) A-I      intronic chr9:133466710(+) A-I      intronic chr9:133468034(+) A-I      intronic chr9:133467363(+) A-I      intronic chr9:133470428(+) A-I      intronic chr9:133474304(+) A-I      intronic chr9:133478686(+) A-I      intronic chr9:133467988(+) A-I      intronic chr9:133470025(+) A-I      intronic chr9:133467390(+) A-I      intronic chr9:133482635(+) A-I      intronic chr9:133477418(+) A-I      intronic chr9:133461437(+) A-I      intronic chr9:133457656(+) A-I      intronic chr9:133459313(+) A-I      intronic chr9:133474294(+) A-I      intronic chr9:133481192(+) A-I      intronic chr9:133482502(+) A-I      intronic chr9:133462358(+) A-I      intronic chr9:133459362(+) A-I      intronic chr9:133461486(+) A-I      intronic chr9:133474548(+) A-I      intronic chr9:133467488(+) A-I      intronic chr9:133482581(+) A-I      intronic chr9:133459812(+) A-I      intronic chr9:133500314(+) A-I      intronic chr9:133461812(+) A-I      intronic chr9:133459829(+) A-I      intronic chr9:133470031(+) A-I      intronic chr9:133462637(+) A-I      intronic chr9:133462335(+) A-I      intronic chr9:133462276(+) A-I      intronic chr9:133475908(+) A-I      intronic chr9:133470111(+) A-I      intronic chr9:133467435(+) A-I      intronic chr9:133478722(+) A-I      intronic chr9:133477288(+) A-I      intronic chr9:133467983(+) A-I      intronic chr9:133482568(+) A-I      intronic chr9:133461858(+) A-I      intronic chr9:133467468(+) A-I      intronic chr9:133459700(+) A-I      intronic chr9:133475903(+) A-I      intronic chr9:133504256(+) A-I      intronic chr9:133468166(+) A-I      intronic chr9:133462278(+) A-I      intronic chr9:133459847(+) A-I      intronic chr9:133474558(+) A-I      intronic chr9:133500312(+) A-I      intronic chr9:133467364(+) A-I      intronic chr9:133457746(+) A-I      intronic chr9:133462635(+) A-I      intronic chr9:133476302(+) A-I      intronic chr9:133482414(+) A-I      intronic chr9:133477461(+) A-I      intronic chr9:133482162(+) A-I      intronic chr9:133476259(+) A-I      intronic chr9:133482620(+) A-I      intronic chr9:133457692(+) A-I      intronic chr9:133461460(+) A-I      intronic chr9:133461409(+) A-I      intronic chr9:133481321(+) A-I      intronic chr9:133468060(+) A-I      intronic chr9:133461889(+) A-I      intronic chr9:133481250(+) A-I      intronic chr9:133464835(+) A-I      intronic chr9:133482427(+) A-I      intronic chr9:133461410(+) A-I      intronic chr9:133464834(+) A-I      intronic chr9:133457605(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	FUBP3	chr9:133476307(+) A-I intron -    22327324 chr9:133461409(+) A-I intron -    21960545 chr9:133461410(+) A-I intron -    21960545 chr9:133479856(+) A-G intron -    22484847 chr9:133482667(+) T-C intron -    22484847 chr9:133465297(+) C-T intron -    22484847 chr9:133468048(+) A-G intron -    22484847 chr9:133476307(+) A-G intron -    22484847 chr9:133481192(+) A-G intron -    22484847 chr9:133482427(+) A-G intron -    22484847 chr9:133482568(+) A-G intron -    22484847 chr9:133482594(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	FUBP3	chr9:133454365-133454366(+) m6A exon       24284625 chr9:133454378-133454379(+) m6A exon       24284625 chr9:133454428-133454429(+) m6A exon       24284625 chr9:133454469-133454470(+) m6A exon       24284625//25456834//27371828//27773536 chr9:133454483-133454484(+) m6A exon       24284625//25456834//27371828//27773536 chr9:133454496-133454497(+) m6A exon       24284625//25456834//27371828//27773536 chr9:133454514-133454515(+) m6A exon       24284625//25456834//27371828//27773536//22608085 chr9:133454609-133454610(+) m6A exon       24284625//25456834//27371828//27773536//22608085 chr9:133454625-133454626(+) m6A exon       24284625//25456834//27371828//27773536//22608085 chr9:133454698-133454699(+) m6A exon       24284625//25456834//27371828//27773536//22608085 chr9:133454708-133454709(+) m6A exon       24284625//25456834//27371828//27773536//22608085 chr9:133454728-133454729(+) m6A exon       25456834//27371828//27773536 chr9:133454757-133454758(+) m6A exon       25456834//27371828//27773536 chr9:133454794-133454795(+) m6A exon       25456834//27371828 chr9:133455003-133455004(+) m6A 5'UTR//exon       - chr9:133456073-133456074(+) m1A exon//intron       26863196//26863410 chr9:133456139-133456140(+) m6A exon//intron       24209618 chr9:133456196-133456197(+) m6A exon//intron       24209618//24981863 chr9:133456216-133456217(+) m6A exon//intron       24209618//24981863 chr9:133456225-133456226(+) m6A exon//intron       24209618//24981863 chr9:133456317-133456318(+) m6A exon//intron       24284625//24981863 chr9:133456349-133456350(+) m6A exon//intron       24284625//24981863 chr9:133456427-133456428(+) m6A exon//intron       24284625//24981863 chr9:133456577-133456578(+) m6A exon//intron       24209618//24981863//22608085 chr9:133456595-133456596(+) m6A exon//intron       24209618//24981863//22608085 chr9:133456607-133456608(+) m6A exon//intron       24209618//24981863//22608085 chr9:133456637-133456638(+) m6A exon//intron       24209618//25456834//24981863//22608085 chr9:133456651-133456652(+) m6A exon//intron       24209618//25456834//24981863//22608085 chr9:133456671-133456672(+) m6A exon//intron       24209618//25456834//24981863//22608085 chr9:133456737-133456738(+) m6A exon//intron       24209618//25456834//24981863//22608085 chr9:133456804-133456805(+) m6A exon//intron       24209618//22608085 chr9:133456884-133456885(+) m6A exon//intron       - chr9:133456895-133456896(+) m6A exon//intron       - chr9:133457461-133457462(+) m6A exon//intron       24209618 chr9:133470924-133470925(+) m6A CDS//exon       24209618 chr9:133491812-133491813(+) m6A CDS       22575960 chr9:133491886-133491887(+) m6A CDS       24981863//26404942//22575960 chr9:133493189-133493190(+) m6A CDS       24981863//26404942//27773535//22575960 chr9:133493241-133493242(+) m6A CDS       24981863//27773535//22575960 chr9:133495780-133495781(+) m6A CDS       24981863//27773535 chr9:133498192-133498193(+) m6A CDS//exon       24284625 chr9:133506023-133506024(+) m6A CDS//exon       24284625//22575960 chr9:133506074-133506075(+) m6A CDS//exon       24284625//22575960 chr9:133506593-133506594(+) m6A exon//intron       24284625 chr9:133506946-133506947(+) m6A CDS//exon       24284625 chr9:133506975-133506976(+) m6A CDS//exon       24284625 chr9:133507363-133507364(+) m6A CDS//exon       24284625 chr9:133507387-133507388(+) m6A CDS//exon       24284625 chr9:133510107-133510108(+) m6A CDS//exon       24284625 chr9:133510120-133510121(+) m6A CDS//exon       24284625 chr9:133511270-133511271(+) m6A exon//intron       24284625 chr9:133511427-133511428(+) m6A CDS//exon       24284625//24981863 chr9:133511458-133511459(+) m6A CDS//exon       24284625//24981863 chr9:133511479-133511480(+) m6A CDS//exon       24284625//24981863 chr9:133512410-133512411(+) m6A 3'UTR//exon       24284625//24981863 chr9:133513279-133513280(+) Y 3'UTR       26075521 chr9:133513527-133513528(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-545-3p	Exosome Brain tissue     23382797 Exosome Serum     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	FUBP3	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Membrane K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-545-3p	Iodine Green 9956454 Drug sensitive Sensorad 99342 Drug sensitive Midostaurin 9829523 Drug resistant Hydrazinecarboximidamide, 2,2'-(carbonylbis(imino-3,1-phenyleneethylidyne))bis-, hydrochloride 9577144 Drug sensitive L-2-Aminobutyric acid 80283 Drug sensitive Sulbentine 67686 Drug sensitive Ixabepilone 6445540 Drug sensitive trans-1,2-Bis(propylsulfonyl)ethylene 5904452 Drug sensitive 1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug sensitive Artelasticin 5471311 Drug sensitive 2-(1,3-Benzodioxol-5-yl)-5-hydroxy-3,7-dimethoxy-4H-chromen-4-one 5466137 Drug sensitive 3,19-(4-Acetamido)benzylidineandrographolide 54612901 Drug sensitive Herveline O 5459269 Drug sensitive Cuspidatin C 5459164 Drug sensitive Thiram 5455 Drug sensitive Indanthren Corinth RK 5351878 Drug sensitive 5-Methyl-2-{[(2)-3-phenylprop-2-enoyl]amino}benzamide 53329052 Drug sensitive Vorinostat 5311 Drug sensitive 8-Hydroxymanzamine A 5270765 Drug sensitive Spiperone 5265 Drug resistant 10-Hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12-dodecahydro-1H-picene-4a-carboxylic acid 495604 Drug sensitive Propyl gallate 4947 Drug resistant Methyl (13S,15S,16R,18S)-13-[(10S,11R,12R,19R)-11-acetyloxy-12-ethyl-10-hydroxy-5-methoxy-10-methoxycarbonyl-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraen-4-yl]-18-ethyl-1-oxido-17-oxa-11-aza-1-azoniapentacyclo[13.4.1.04,12.05,10.016,18]icosa-4(12),5,7,9-tetraene-13-carboxylate 462173 Drug sensitive 1-(4-(Benzyloxy)phenyl)-3-(3-(1-ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl)phenyl)urea 44587530 Drug sensitive Triciribine phosphate 43860 Drug resistant Di-n-octyl-secalonsaure A 430141 Drug sensitive Phosphine, 1,2-ethanediylbis[bis[2-(methylthio)phenyl]- 397601 Drug sensitive 2-Amino-4-(2-hydroxy-4-methylphenyl)-5-phenylpyrimidine 392744 Drug sensitive Leflunomide 3899 Drug sensitive Acetic acid,4,7,10-tetraazacyclododecane-1,7-diyl]bis 387352 Drug sensitive 4-Phenacyloxychromen-2-one 386272 Drug resistant 4,5-Dimethyl-11H-pyrido[4,3-a]carbazole 382590 Drug sensitive 2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant Maxima isoflavone D 343081 Drug sensitive Predorine 333830 Drug sensitive Rustaiyan A 324967 Drug sensitive Bromocriptine 31101 Drug sensitive Antimycin A3 245869 Drug sensitive 5-Hydroxy-3-phenylpyrano[3,2-c]chromen-2(5H)-one 24205741 Drug sensitive Prumycin HCl 24197905 Drug resistant Drostanolone propionate 224004 Drug sensitive Kinetin riboside 20345 Drug resistant Sudan II 18386 Drug sensitive Butyltriphenylphosphonium bromide 159628 Drug sensitive Antineoplastic-633273 15954131 Drug sensitive Astrazon Orange R 135747272 Drug sensitive (2Z)-3-Ethyl-2-[(E)-3-(3-ethyl-1,3-benzothiazol-3-ium-2-yl)-2-methylprop-2-enylidene]-1,3-benzothiazole;hydroiodide 129893658 Drug sensitive (2S,4S,5R)-20-De(1-hydroxypropyl)-6-demethyl-2,6-diethyl-5-hydroxy-20-(1-hydroxybutyl)lysocellin 124081057 Drug sensitive Fusariotoxin T-2 102515111 Drug sensitive 1-[(2-cyclohexymethoxy)methyl]-5-ethyl-6-iodouracil - Drug resistant tp4ek - Drug resistant (z) 3,3',4,5-tetramethoxystilbene - Drug sensitive (z) 4-acetoxy-(3,4',5)-trimethoxystilbene - Drug sensitive 1h-1,4,7-triazonine-1,4-diacetic acid, octahydro- - Drug sensitive 1h-benzimidazole, 5,5'-dithiobis[2-(trifluoromethyl)- (9ci) - Drug sensitive 2-[(3,4-dicloro)anilino]-3-phenyl-5,7-diamino quinoxaline - Drug sensitive 4-[4-(3-Methoxy-phenyl)-piperazin-1 -yl]-5H-pyrrolo[3,2-d]pyrimidine - Drug sensitive 4-morpholinecarbodithioic acid, antimony complex - Drug sensitive 4-thiomorpholinecarbodithioic acid, antimony complex - Drug sensitive 7-n,n-dimethylamino brefeldin a hydrochloride - Drug sensitive 9h-purine, 2-amino-6-(2,4-dichlorobenzylthio)-9-isobutyl- - Drug sensitive benzamide, 5-bromo-2-hydroxy-n-[3-(trifluoromethyl)phenyl]- - Drug sensitive E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive isoflavone, 5,7-dihydroxy-4'-nitro- - Drug sensitive phosphonium, (3-bromopropyl)triphenyl- bromide - Drug sensitive (Z)-3-((2-(4-(trifluoromethyl)phenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive (Z)-6-chloro-3-((2-(4-methoxyphenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive 1-[(2-phenylethoxy)methyl]-5-ethyl-6-(phenylseleno)uracil - Drug sensitive 9-(3-fluorobenzyl)-7-(3-fluorobenzyloxy)-2-(4-fluorobenzyl)-1-methyl-9H-beta-carbolinium bromide - Drug sensitive antineoplastic-615538 - Drug sensitive antineoplastic-641296 - Drug sensitive dichlorobisoxinatotitanium(iv) - Drug sensitive isatin dr - Drug sensitive n-myristoyl-(s)-phenylalaninal diethylcetal - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-545-3p	D-Glucose 5793 Drug interaction    RC00005847 Doxorubicin 31703 Drug interaction    RC00005848 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00005846 Verapamil 2520 Drug interaction    RC00005845 Chemotherapy - Drug interaction    RC00008874

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-545-3p
Interactor2: FUBP3

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.