Basic Information:

  VIRBase ID:  

HHID00060155

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-455-5p:  MIMAT0003150          ZNF138:  NR_073389     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-455-5p	ZNF138
miRBase Accession/Entrez ID	MIMAT0003150	7697
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	pHZ-32

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-455-5p	rs1288139869 chr9:114209467    A/G rs1414847416 chr9:114209466    C/T rs552585852 chr9:114209470    G/A rs552585852 chr9:114209470    G/T rs776650840 chr9:114209469    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ZNF138	chr7:64284145(+) A-I      intronic chr7:64284140(+) A-I      intronic chr7:64283974(+) A-I      intronic chr7:64283863(+) A-I      intronic chr7:64283799(+) A-I      intronic chr7:64283438(+) A-I      intronic chr7:64283432(+) A-I      intronic chr7:64283398(+) A-I      intronic chr7:64275973(+) A-I      NonSyn:Thr->Ala chr7:64283385(+) A-I      intronic chr7:64282035(+) A-I      intronic chr7:64281091(+) A-I      intronic chr7:64280985(+) A-I      intronic chr7:64280223(+) A-I      intronic chr7:64280021(+) A-I      intronic chr7:64280009(+) A-I      intronic chr7:64279882(+) A-I      intronic chr7:64279839(+) A-I      intronic chr7:64279832(+) A-I      intronic chr7:64278875(+) A-I      intronic chr7:64278640(+) A-I      intronic chr7:64278549(+) A-I      intronic chr7:64273997(+) A-I      intronic chr7:64273941(+) A-I      intronic chr7:64278451(+) A-I      intronic chr7:64275123(+) A-I      intronic chr7:64275003(+) A-I      intronic chr7:64274957(+) A-I      intronic chr7:64274933(+) A-I      intronic chr7:64271804(+) A-I      intronic chr7:64265065(+) A-I      intronic chr7:64265007(+) A-I      intronic chr7:64274086(+) A-I      intronic chr7:64284231(+) A-I      intronic chr7:64259662(+) A-I      intronic chr7:64272588(+) A-I      intronic chr7:64271863(+) A-I      intronic chr7:64264989(+) A-I      intronic chr7:64259744(+) A-I      intronic chr7:64257297(+) A-I      intronic chr7:64284276(+) A-I      intronic chr7:64284236(+) A-I      intronic chr7:64284222(+) A-I      intronic chr7:64284205(+) A-I      intronic chr7:64259728(+) A-I      intronic chr7:64284166(+) A-I      intronic chr7:64284158(+) A-I      intronic chr7:64284157(+) A-I      intronic chr7:64284154(+) A-I      intronic chr7:64258541(+) A-I      intronic chr7:64258528(+) A-I      intronic chr7:64258434(+) A-I      intronic chr7:64284151(+) A-I      intronic chr7:64259077(+) A-I      intronic chr7:64259724(+) A-I      intronic chr7:64281203(+) A-I      intronic chr7:64279013(+) A-I      intronic chr7:64257211(+) A-I      intronic chr7:64284049(+) A-I      intronic chr7:64272777(+) A-I      intronic chr7:64279040(+) A-I      intronic chr7:64283307(+) A-I      intronic chr7:64283949(+) A-I      intronic chr7:64283826(+) A-I      intronic chr7:64283904(+) A-I      intronic chr7:64272585(+) A-I      intronic chr7:64287242(+) A-I      intronic chr7:64259139(+) A-I      intronic chr7:64281022(+) A-I      intronic chr7:64259644(+) A-I      intronic chr7:64278966(+) A-I      intronic chr7:64258458(+) A-I      intronic chr7:64285337(+) A-I      intronic chr7:64265574(+) A-I      intronic chr7:64274889(+) A-I      intronic chr7:64284062(+) A-I      intronic chr7:64278952(+) A-I      intronic chr7:64283315(+) A-I      intronic chr7:64274019(+) A-I      intronic chr7:64278403(+) A-I      intronic chr7:64279956(+) A-I      intronic chr7:64281042(+) A-I      intronic chr7:64259674(+) A-I      intronic chr7:64278638(+) A-I      intronic chr7:64278866(+) A-I      intronic chr7:64281043(+) A-I      intronic chr7:64287263(+) A-I      intronic chr7:64279048(+) A-I      intronic chr7:64278989(+) A-I      intronic chr7:64280250(+) A-I      intronic chr7:64280363(+) A-I      intronic chr7:64286813(+) A-I      intronic chr7:64258521(+) A-I      intronic chr7:64259750(+) A-I      intronic chr7:64271853(+) A-I      intronic chr7:64259684(+) A-I      intronic chr7:64283814(+) A-I      intronic chr7:64285319(+) A-I      intronic chr7:64283993(+) A-I      intronic chr7:64278544(+) A-I      intronic chr7:64275091(+) A-I      intronic chr7:64283996(+) A-I      intronic chr7:64285320(+) A-I      intronic chr7:64280195(+) A-I      intronic chr7:64272776(+) A-I      intronic chr7:64279007(+) A-I      intronic chr7:64257237(+) A-I      intronic chr7:64259769(+) A-I      intronic chr7:64258505(+) A-I      intronic chr7:64257393(+) A-I      intronic chr7:64278942(+) A-I      intronic chr7:64259606(+) A-I      intronic chr7:64281176(+) A-I      intronic chr7:64258519(+) A-I      intronic chr7:64258385(+) A-I      intronic chr7:64278564(+) A-I      intronic chr7:64280390(+) A-I      intronic chr7:64281674(+) A-I      intronic chr7:64258342(+) A-I      intronic chr7:64284268(+) A-I      intronic chr7:64258350(+) A-I      intronic chr7:64258974(+) A-I      intronic chr7:64258581(+) A-I      intronic chr7:64281083(+) A-I      intronic chr7:64273951(+) A-I      intronic chr7:64271913(+) A-I      intronic chr7:64274966(+) A-I      intronic chr7:64284237(+) A-I      intronic chr7:64271780(+) A-I      intronic chr7:64265616(+) A-I      intronic chr7:64271986(+) A-I      intronic chr7:64283358(+) A-I      intronic chr7:64258971(+) A-I      intronic chr7:64287290(+) A-I      intronic chr7:64283987(+) A-I      intronic chr7:64278547(+) A-I      intronic chr7:64259770(+) A-I      intronic chr7:64259727(+) A-I      intronic chr7:64271774(+) A-I      intronic chr7:64259601(+) A-I      intronic chr7:64259815(+) A-I      intronic chr7:64282185(+) A-I      intronic chr7:64285264(+) A-I      intronic chr7:64283843(+) A-I      intronic chr7:64259716(+) A-I      intronic chr7:64275024(+) A-I      intronic chr7:64283853(+) A-I      intronic chr7:64284063(+) A-I      intronic chr7:64283855(+) A-I      intronic chr7:64275001(+) A-I      intronic chr7:64257369(+) A-I      intronic chr7:64272676(+) A-I      intronic chr7:64272812(+) A-I      intronic chr7:64280201(+) A-I      intronic chr7:64259036(+) A-I      intronic chr7:64281151(+) A-I      intronic chr7:64280371(+) A-I      intronic chr7:64280231(+) A-I      intronic chr7:64279846(+) A-I      intronic chr7:64257245(+) A-I      intronic chr7:64283831(+) A-I      intronic chr7:64282005(+) A-I      intronic chr7:64258969(+) A-I      intronic chr7:64260224(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ZNF138	chr7:64258342(+) A-G intron -    22484847 chr7:64258350(+) A-G intron -    22484847 chr7:64258458(+) A-G intron -    22484847 chr7:64258521(+) A-G intron -    22484847 chr7:64258539(+) A-G intron -    22484847 chr7:64258571(+) A-G intron -    22484847 chr7:64258936(+) A-G intron -    22484847 chr7:64259036(+) A-G intron -    22484847 chr7:64259037(+) A-G intron -    22484847 chr7:64259078(+) A-G intron -    22484847 chr7:64259567(+) A-G intron -    22484847 chr7:64259601(+) A-G intron -    22484847 chr7:64259606(+) A-G intron -    22484847 chr7:64259644(+) A-G intron -    22484847 chr7:64259674(+) A-G intron -    22484847 chr7:64259681(+) A-G intron -    22484847 chr7:64259684(+) A-G intron -    22484847 chr7:64259793(+) T-A intron -    22484847 chr7:64271780(+) A-G intron -    22484847 chr7:64271853(+) A-G intron -    22484847 chr7:64271913(+) A-G intron -    22484847 chr7:64272585(+) A-G intron -    22484847 chr7:64273951(+) A-G intron -    22484847 chr7:64274961(+) A-G intron -    22484847 chr7:64274966(+) A-G intron -    22484847 chr7:64275001(+) A-G intron -    22484847 chr7:64275033(+) A-G intron -    22484847 chr7:64275091(+) A-G intron -    22484847 chr7:64278403(+) A-G intron -    22484847 chr7:64278544(+) A-G intron -    22484847 chr7:64278547(+) A-G intron -    22484847 chr7:64278564(+) A-G intron -    22484847 chr7:64278578(+) A-G intron -    22484847 chr7:64278874(+) A-G intron -    22484847 chr7:64278966(+) A-G intron -    22484847 chr7:64279013(+) A-G intron -    22484847 chr7:64279021(+) A-G intron -    22484847 chr7:64279049(+) A-G intron -    22484847 chr7:64279879(+) A-G intron -    22484847 chr7:64280231(+) A-G intron -    22484847 chr7:64280362(+) A-G intron -    22484847 chr7:64280363(+) A-G intron -    22484847 chr7:64281022(+) A-G intron -    22484847 chr7:64281043(+) A-G intron -    22484847 chr7:64283261(+) T-A intron -    22484847 chr7:64283307(+) A-G intron -    22484847 chr7:64283315(+) A-G intron -    22484847 chr7:64283358(+) A-G intron -    22484847 chr7:64283813(+) A-G intron -    22484847 chr7:64283814(+) A-G intron -    22484847 chr7:64283825(+) A-G intron -    22484847 chr7:64283826(+) A-G intron -    22484847 chr7:64283831(+) A-G intron -    22484847 chr7:64283853(+) A-G intron -    22484847 chr7:64283855(+) A-G intron -    22484847 chr7:64283987(+) A-G intron -    22484847 chr7:64283989(+) A-G intron -    22484847 chr7:64283996(+) A-G intron -    22484847 chr7:64284063(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZNF138	chr7:64291407-64291408(+) m6A CDS//intron       22608085 chr7:64291413-64291414(+) m6A CDS//intron       22608085 chr7:64291852-64291853(+) m6A 3'UTR//CDS//exon       24284625//24981863//27773535//22608085 chr7:64291870-64291871(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22608085 chr7:64291922-64291923(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr7:64291976-64291977(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr7:64291997-64291998(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr7:64292087-64292088(+) m6A 3'UTR//CDS//exon       24284625//24981863//27773535//22608085 chr7:64292099-64292100(+) m6A 3'UTR//CDS//exon       24284625//24981863//27773535//22608085 chr7:64292114-64292115(+) m6A 3'UTR//CDS//exon       24981863//27773535//22608085 chr7:64292226-64292227(+) m6A 3'UTR//CDS//exon       24981863//22608085 chr7:64292245-64292246(+) m6A 3'UTR//CDS//exon       24981863//22608085 chr7:64292255-64292256(+) m6A 3'UTR//CDS//exon       24981863//22608085 chr7:64292282-64292283(+) m6A 3'UTR//CDS//exon       24284625//24981863//22608085 chr7:64292339-64292340(+) m6A 3'UTR//CDS//exon       24284625//24981863//22608085 chr7:64292366-64292367(+) m6A 3'UTR//CDS//exon       24284625//24981863//22608085 chr7:64292402-64292403(+) m6A 3'UTR//CDS//exon       24284625//24981863//22608085 chr7:64292423-64292424(+) m6A 3'UTR//CDS//exon       24284625//24981863//22608085 chr7:64292450-64292451(+) m6A 3'UTR//CDS//exon       24284625//24981863//22608085 chr7:64292465-64292466(+) m6A 3'UTR//CDS//exon       24284625//24981863//22608085 chr7:64292507-64292508(+) m6A 3'UTR//CDS//exon       24284625//24981863//22608085 chr7:64292534-64292535(+) m6A 3'UTR//CDS//exon       24284625//24981863//22608085 chr7:64292591-64292592(+) m6A 3'UTR//exon       24981863//22608085 chr7:64292702-64292703(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr7:64292759-64292760(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr7:64292786-64292787(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr7:64292870-64292871(+) m6A 3'UTR//exon       24981863//22608085 chr7:64292954-64292955(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr7:64293011-64293012(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr7:64293038-64293039(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr7:64293053-64293054(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr7:64293122-64293123(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr7:64293169-64293170(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr7:64293179-64293180(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr7:64293206-64293207(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr7:64293290-64293291(+) m6A 3'UTR//exon       24981863//22608085 chr7:64293337-64293338(+) m6A 3'UTR//exon       24981863//22608085 chr7:64293363-64293364(+) m6A 3'UTR//exon       24981863//22608085 chr7:64293374-64293375(+) m6A 3'UTR//exon       24981863//22608085 chr7:64293458-64293459(+) m6A 3'UTR//exon       24981863//22608085 chr7:64293486-64293487(+) m6A 3'UTR//exon       24981863//22608085 chr7:64293502-64293503(+) m6A 3'UTR//exon       24981863//22608085 chr7:64293535-64293536(+) m6A 3'UTR//exon       24981863//22608085 chr7:64293619-64293620(+) m6A 3'UTR//exon       24981863//22608085 chr7:64293676-64293677(+) m6A 3'UTR//exon       24981863//22608085 chr7:64293703-64293704(+) m6A 3'UTR//exon       22608085 chr7:64293734-64293735(+) m6A 3'UTR//exon       22608085 chr7:64293752-64293753(+) m6A 3'UTR//exon       22608085 chr7:64293862-64293863(+) m6A 3'UTR//exon       22608085 chr7:64293891-64293892(+) m6A 3'UTR//exon       22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-455-5p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Pulmonary epithelial cell line (BEAS-2B)     31520698 Exosome Serum     18589210 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Tongue tissue     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	ZNF138	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-455-5p	4-Methyl-3-{[6-(Methylsulfonyl)quinolin-4-Yl]amino}phenol 9927432 Drug sensitive N~4~-(3-Methyl-1h-Indazol-6-Yl)-N~2~-(3,4,5-Trimethoxyphenyl)pyrimidine-2,4-Diamine 9822610 Drug sensitive (7S,13E,16S,18R,19E,21R)-21-(Acetyloxy)-7,18-dihydroxy-16,18-dimethyl-10-phenyl[11]cytochalasa-6(12),13,19-triene-1,17-dione 98137101 Drug sensitive CID 9604911 9604911 Drug sensitive 7-Hydroxystaurosporine 72271 Drug sensitive 5-Nitro-N-(pyridin-3-ylmethyl)furan-2-carboxamide 693996 Drug sensitive Chalcone analog 6296717 Drug resistant 3-[4-(1H-Indol-3-yl)-1,3-thiazol-2-yl]-1-methyl-1H-indole 60147979 Drug resistant 1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug resistant Antibiotic 1907-VIII 5477807 Drug resistant 3,19-(4-Acetamido)benzylidineandrographolide 54612901 Drug resistant Simvastatin 54454 Drug sensitive Lovastatin 53232 Drug sensitive N'-(3-Pyridin-2-ylisoquinolin-1-yl)pyridine-2-carboximidamide 463108 Drug resistant Latrunculin a 445420 Drug sensitive Trichopolyn 431962 Drug resistant 1H-Indole, 5-bromo-3-[2-(2-pyridinyl)-4-thiazolyl]- 397551 Drug sensitive Thiosangivamycin 3580213 Drug resistant Dasatinib 3062316 Drug sensitive [(4E,6Z,10Z)-20,22-Dihydroxy-13,14,17-trimethoxy-4,8,10,12,16-pentamethyl-3-oxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18(22),19-hexaen-9-yl] carbamate 24199492 Drug resistant 6,7-Dimethoxy-4-(3-hydroxy-4-methylanilino)quinazoline hydrochloride 21701565 Drug sensitive 5-Fluoro deoxy uridine 10mer 16130072 Drug sensitive N-(3-(1-Aziridinyl)propyl)-1,4-butanediamine 160394 Drug sensitive Butyltriphenylphosphonium bromide 159628 Drug resistant Antineoplastic-633273 15954131 Drug resistant 2-Acetylimidazo[4,5-b]pyridin 4 tolyl 3 thiosemicarbazone 135440014 Drug resistant 43-Dioxypectenotoxin 131751434 Drug sensitive Berberine chloride 12456 Drug resistant p-Toluquinone 11122 Drug resistant 15,16-Dihydrocuracin A 101683509 Drug resistant 1,4-benzenediamine (9ci), n-butyl-n'-phenyl- - Drug resistant phosphonium, triphenylpropenyl-, bromide, (e)- (8ci) - Drug resistant dichlorobisoxinatotitanium(iv) - Drug resistant leucinostatine d - Drug resistant n-acetyl-4-s-cystaminyl phenol - Drug resistant tetra(isobutenyl)antimony bromide - Drug resistant 1,3-diphenyl-4-(3-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1H-pyrazole - Drug sensitive (-)-furodysinin - Drug sensitive geldanamycin dimethylglycinate - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-455-5p	Gemcitabine 60750 Drug interaction    RC00005824 Vincristine 5978 Drug interaction    RC00005821 Prednisone 5865 Drug interaction    RC00005820 Temozolomide 5394 Drug interaction    RC00005819 Etoposide 36462 Drug interaction    RC00005823 5-Fluorouracil 3385 Drug interaction    RC00005818 Doxorubicin 31703 Drug interaction    RC00005822 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00005817 Verapamil 2520 Drug interaction    RC00005816 Docetaxel 148124 Drug interaction    RC00005826 Methotrexate 126941 Drug interaction    RC00005825

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-455-5p	Cisplatin 5702198       21575166 5-Fluorouracil 3385       25356050

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-455-5p	Panobinostat       6918837 Irinotecan       60838 l-685,458       5479543

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-455-5p
Interactor2: ZNF138

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.