Detail Information

Basic Information:


  VIRBase ID:  

HHID00060168

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-455-5p:           NUP54:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-455-5p NUP54
miRBase
Accession/Entrez ID		 MIMAT0003150 53371
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - -

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-455-5p
rs1288139869 chr9:114209467    A/G
rs1414847416 chr9:114209466    C/T
rs552585852 chr9:114209470    G/A
rs552585852 chr9:114209470    G/T
rs776650840 chr9:114209469    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR NUP54
chr4:77051354(-) A-I      intronic
chr4:77058257(-) A-I      intronic
chr4:77046615(-) A-I      intronic
chr4:77042758(-) A-I      intronic
chr4:77051205(-) A-I      intronic
chr4:77051200(-) A-I      intronic
chr4:77051231(-) A-I      intronic
chr4:77051255(-) A-I      intronic
chr4:77051266(-) A-I      intronic
chr4:77039596(-) A-I      intronic
chr4:77039601(-) A-I      intronic
chr4:77039953(-) A-I      intronic
chr4:77040153(-) A-I      intronic
chr4:77044855(-) A-I      intronic
chr4:77050854(-) A-I      intronic
chr4:77050949(-) A-I      intronic
chr4:77051181(-) A-I      intronic
chr4:77051301(-) A-I      intronic
chr4:77051304(-) A-I      intronic
chr4:77039611(-) A-I      intronic
chr4:77051154(-) A-I      intronic
chr4:77051349(-) A-I      intronic
chr4:77050906(-) A-I      intronic
chr4:77040019(-) A-I      intronic
chr4:77039820(-) A-I      intronic
chr4:77046621(-) A-I      intronic
chr4:77039914(-) A-I      intronic
chr4:77051317(-) A-I      intronic
chr4:77039968(-) A-I      intronic
chr4:77040617(-) A-I      intronic
chr4:77040734(-) A-I      intronic
chr4:77046614(-) A-I      intronic
chr4:77051314(-) A-I      intronic
chr4:77040049(-) A-I      intronic
chr4:77039913(-) A-I      intronic
chr4:77046530(-) A-I      intronic
chr4:77051219(-) A-I      intronic
chr4:77054665(-) A-I      intronic
chr4:77050971(-) A-I      intronic
chr4:77051313(-) A-I      intronic
chr4:77051239(-) A-I      intronic
chr4:77040658(-) A-I      intronic
chr4:77044804(-) A-I      intronic
chr4:77040804(-) A-I      intronic
chr4:77046706(-) A-I      intronic
chr4:77044939(-) A-I      intronic
chr4:77039830(-) A-I      intronic
chr4:77039694(-) A-I      intronic
chr4:77040036(-) A-I      intronic
chr4:77039822(-) A-I      intronic
chr4:77040157(-) A-I      intronic
chr4:77044862(-) A-I      intronic
chr4:77046640(-) A-I      intronic
chr4:77051186(-) A-I      intronic
chr4:77051331(-) A-I      intronic
chr4:77039744(-) A-I      intronic
chr4:77044728(-) A-I      intronic
chr4:77051328(-) A-I      intronic
chr4:77040657(-) A-I      intronic
chr4:77051230(-) A-I      intronic
chr4:77039666(-) A-I      intronic
chr4:77054689(-) A-I      intronic
chr4:77039569(-) A-I      intronic
chr4:77054587(-) A-I      intronic
chr4:77046361(-) A-I      intronic
chr4:77042739(-) A-I      intronic
chr4:77039678(-) A-I      intronic
chr4:77050896(-) A-I      intronic
chr4:77040612(-) A-I      intronic
chr4:77039763(-) A-I      intronic
chr4:77046594(-) A-I      intronic
chr4:77039821(-) A-I      intronic
chr4:77039662(-) A-I      intronic
chr4:77046335(-) A-I      intronic
chr4:77051271(-) A-I      intronic
chr4:77039572(-) A-I      intronic
chr4:77040008(-) A-I      intronic
chr4:77051206(-) A-I      intronic
chr4:77046332(-) A-I      intronic
chr4:77039658(-) A-I      intronic
chr4:77051298(-) A-I      intronic
chr4:77054675(-) A-I      intronic
chr4:77050931(-) A-I      intronic
chr4:77042742(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED NUP54
chr4:77039658(-) A-I intron -    22327324
chr4:77039662(-) A-I intron -    22327324
chr4:77040046(-) A-I intron -    22327324
chr4:77040019(-) A-I intron -    21960545
chr4:77039569(-) A-G intron -    22484847
chr4:77039658(-) A-G intron -    22484847
chr4:77039662(-) A-G intron -    22484847
chr4:77039913(-) A-G intron -    22484847
chr4:77039914(-) A-G intron -    22484847
chr4:77039924(-) T-C intron -    22484847
chr4:77040046(-) A-G intron -    22484847
chr4:77040658(-) A-G intron -    22484847
chr4:77040680(-) A-G intron -    22484847
chr4:77044728(-) A-G intron -    22484847
chr4:77050896(-) A-G intron -    22484847
chr4:77051271(-) A-G intron -    22484847
chr4:77051298(-) A-G intron -    22484847
chr4:77051317(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase NUP54
chr4:77036327-77036328(-) m6A 3'UTR//exon       24981863//26404942
chr4:77036420-77036421(-) m6A 3'UTR//exon       24284625//24981863//22608085
chr4:77036446-77036447(-) m6A 3'UTR//exon       24284625//24981863//22608085
chr4:77036464-77036465(-) m6A 3'UTR//exon       24284625//24981863//22608085
chr4:77036507-77036508(-) m6A 3'UTR//exon       24284625//24981863//22608085
chr4:77036550-77036551(-) m6A 3'UTR//CDS//exon       24284625//24981863//22608085
chr4:77036566-77036567(-) m6A 3'UTR//CDS//exon       24284625//24981863//22608085
chr4:77036638-77036639(-) m6A 3'UTR//CDS//exon       24981863
chr4:77055343-77055344(-) m6A 3'UTR//CDS//exon//intron       24981863
chr4:77065605-77065606(-) m6A 3'UTR//CDS//exon//intron       -
chr4:77066727-77066728(-) m6A CDS//exon//intron       -
chr4:77069348-77069349(-) m6A exon//intron       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-455-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Pulmonary epithelial cell line (BEAS-2B)     31520698
Exosome Serum     18589210
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Tongue tissue     -
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
NUP54
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells     -
Ribosome-free cytosol Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-455-5p
4-Methyl-3-{[6-(Methylsulfonyl)quinolin-4-Yl]amino}phenol 9927432 Drug sensitive
N~4~-(3-Methyl-1h-Indazol-6-Yl)-N~2~-(3,4,5-Trimethoxyphenyl)pyrimidine-2,4-Diamine 9822610 Drug sensitive
(7S,13E,16S,18R,19E,21R)-21-(Acetyloxy)-7,18-dihydroxy-16,18-dimethyl-10-phenyl[11]cytochalasa-6(12),13,19-triene-1,17-dione 98137101 Drug sensitive
CID 9604911 9604911 Drug sensitive
7-Hydroxystaurosporine 72271 Drug sensitive
5-Nitro-N-(pyridin-3-ylmethyl)furan-2-carboxamide 693996 Drug sensitive
Chalcone analog 6296717 Drug resistant
3-[4-(1H-Indol-3-yl)-1,3-thiazol-2-yl]-1-methyl-1H-indole 60147979 Drug resistant
1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug resistant
Antibiotic 1907-VIII 5477807 Drug resistant
3,19-(4-Acetamido)benzylidineandrographolide 54612901 Drug resistant
Simvastatin 54454 Drug sensitive
Lovastatin 53232 Drug sensitive
N'-(3-Pyridin-2-ylisoquinolin-1-yl)pyridine-2-carboximidamide 463108 Drug resistant
Latrunculin a 445420 Drug sensitive
Trichopolyn 431962 Drug resistant
1H-Indole, 5-bromo-3-[2-(2-pyridinyl)-4-thiazolyl]- 397551 Drug sensitive
Thiosangivamycin 3580213 Drug resistant
Dasatinib 3062316 Drug sensitive
[(4E,6Z,10Z)-20,22-Dihydroxy-13,14,17-trimethoxy-4,8,10,12,16-pentamethyl-3-oxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18(22),19-hexaen-9-yl] carbamate 24199492 Drug resistant
6,7-Dimethoxy-4-(3-hydroxy-4-methylanilino)quinazoline hydrochloride 21701565 Drug sensitive
5-Fluoro deoxy uridine 10mer 16130072 Drug sensitive
N-(3-(1-Aziridinyl)propyl)-1,4-butanediamine 160394 Drug sensitive
Butyltriphenylphosphonium bromide 159628 Drug resistant
Antineoplastic-633273 15954131 Drug resistant
2-Acetylimidazo[4,5-b]pyridin 4 tolyl 3 thiosemicarbazone 135440014 Drug resistant
43-Dioxypectenotoxin 131751434 Drug sensitive
Berberine chloride 12456 Drug resistant
p-Toluquinone 11122 Drug resistant
15,16-Dihydrocuracin A 101683509 Drug resistant
1,4-benzenediamine (9ci), n-butyl-n'-phenyl- - Drug resistant
phosphonium, triphenylpropenyl-, bromide, (e)- (8ci) - Drug resistant
dichlorobisoxinatotitanium(iv) - Drug resistant
leucinostatine d - Drug resistant
n-acetyl-4-s-cystaminyl phenol - Drug resistant
tetra(isobutenyl)antimony bromide - Drug resistant
1,3-diphenyl-4-(3-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1H-pyrazole - Drug sensitive
(-)-furodysinin - Drug sensitive
geldanamycin dimethylglycinate - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-455-5p
Gemcitabine 60750 Drug interaction    RC00005824
Vincristine 5978 Drug interaction    RC00005821
Prednisone 5865 Drug interaction    RC00005820
Temozolomide 5394 Drug interaction    RC00005819
Etoposide 36462 Drug interaction    RC00005823
5-Fluorouracil 3385 Drug interaction    RC00005818
Doxorubicin 31703 Drug interaction    RC00005822
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00005817
Verapamil 2520 Drug interaction    RC00005816
Docetaxel 148124 Drug interaction    RC00005826
Methotrexate 126941 Drug interaction    RC00005825
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-455-5p
Cisplatin 5702198       21575166
5-Fluorouracil 3385       25356050
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-455-5p
Panobinostat       6918837
Irinotecan       60838
l-685,458       5479543

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-455-5p
Interactor2: NUP54

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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