Detail Information

Basic Information:


  VIRBase ID:  

HHID00060158

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-455-5p:           SOCS3:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-455-5p SOCS3
miRBase
Accession/Entrez ID		 MIMAT0003150 9021
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - ATOD4//CIS3//Cish3//SOCS-3//SSI-3//SSI3

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-455-5p
rs1288139869 chr9:114209467    A/G
rs1414847416 chr9:114209466    C/T
rs552585852 chr9:114209470    G/A
rs552585852 chr9:114209470    G/T
rs776650840 chr9:114209469    C/T

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SOCS3
chr17:76352903-76352904(-) m6A 3'UTR       24981863//27773535
chr17:76352939-76352940(-) m6A 3'UTR       24284625//24981863//27773535
chr17:76352966-76352967(-) m6A 3'UTR       24284625//24981863//27773535
chr17:76353177-76353178(-) m6A 3'UTR       24284625
chr17:76353229-76353230(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828
chr17:76353316-76353317(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828
chr17:76353479-76353480(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535
chr17:76353537-76353538(-) m6A 3'UTR       24284625//24209618//25456834//27773535
chr17:76353590-76353591(-) m6A 3'UTR       24284625//24209618//25456834//27773535
chr17:76353670-76353671(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535
chr17:76353702-76353703(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535
chr17:76353874-76353875(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828
chr17:76353887-76353888(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828
chr17:76353920-76353921(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27371828
chr17:76354069-76354070(-) Am 3'UTR       -
chr17:76354095-76354096(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr17:76354122-76354123(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr17:76354135-76354136(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr17:76354154-76354155(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr17:76354164-76354165(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr17:76354182-76354183(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr17:76354189-76354190(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr17:76354325-76354326(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr17:76354370-76354371(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr17:76354520-76354521(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr17:76354571-76354572(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960
chr17:76354590-76354591(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960
chr17:76354750-76354751(-) m6A CDS       24284625//24209618//24981863//22575960
chr17:76354901-76354902(-) m6A CDS       24284625//24981863//22575960
chr17:76354908-76354909(-) m6A CDS       24284625//24981863//27371828//22575960
chr17:76354920-76354921(-) m6A CDS       24284625//24981863//27371828//22575960
chr17:76354952-76354953(-) m6A CDS       24284625//24981863//27371828//22575960
chr17:76355006-76355007(-) m6A CDS       24284625//24981863//27371828//22575960
chr17:76355106-76355107(-) m6A CDS       24284625//27371828
chr17:76355126-76355127(-) m6A CDS       24284625//27371828
chr17:76355834-76355835(-) m6A 5'UTR//intron       27371828
chr17:76355847-76355848(-) m6A 5'UTR//intron       27371828
chr17:76355877-76355878(-) m6A 5'UTR//intron       27371828
chr17:76356144-76356145(-) m6A 5'UTR       24209618

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-455-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Pulmonary epithelial cell line (BEAS-2B)     31520698
Exosome Serum     18589210
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Tongue tissue     -
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
SOCS3
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleus K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-455-5p
4-Methyl-3-{[6-(Methylsulfonyl)quinolin-4-Yl]amino}phenol 9927432 Drug sensitive
N~4~-(3-Methyl-1h-Indazol-6-Yl)-N~2~-(3,4,5-Trimethoxyphenyl)pyrimidine-2,4-Diamine 9822610 Drug sensitive
(7S,13E,16S,18R,19E,21R)-21-(Acetyloxy)-7,18-dihydroxy-16,18-dimethyl-10-phenyl[11]cytochalasa-6(12),13,19-triene-1,17-dione 98137101 Drug sensitive
CID 9604911 9604911 Drug sensitive
7-Hydroxystaurosporine 72271 Drug sensitive
5-Nitro-N-(pyridin-3-ylmethyl)furan-2-carboxamide 693996 Drug sensitive
Chalcone analog 6296717 Drug resistant
3-[4-(1H-Indol-3-yl)-1,3-thiazol-2-yl]-1-methyl-1H-indole 60147979 Drug resistant
1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug resistant
Antibiotic 1907-VIII 5477807 Drug resistant
3,19-(4-Acetamido)benzylidineandrographolide 54612901 Drug resistant
Simvastatin 54454 Drug sensitive
Lovastatin 53232 Drug sensitive
N'-(3-Pyridin-2-ylisoquinolin-1-yl)pyridine-2-carboximidamide 463108 Drug resistant
Latrunculin a 445420 Drug sensitive
Trichopolyn 431962 Drug resistant
1H-Indole, 5-bromo-3-[2-(2-pyridinyl)-4-thiazolyl]- 397551 Drug sensitive
Thiosangivamycin 3580213 Drug resistant
Dasatinib 3062316 Drug sensitive
[(4E,6Z,10Z)-20,22-Dihydroxy-13,14,17-trimethoxy-4,8,10,12,16-pentamethyl-3-oxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18(22),19-hexaen-9-yl] carbamate 24199492 Drug resistant
6,7-Dimethoxy-4-(3-hydroxy-4-methylanilino)quinazoline hydrochloride 21701565 Drug sensitive
5-Fluoro deoxy uridine 10mer 16130072 Drug sensitive
N-(3-(1-Aziridinyl)propyl)-1,4-butanediamine 160394 Drug sensitive
Butyltriphenylphosphonium bromide 159628 Drug resistant
Antineoplastic-633273 15954131 Drug resistant
2-Acetylimidazo[4,5-b]pyridin 4 tolyl 3 thiosemicarbazone 135440014 Drug resistant
43-Dioxypectenotoxin 131751434 Drug sensitive
Berberine chloride 12456 Drug resistant
p-Toluquinone 11122 Drug resistant
15,16-Dihydrocuracin A 101683509 Drug resistant
1,4-benzenediamine (9ci), n-butyl-n'-phenyl- - Drug resistant
phosphonium, triphenylpropenyl-, bromide, (e)- (8ci) - Drug resistant
dichlorobisoxinatotitanium(iv) - Drug resistant
leucinostatine d - Drug resistant
n-acetyl-4-s-cystaminyl phenol - Drug resistant
tetra(isobutenyl)antimony bromide - Drug resistant
1,3-diphenyl-4-(3-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1H-pyrazole - Drug sensitive
(-)-furodysinin - Drug sensitive
geldanamycin dimethylglycinate - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-455-5p
Gemcitabine 60750 Drug interaction    RC00005824
Vincristine 5978 Drug interaction    RC00005821
Prednisone 5865 Drug interaction    RC00005820
Temozolomide 5394 Drug interaction    RC00005819
Etoposide 36462 Drug interaction    RC00005823
5-Fluorouracil 3385 Drug interaction    RC00005818
Doxorubicin 31703 Drug interaction    RC00005822
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00005817
Verapamil 2520 Drug interaction    RC00005816
Docetaxel 148124 Drug interaction    RC00005826
Methotrexate 126941 Drug interaction    RC00005825
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-455-5p
Cisplatin 5702198       21575166
5-Fluorouracil 3385       25356050
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-455-5p
Panobinostat       6918837
Irinotecan       60838
l-685,458       5479543

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-455-5p
Interactor2: SOCS3

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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