Basic Information:

  VIRBase ID:  

HHID00060188

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-545-3p:  MIMAT0003165          PDE4B:  NM_001037340     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-545-3p	PDE4B
miRBase Accession/Entrez ID	MIMAT0003165	5142
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	DPDE4//PDEIVB

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-545-3p	rs1283564708 chrX:74287146    G/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PDE4B	chr1:66630108(+) A-I      intronic chr1:66630104(+) A-I      intronic chr1:66630040(+) A-I      intronic chr1:66630041(+) A-I      intronic chr1:66630042(+) A-I      intronic chr1:66630047(+) A-I      intronic chr1:66630088(+) A-I      intronic chr1:66630098(+) A-I      intronic chr1:66630099(+) A-I      intronic chr1:66630651(+) A-I      intronic chr1:66630229(+) A-I      intronic chr1:66630198(+) A-I      intronic chr1:66630184(+) A-I      intronic chr1:66602326(+) A-I      intronic chr1:66602313(+) A-I      intronic chr1:66750234(+) A-I      intronic chr1:66676145(+) A-I      intronic chr1:66734308(+) A-I      intronic chr1:66759746(+) A-I      intronic chr1:66640332(+) A-I      intronic chr1:66676070(+) A-I      intronic chr1:66613833(+) A-I      intronic chr1:66502765(+) A-I      intronic chr1:66454928(+) A-I      intronic chr1:66639569(+) A-I      intronic chr1:66630032(+) A-I      intronic chr1:66613767(+) A-I      intronic chr1:66602338(+) A-I      intronic chr1:66630018(+) A-I      intronic chr1:66274759(+) A-I      intronic chr1:66630241(+) A-I      intronic chr1:66612141(+) A-I      intronic chr1:66630205(+) A-I      intronic chr1:66745249(+) A-I      intronic chr1:66639675(+) A-I      intronic chr1:66401376(+) A-I      intronic chr1:66613885(+) A-I      intronic chr1:66602331(+) A-I      intronic chr1:66804199(+) A-I      intronic chr1:66611931(+) A-I      intronic chr1:66288823(+) A-I      intronic chr1:66639570(+) A-I      intronic chr1:66630031(+) A-I      intronic chr1:66630201(+) A-I      intronic chr1:66496468(+) A-I      intronic chr1:66630168(+) A-I      intronic chr1:66734339(+) A-I      intronic chr1:66632170(+) A-I      intronic chr1:66502695(+) A-I      intronic chr1:66496495(+) A-I      intronic chr1:66485143(+) A-I      intronic chr1:66602306(+) A-I      intronic chr1:66632951(+) A-I      intronic chr1:66630511(+) A-I      intronic chr1:66485118(+) A-I      intronic chr1:66743140(+) A-I      intronic chr1:66501464(+) A-I      intronic chr1:66519422(+) A-I      intronic chr1:66613725(+) A-I      intronic chr1:66694224(+) A-I      intronic chr1:66582270(+) A-I      intronic chr1:66630022(+) A-I      intronic chr1:66274750(+) A-I      intronic chr1:66630140(+) A-I      intronic chr1:66630479(+) A-I      intronic chr1:66753644(+) A-I      intronic chr1:66761212(+) A-I      intronic chr1:66835755(+) A-I      intronic chr1:66456847(+) A-I      intronic chr1:66485132(+) A-I      intronic chr1:66483938(+) A-I      intronic chr1:66734240(+) A-I      intronic chr1:66720791(+) A-I      intronic chr1:66467551(+) A-I      intronic chr1:66761170(+) A-I      intronic chr1:66639642(+) A-I      intronic chr1:66542076(+) A-I      intronic chr1:66270910(+) A-I      intronic chr1:66377951(+) A-I      intronic chr1:66406155(+) A-I      intronic chr1:66540622(+) A-I      intronic chr1:66502705(+) A-I      intronic chr1:66745201(+) A-I      intronic chr1:66483881(+) A-I      intronic chr1:66454929(+) A-I      intronic chr1:66485138(+) A-I      intronic chr1:66485219(+) A-I      intronic chr1:66639653(+) A-I      intronic chr1:66496547(+) A-I      intronic chr1:66630062(+) A-I      intronic chr1:66632928(+) A-I      intronic chr1:66612073(+) A-I      intronic chr1:66483934(+) A-I      intronic chr1:66406036(+) A-I      intronic chr1:66630203(+) A-I      intronic chr1:66542063(+) A-I      intronic chr1:66501453(+) A-I      intronic chr1:66743351(+) A-I      intronic chr1:66613832(+) A-I      intronic chr1:66694227(+) A-I      intronic chr1:66406221(+) A-I      intronic chr1:66613699(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PDE4B	chr1:66829350(+) C-T intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PDE4B	chr1:66458314-66458315(+) m6A 5'UTR//exon//intron       24981863 chr1:66458483-66458484(+) m6A 5'UTR//exon//intron       24981863 chr1:66458501-66458502(+) m6A 5'UTR//exon//intron       24981863 chr1:66458587-66458588(+) m6A 5'UTR//exon//intron       24981863//26404942 chr1:66458615-66458616(+) m6A CDS//exon//intron       24981863//26404942 chr1:66458630-66458631(+) m6A CDS//exon//intron       24981863//26404942 chr1:66458649-66458650(+) m6A CDS//exon//intron       24981863//26404942 chr1:66458675-66458676(+) m6A CDS//exon//intron       24981863//26404942 chr1:66458701-66458702(+) m6A CDS//exon//intron       24981863//26404942 chr1:66458746-66458747(+) m6A CDS//exon//intron       24981863 chr1:66797807-66797808(+) m6A 5'UTR//intron       - chr1:66797843-66797844(+) m6A 5'UTR//intron       24981863 chr1:66797874-66797875(+) m6A 5'UTR//intron       24981863 chr1:66797903-66797904(+) m6A 5'UTR//intron       24981863 chr1:66797984-66797985(+) m6A 5'UTR//intron       24981863 chr1:66798139-66798140(+) m6A CDS//intron       24981863 chr1:66798235-66798236(+) m6A CDS       24981863 chr1:66833820-66833821(+) m6A exon//intron       - chr1:66834497-66834498(+) m6A CDS       - chr1:66834541-66834542(+) m6A CDS       - chr1:66834578-66834579(+) m6A CDS       - chr1:66834624-66834625(+) m6A CDS       24981863 chr1:66838034-66838035(+) m6A CDS       25456834//24981863//26404942 chr1:66838068-66838069(+) m6A CDS       25456834//24981863//26404942//22608085 chr1:66838098-66838099(+) m6A CDS       25456834//24981863//26404942//22575960//22608085 chr1:66838152-66838153(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr1:66838158-66838159(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr1:66838192-66838193(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr1:66838222-66838223(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr1:66838243-66838244(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr1:66838293-66838294(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr1:66838313-66838314(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr1:66838323-66838324(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr1:66838338-66838339(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr1:66838384-66838385(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr1:66838446-66838447(+) m6A 3'UTR       24209618//25456834//24981863//26404942//22575960//22608085 chr1:66838457-66838458(+) m6A 3'UTR       24209618//25456834//24981863//26404942//22575960//22608085 chr1:66838508-66838509(+) m6A 3'UTR       24209618//25456834//24981863//26404942//22608085 chr1:66838613-66838614(+) m6A 3'UTR       25456834//24981863//26404942 chr1:66838635-66838636(+) m6A 3'UTR       25456834//24981863//26404942 chr1:66838642-66838643(+) m6A 3'UTR       25456834//24981863//26404942 chr1:66838674-66838675(+) m6A 3'UTR       25456834//24981863//26404942 chr1:66838696-66838697(+) m6A 3'UTR       25456834//24981863//26404942 chr1:66838774-66838775(+) m6A 3'UTR       24981863//26404942 chr1:66838948-66838949(+) m6A 3'UTR       24981863 chr1:66839028-66839029(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-545-3p	Exosome Brain tissue     23382797 Exosome Serum     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	PDE4B	Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-545-3p	Iodine Green 9956454 Drug sensitive Sensorad 99342 Drug sensitive Midostaurin 9829523 Drug resistant Hydrazinecarboximidamide, 2,2'-(carbonylbis(imino-3,1-phenyleneethylidyne))bis-, hydrochloride 9577144 Drug sensitive L-2-Aminobutyric acid 80283 Drug sensitive Sulbentine 67686 Drug sensitive Ixabepilone 6445540 Drug sensitive trans-1,2-Bis(propylsulfonyl)ethylene 5904452 Drug sensitive 1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug sensitive Artelasticin 5471311 Drug sensitive 2-(1,3-Benzodioxol-5-yl)-5-hydroxy-3,7-dimethoxy-4H-chromen-4-one 5466137 Drug sensitive 3,19-(4-Acetamido)benzylidineandrographolide 54612901 Drug sensitive Herveline O 5459269 Drug sensitive Cuspidatin C 5459164 Drug sensitive Thiram 5455 Drug sensitive Indanthren Corinth RK 5351878 Drug sensitive 5-Methyl-2-{[(2)-3-phenylprop-2-enoyl]amino}benzamide 53329052 Drug sensitive Vorinostat 5311 Drug sensitive 8-Hydroxymanzamine A 5270765 Drug sensitive Spiperone 5265 Drug resistant 10-Hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12-dodecahydro-1H-picene-4a-carboxylic acid 495604 Drug sensitive Propyl gallate 4947 Drug resistant Methyl (13S,15S,16R,18S)-13-[(10S,11R,12R,19R)-11-acetyloxy-12-ethyl-10-hydroxy-5-methoxy-10-methoxycarbonyl-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraen-4-yl]-18-ethyl-1-oxido-17-oxa-11-aza-1-azoniapentacyclo[13.4.1.04,12.05,10.016,18]icosa-4(12),5,7,9-tetraene-13-carboxylate 462173 Drug sensitive 1-(4-(Benzyloxy)phenyl)-3-(3-(1-ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl)phenyl)urea 44587530 Drug sensitive Triciribine phosphate 43860 Drug resistant Di-n-octyl-secalonsaure A 430141 Drug sensitive Phosphine, 1,2-ethanediylbis[bis[2-(methylthio)phenyl]- 397601 Drug sensitive 2-Amino-4-(2-hydroxy-4-methylphenyl)-5-phenylpyrimidine 392744 Drug sensitive Leflunomide 3899 Drug sensitive Acetic acid,4,7,10-tetraazacyclododecane-1,7-diyl]bis 387352 Drug sensitive 4-Phenacyloxychromen-2-one 386272 Drug resistant 4,5-Dimethyl-11H-pyrido[4,3-a]carbazole 382590 Drug sensitive 2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant Maxima isoflavone D 343081 Drug sensitive Predorine 333830 Drug sensitive Rustaiyan A 324967 Drug sensitive Bromocriptine 31101 Drug sensitive Antimycin A3 245869 Drug sensitive 5-Hydroxy-3-phenylpyrano[3,2-c]chromen-2(5H)-one 24205741 Drug sensitive Prumycin HCl 24197905 Drug resistant Drostanolone propionate 224004 Drug sensitive Kinetin riboside 20345 Drug resistant Sudan II 18386 Drug sensitive Butyltriphenylphosphonium bromide 159628 Drug sensitive Antineoplastic-633273 15954131 Drug sensitive Astrazon Orange R 135747272 Drug sensitive (2Z)-3-Ethyl-2-[(E)-3-(3-ethyl-1,3-benzothiazol-3-ium-2-yl)-2-methylprop-2-enylidene]-1,3-benzothiazole;hydroiodide 129893658 Drug sensitive (2S,4S,5R)-20-De(1-hydroxypropyl)-6-demethyl-2,6-diethyl-5-hydroxy-20-(1-hydroxybutyl)lysocellin 124081057 Drug sensitive Fusariotoxin T-2 102515111 Drug sensitive 1-[(2-cyclohexymethoxy)methyl]-5-ethyl-6-iodouracil - Drug resistant tp4ek - Drug resistant (z) 3,3',4,5-tetramethoxystilbene - Drug sensitive (z) 4-acetoxy-(3,4',5)-trimethoxystilbene - Drug sensitive 1h-1,4,7-triazonine-1,4-diacetic acid, octahydro- - Drug sensitive 1h-benzimidazole, 5,5'-dithiobis[2-(trifluoromethyl)- (9ci) - Drug sensitive 2-[(3,4-dicloro)anilino]-3-phenyl-5,7-diamino quinoxaline - Drug sensitive 4-[4-(3-Methoxy-phenyl)-piperazin-1 -yl]-5H-pyrrolo[3,2-d]pyrimidine - Drug sensitive 4-morpholinecarbodithioic acid, antimony complex - Drug sensitive 4-thiomorpholinecarbodithioic acid, antimony complex - Drug sensitive 7-n,n-dimethylamino brefeldin a hydrochloride - Drug sensitive 9h-purine, 2-amino-6-(2,4-dichlorobenzylthio)-9-isobutyl- - Drug sensitive benzamide, 5-bromo-2-hydroxy-n-[3-(trifluoromethyl)phenyl]- - Drug sensitive E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive isoflavone, 5,7-dihydroxy-4'-nitro- - Drug sensitive phosphonium, (3-bromopropyl)triphenyl- bromide - Drug sensitive (Z)-3-((2-(4-(trifluoromethyl)phenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive (Z)-6-chloro-3-((2-(4-methoxyphenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive 1-[(2-phenylethoxy)methyl]-5-ethyl-6-(phenylseleno)uracil - Drug sensitive 9-(3-fluorobenzyl)-7-(3-fluorobenzyloxy)-2-(4-fluorobenzyl)-1-methyl-9H-beta-carbolinium bromide - Drug sensitive antineoplastic-615538 - Drug sensitive antineoplastic-641296 - Drug sensitive dichlorobisoxinatotitanium(iv) - Drug sensitive isatin dr - Drug sensitive n-myristoyl-(s)-phenylalaninal diethylcetal - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-545-3p	D-Glucose 5793 Drug interaction    RC00005847 Doxorubicin 31703 Drug interaction    RC00005848 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00005846 Verapamil 2520 Drug interaction    RC00005845 Chemotherapy - Drug interaction    RC00008874

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-545-3p
Interactor2: PDE4B

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.