Basic Information:

  VIRBase ID:  

HHID00060162

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-455-5p:  MIMAT0003150          MTF2:  NM_001164393     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-455-5p	MTF2
miRBase Accession/Entrez ID	MIMAT0003150	22823
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	dJ976O13.2//M96//PCL2//TDRD19A

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-455-5p	rs1288139869 chr9:114209467    A/G rs1414847416 chr9:114209466    C/T rs552585852 chr9:114209470    G/A rs552585852 chr9:114209470    G/T rs776650840 chr9:114209469    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MTF2	chr1:93551899(+) A-I      intronic chr1:93600183(+) A-I      intronic chr1:93551920(+) A-I      intronic chr1:93551903(+) A-I      intronic chr1:93601271(+) A-I      intronic chr1:93551910(+) A-I      intronic chr1:93600161(+) A-I      intronic chr1:93551177(+) A-I      intronic chr1:93551183(+) A-I      intronic chr1:93601320(+) A-I      intronic chr1:93601301(+) A-I      intronic chr1:93601210(+) A-I      intronic chr1:93601180(+) A-I      intronic chr1:93600218(+) A-I      intronic chr1:93600168(+) A-I      intronic chr1:93600167(+) A-I      intronic chr1:93581748(+) A-I      intronic chr1:93569608(+) A-I      intronic chr1:93565979(+) A-I      intronic chr1:93565966(+) A-I      intronic chr1:93565955(+) A-I      intronic chr1:93555663(+) A-I      intronic chr1:93558506(+) A-I      intronic chr1:93555740(+) A-I      intronic chr1:93558579(+) A-I      intronic chr1:93558576(+) A-I      intronic chr1:93555595(+) A-I      intronic chr1:93555592(+) A-I      intronic chr1:93565942(+) A-I      intronic chr1:93550306(+) A-I      intronic chr1:93550346(+) A-I      intronic chr1:93550354(+) A-I      intronic chr1:93550813(+) A-I      intronic chr1:93550862(+) A-I      intronic chr1:93550936(+) A-I      intronic chr1:93593851(+) A-I      intronic chr1:93600208(+) A-I      intronic chr1:93569983(+) A-I      intronic chr1:93569625(+) A-I      intronic chr1:93593953(+) A-I      intronic chr1:93551820(+) A-I      intronic chr1:93601158(+) A-I      intronic chr1:93569570(+) A-I      intronic chr1:93567156(+) A-I      intronic chr1:93570115(+) A-I      intronic chr1:93583310(+) A-I      intronic chr1:93554307(+) A-I      intronic chr1:93600343(+) A-I      intronic chr1:93568098(+) A-I      intronic chr1:93570116(+) A-I      intronic chr1:93582336(+) A-I      intronic chr1:93593877(+) A-I      intronic chr1:93593950(+) A-I      intronic chr1:93600146(+) A-I      intronic chr1:93555522(+) A-I      intronic chr1:93582187(+) A-I      intronic chr1:93601266(+) A-I      intronic chr1:93601166(+) A-I      intronic chr1:93600186(+) A-I      intronic chr1:93600316(+) A-I      intronic chr1:93583471(+) A-I      intronic chr1:93600546(+) A-I      intronic chr1:93601141(+) A-I      intronic chr1:93551805(+) A-I      intronic chr1:93601283(+) A-I      intronic chr1:93600185(+) A-I      intronic chr1:93601136(+) A-I      intronic chr1:93593955(+) A-I      intronic chr1:93550919(+) A-I      intronic chr1:93601211(+) A-I      intronic chr1:93600130(+) A-I      intronic chr1:93571333(+) A-I      intronic chr1:93559345(+) A-I      intronic chr1:93551942(+) A-I      intronic chr1:93560608(+) A-I      intronic chr1:93600243(+) A-I      intronic chr1:93600693(+) A-I      intronic chr1:93581715(+) A-I      intronic chr1:93570459(+) A-I      intronic chr1:93568045(+) A-I      intronic chr1:93567221(+) A-I      intronic chr1:93588888(+) A-I      intronic chr1:93600221(+) A-I      intronic chr1:93559340(+) A-I      intronic chr1:93581714(+) A-I      intronic chr1:93566027(+) A-I      intronic chr1:93581684(+) A-I      intronic chr1:93566076(+) A-I      intronic chr1:93567924(+) A-I      intronic chr1:93600132(+) A-I      intronic chr1:93601157(+) A-I      intronic chr1:93594035(+) A-I      intronic chr1:93600113(+) A-I      intronic chr1:93572146(+) A-I      intronic chr1:93555519(+) A-I      intronic chr1:93593905(+) A-I      intronic chr1:93582294(+) A-I      intronic chr1:93569982(+) A-I      intronic chr1:93600238(+) A-I      intronic chr1:93583529(+) A-I      intronic chr1:93550872(+) A-I      intronic chr1:93556966(+) A-I      intronic chr1:93551231(+) A-I      intronic chr1:93601265(+) A-I      intronic chr1:93555352(+) A-I      intronic chr1:93550332(+) A-I      intronic chr1:93601338(+) A-I      intronic chr1:93601133(+) A-I      intronic chr1:93569575(+) A-I      intronic chr1:93569725(+) A-I      intronic chr1:93563255(+) A-I      intronic chr1:93550850(+) A-I      intronic chr1:93600125(+) A-I      intronic chr1:93601262(+) A-I      intronic chr1:93569635(+) A-I      intronic chr1:93551943(+) A-I      intronic chr1:93600105(+) A-I      intronic chr1:93552001(+) A-I      intronic chr1:93568131(+) A-I      intronic chr1:93601212(+) A-I      intronic chr1:93551879(+) A-I      intronic chr1:93601248(+) A-I      intronic chr1:93593954(+) A-I      intronic chr1:93551901(+) A-I      intronic chr1:93600639(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	MTF2	chr1:93585654(+) A-I intron -    15258596 chr1:93585656(+) A-I intron -    15258596 chr1:93585664(+) A-I intron -    15258596 chr1:93593851(+) A-I intron -    15258596 chr1:93593853(+) A-I intron -    15258596 chr1:93593877(+) A-I intron -    15258596 chr1:93593905(+) A-I intron -    15258596 chr1:93593950(+) A-I intron -    15258596 chr1:93593955(+) A-I intron -    15258596 chr1:93551943(+) A-I intron -    22327324 chr1:93600105(+) A-I intron -    22327324 chr1:93601166(+) A-I intron -    22327324 chr1:93601266(+) A-I intron -    22327324 chr1:93550332(+) A-G intron -    22484847 chr1:93550844(+) T-C intron -    22484847 chr1:93550850(+) A-G intron -    22484847 chr1:93550872(+) A-G intron -    22484847 chr1:93550919(+) A-G intron -    22484847 chr1:93551053(+) C-T intron -    22484847 chr1:93551231(+) A-G intron -    22484847 chr1:93551820(+) A-G intron -    22484847 chr1:93551848(+) G-C intron -    22484847 chr1:93551879(+) A-G intron -    22484847 chr1:93551901(+) A-G intron -    22484847 chr1:93551942(+) A-G intron -    22484847 chr1:93551943(+) A-G intron -    22484847 chr1:93567924(+) A-G intron -    22484847 chr1:93568131(+) A-G intron -    22484847 chr1:93569570(+) A-G intron -    22484847 chr1:93569982(+) A-G intron -    22484847 chr1:93569983(+) A-G intron -    22484847 chr1:93570115(+) A-G intron -    22484847 chr1:93570116(+) A-G intron -    22484847 chr1:93570700(+) C-A intron -    22484847 chr1:93572146(+) A-G intron -    22484847 chr1:93581715(+) A-G intron -    22484847 chr1:93582294(+) A-G intron -    22484847 chr1:93582336(+) A-G intron -    22484847 chr1:93600105(+) A-G intron -    22484847 chr1:93600130(+) A-G intron -    22484847 chr1:93600208(+) A-G intron -    22484847 chr1:93600238(+) A-G intron -    22484847 chr1:93600243(+) A-G intron -    22484847 chr1:93600639(+) A-G intron -    22484847 chr1:93601166(+) A-G intron -    22484847 chr1:93601172(+) C-T intron -    22484847 chr1:93601211(+) A-G intron -    22484847 chr1:93601212(+) A-G intron -    22484847 chr1:93601248(+) A-G intron -    22484847 chr1:93601266(+) A-G intron -    22484847 chr1:93601283(+) A-G intron -    22484847 chr1:93601338(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MTF2	chr1:93544851-93544852(+) m6A 5'UTR//exon       24981863 chr1:93544940-93544941(+) m6A 5'UTR//exon       24284625//24981863 chr1:93594862-93594863(+) m1A CDS//exon//intron       26863410 chr1:93594936-93594937(+) m6A CDS//exon//intron       24981863//27773535 chr1:93594946-93594947(+) m6A CDS//exon//intron       24981863//27773535 chr1:93594987-93594988(+) m6A CDS//exon//intron       24981863//27773535 chr1:93599720-93599721(+) m6A CDS//exon       27773535 chr1:93602329-93602330(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22608085 chr1:93602336-93602337(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr1:93602351-93602352(+) Am CDS//exon       - chr1:93602388-93602389(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr1:93602417-93602418(+) Cm CDS//exon       - chr1:93602450-93602451(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr1:93602591-93602592(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr1:93602596-93602597(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr1:93602785-93602786(+) m6A 3'UTR       22608085 chr1:93602791-93602792(+) m6A 3'UTR       22608085 chr1:93602933-93602934(+) m6A 3'UTR       27773535 chr1:93603058-93603059(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-455-5p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Pulmonary epithelial cell line (BEAS-2B)     31520698 Exosome Serum     18589210 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Tongue tissue     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	MTF2	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-455-5p	4-Methyl-3-{[6-(Methylsulfonyl)quinolin-4-Yl]amino}phenol 9927432 Drug sensitive N~4~-(3-Methyl-1h-Indazol-6-Yl)-N~2~-(3,4,5-Trimethoxyphenyl)pyrimidine-2,4-Diamine 9822610 Drug sensitive (7S,13E,16S,18R,19E,21R)-21-(Acetyloxy)-7,18-dihydroxy-16,18-dimethyl-10-phenyl[11]cytochalasa-6(12),13,19-triene-1,17-dione 98137101 Drug sensitive CID 9604911 9604911 Drug sensitive 7-Hydroxystaurosporine 72271 Drug sensitive 5-Nitro-N-(pyridin-3-ylmethyl)furan-2-carboxamide 693996 Drug sensitive Chalcone analog 6296717 Drug resistant 3-[4-(1H-Indol-3-yl)-1,3-thiazol-2-yl]-1-methyl-1H-indole 60147979 Drug resistant 1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug resistant Antibiotic 1907-VIII 5477807 Drug resistant 3,19-(4-Acetamido)benzylidineandrographolide 54612901 Drug resistant Simvastatin 54454 Drug sensitive Lovastatin 53232 Drug sensitive N'-(3-Pyridin-2-ylisoquinolin-1-yl)pyridine-2-carboximidamide 463108 Drug resistant Latrunculin a 445420 Drug sensitive Trichopolyn 431962 Drug resistant 1H-Indole, 5-bromo-3-[2-(2-pyridinyl)-4-thiazolyl]- 397551 Drug sensitive Thiosangivamycin 3580213 Drug resistant Dasatinib 3062316 Drug sensitive [(4E,6Z,10Z)-20,22-Dihydroxy-13,14,17-trimethoxy-4,8,10,12,16-pentamethyl-3-oxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18(22),19-hexaen-9-yl] carbamate 24199492 Drug resistant 6,7-Dimethoxy-4-(3-hydroxy-4-methylanilino)quinazoline hydrochloride 21701565 Drug sensitive 5-Fluoro deoxy uridine 10mer 16130072 Drug sensitive N-(3-(1-Aziridinyl)propyl)-1,4-butanediamine 160394 Drug sensitive Butyltriphenylphosphonium bromide 159628 Drug resistant Antineoplastic-633273 15954131 Drug resistant 2-Acetylimidazo[4,5-b]pyridin 4 tolyl 3 thiosemicarbazone 135440014 Drug resistant 43-Dioxypectenotoxin 131751434 Drug sensitive Berberine chloride 12456 Drug resistant p-Toluquinone 11122 Drug resistant 15,16-Dihydrocuracin A 101683509 Drug resistant 1,4-benzenediamine (9ci), n-butyl-n'-phenyl- - Drug resistant phosphonium, triphenylpropenyl-, bromide, (e)- (8ci) - Drug resistant dichlorobisoxinatotitanium(iv) - Drug resistant leucinostatine d - Drug resistant n-acetyl-4-s-cystaminyl phenol - Drug resistant tetra(isobutenyl)antimony bromide - Drug resistant 1,3-diphenyl-4-(3-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1H-pyrazole - Drug sensitive (-)-furodysinin - Drug sensitive geldanamycin dimethylglycinate - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-455-5p	Gemcitabine 60750 Drug interaction    RC00005824 Vincristine 5978 Drug interaction    RC00005821 Prednisone 5865 Drug interaction    RC00005820 Temozolomide 5394 Drug interaction    RC00005819 Etoposide 36462 Drug interaction    RC00005823 5-Fluorouracil 3385 Drug interaction    RC00005818 Doxorubicin 31703 Drug interaction    RC00005822 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00005817 Verapamil 2520 Drug interaction    RC00005816 Docetaxel 148124 Drug interaction    RC00005826 Methotrexate 126941 Drug interaction    RC00005825

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-455-5p	Cisplatin 5702198       21575166 5-Fluorouracil 3385       25356050

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-455-5p	Panobinostat       6918837 Irinotecan       60838 l-685,458       5479543

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-455-5p
Interactor2: MTF2

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.