Detail Information

Basic Information:


  VIRBase ID:  

HHID00060159

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-455-5p:           PJA2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-455-5p PJA2
miRBase
Accession/Entrez ID		 MIMAT0003150 9867
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - Neurodap1//RNF131

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-455-5p
rs1288139869 chr9:114209467    A/G
rs1414847416 chr9:114209466    C/T
rs552585852 chr9:114209470    G/A
rs552585852 chr9:114209470    G/T
rs776650840 chr9:114209469    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR PJA2
chr5:108732301(-) A-I      intronic
chr5:108674173(-) A-I      intronic
chr5:108674286(-) A-I      intronic
chr5:108716740(-) A-I      intronic
chr5:108716747(-) A-I      intronic
chr5:108729841(-) A-I      intronic
chr5:108731531(-) A-I      intronic
chr5:108731181(-) A-I      intronic
chr5:108730954(-) A-I      intronic
chr5:108732260(-) A-I      intronic
chr5:108729860(-) A-I      intronic
chr5:108730007(-) A-I      intronic
chr5:108693841(-) A-I      intronic
chr5:108674299(-) A-I      intronic
chr5:108731579(-) A-I      intronic
chr5:108715906(-) A-I      intronic
chr5:108716733(-) A-I      intronic
chr5:108731618(-) A-I      intronic
chr5:108732299(-) A-I      intronic
chr5:108732298(-) A-I      intronic
chr5:108715891(-) A-I      intronic
chr5:108716459(-) A-I      intronic
chr5:108739602(-) A-I      intronic
chr5:108732252(-) A-I      intronic
chr5:108731512(-) A-I      intronic
chr5:108730988(-) A-I      intronic
chr5:108733443(-) A-I      intronic
chr5:108729982(-) A-I      intronic
chr5:108731026(-) A-I      intronic
chr5:108739603(-) A-I      intronic
chr5:108733358(-) A-I      intronic
chr5:108732131(-) A-I      intronic
chr5:108674218(-) A-I      intronic
chr5:108732265(-) A-I      intronic
chr5:108731619(-) A-I      intronic
chr5:108733374(-) A-I      intronic
chr5:108674149(-) A-I      intronic
chr5:108719462(-) A-I      intronic
chr5:108741856(-) A-I      intronic
chr5:108715892(-) A-I      intronic
chr5:108732292(-) A-I      intronic
chr5:108729335(-) A-I      intronic
chr5:108731184(-) A-I      intronic
chr5:108731047(-) A-I      intronic
chr5:108732225(-) A-I      intronic
chr5:108732399(-) A-I      intronic
chr5:108729950(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED PJA2
chr5:108671198(-) A-I exon 3'UTR    22327324
chr5:108674158(-) A-G intron -    22484847
chr5:108719462(-) A-G intron -    22484847
chr5:108728261(-) G-T intron -    22484847
chr5:108729950(-) A-G intron -    22484847
chr5:108729982(-) A-G intron -    22484847
chr5:108731075(-) A-G intron -    22484847
chr5:108731184(-) A-G intron -    22484847
chr5:108732252(-) A-G intron -    22484847
chr5:108732292(-) A-G intron -    22484847
chr5:108733374(-) A-G intron -    22484847
chr5:108674411(-) G-A intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PJA2
chr5:108698719-108698720(-) m6A CDS       24981863//27773535
chr5:108704285-108704286(-) m6A CDS       24981863//27773535
chr5:108704326-108704327(-) m6A CDS       24981863//27773535
chr5:108704352-108704353(-) m6A CDS       24981863//27773535
chr5:108714022-108714023(-) m6A CDS       24981863//27773535//27371828//22608085
chr5:108714170-108714171(-) m6A CDS       24981863//28052920//26404942//27773535//22608085
chr5:108714196-108714197(-) m6A CDS       24981863//28052920//26404942//27773535//22608085
chr5:108714204-108714205(-) m6A CDS       24981863//28052920//26404942//27773535//22608085
chr5:108714227-108714228(-) m6A CDS       24981863//28052920//26404942//27773535//22608085
chr5:108714254-108714255(-) m6A CDS       24981863//28052920//27773535//22608085
chr5:108714273-108714274(-) m6A CDS       24981863//28052920//27773535//22608085
chr5:108714299-108714300(-) m6A CDS       24981863//27773535//22608085
chr5:108714347-108714348(-) m6A CDS       24981863//27773535
chr5:108714352-108714353(-) m6A CDS       24981863//27773535
chr5:108714356-108714357(-) m6A CDS       27773535
chr5:108714383-108714384(-) m6A CDS       27773535
chr5:108714570-108714571(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr5:108714668-108714669(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085
chr5:108714690-108714691(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085
chr5:108717297-108717298(-) m6A CDS//exon       24981863
chr5:108717318-108717319(-) m6A CDS//exon       24981863
chr5:108717347-108717348(-) m6A CDS//exon       24981863
chr5:108717366-108717367(-) m6A CDS//exon       24981863
chr5:108717397-108717398(-) m6A CDS//exon       24981863
chr5:108719158-108719159(-) m6A 5'UTR//exon       24981863
chr5:108745604-108745605(-) m1A 5'UTR       26863196

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-455-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Pulmonary epithelial cell line (BEAS-2B)     31520698
Exosome Serum     18589210
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Tongue tissue     -
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
PJA2
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|K562 cells     -
Ribosome HEK-293 cells     22199352

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-455-5p
4-Methyl-3-{[6-(Methylsulfonyl)quinolin-4-Yl]amino}phenol 9927432 Drug sensitive
N~4~-(3-Methyl-1h-Indazol-6-Yl)-N~2~-(3,4,5-Trimethoxyphenyl)pyrimidine-2,4-Diamine 9822610 Drug sensitive
(7S,13E,16S,18R,19E,21R)-21-(Acetyloxy)-7,18-dihydroxy-16,18-dimethyl-10-phenyl[11]cytochalasa-6(12),13,19-triene-1,17-dione 98137101 Drug sensitive
CID 9604911 9604911 Drug sensitive
7-Hydroxystaurosporine 72271 Drug sensitive
5-Nitro-N-(pyridin-3-ylmethyl)furan-2-carboxamide 693996 Drug sensitive
Chalcone analog 6296717 Drug resistant
3-[4-(1H-Indol-3-yl)-1,3-thiazol-2-yl]-1-methyl-1H-indole 60147979 Drug resistant
1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug resistant
Antibiotic 1907-VIII 5477807 Drug resistant
3,19-(4-Acetamido)benzylidineandrographolide 54612901 Drug resistant
Simvastatin 54454 Drug sensitive
Lovastatin 53232 Drug sensitive
N'-(3-Pyridin-2-ylisoquinolin-1-yl)pyridine-2-carboximidamide 463108 Drug resistant
Latrunculin a 445420 Drug sensitive
Trichopolyn 431962 Drug resistant
1H-Indole, 5-bromo-3-[2-(2-pyridinyl)-4-thiazolyl]- 397551 Drug sensitive
Thiosangivamycin 3580213 Drug resistant
Dasatinib 3062316 Drug sensitive
[(4E,6Z,10Z)-20,22-Dihydroxy-13,14,17-trimethoxy-4,8,10,12,16-pentamethyl-3-oxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18(22),19-hexaen-9-yl] carbamate 24199492 Drug resistant
6,7-Dimethoxy-4-(3-hydroxy-4-methylanilino)quinazoline hydrochloride 21701565 Drug sensitive
5-Fluoro deoxy uridine 10mer 16130072 Drug sensitive
N-(3-(1-Aziridinyl)propyl)-1,4-butanediamine 160394 Drug sensitive
Butyltriphenylphosphonium bromide 159628 Drug resistant
Antineoplastic-633273 15954131 Drug resistant
2-Acetylimidazo[4,5-b]pyridin 4 tolyl 3 thiosemicarbazone 135440014 Drug resistant
43-Dioxypectenotoxin 131751434 Drug sensitive
Berberine chloride 12456 Drug resistant
p-Toluquinone 11122 Drug resistant
15,16-Dihydrocuracin A 101683509 Drug resistant
1,4-benzenediamine (9ci), n-butyl-n'-phenyl- - Drug resistant
phosphonium, triphenylpropenyl-, bromide, (e)- (8ci) - Drug resistant
dichlorobisoxinatotitanium(iv) - Drug resistant
leucinostatine d - Drug resistant
n-acetyl-4-s-cystaminyl phenol - Drug resistant
tetra(isobutenyl)antimony bromide - Drug resistant
1,3-diphenyl-4-(3-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1H-pyrazole - Drug sensitive
(-)-furodysinin - Drug sensitive
geldanamycin dimethylglycinate - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-455-5p
Gemcitabine 60750 Drug interaction    RC00005824
Vincristine 5978 Drug interaction    RC00005821
Prednisone 5865 Drug interaction    RC00005820
Temozolomide 5394 Drug interaction    RC00005819
Etoposide 36462 Drug interaction    RC00005823
5-Fluorouracil 3385 Drug interaction    RC00005818
Doxorubicin 31703 Drug interaction    RC00005822
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00005817
Verapamil 2520 Drug interaction    RC00005816
Docetaxel 148124 Drug interaction    RC00005826
Methotrexate 126941 Drug interaction    RC00005825
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-455-5p
Cisplatin 5702198       21575166
5-Fluorouracil 3385       25356050
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-455-5p
Panobinostat       6918837
Irinotecan       60838
l-685,458       5479543

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-455-5p
Interactor2: PJA2

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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