Detail Information

Basic Information:


  VIRBase ID:  

HHID00060160

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-455-5p:           NUDT21:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-455-5p NUDT21
miRBase
Accession/Entrez ID		 MIMAT0003150 11051
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CFIM25//CPSF5

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-455-5p
rs1288139869 chr9:114209467    A/G
rs1414847416 chr9:114209466    C/T
rs552585852 chr9:114209470    G/A
rs552585852 chr9:114209470    G/T
rs776650840 chr9:114209469    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR NUDT21
chr16:56469204(-) A-I      intronic
chr16:56469213(-) A-I      intronic
chr16:56469214(-) A-I      intronic
chr16:56469244(-) A-I      intronic
chr16:56477292(-) A-I      intronic
chr16:56469395(-) A-I      intronic
chr16:56477301(-) A-I      intronic
chr16:56469088(-) A-I      intronic
chr16:56469200(-) A-I      intronic
chr16:56469282(-) A-I      intronic
chr16:56469394(-) A-I      intronic
chr16:56469396(-) A-I      intronic
chr16:56469624(-) A-I      intronic
chr16:56475426(-) A-I      intronic
chr16:56477118(-) A-I      intronic
chr16:56477119(-) A-I      intronic
chr16:56477127(-) A-I      intronic
chr16:56477217(-) A-I      intronic
chr16:56477221(-) A-I      intronic
chr16:56479089(-) A-I      intronic
chr16:56478894(-) A-I      intronic
chr16:56469212(-) A-I      intronic
chr16:56477261(-) A-I      intronic
chr16:56474980(-) A-I      intronic
chr16:56469173(-) A-I      intronic
chr16:56478973(-) A-I      intronic
chr16:56479009(-) A-I      intronic
chr16:56478879(-) A-I      intronic
chr16:56479074(-) A-I      intronic
chr16:56478851(-) A-I      intronic
chr16:56478933(-) A-I      intronic
chr16:56478885(-) A-I      intronic
chr16:56474941(-) A-I      intronic
chr16:56478080(-) A-I      intronic
chr16:56469108(-) A-I      intronic
chr16:56478823(-) A-I      intronic
chr16:56469174(-) A-I      intronic
chr16:56479039(-) A-I      intronic
chr16:56469474(-) A-I      intronic
chr16:56478930(-) A-I      intronic
chr16:56469210(-) A-I      intronic
chr16:56478928(-) A-I      intronic
chr16:56478084(-) A-I      intronic
chr16:56477961(-) A-I      intronic
chr16:56478384(-) A-I      intronic
chr16:56475281(-) A-I      intronic
chr16:56479057(-) A-I      intronic
chr16:56478839(-) A-I      intronic
chr16:56475245(-) A-I      intronic
chr16:56478884(-) A-I      intronic
chr16:56469203(-) A-I      intronic
chr16:56477227(-) A-I      intronic
chr16:56469471(-) A-I      intronic
chr16:56469217(-) A-I      intronic
chr16:56469382(-) A-I      intronic
chr16:56474815(-) A-I      intronic
chr16:56477359(-) A-I      intronic
chr16:56479013(-) A-I      intronic
chr16:56475277(-) A-I      intronic
chr16:56479049(-) A-I      intronic
chr16:56478196(-) A-I      intronic
chr16:56477295(-) A-I      intronic
chr16:56478194(-) A-I      intronic
chr16:56469490(-) A-I      intronic
chr16:56469205(-) A-I      intronic
chr16:56477262(-) A-I      intronic
chr16:56469298(-) A-I      intronic
chr16:56477306(-) A-I      intronic
chr16:56477365(-) A-I      intronic
chr16:56476012(-) A-I      intronic
chr16:56477381(-) A-I      intronic
chr16:56478852(-) A-I      intronic
chr16:56477942(-) A-I      intronic
chr16:56476066(-) A-I      intronic
chr16:56469299(-) A-I      intronic
chr16:56469065(-) A-I      intronic
chr16:56474840(-) A-I      intronic
chr16:56475440(-) A-I      intronic
chr16:56478972(-) A-I      intronic
chr16:56469489(-) A-I      intronic
chr16:56467888(-) A-I      intronic
chr16:56478984(-) A-I      intronic
chr16:56475956(-) A-I      intronic
chr16:56478924(-) A-I      intronic
chr16:56478974(-) A-I      intronic
chr16:56478144(-) A-I      intronic
chr16:56477358(-) A-I      intronic
chr16:56477226(-) A-I      intronic
chr16:56469211(-) A-I      intronic
chr16:56475260(-) A-I      intronic
chr16:56469078(-) A-I      intronic
chr16:56469380(-) A-I      intronic
chr16:56476021(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED NUDT21
chr16:56478823(-) A-I intron -    22028664
chr16:56478839(-) A-I intron -    22028664
chr16:56478851(-) A-I intron -    22028664
chr16:56478852(-) A-I intron -    22028664
chr16:56478879(-) A-I intron -    22028664
chr16:56478885(-) A-I intron -    22028664
chr16:56478894(-) A-I intron -    22028664
chr16:56478924(-) A-I intron -    22028664
chr16:56478928(-) A-I intron -    22028664
chr16:56478930(-) A-I intron -    22028664
chr16:56478933(-) A-I intron -    22028664
chr16:56478972(-) A-I intron -    22028664
chr16:56478973(-) A-I intron -    22028664
chr16:56478974(-) A-I intron -    22028664
chr16:56478984(-) A-I intron -    22028664
chr16:56479009(-) A-I intron -    22028664
chr16:56479013(-) A-I intron -    22028664
chr16:56479039(-) A-I intron -    22028664
chr16:56479074(-) A-I intron -    22028664
chr16:56479089(-) A-I intron -    22028664
chr16:56464388(-) C-T exon 3'UTR    21725310

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase NUDT21
chr16:56465647-56465648(-) m6A 3'UTR       27773535
chr16:56465687-56465688(-) m6A 3'UTR       27773535
chr16:56465706-56465707(-) m6A 3'UTR       27773535
chr16:56465972-56465973(-) m6A 3'UTR       27773535
chr16:56466022-56466023(-) m6A 3'UTR       27773535
chr16:56466033-56466034(-) m6A 3'UTR       27773535
chr16:56466040-56466041(-) m6A 3'UTR       27773535
chr16:56466106-56466107(-) m6A 3'UTR       -
chr16:56466164-56466165(-) m6A 3'UTR       -
chr16:56473080-56473081(-) m6A exon//intron       24981863
chr16:56473112-56473113(-) m6A exon//intron       24981863
chr16:56473123-56473124(-) m6A exon//intron       24981863
chr16:56473154-56473155(-) m6A exon//intron       24981863
chr16:56473179-56473180(-) m6A exon//intron       24981863
chr16:56481716-56481717(-) m6A CDS//exon       26404942
chr16:56481782-56481783(-) m6A CDS//exon       26404942//27773535
chr16:56481847-56481848(-) m6A 5'UTR//CDS//exon       26404942//27773535
chr16:56485083-56485084(-) m6A CDS//exon//intron       24284625

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-455-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Pulmonary epithelial cell line (BEAS-2B)     31520698
Exosome Serum     18589210
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Tongue tissue     -
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
NUDT21
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Insoluble cytoplasm K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-455-5p
4-Methyl-3-{[6-(Methylsulfonyl)quinolin-4-Yl]amino}phenol 9927432 Drug sensitive
N~4~-(3-Methyl-1h-Indazol-6-Yl)-N~2~-(3,4,5-Trimethoxyphenyl)pyrimidine-2,4-Diamine 9822610 Drug sensitive
(7S,13E,16S,18R,19E,21R)-21-(Acetyloxy)-7,18-dihydroxy-16,18-dimethyl-10-phenyl[11]cytochalasa-6(12),13,19-triene-1,17-dione 98137101 Drug sensitive
CID 9604911 9604911 Drug sensitive
7-Hydroxystaurosporine 72271 Drug sensitive
5-Nitro-N-(pyridin-3-ylmethyl)furan-2-carboxamide 693996 Drug sensitive
Chalcone analog 6296717 Drug resistant
3-[4-(1H-Indol-3-yl)-1,3-thiazol-2-yl]-1-methyl-1H-indole 60147979 Drug resistant
1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug resistant
Antibiotic 1907-VIII 5477807 Drug resistant
3,19-(4-Acetamido)benzylidineandrographolide 54612901 Drug resistant
Simvastatin 54454 Drug sensitive
Lovastatin 53232 Drug sensitive
N'-(3-Pyridin-2-ylisoquinolin-1-yl)pyridine-2-carboximidamide 463108 Drug resistant
Latrunculin a 445420 Drug sensitive
Trichopolyn 431962 Drug resistant
1H-Indole, 5-bromo-3-[2-(2-pyridinyl)-4-thiazolyl]- 397551 Drug sensitive
Thiosangivamycin 3580213 Drug resistant
Dasatinib 3062316 Drug sensitive
[(4E,6Z,10Z)-20,22-Dihydroxy-13,14,17-trimethoxy-4,8,10,12,16-pentamethyl-3-oxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18(22),19-hexaen-9-yl] carbamate 24199492 Drug resistant
6,7-Dimethoxy-4-(3-hydroxy-4-methylanilino)quinazoline hydrochloride 21701565 Drug sensitive
5-Fluoro deoxy uridine 10mer 16130072 Drug sensitive
N-(3-(1-Aziridinyl)propyl)-1,4-butanediamine 160394 Drug sensitive
Butyltriphenylphosphonium bromide 159628 Drug resistant
Antineoplastic-633273 15954131 Drug resistant
2-Acetylimidazo[4,5-b]pyridin 4 tolyl 3 thiosemicarbazone 135440014 Drug resistant
43-Dioxypectenotoxin 131751434 Drug sensitive
Berberine chloride 12456 Drug resistant
p-Toluquinone 11122 Drug resistant
15,16-Dihydrocuracin A 101683509 Drug resistant
1,4-benzenediamine (9ci), n-butyl-n'-phenyl- - Drug resistant
phosphonium, triphenylpropenyl-, bromide, (e)- (8ci) - Drug resistant
dichlorobisoxinatotitanium(iv) - Drug resistant
leucinostatine d - Drug resistant
n-acetyl-4-s-cystaminyl phenol - Drug resistant
tetra(isobutenyl)antimony bromide - Drug resistant
1,3-diphenyl-4-(3-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1H-pyrazole - Drug sensitive
(-)-furodysinin - Drug sensitive
geldanamycin dimethylglycinate - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-455-5p
Gemcitabine 60750 Drug interaction    RC00005824
Vincristine 5978 Drug interaction    RC00005821
Prednisone 5865 Drug interaction    RC00005820
Temozolomide 5394 Drug interaction    RC00005819
Etoposide 36462 Drug interaction    RC00005823
5-Fluorouracil 3385 Drug interaction    RC00005818
Doxorubicin 31703 Drug interaction    RC00005822
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00005817
Verapamil 2520 Drug interaction    RC00005816
Docetaxel 148124 Drug interaction    RC00005826
Methotrexate 126941 Drug interaction    RC00005825
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-455-5p
Cisplatin 5702198       21575166
5-Fluorouracil 3385       25356050
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-455-5p
Panobinostat       6918837
Irinotecan       60838
l-685,458       5479543

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-455-5p
Interactor2: NUDT21

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region CDS
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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